Patents Assigned to The Trustees of the Leland Stanford Junior University
  • Patent number: 11980613
    Abstract: This disclosure provides methods of using BAF complex modulating compounds as inhibitors of BAF-mediated transcription in target cells. The BAF complex modulating compounds include 12-membered macrolactam compounds that can target a BAF-specific subunit (e.g., ARID1A) to prevent nucleosomal positioning, relieving transcriptional repression of HIV-1. The subject methods can provide for reversal of latency of HIV-1 in cells in vitro or in vivo. Use of the macrolactam BAF complex modulating compounds represent a method of HIV latency reversal with a unique mechanism of action, which can be optionally combined with other Latency Reversal Agents to improve reservoir targeting. The subject methods can be utilized in conjunction with any convenient methods of treating HIV or HIV latency, including methods related to immune system activation, antiretroviral therapies and/or anti-HIV agents.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: May 14, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Purdue Research Foundation, Erasmus University Medical Center Rotterdam
    Inventors: Emily C. Dykhuizen, Gerald R. Crabtree, Tokameh Mahmoudi
  • Publication number: 20240153107
    Abstract: Systems and methods for performing three-dimensional multi-object tracking are disclosed herein. In one example, a method includes the steps of determining a residual based on augmented current frame detection bounding boxes, augmented previous frame detection bounding boxes, augmented current frame shape descriptors, and augmented previous frame shape descriptors and predicting an affinity matrix using the residual. The residual indicates a spatiotemporal and shape similarity between current detections in a current frame point cloud data and previous detections in a previous frame point cloud data. The affinity matrix indicates associations between the previous detections and the current detections, as well as the augmented anchors.
    Type: Application
    Filed: May 10, 2023
    Publication date: May 9, 2024
    Applicants: Toyota Research Institute, Inc., The Board of Trustees of the Leland Stanford Junior University, Toyota Jidosha Kabushiki Kaisha
    Inventors: Jie Li, Rares A. Ambrus, Taraneh Sadjadpour, Christin Jeannette Bohg
  • Publication number: 20240153101
    Abstract: A method for scene synthesis from human motion is described. The method includes computing three-dimensional (3D) human pose trajectories of human motion in a scene. The method also includes generating contact labels of unseen objects in the scene based on the computing of the 3D human pose trajectories. The method further includes estimating contact points between human body vertices of the 3D human pose trajectories and the contact labels of the unseen objects that are in contact with the human body vertices. The method also includes predicting object placements of the unseen objects in the scene based on the estimated contact points.
    Type: Application
    Filed: October 25, 2023
    Publication date: May 9, 2024
    Applicants: TOYOTA RESEARCH INSTITUTE, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Sifan YE, Yixing WANG, Jiaman LI, Dennis PARK, C. Karen LIU, Huazhe XU, Jiajun WU
  • Publication number: 20240148858
    Abstract: There are provided herein, inter alia, complexes, compositions and methods for a vaccine for COVID-19. The cell-penetrating complexes provided herein may include a nucleic acid non-covalently bound to a cationic amphipathic polymer, the cationic amphipathic polymer including a pH-sensitive immolation domain. The cell-penetrating complexes provided herein are, inter alia, useful in vaccines, wherein the vaccine includes a ribonucleic acid including a sequence encoding a viral protein, a nucleic acid adjuvant and a cationic amphipathic polymer provided herein including embodiments thereof.
    Type: Application
    Filed: July 26, 2021
    Publication date: May 9, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ronald Levy, Ole Audun Werner Haabeth, Adrienne Sallets, Timothy R. Blake, Paul Wender, Robert M. Waymouth, Debra Czerwinski, Idit Sagiv-Barfi, Julian Johannes Lohmeyer
  • Publication number: 20240149267
    Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.
    Type: Application
    Filed: August 11, 2023
    Publication date: May 9, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mahdokht Masaeli, Euan A. Ashley
  • Patent number: 11974981
    Abstract: Methods and compositions are provided for treating endometriosis in an individual, and the pain associated with endometriosis. Aspects of the methods include administering to the individual an agent that promotes ALDH activity.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: May 7, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric Gross, Daria Mochly-Rosen, Stacy Lynn McAllister
  • Patent number: 11977312
    Abstract: Provided is an optical modulator including a substrate, and a plurality of meta units provided on the substrate and spaced apart from each other, wherein at least one of the plurality of meta units includes a metal layer provided on the substrate, a dielectric layer provided an upper surface and side surfaces of the metal layer, and an antenna provided on an upper surface of the dielectric layer, the antenna including phase change material, wherein a refractive index of the phase change material changes based on a voltage applied to the metal layer to modulate incident light.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: May 7, 2024
    Assignees: SAMSUNG ELECTRONICS CO., LTD., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Junghyun Park, Mark L. Brongersma, Yifei Wang
  • Patent number: 11975123
    Abstract: A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: May 7, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric Andrew Appel, Y. Joseph Woo, Lyndsay Stapleton
  • Patent number: 11979028
    Abstract: Described is a locomotive implant for usage within a predetermined magnetic field. In one embodiment magnetohydrodynamics is used to generate thrust with a plurality of electrodes. In another embodiment, asymmetric drag forces are used to generate thrust.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: May 7, 2024
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Daniel M. Pivonka, Anatoly Anatolievich Yakovlev, Ada Shuk Yan Poon, Teresa H. Meng
  • Publication number: 20240144663
    Abstract: A system is disclosed that includes a computer that includes a processor and a memory, the memory including instructions executable by the processor to input an image acquired by a sensor to a neural network to output a prediction regarding an object included in the image. The neural network can be trained, based on (a) a distributed robust optimization that minimizes an expectation applied to probability distributions of loss functions to select training images that yield a solution with a selected uncertainty level and (b) generating additional input images based on adversarial images.
    Type: Application
    Filed: November 1, 2022
    Publication date: May 2, 2024
    Applicants: Ford Global Technologies, LLC, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Xinru Hua, Huanzhong Xu, Jose Blanchet, Viet Anh Nguyen, Marcos Paul Gerardo Castro
  • Publication number: 20240144584
    Abstract: A method of training a neural network model to generate a three-dimensional (3D) model of a scene includes: generating the 3D model based on a latent code; based on the 3D model, sampling a camera view including a camera position and a camera angle corresponding to the 3D model of the scene; generating a two-dimensional (2D) image based on the 3D model and the sampled camera view; and training the neural network model to, using the 3D model, generate a scene corresponding to the sampled camera view based on the generated 2D image and a real 2D image.
    Type: Application
    Filed: July 24, 2023
    Publication date: May 2, 2024
    Applicants: Samsung Electronics Co., Ltd., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Minjung SON, Jeong Joon PARK, Gordon WETZSTEIN
  • Patent number: 11973233
    Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: April 30, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Volkswagen Aktiengesellschaft
    Inventors: Friedrich B. Prinz, Shicheng Xu, Yongmin Kim, Thomas Jaramillo, Drew C. Higgins, Maha Yusuf, Zhaoxuan Wang, Kyung Min Lee, Marat Orazov, Dong Un Lee, Tanja Graf, Thomas Schladt, Gerold Huebner, Hanna-Lena Wittern, Jonathan Edward Mueller
  • Patent number: 11969526
    Abstract: A tissue adhesion prevention hydrogel is provided and engineered with essential features for maintaining separation between tissues and organs in any part of the body, thus preventing adhesion formation, are their shear-thinning, viscoelasticity, and rapid self-healing. A method of using the tissue adhesion prevention hydrogel for tissue adhesion prevention is also provided. A method of interposing the tissue adhesion prevention in between tissue layers for tissue adhesion prevention is further provided.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: April 30, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Eric Andrew Appel, Y. Joseph Woo, Lyndsay Stapleton
  • Patent number: 11969433
    Abstract: Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: April 30, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Helen M. Blau, Andrew Tri Van Ho, Adelaida R. Palla
  • Publication number: 20240131196
    Abstract: Embodiments herein describe systems and methods to enhance RNA stability and uses thereof. Many embodiments alter the sequence of an RNA therapeutic molecule (e.g., vaccines) to encode for a variant peptide while maintaining and/or increasing stability of the RNA therapeutic.
    Type: Application
    Filed: June 30, 2021
    Publication date: April 25, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Rhiju Das, Hannah K. Wayment-Steele
  • Patent number: 11963998
    Abstract: Compositions and methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: April 23, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Peter Luke Santa Maria, Yunzhi Yang, Sungwoo Kim, Chloe Domville-Lewis
  • Patent number: 11965215
    Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: April 23, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
  • Patent number: 11968263
    Abstract: A method and a system for managing power resources. One or more measurements received from one or more sensors communicatively coupled to at least one processor are processed. The sensors monitor and measure at least one of: one or more operational parameters associated with operation of at least one equipment, one or more external parameters associated with an environment of the equipment, and one or more power parameters associated with a power consumption by the equipment. Based on the processed one or more measurements, one or more future operational parameters associated with an operation of the are determined. The operation of the equipment is controlled using the determined future operational parameters.
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: April 23, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ram Rajagopal, Gustavo Vianna Cezar, Thomas Navidi, Elizabeth Buechler, Abbas El Gamal
  • Patent number: 11965780
    Abstract: Improved resolution of a time-varying optical measurement is provided with optical intensity modulator(s) having a bandwidth greater than that of the detector array(s). The modulator configuration can have high photon collection efficiency, e.g. by using polarization modulation to split the incident light into several time-gated channels.
    Type: Grant
    Filed: August 29, 2022
    Date of Patent: April 23, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Adam Bowman, Mark A. Kasevich, Brannon Klopfer
  • Patent number: 11965034
    Abstract: Compositions and methods are provided for treating fibrosis in a mammal by administering a therapeutic dose of a pharmaceutical composition.
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: April 23, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Gerlinde Wernig, Irving L. Weissman