Abstract: Systems and methods for structuring unstructured data according to a data object structure that enables fast query look-ups across a variety of space and time dimensions. Furthermore, many embodiments optimize the storage of the data objects using a set of compression techniques that configure the data types used for the data objects based on properties of the stored data. Furthermore, many embodiments provide are able to service query look-up requests without having to deserialize data within the byte stream format as stored in memory by encoding information that provide memory locations for requested data, thereby allowing for the immediate retrieval of the data as it is stored in the persistent memory.

Abstract: This document describes techniques for radio frequency (RF) based micro-motion tracking. These techniques enable even millimeter-scale hand motions to be tracked. To do so, radar signals are used from radar systems that, with conventional techniques, would only permit resolutions of a centimeter or more.

Abstract: In some embodiments, a device for generating mid-infrared radiation is provided. The device may include a thin film quadratic nonlinear waveguide formed on a mid-infrared transparent cladding by a thin film material of a predetermined film thickness, the waveguide having a predetermined etch depth and a predetermined top width. At least one of the predetermined film thickness, the predetermined etch depth, and the predetermined top width may be tuned for the device to generate a coherent idler wave as a mid-infrared radiation from a fixed pump wave and a tunable signal wave.

Abstract: An apparatus and method for extracting nitrogen including compounds from wastewater is disclosed herein. The methods and apparatus use molecularly designed selective electrocatalysts, electrolytes, and separation reactors to enable automated, distributed ammonia manufacturing with minimal environmental impacts. In some embodiments, a method of nitrogen reduction of wastewater is provided. The method includes: providing an apparatus including: a first chamber comprising a salt solution; a second chamber comprising a wastewater source; a third chamber comprising a salt solution and a third electrode, wherein the second chamber is positioned between the first chamber and the third chamber; an anion exchange membrane positioned between the first chamber and the second chamber; and a cation exchange membrane positioned between the second chamber and the third chamber; applying a potential bias between any two of the first chamber, the second chamber, and the third chamber.

Abstract: A non-reciprocal microwave network is provided that includes an in-line ferromagnetic element with adjoining polarizing adapters to achieve directivity via a multi-mode interaction at or near the ferrite to act as new class of 4-port circulator or 2-port isolator, with standard waveguide inputs for assembly in larger networks.

Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.

Abstract: A method of producing para-hydroxybenzoic acid (pHBA) or a derivative thereof includes culturing the recombinant microorganism in a fermentation broth, wherein said recombinant microorganism comprising a genetically engineered pathway expressing at least one nucleic acid sequence encoding a polypeptide selected from: an exogenous chorismate pyruvate lyase of EC 5.4.4.2 or EC 4.1.3.40; an exogenous 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase of EC 4.1.2.15, or EC 2.5.1.54; an exogenous shikimate kinase of EC 2.7.1.71; or an exogenous 3-dehydroquinate dehydratase (DHQ) of EC 4.2.1.10; adding a carbon source to the fermentation broth; and isolating the pHBA from the fermentation broth.

Abstract: Many embodiments provide the formation of active Pd sites upon steam treatment. Steam treatment of Pd catalysts can improve redox combustion reaction efficiencies. Several embodiments provide the formation of twin boundaries under steam treatment can improve catalytic activities of nanoparticle catalysts.

Abstract: The present disclosure provides methods and compositions for treating X-CGD in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a functional, codon-optimized CYBB cDNA at the endogenous CYBB locus.

Abstract: A method for treating a subject suffering from a disease is provided. The method includes diagnosing the subject as suffering from a disease; upregulating the cathelicidin gene CAMP in the subject; and administering to the subject at least one treatment for the disease.

Abstract: Systems and methods for increasing hypnotizability in accordance with embodiments of the invention are illustrated. One embodiment includes a method of treating a recipient using hypnotherapy, including applying neurostimulation to a recipient's brain such that functional connectivity between an anterior cingulate cortex (ACC) and a dorsolateral prefrontal cortex (DLPFC) of the recipient's brain is increased, and activity in the ACC is decreased, and applying hypnotherapy in order to treat a condition of the recipient. In a further embodiment, the condition is selected from the group consisting of depression, anxiety, phobia, pain, stress, disordered eating, sleep disorders, posttraumatic stress, and addiction.

Abstract: A treatment planning prediction method to predict a Dose-Volume Histogram (DVH) or Dose Distribution (DD) for patient data using a machine-learning computer framework is provided with the key inclusion of a Planning Target Volume (PTV) only treatment plan in the framework. A dosimetric parameter is used as an additional parameter to the framework and which is obtained from a prediction of the PTV-only treatment plan. The method outputs a Dose-Volume Histogram and/or a Dose Distribution for the patient including the prediction of the PTV-only treatment plan. The method alleviates the complicated process of quantifying anatomical features and harnesses directly the inherent correlation between the PTV-only plan and the clinical plan in the dose domain. The method provides a more robust and efficient solution to the important DVHs prediction problem in treatment planning and plan quality assurance.

Abstract: Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies.

Abstract: Systems, methods, and other embodiments described herein relate to improving controls in a device according to risk. In one embodiment, a method includes, in response to receiving sensor data about a surrounding environment of the device, identifying objects from the sensor data that are present in the surrounding environment. The method includes generating a control sequence for controlling the device according to a risk-sensitivity parameter to navigate toward a destination while considering risk associated with encountering the objects defined by the risk-sensitivity parameter. The method includes controlling the device according to the control sequence.

Abstract: Kerr and electro-optic frequency comb generation in integrated lithium niobate devices is provided. In various embodiments, a microring resonator comprising lithium niobate is disposed on a thermal oxide substrate. The microring resonator has inner and outer edges. Electrodes are positioned along the inner and outer edges of the microring resonator. The electrodes are adapted to modulate the refractive index of the microring. A pump laser is optically coupled to the microring resonator. The microring resonator is adapted to emit an electro-optical frequency comb when receiving a pump mode from the pump laser and when the electrodes are driven at a frequency equal to a free-spectral-range of the microring resonator.

Abstract: The present disclosure provides meta-optical elements and image sensors using a meta-pattern and apparatuses including the image sensors. In an embodiment, an image sensor includes a plurality of pixels. Each pixel of the plurality of pixels includes a photoelectric conversion layer including at least one photoelectric conversion element, and a color routing meta-structure layer provided at a position facing the photoelectric conversion layer. The color routing meta-structure layer includes a meta-structure having a symmetrical structure with respect to a center of a corresponding pixel, and a multi-layer structure having a refractive index that varies in a direction perpendicular to a light-incident surface.

Abstract: Systems and methods for predicting a future cardiovascular event are provided. Electrocardiogram waveform data can be acquired and utilized in a trained computational model to predict a future cardiovascular event. Clinical interventions, clinical surveillance, and clinical treatments can be performed based on a future cardiovascular event prediction.

Abstract: A method for scarless genome editing is disclosed. In particular, the method provides scarless genome modification by using homology directed repair (HDR) steps to genetically modify cells and remove unwanted sequences. This method can be used for genome editing, including introducing mutations, deletions, or insertions at any position in the genome without leaving silent mutations, selection marker sequences, or other additional undesired sequences in the genome.

Abstract: Methods of deconvolving a feature profile of a physical system are provided herein. The present method may include: optimizing a regression between a) a feature profile of a first plurality of distinct components and b) a reference matrix of feature signatures for a second plurality of distinct components, wherein the feature profile is modeled as a linear combination of the reference matrix, and wherein the optimizing includes solving a set of regression coefficients of the regression, wherein the solution minimizes 1) a linear loss function and 2) an L2-norm penalty function; and estimating the fractional representation of one or more distinct components among the second plurality of distinct components present in the sample based on the set of regression coefficients. Systems and computer readable media for performing the subject methods are also provided.

Abstract: The present disclosure provides variant light-responsive polypeptides, and nucleic acids comprising nucleotide sequences encoding the light-responsive polypeptides. The present disclosure provides methods, devices, and systems for controlling the activity of a cell expressing a variant light-responsive polypeptide of the present disclosure.