Abstract: Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed.

Abstract: The present invention provides compositions, vaccines and methods for inducing protective immunity against filovirus infection, particularly protective immunity against infection of one or more subtypes of Ebola viruses and Marburg virus.

Abstract: Provided herein are polypeptides that are truncated modified recombinant forms of ADAMTS13, nucleic acid molecules encoding the polypeptides, drug delivery compositions and pharmaceutical compositions comprising the polypeptides, and methods of using the polypeptides and compositions (e.g., in the treatment of thrombotic thrombocytopenic purpura (TTP)).

Abstract: Methods, apparatus, and systems are disclosed for implementing a fiber optic reflectance standard (FORS) for testing and/or calibration of a test instrument (TI), which provides a traceable means to calibrate the making optical return loss measurements (ORLM). The apparatus for implementing the FORS may include an optical splitter, first and second optical inputs coupled to the optical splitter, and an optical fiber having first and second ends, and coupled to the optical splitter at the first end of the optical fiber. Furthermore, the apparatus includes an attenuator (e.g., a mechanical attenuator) configured to contain a portion of the optical fiber between the first and second ends and selectively attenuate optical signal gain of the optical fiber. The testing and/or calibration results in an uncertainty that is at least four times better than a typical test instrument.

Abstract: Deposition of Pt nanoparticles on UiO metal organic frameworks via solvothermal reduction is achieved by reducing Pt acetylacetonate (Pt(acac)2) in a UiO-66 and N,N-dimethylformamide (DMF) mixture at, for example, 130° C. for 18 hrs. Modification of reaction temperature and time can control the size of the Pt nanoparticles.

Abstract: Disclosed are apparatus and methods for sensing and measurement of magnetic fields that are insensitive to temperature, and respond linearly to the magnitude of the magnetic field. In particular, the apparatus and methods include the use of a resistance network including at least one fluorinated graphene foam (FGF) magnetoresistive device. Measurement of a voltage drop across at least one FGF magnetoresistive device is correlated to either merely the presence of a magnetic field or for measurement of at least a scalar magnitude value of the magnetic field. The use of FGF affords both temperature-insensitivity and linear magnetic field responsivity.

Abstract: An in vitro release test (IVRT) method and system is provided for drug release testing. The IVRT method, referred to herein as adaptive perfusion, employ tangential-flow filtration (TFF), where released drug products that are smaller than a molecular weight cutoff (MWCO) of a membrane filter pass therethrough into the permeate. Unreleased drug products are retained by the pores of the filter and are recirculated to a retentate reservoir. Fresh media is provided to the retentate in order to maintain a constant total volume for the sample as well as to maintain sink conditions for the drug release. Drug concentration in the retentate and permeate are evaluated by in situ monitoring with one or more sensors and/or by periodic removal of aliquots from the respective reservoirs. In some embodiments, the membrane filter can be conditioned prior to use in order to improve the accuracy, precision, or both of the subsequent testing.

Abstract: Described herein is the preparation of solid acid fuel cell (SAFC) electrode materials suitable for intermediate temperature (200° C.-300° C.) oxygen reduction reaction (ORR) catalysis via anaerobic, in vacuo pyrolysis of metal-organic coordination polymer precursor materials with divalent metals (e.g. Pt or Pd) as nodes to form small, catalytically active nanoparticles inside a porous, electrically conductive carbonized framework.

Abstract: Provided herein are shaped-charges for focusing a filler, such as a fluid mass, and related methods of using the shaped-charges for disruption of an explosive target. The shaped-charge comprises an attenuating body positioned and configured to attenuate rarefaction waves to increase filler, including a fluid mass, explosively driven out of the container toward a target while also maintaining and enhancing fluid jet integrity. To further control impact and impulse forces on a target, additional layers may be used, including a foam layer and a jet-clipping layer positioned between the shaped-charge and the target surface. Also provided are propellant driven liquid disrupters having special attenuating bodies to improve liquid jet column characteristics.

Abstract: A method of determining geo-reference data for a portion of a measurement area includes providing a monitoring assembly comprising a ground station, providing an imaging assembly comprising an imaging device with a lens operably coupled to an aerial device, hovering the aerial device over a measurement area, capturing at least one image of the measurement area within the imaging device, transmitting the at least one image to the ground station using a data transmitting assembly, and scaling the at least one image to determine the geo-reference data for the portion of the measurement area by calculating a size of a field-of-view (FOV) of the lens based on a distance between the imaging device and the measurement area.

Abstract: A pneumatic cryocooler using a pneumatic motor for use in cryogenically cooling superconductors, which pneumatic cryocooler is capable of operation in strong magnetic fields.

Abstract: An apparatus and method for detecting an analyte of interest using paper spray mass spectrometry includes a spray material; a sample on the spray material including an enzyme of interest; a solvent to hydrate the sample, promote enzymatic activity, and extract analytes of interest from the sample; a substrate specific to the enzyme of interest, wherein any of the spray material and the solvent includes the substrate; a voltage source to apply a voltage to the spray material to create charged droplets of a mixture containing the sample; and a mass spectrometer to perform spectrometry on the droplets to perform any of: identify the analytes of interest in the sample; and measure a level of inhibition in any enzymes contained in the sample.

Abstract: This application relates generally to an optical fiber for the delivery of infrared light where the polarization state of the light entering the fiber is preserved upon exiting the fiber and the related methods for making thereof. The optical fiber has a wavelength between about 0.9 ?m and 15 ?m, comprises at least one infrared-transmitting glass, and has a polarization-maintaining (PM) transverse cross-sectional structure. The infrared-transmitting, polarization-maintaining (IR-PM) optical fiber has a birefringence greater than 10?5 and has applications in dual-use technologies including laser power delivery, sensing and imaging.

Abstract: An electrode comprising a conductive textile structure having an inner surface that is connected to one of an electrical power supply and an electrical ground; the conductive textile structure having an outer surface, the outer surface comprising a carbon nanotube (CNT) fiber fabric fixed thereon, the CNT fiber fabric having continuous CNT fiber on the outer surface, wherein the CNT fiber fabric comprises at least one of a CNT fiber, and is at least one of knitted, woven, sewn, and embroidered. The continuous CNT fiber may be a yarn, ribbon, or thread. The CNT fiber fabric includes at least one face having a looped or interlaced structure made from the continuous CNT fiber. The CNT fiber yarn, ribbon, or thread is knitted, woven, sewn, and/or embroidered so that at least one surface comprises a textile made with CNT fiber yarns, ribbons, or threads.

Abstract: An internal combustion rotary engine that produces mechanical torque is provided. The engine includes an annular planar housing, a rotor, and first and second valves. The planar housing has a substantially circular annulus flanked by first and second cavities and an axial shaft disposed between the cavities. The rotor is disposed on the shaft and rotates within the annulus; The first and second valves are disposed within respective the cavities. Each valve has an arc wedge having outer convex surface and an inner concave surface, a shaft hole between and parallel to the surfaces along a rocking axis, and a pivot shaft that passes through the shaft hole to enable the wedge to rock back and forth within the cavity.

Abstract: Compounds that inhibit p38? MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.

Abstract: Compounds that inhibit p38? MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.

Abstract: A method for radiating a co-located antenna including radiating the co-located antenna using a dual mode, where the co-located antenna has an inter-element spacing of about 1? and the dual mode includes a TM11 mode and a TM21 mode. The TM11 mode is radiated to generate a TM11 far field pattern, where the TM11 mode has a broadside pattern characterized with a beam peak at broadside and the TM11 mode produces grating lobes in addition to the beam peak at broadside. The TM21 mode is radiated to generate a TM21 far field pattern orthogonal to the TM11 far field pattern, thereby causing the TM21 mode to produce a null at broadside to suppress the grating lobes produced by the TM11 mode.

Abstract: The present invention relates to a quantum radar system for using entangled photons to detect and range objects. According to an illustrative embodiment of the present disclosure, an entangled photon source generates at least one group of entangled photons each comprising at least one signal photon and an idler photon. The entangled photon source directs the at least one signal photon toward an object of interest and the idler photon towards a slow light section comprising a slow light material. The idler photon passes through the slow light section and continues to a photon detector. The at least one entangled photon reflects off of the objection of interest and continues to the detector.

Abstract: Provided herein are methods of making a training aid for detecting a biohazard, and related devices and methods of using the device, including a canine training aid. The devices are made by positioning a polymer layer in proximity and physically separated from a biological material, so that volatile organic compounds contact and bind or infuse the polymer layer. The device is made render-safe by inactivating the infused polymer layer, such as by heating to a temperature sufficient to inactivate biological agents on or in the analyte-infused polymer layer. The device can be stored in a substantially air-tight configuration for subsequent use in training, such as canine and/or or artificial detectors.