Patents Assigned to The University of Bath
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Publication number: 20230313258Abstract: Disclosed are methods and kits for producing a conformationally constrained peptide, such as a helix constrained peptide, in a cell. In some cases, the methods comprise contacting a cell comprising an intracellularly-localised recombinant peptide with a cross-linker and culturing the cell in the presence of the cross-linker, wherein the cross-linker forms thioether cross-links with at least two derivatisable amino acids located at anchoring positions in the recombinant peptide. The methods and kits and cells find application, for example, in the identification of inhibitors that can be used to disrupt protein-protein interactions.Type: ApplicationFiled: June 23, 2021Publication date: October 5, 2023Applicant: The University of BathInventor: Jody Michael MASON
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Publication number: 20230234987Abstract: The invention relates to compounds capable of modulating the permeability of junctions between epithelial cells, and their use to facilitate delivery of substances such as therapeutic and diagnostic agents across epithelial surfaces.Type: ApplicationFiled: June 11, 2021Publication date: July 27, 2023Applicant: The University of BathInventors: Randy MRSNY, Alistair TAVERNER, Khaled ALMANSOUR
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Patent number: 11696676Abstract: A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light.Type: GrantFiled: May 4, 2018Date of Patent: July 11, 2023Assignees: THE UNIVERSITY OF BATH, HERIOT-WATT UNIVERSITYInventors: Robert R Thomson, Debaditya Choudhury, Tim Birks
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Publication number: 20230146038Abstract: Disclosed are methods, kits and cells for screening an inhibitor of association between candidate binding partners, such as for screening antagonists of amyloid peptides. The methods, kits and cells employ a reporter expression cassette and hybrid proteins. The reporter expression cassette encodes a reporter and comprises at least one DNA binding site. Each hybrid protein comprises a candidate binding partner and a component of a DNA binding protein and, upon association, form a DNA-binding complex capable of binding to the at least one binding site and inhibiting expression of the reporter. The methods, kits and cells find application, for example, in the identification of inhibitors that may be useful in treating diseases associated with protein aggregation, such as Alzheimer's Disease and Parkinson's Disease.Type: ApplicationFiled: February 3, 2021Publication date: May 11, 2023Applicant: The University of BathInventors: Jody Michael MASON, Neil Mark KAD
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Patent number: 11278218Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.Type: GrantFiled: April 26, 2017Date of Patent: March 22, 2022Assignee: The University of BathInventors: Richard Guy, Adelina Ilie, Luca Lipani, Floriant Doungmene, Bertrand Gilbert Roger Jacques Dupont
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Patent number: 10662222Abstract: A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents; and related methods.Type: GrantFiled: June 12, 2015Date of Patent: May 26, 2020Assignee: The University of BathInventor: Randall Jay Mrsny
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Publication number: 20200008717Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.Type: ApplicationFiled: April 26, 2017Publication date: January 9, 2020Applicant: The University of BathInventors: Richard GUY, Adelina ILIE, Luca LIPANI, Floriant DOUNGMENE, Bertrand Gilbert Roger Jacques DUPONT
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Publication number: 20190282683Abstract: The invention relates to methods and compositions for use in stimulating an immune response against a target antigen. More specifically, it relates to use of domains III and IV of the Staphylococcal Sbi protein as an immunological adjuvant, for enhancing an immune response against a target antigen.Type: ApplicationFiled: November 24, 2017Publication date: September 19, 2019Applicant: THE UNIVERSITY OF BATHInventors: Jean VAN DEN ELSEN, Andrew Graham WATTS, Kevin James MARCHBANK
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Patent number: 10030031Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.Type: GrantFiled: October 3, 2017Date of Patent: July 24, 2018Assignee: The University of BathInventors: John Lewis, Stephen Husbands
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Patent number: 9969746Abstract: The present invention relates to opioid compounds, especially to C14 esters and ethers of naltrexone and analogs thereof. The present invention also relates to compositions, methods and medical uses that employ such compounds. More specifically, the present invention pertains to compounds of formula: and to their use in the treatment of diseases and disorders including pain, hyperalgesia, addiction, substance abuse disorders, stress, anorexia, anxiety, depression, cough, asthma, hypertension, gastrointestinal motility disorder, water retention, cognitive disorders, and locomotor disorders.Type: GrantFiled: December 5, 2014Date of Patent: May 15, 2018Assignee: The University of BathInventors: John Lewis, Stephen Husbands, Lawrence Toll
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Patent number: 9890170Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.Type: GrantFiled: October 27, 2016Date of Patent: February 13, 2018Assignee: The University of BathInventors: John Lewis, Stephen Husbands
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Publication number: 20180030062Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.Type: ApplicationFiled: October 3, 2017Publication date: February 1, 2018Applicant: The University of BathInventors: John Lewis, Stephen Husbands
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Publication number: 20170342025Abstract: The invention discloses compounds of the formula wherein A, B, X, Y and Z are defined. The compounds of the invention show activity against a range of bacteria, and are useful in the treatment or prophylaxis of a bacterial infection in an animal.Type: ApplicationFiled: December 29, 2015Publication date: November 30, 2017Applicants: The University of Bath, Swansea UniversityInventors: Barry Victor Lloyd POTTER, Wolfgang DOHLE, Xiangdong SU, John NORMANTON, Edward DUDLEY, Yamni NIGAM
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Patent number: 9733254Abstract: Methods and apparatus for the in vitro modelling of changes that occur on administration of a drug formulation are described, in particular for studying the changes that take place on administration of protein or peptide drug formulations by subcutaneous injection.Type: GrantFiled: October 3, 2013Date of Patent: August 15, 2017Assignee: The University of BathInventors: Randall Jay Mrsny, Hanne Maarit Kinnunen
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Publication number: 20170044173Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.Type: ApplicationFiled: October 27, 2016Publication date: February 16, 2017Applicant: The University of BathInventors: John LEWIS, Stephen Husbands
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Patent number: 9563839Abstract: A non-biological asynchronous neural network system comprising multiple neurons to receive respective input signals representing an input stimulus for the network, supply an output signal representing a spatio-temporal sequence of rhythmic electric pulses to an external system, wherein respective ones of the multiple neurons are connected using multiple mutually inhibitory links.Type: GrantFiled: May 7, 2013Date of Patent: February 7, 2017Assignee: The University of BathInventor: Alain Nogaret
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Patent number: 9534228Abstract: This invention relates to methods for altering cell proliferation in a plant by modulating the expression of an endogenous plant gene whose expression product affects cell proliferation. These methods can be used to modify plant characteristics, such as seed size. In particular, the invention provides methods for modifying cell proliferation in the integuments and/or seed coats of a plant by inhibiting expression of endogenous gene encoding Auxin response factor 2 (ARF2/MNT) or an orthologue thereof, such that the number of cells in the integuments and/or seed coat is increased, resulting in increased seed size. The plant or plant propagating material can be transformed, e.g., with a nucleic acid construct, to increase or decrease the expression of endogenous genes or the orthologues thereof that affect cell proliferation. The invention also relates to modified plants and reproducible plant material produced by the methods, and nucleic acid constructs for use in such methods.Type: GrantFiled: May 24, 2011Date of Patent: January 3, 2017Assignee: The University of BathInventor: Roderick Scott
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Patent number: 9499852Abstract: The invention provides vesicles that may be used in diagnosing infection, especially with infection by bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. The vesicles can be used in wound dressings.Type: GrantFiled: July 27, 2012Date of Patent: November 22, 2016Assignee: The University of BathInventors: Andrew Tobias Jenkins, Naig Tun Thet, June Mercer-Chalmers
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Patent number: 9480684Abstract: The invention provides a method of treating anxiety or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.Type: GrantFiled: January 20, 2016Date of Patent: November 1, 2016Assignee: The University of BathInventors: John Lewis, Stephen Husbands
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Publication number: 20160304529Abstract: The present invention relates to opioid compounds, especially to C14 esters and ethers of naltrexone and analogues thereof. The present invention also relates to compositions, methods and medical uses that employ such compounds. More specifically, the present invention pertains to compounds of formula: and to their use in the treatment of diseases and disorders including pain, hyperalgesia, addiction, substance abuse disorders, stress, anorexia, anxiety, depression, cough, asthma, hypertension, gastrointestinal motility disorder, water retention, cognitive disorders, and locomotor disorders.Type: ApplicationFiled: December 5, 2014Publication date: October 20, 2016Applicants: THE UNIVERSITY OF BATH, THE TORREY PINES INSTITUTE FOR MOLECULAR STUDIES, SRI INTERNATIONALInventors: John LEWIS, Stephen HUSBANDS, Lawrence TOLL