Patents Assigned to The Trustees of the Leland Stanford Junior University
  • High-throughput precision genome editing
    Patent number: 11760998
    Abstract: The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: September 19, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zachery Smith, Hunter Fraser
  • Personalized 3D neural culture system for generating human oligodendrocytes and studying myelination in vitro
    Patent number: 11760974
    Abstract: Human pluripotent stem cells are differentiated in vitro into oligodendro-spheroids comprising oligodendrocytes for use in analysis, screening programs, and the like.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: September 19, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Rebecca Marton, Sergiu P. Pasca
  • Exosome-total-isolation-chip (ExoTIC) device for isolation of exosome-based biomarkers
    Patent number: 11761952
    Abstract: A device (“the ExoTIC device”) for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: September 19, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Fei Liu, Utkan Demirci, Sanjiv Sam Gambhir, Viswam S. Nair
  • Modified immunoglobulin hinge regions to reduce hemagglutination
    Patent number: 11760810
    Abstract: Polypeptide compositions comprising a human immunoglobulin constant region with a modified IgG4 hinge region having an N-terminal deletion of 1, 2, 3, 4, 5 amino acids, relative to a native human IgG4 hinge sequence are provided. In some embodiments the hinge sequence further comprises the amino acid substitution S228P (Eu numbering). Polypeptides comprising the modified sequence optionally comprise a binding moiety specific for an epitope that is present on red blood cells; and can provide for reduced agglutination of hematopoietic cells compared to a comparable polypeptide with a native hinge region.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: September 19, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jie Liu, Irving L. Weissman, Ravindra Majeti
  • N-path spectral decomposition in acoustic signals
    Patent number: 11763827
    Abstract: A method and device for extracting information from acoustic signals receives acoustic signals by a microphone, processes them in an analog front-end circuit, converts the processed signals from the analog front-end circuit to digital signals by sampling at a rate of less than 1 kHz or more preferably less than 500 kHz; and processes the digital signals by a digital back-end classifier circuit. The analog front-end processing decomposes the received signals into frequency components using a bank of analog N-path bandpass filters having different subband center frequencies.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: September 19, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Boris Murmann, Daniel Augusto Villamizar
  • NON-INVASIVE FETAL GENETIC SCREENING BY DIGTAL ANALYSIS
    Publication number: 20230287503
    Abstract: The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital analysis is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents.
    Type: Application
    Filed: April 26, 2023
    Publication date: September 14, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen QUAKE, Hei-Mun Christina FAN
  • Systems and Methods for Gestational Age Dating and Applications Thereof
    Publication number: 20230288398
    Abstract: Methods to compute gestational age and applications thereof are described. Generally, systems utilize analyte measurements derived from a urine sample to determine a gestational age, which can be used as a basis to perform interventions and treat individuals.
    Type: Application
    Filed: November 8, 2021
    Publication date: September 14, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kevin Contrepois, Michael P. Snyder, Songjie Chen, Nima Aghaeepour, Mohammad Sajjad Ghaemi
  • Composite lithium metal anodes for lithium batteries with reduced volumetric fluctuation during cycling and dendrite suppression
    Patent number: 11757086
    Abstract: A lithium battery includes a cathode, a composite lithium metal anode, and an electrolyte in contact with the cathode and the composite lithium metal anode. The composite lithium metal anode includes a porous matrix and lithium metal disposed within the porous matrix.
    Type: Grant
    Filed: October 11, 2021
    Date of Patent: September 12, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yi Cui, Zheng Liang, Yayuan Liu, Dingchang Lin
  • Octogrid constructions and applications utilizing double-double laminate structures
    Patent number: 11752707
    Abstract: An octogrid structure and method of forming the same for a composite laminate structure is provided. The octogrid sub-structure comprises: a first ply layer comprising a plurality of first elongate tapes oriented in a first direction and a plurality of second elongate tapes oriented in a second direction; and a second ply layer comprising a plurality of third elongate tapes oriented in the first direction and a plurality of fourth elongate tapes oriented in the second direction, the second ply layer being overlaid atop the first ply layer. A first end of each of the elongate tapes is positioned approximately adjacent a midpoint of an adjacently positioned one of the elongate tapes; and a second and opposing end of each of elongate tapes extends freely beyond a central grid portion defined by a length of a portion between the first end and the midpoint of the elongate tapes.
    Type: Grant
    Filed: May 13, 2022
    Date of Patent: September 12, 2023
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Stephen W. Tsai, Chuanxiang Zheng, Surajit Roy
  • VACCINE COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20230277646
    Abstract: Provided herein, inter alia, are complexes comprising nanoparticles attached to viral proteins or nucleic acids encoding said viral proteins. Methods for making and using said complexes are provided. Compositions including the complexes are contemplated to be useful for treating and/or preventing viral infections.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 7, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tarik F. MASSOUD, Ramasamy PAULMURUGAN, Uday SUKUMAR
  • AIR FILTER FOR HIGH-EFFICIENCY PM2.5 CAPTURE
    Publication number: 20230277967
    Abstract: Described here is an air filter comprising a substrate and a network of polymeric nanofibers deposited on the substrate, wherein the air filter a removal efficiency for PM2.5 of at least 70% when a light transmittance is below 50%. Also described here is an electric air filter comprising a first layer adapted to receive a first electric voltage, wherein the first layer comprises an organic fiber coated with a conductive material. Further described is an air filter for high temperature filtration, comprising a substrate and a network of polymeric nanofibers deposited on the substrate, wherein the air filter has a removal efficiency for PM2.5 of at least 70% at a temperature of a least 70° C.
    Type: Application
    Filed: December 20, 2022
    Publication date: September 7, 2023
    Applicant: Board of Trustees of the Leland Stanford Junior University
    Inventors: Yi Cui, Rufan Zhang, Chong Liu, Po-Chun Hsu, Steven Chu
  • Endoscope Systems with Detachable Scopes
    Publication number: 20230277049
    Abstract: Endoscope systems with detachable scopes in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an endoscope system comprises an endoscope body and a detachable scope. The endoscope body comprises a cable capable of transmitting image data to a computing system, and a body connector. The detachable scope comprises a scope connector configured to couple with the body connector, and a tip, comprising an illumination module and an image sensor, wherein image data produced by the image sensor is transmitted to the endoscope body via the scope connector.
    Type: Application
    Filed: March 6, 2023
    Publication date: September 7, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Anna Sophie von Wendorff
  • Systems and Methods for Spatial Graph Convolutions with Applications to Drug Discovery and Molecular Simulation
    Publication number: 20230281465
    Abstract: Systems and methods for spatial graph convolutions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting characteristics for molecules, wherein the method includes performing a first set of graph convolutions with a spatial graph representation of a set of molecules, wherein the first set of graph convolutions are based on bonds between the set of molecules, performing a second set of graph convolutions with the spatial graph representation, wherein the second set of graph convolutions are based on at least a distance between each atom and other atoms of the set of molecules, performing a graph gather with the spatial graph representation to produce a feature vector, and predicting a set of one or more characteristics for the set of molecules based on the feature vector.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 7, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Evan Nathaniel Feinberg, Vijay Satyanand Pande, Bharath Ramsundar
  • Diffraction grating device, method of manufacturing the same, and optical apparatus including the diffraction grating device
    Patent number: 11747528
    Abstract: Provided are a diffraction grating device, a method of manufacturing the diffraction grating device, and an optical apparatus including the diffraction grating device. The diffraction grating device includes a diffraction grating arranged on a light reflection substrate. The diffraction grating includes a plurality of diffraction elements, each diffraction element from among the plurality of diffraction elements having a height that causes a destructive interference between first light rays reflected by a top surface therefore and second light rays reflected by a bottom surface thereof, the first and second light rays being incident on the top and bottom surfaces, respectively, at an incidence angle greater than 45°.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 5, 2023
    Assignees: SAMSUNG ELECTRONICS CO., LTD., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brandon Born, Mark L. Brongersma, Sunghoon Lee
  • Systems and methods for cohort analysis using compressed data objects enabling fast memory lookups
    Patent number: 11748359
    Abstract: Systems and methods for structuring unstructured data according to a data object structure that enables fast query look-ups across a variety of space and time dimensions. Furthermore, many embodiments optimize the storage of the data objects using a set of compression techniques that configure the data types used for the data objects based on properties of the stored data. Furthermore, many embodiments provide are able to service query look-up requests without having to deserialize data within the byte stream format as stored in memory by encoding information that provide memory locations for requested data, thereby allowing for the immediate retrieval of the data as it is stored in the persistent memory.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: September 5, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nigam H. Shah, Vladimir Polony, Juan Manuel Banda, Alison Victoria Callahan
  • Bryostatin compounds and methods of preparing the same
    Patent number: 11746105
    Abstract: Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: September 5, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Paul Wender, Ryan Quiroz, Stephen Ho, Akira Shimizu, Steven Ryckbosch, Matthew C. Stevens, Matthew S. Jeffreys, Clayton Hardman, Jack Sloane
  • Systems and Methods to Enhance RNA Transcription and Uses Thereof
    Publication number: 20230272465
    Abstract: Turning now to the drawings, systems and methods to enhance RNA transcription in a cost-effective manner and uses thereof are provided. One of the most common enzymes for RNA transcription is T7 RNA polymerase. Many embodiments increase RNA yield in transcription reactions by adding ribonucleoside vanadyl complex (VRC) to the transcription reaction. Various embodiments use VRC at low concentrations in an RNA transcription reaction. Reactions in accordance with many embodiments are capable of increasing RNA yield by approximately 2-fold or more.
    Type: Application
    Filed: July 13, 2021
    Publication date: August 31, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eesha Sharma, Ivan Zheludev
  • Biomarkers for assessing subjects with multiple sclerosis
    Patent number: 11740248
    Abstract: Disclosed herein are methods in which an individual with multiple sclerosis (MS) can be classified into one of six subject groups, each subject group predictive for the patient's responsiveness to an interferon-? (IFN-?) therapy. The individual with MS can be classified according to the individual's serum marker levels, e.g., at baseline or following treatment with therapy. Depending on the classification, the individual with MS can be treated with standard therapies (e.g. IFN-?) or one or more alternative therapies with or without IFN-?.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: August 29, 2023
    Assignees: OKLAHOMA MEDICAL RESEARCH FOUNDATION, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Robert C. Axtell, Lawrence Steinman
  • Systems and methods to assess RNA stability
    Patent number: 11739317
    Abstract: Systems and methods for assessing mRNA in vivo and/or in vitro stability are disclosed. Some embodiments methods obtain RNA indexed or barcoded RNA molecules which are then tested against various conditions including stability inside of cells, stability in cell lysate, and stability in solution (e.g., for storage and/or transportation). Additional embodiments describe methods to determine degradation points with single base resolution.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: August 29, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Maria Barna, Kathrin Leppek, Gun Woo Byeon
  • Pareto optimal projection search (POPS) for automated radiation therapy treatment planning
    Patent number: 11738208
    Abstract: A method for radiation therapy treatment planning includes: a) defining a decision variable search space by projecting an initial seed point onto a pareto front, where the pareto front and decision variable search space are defined in the same coordinate space; b) projecting search points in the decision variable search space to the pareto front using a one-dimensional search algorithm to produce projected points on the pareto front; c) updating the search points by performing a gradient-free optimization that evaluates a treatment planning scoring function at the projected points on the pareto front; and d) repeating steps (b), (c) to search within the decision variable search space until a convergence criterion is satisfied, thereby producing a pareto optimal and clinically acceptable treatment plan.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: August 29, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Charles Huang, Lei Xing