Patents Assigned to The United States of America, As Represented By
  • M971 CHIMERIC ANTIGEN RECEPTORS
    Publication number: 20240084008
    Abstract: The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
    Type: Application
    Filed: November 6, 2023
    Publication date: March 14, 2024
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Rimas J. Orentas, Ira H. Pastan, Dimiter S. Dimitrov, Crystal L. MacKall
  • Antibodies and methods for the diagnosis and treatment of Epstein Barr Virus infection
    Patent number: 11926656
    Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus (EBV) infection in mammals, and methods of using those compositions of matter for the detection, diagnosis and treatment of EBV infection are described. Also described are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: March 12, 2024
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Wei Bu, Masaru Kanekiyo, Michael Gordon Joyce, Jeffrey I. Cohen
  • Microfluidic process for the general electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds
    Patent number: 11926911
    Abstract: A process for the microfluidic electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds comprising the steps of pumping a solution comprising a compound of Formula I into a microfluidic electrochemical reactor in the presence of a base, one of a halide or pseudohalide salt (MY), and a mediator; applying an electrical current through the microfluidic electrochemical reactor; and performing oxidative addition to create a geminal dipseudohalide or halide-pseudohalide compound of the general Formula II
    Type: Grant
    Filed: January 12, 2023
    Date of Patent: March 12, 2024
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Thorsten G. Schroer, Gregory E. LeCroy, Miguel Aguila, Mayra R. Rodriguez, Tyler J. Downard, Brianna L. MacLeod
  • Non-linear charge pump for phased lock loops
    Patent number: 11929753
    Abstract: A non-linear charge pump for phased lock loops. Furthermore, an auxiliary charge pump apparatus, comprising a positive switch electrically connected to a current source configured to supplement power to a charge pump, a negative switch electrically connected to a current sink configured to discharge power from the charge pump, a windowing comparator, further comprising an input signal received from a phase-locked loop, a first comparator configured to compare the input signal against a high voltage threshold, a second comparator configured to compare the input signal against a low voltage threshold, an AND logic gate configured to provide a window signal and an activation circuit electrically connected to the positive switch and negative switch. Additionally, a non-linear charge pump system and method for reacquiring frequency lock of a phase lock loop.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: March 12, 2024
    Assignee: United States of America as represented by the Secretary of the Navy
    Inventors: Jia-Chi Samuel Chieh, Henry Ngo
  • Coronary sinus mitral valve annuloplasty procedure and coronary artery and myocardial protection device
    Patent number: 11925558
    Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. A protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: March 12, 2024
    Assignee: The United States of America, As Represented By The Secretary, Department of Health and Human Services
    Inventors: June-Hong Kim, Robert J. Lederman, Ozgur Kocaturk
  • Liquid crystal elastomers
    Patent number: 11926686
    Abstract: Shape-programmable liquid crystal elastomers. The shape-programmable liquid crystal elastomers being synthesized by filling an alignment cell with liquid crystal monomers. The liquid crystal monomers align to a surface of the alignment cell and then are polymerized with a dithiol chain transfer agent. The alignment cell is configured to impose a director orientation on a portion of the shape-programmable liquid crystal elastomer. For some embodiments, liquid crystal elastomer laminates are prepared by arranging a plurality of liquid crystal elastomers such that a director orientation of each liquid crystal elastomer of the plurality is in registered alignment with an adjacent liquid crystal elastomer of the plurality. The arrangement is secured and the plurality of liquid crystal elastomers cured.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: March 12, 2024
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Nicholas P Godman, Timothy J White, Hilmar Koerner, Benjamin A Kowalski, Anesia D Auguste, Tyler C Guin
  • Diving helmet apparatus
    Patent number: 11926398
    Abstract: A diving helmet apparatus includes a diving helmet that is based on a 98th percentile anthropomorphic head form. The helmet is relatively smaller and lighter than convention diving helmets. The center-of-gravity and center-of-buoyancy of the helmet are co-located to reduce diver fatigue. The apparatus has unique neck dam latch devices that use cam mechanisms. The neck dam and the opening in the helmet that receives the diver's head both have a substantially oval shape that contributes to a significant reduction in the volume of the helmet. The apparatus also uses unique face mask latch devices. The neck dam and face mask latch devices allow a diver to easily secure and remove the helmet and face mask without the assistance of dive tenders.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: March 12, 2024
    Assignee: United States of America as represented by the Secretary of the Navy
    Inventor: Edward Downs, Jr.
  • Intracellular genomic transplant and methods of therapy
    Patent number: 11925664
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 12, 2024
    Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
  • Direct impingement cook-off mechanism and system
    Patent number: 11927433
    Abstract: Embodiments are directed to direct impingement cook-off mitigation systems. As assembled, a munition fuzewell is torqued into the aft end of a munition. During a cook-off event, the expanding gases from the booster energetic will burn instead of detonating. The hot expanding booster gases are vented to the munition's main fill energetic causing the main fill energetic to burn concurrently with the booster energetic. The combined expanding gases from both the booster and main fill energetics are then vented through longitudinal vents.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: March 12, 2024
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Benjamin M. Blazek, Lee R. Hardt
  • Polyimide-gold-nanorod J-aggregates with broadened surface plasmonic resonance band and method of manufacture
    Patent number: 11926726
    Abstract: The invention relates to nanohybrids that are gold nanorod J-aggregates having a broadened surface plasmonic resonance band, processes of making such gold nanorod J-aggregates and products comprising such gold nanorod J-aggregates. Such gold nanorod J-aggregates exhibit broad localized surface plasmonic reasonable range from 800 nm to 2000 nm.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: March 12, 2024
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, Zhenning Yu, Kyoungweon Park, Richard A. Vaia
  • High performance resveratrol cyanate ester formulations
    Patent number: 11926735
    Abstract: The invention relates to cyanate ester resin blends containing resveratrol-based cyanate esters. At room temperature, the cyanate ester resin blend offers improved processability by remaining a liquid or forming a solid that melts at less than 70° C. The cyanate ester resin blend includes a resveratrol-based cyanate ester and a flexible cyanate ester having a configuration different than that of the resveratrol-based cyanate ester, where the resveratrol-based cyanate ester is no more than 80% of the total mass of the cyanate esters in the cyanate ester resin blend. A composite product can include the cyanate ester resin blend and a support material. When making the composite product, the support material is combined with the cyanate resin blend and cured at temperatures ranging from about 100° C. to about 300° C.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: March 12, 2024
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Benjamin G. Harvey, Michael D. Garrison
  • Modular unmanned line/tool emplacement (MULE) hook
    Patent number: 11926507
    Abstract: A hook assembly includes a first hook having a first open end and a second hook having a second open end. The first hook is parallel to the second hook where the first open end is adjacent to the second open end. Extensions extend from each of the first hook and the second hook. The extensions extend perpendicular to a hook plane of the first hook and the second hook members. The first hook is a mirror image of the second hook. A hinge connects the first hook to the second hook. The hinge is located at an opposite end of the hook from where the extensions are located. A resilient member exerts a constant force at the hinge to bias the first hook and the second hook toward an open position.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: March 12, 2024
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Lee Foltz, Adam Pegouske
  • Systems and Methods for Detecting a Travelling Object Vortex
    Publication number: 20240078795
    Abstract: Systems and methods of detecting a vortex made by a travelling object is disclosed. In some configurations, a graphic recognition algorithm and vortex similarity engine are used to determine whether a visual media file captured by a media collector contains a vortex. The vortex similarity engine may be configured to determine or identify certain properties about the travelling object based on the travelling object vortex. In some configurations, a computer may trigger an alert if a travelling object vortex is not expected to be in the visual media file.
    Type: Application
    Filed: November 2, 2023
    Publication date: March 7, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: Mark Fry
  • Method for producing high-performance aviation fuel blendstocks from monoterpenes
    Patent number: 11919847
    Abstract: The invention relates to an efficient, high-throughput method of converting monoterpenes to high performance aviation fuel blendstocks. The method is a one pot, two-step process that includes a dehydration step followed by a hydrogenation step. Both steps can proceed without the use of solvents. Use of biosynthetically generated monoterpenes by this method produces sustainable aviation fuel blendstocks having applications that include use as a full-performance or an ultra-performance jet fuel blendstock.
    Type: Grant
    Filed: February 9, 2023
    Date of Patent: March 5, 2024
    Assignee: United States of America, as represented by the Secretary of the Navy
    Inventors: Benjamin G. Harvey, Karan R. Doppalapudi, Calvin Luke Keller
  • High-resolution cerebrospinal fluid-suppressed T2*-weighted magnetic resonance imaging of cortical lesions
    Patent number: 11921181
    Abstract: Provided herein are methods and systems for high-resolution, cerebrospinal fluid-suppressed T2*-weighted magnetic resonance imaging of cortical lesions.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: March 5, 2024
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Daniel Salo Reich, Erin Savner Beck, Govind Nair, Neville Dali Gai
  • Electrically conducting poly(pyrazoles)
    Patent number: 11920035
    Abstract: This disclosure concerns electrically conducting poly(pyrazoles). The concept of oligomerizing and polymerizing substituted aminopyrazole derivatives combined with a monomer activation procedure involving base-mediated conversion of the protonated pyrazole ring nitrogen to amine salt was developed. This disclosure concerns the specific chemistries needed for the synthesis of a pyrazole monomer used in the polymer synthesis. The procedure used for blending the novel polypyrazoles with other compounds needed for construction of solar cells for testing was developed. This disclosure concerns the concept of using these types of heteroatom-rich, electron-deficient oligomers or polymers as n-dopable or p-dopable electron acceptors in photovoltaic cells. This disclosure concerns synthesizing the starting monomer compounds and polypyrazoles.
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: March 5, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Brett D. Martin, Ian D. Giles, Jawad Naciri, Paul T. Charles, Scott A. Trammell, Jeffrey R. Deschamps, Jeffrey C. Depriest
  • Deformable array of semiconductor devices
    Patent number: 11923472
    Abstract: A deformable array of semiconductor devices, and a method of manufacturing such a deformable array. The deformable array comprises a plurality of islands, where each island contains at least one semiconductor device, and the plurality of islands are arranged in an auxetic geometry.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: March 5, 2024
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Sabrina M. Curtis, Haotian Wang, Gabriel P. Anfinrud, Alexander O. Randolph, Gabriel L. Smith, Nathan S. Lazarus
  • Third party biometric homomorphic encryption matching for privacy protection
    Patent number: 11924349
    Abstract: Systems and methods for secure distribution of biometric matching processing are provided. Certain configurations include homomorphic encrypting of captured biometric information. In some configurations, the biometric information is classified without decryption between a first identity class and a second identity class. The biometric information may be formed as a feature vector. A homomorphic encrypted feature vector may be formed by homomorphic encrypting of the biometric information.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: March 5, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: Arun Vemury
  • Systems and methods for detecting a travelling object vortex
    Patent number: 11922676
    Abstract: Systems and methods of detecting a vortex made by a travelling object is disclosed. Techniques include positioning a media collector to capture a visual media file of the vortex. In some configurations, a graphic recognition algorithm and vortex similarity engine are used to determine whether a visual media file captured by a media collector contains a vortex. In some configurations, a computer may trigger an alert if a travelling object vortex is not expected to be in the visual media file.
    Type: Grant
    Filed: November 15, 2022
    Date of Patent: March 5, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: Mark A. Fry
  • Recombinant respiratory syncytial virus strains comprising NS1 and NS2 gene shifts
    Patent number: 11918638
    Abstract: Reported herein are novel recombinant respiratory syncytial viruses (RSV) having an attenuated phenotype in which the native positions of the NS1 and/or NS2 genes in the RSV genome are shifted to a higher position, that is at positions that are more distal to the promoter. The changes in the gene positions may be present in combination with mutations at other loci to achieve desired levels of attenuation and immunogenicity. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: March 5, 2024
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Peter L. Collins, Thomas Charles McCarty