Abstract: Systems and methods for the detection of musculoskeletal anomalies are disclosed. Various embodiments are directed to methods to detect and treat anomalies, including fracture (e.g. clavicle), deformity (e.g. scoliosis), and other anomalies. Various embodiments utilize structured white light scanners, while additional embodiments utilize LiDAR to generate 3-dimensional (3D) topographic scans. Various embodiments obtain these scans via a mobile device, such as a mobile phone or tablet. Further embodiments utilize machine learning models to analyze the 3D scans to identify an anomaly and/or a treatment for such anomaly and/or monitor change of that condition over time.

Abstract: Various methods and devices for treatment or assessment of structures or nerves accessible via the nasal cavity utilizing electrical stimulation or signal recording are provided. Devices can include one or more electrodes to provide electrical stimulation or signal recording. Electrodes can be disposed upon an inflatable balloon or a flat-surfaced tool or a precision tip.

Abstract: Methods and systems for synthesizing contrast images from a quantitative acquisition are disclosed. An exemplary method includes performing a quantification scan, using a trained deep neural network to synthesize a contrast image from the quantification scan, and outputting the contrast image synthesized by the trained deep neural network. In another exemplary method, an operator can identify a target contrast type for the synthesized contrast image. A trained discriminator and classifier module determines whether the synthesized contrast image is of realistic image quality and whether the synthesized contrast image matches the target contrast type.

Abstract: Survivors of central nervous system injury commonly present with spastic hypertonia. The affected muscles are hyperexcitable and can display involuntary static muscle tone and an exaggerated stretch reflex. These symptoms affect posture and disrupt activities of daily living. Symptoms are typically measured using subjective manual tests such as the Modified Ashworth Scale; however, more quantitative measures are necessary to evaluate potential treatments. The hands are one of the most common targets for intervention, but few investigators attempt to quantify symptoms of spastic hypertonia affecting the fingers. An Isometric Force Pillow (IFP) is provided herein to quantify involuntary grip force. This lightweight, computerized tool provides a holistic measure of finger flexion force and can be used in various orientations for clinical testing and to measure the impact of assistive devices.

Abstract: Systems and methods of capturing privacy protected images and performing machine vision tasks are described. An embodiment includes a system that includes an optical component and an image processing application configured to capture distorted video using the optical component, where the optical component includes a set of optimal camera lens parameters ?*o learned using machine learning, performing a machine vision task on the distorted video, where the machine vision task includes a set of optimal action recognition parameters ?*c learned using the machine learning, and generating a classification based on the machine vision task, where the machine learning is jointly trained to optimize the optical element and the machine vision task.

Abstract: Provided herein are novel azopodophyllotoxin analog compounds, pharmaceutical compositions comprising them, and their use as inhibitors of Y box protein 1 (YB1 or YBX1) in treatments for conditions including gynecological, breast, bladder, kidney, head and neck, neuronal, and prostate cancers, lymphomas, and leukemias. Methods of their use in sensitizing resistant cancers to treatment with anticancer agents and radiation are also provided.

Abstract: The present disclosure provides compositions, systems, and methods for genome editing, efficient knock-in of large DNA fragments, and long-term, stable, high expression of integrated transgenes. Also provided are modified cells, vaccines comprising modified cells, and methods of using such cells to induce an immune response.

Abstract: Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.

Abstract: Systems and methods for digitographic measurement of Parkinson's disease in accordance with embodiments of the invention are illustrated. One embodiment includes a digitographic measurement device, including a housing, a plurality of keys attached to the housing, a plurality of sensors, sensor in the plurality of sensors is associated with a key in the plurality of keys and is capable of measuring the amplitude of a key press, and an input/output interface within the housing, where the digitographic measurement device is configured to transmit key press data generated by the sensors to a controller via the input/output interface, and where the key press data is used to generate a plurality of digitographic metrics that describe motor symptoms of a user of the digitographic measurement device.

Abstract: Systems and methods for managing and operating a water supply system in accordance with embodiments on the invention are described. In an embodiment, the system calculates a set of one or more marginal values for a water supply system by: determining a set of transmission marginal values for a transmission stage, determining a set of treatment marginal values for a treatment stage, and determining a set of distribution marginal values for a distribution stage for a set of consumers, where the determining includes backtracking consumed water to a set of one or more raw water sources, identifying a set of one or more marginal paths of water supply from each raw water source to the consumer, and quantifying the intensity of inputs associated with the marginal paths.

Abstract: A method for multiple object tracking includes receiving, with a computing device, a point cloud dataset, detecting one or more objects in the point cloud dataset, each of the detected one or more objects defined by points of the point cloud dataset and a bounding box, querying one or more historical tracklets for historical tracklet states corresponding to each of the one or more detected objects, implementing a 4D encoding backbone comprising two branches: a first branch configured to compute per-point features for each of the one or more objects and the corresponding historical tracklet states, and a second branch configured to obtain 4D point features, concatenating the per-point features and the 4D point features, and predicting, with a decoder receiving the concatenated per-point features, current tracklet states for each of the one or more objects.

Abstract: Provided herein are chimeric transmembrane receptor polypeptides configured to oligomerize upon recognition of an extramembrane signal. The receptors include an extramembrane domain, a transmembrane domain, and an intramembrane domain configured to induce activation of one or more intramembrane signal pathways upon oligomerization of the receptor. The provided receptors are particularly useful for engineered cell therapies. Also provided are systems and host cells including the disclosed receptors, and methods for using the disclosed materials.

Abstract: The present disclosure provides methods of increasing mitochondrial biogenesis, function, or both in a tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating diseases, disorders, or conditions associated with dysfunctional mitochondria and/or increased oxidative stress including mitochondrial diseases.

Abstract: Systems and methods to assess insulin resistance are described. Further, compounds and methods for treatment of insulin resistance or hyperglycemia are described. In some instances, immunoglobins of an individual are utilized in an insulin-stimulated mitochondrial function assay, which can be utilized to determine insulin resistance. In some instances, glycosylation, including sialylation, of immunoglobins of an individual are assessed, which can be utilized to assess insulin resistance. In some instances, immunoglobins, such as immunoglobin G, are utilized as a treatment for insulin resistance or hyperglycemia.

Abstract: Systems and methods for enhancing mRNA translation are disclosed. Some embodiments describe expression constructs for producing a peptide and include a translational enhancer. Additional embodiments describe methods for producing a peptide using a construct including a translational enhancer.

Abstract: A method of epimerizing an (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid is provided. The method comprises contacting the (S)-1-benzylisoquinoline alkaloid with at least one enzyme. Contacting the (S)-1-benzylisoquinoline alkaloid with the at least one enzyme converts the (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid.

Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.

Abstract: A sub-laminate module is described for use in forming composite laminate structures. The module includes a first ply set containing a first ply layer oriented at a first angle and a second ply layer oriented at a second angle, the second angle being unequal the first angle; a second ply set containing a third ply layer oriented at a third angle and a fourth ply layer oriented at a fourth angle, the fourth angle being unequal the third angle; first and second equal acute angles are defined by differences between an absolute value of the first and second angles and the third and fourth angles, respectively, wherein the second ply layer is positioned adjacent the third ply layer and the second and third ply layers are both positioned intermediate the first and fourth ply layers, so as to define a staggered double-double helix sequence of the respective ply layers. Associated composite laminate structures and methods are also disclosed.

Abstract: Blockchain-based, smart contract platforms have great promise to remove trust and add transparency to distributed applications. However, this benefit often comes at the cost of greatly reduced privacy. Techniques for implementing a privacy-preserving smart contract is described. The system can keep accounts private while not losing functionality and with only a limited performance overhead. This is achieved by building a confidential and anonymous token on top of a cryptocurrency. Multiple complex applications can also be built using the smart contract system.

Abstract: Systems and methods are disclosed related to using acoustic waves to detect neural activity in a brain and/or localize the neural activity in the brain. Sensors positioned outside of a skull encasing the brain can detect acoustic waves associated with the neural activity in the brain. From output signals of the sensors, a particular type of neural activity (e.g., a seizure) can be detected. A location of the neural activity can be determined based on outputs of the sensors. In some embodiments, the ultrasound energy can be applied to the location of the neural activity in response to detecting the neural activity.