Abstract: Methods and devices for detecting chiral properties from a sample are provided. Light may be directed towards a sample in contact with a chiral nanoparticle. Third harmonic Mie scattering (THMS) optical activity generated by the chiral nanoparticle in contact with the sample can then be detected. A device for detecting chiral properties of a sample is also contemplated that includes at least one microwell having a volume of ?about 1 microliter configured to hold a chiral nanoparticle capable of generating third harmonic Mie scattering (THMS) optical activity and a sample to be analyzed. The device includes a source of light configured to generate and direct light toward the at least one microwell containing the chiral nanoparticle and the sample and at least one detector configured to detect third harmonic Mie scattering (THMS) generated by the chiral nanoparticle in the microwell.

Abstract: A method for controlling flight of an aircraft system comprises deriving a liability map using mapping data related to one or more ground hazard categories, wherein each ground hazard category is associated with a type of hazard on a ground surface. The liability map comprises a plurality of risk liability values (L1 and/or L2) associated with the one or more ground hazard categories. The liability map is used to control one or more parameters for controlling flight of the aircraft system.

Abstract: A system for detecting objects in space comprises an array of satellite nodes. The array of satellite nodes comprise at least one transmitter module for transmitting an electromagnetic signal, and a plurality of receiver modules for receiving diffractions from electromagnetic waves scattered from objects in space. The system comprises a control module for focussing the plurality of receiver modules to receive diffractions from a focussed virtual aperture in space.

Abstract: Disclosed herein are methods and compositions for treating neutrophil-mediated inflammation by targeting, in any combination, the pro-inflammatory MRP2/HXA3 pathway and/or the anti-inflammatory P-gp/endocannabinoid pathway and/or the anti-inflammatory MRP 1/L-AMEND pathway, comprising administering to the subject a therapeutically effective amount of (a) one or more first compound that inhibits the activity and/or level of one or more of multidrug resistance protein 2 (MRP2) and hepoxilin A3 (HXA3) synthase, and/or (b) one or more second compound that increases the level and/or activity of one or more N-acylethanolamines (NAEs), and/or (c) one or more third compound that increases the level and/or activity of multidrug resistance protein 1 (MRP1), wherein the therapeutic amount of the first, second, and third compounds reduces migration of neutrophils into the target tissue.

Abstract: The present invention provides an air filter comprising a polymer foam and an adsorbent material wherein said polymer foam comprises metal particles.

Abstract: Disclosed are methods and kits for producing a conformationally constrained peptide, such as a helix constrained peptide, in a cell. In some cases, the methods comprise contacting a cell comprising an intracellularly-localised recombinant peptide with a cross-linker and culturing the cell in the presence of the cross-linker, wherein the cross-linker forms thioether cross-links with at least two derivatisable amino acids located at anchoring positions in the recombinant peptide. The methods and kits and cells find application, for example, in the identification of inhibitors that can be used to disrupt protein-protein interactions.

Abstract: The invention relates to compounds capable of modulating the permeability of junctions between epithelial cells, and their use to facilitate delivery of substances such as therapeutic and diagnostic agents across epithelial surfaces.

Abstract: A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light.

Abstract: Disclosed are methods, kits and cells for screening an inhibitor of association between candidate binding partners, such as for screening antagonists of amyloid peptides. The methods, kits and cells employ a reporter expression cassette and hybrid proteins. The reporter expression cassette encodes a reporter and comprises at least one DNA binding site. Each hybrid protein comprises a candidate binding partner and a component of a DNA binding protein and, upon association, form a DNA-binding complex capable of binding to the at least one binding site and inhibiting expression of the reporter. The methods, kits and cells find application, for example, in the identification of inhibitors that may be useful in treating diseases associated with protein aggregation, such as Alzheimer's Disease and Parkinson's Disease.

Abstract: A method of forming an imaging fibre apparatus comprises arranging rods to form a plurality of stacks each comprising a respective plurality of rods, wherein: for each stack, the respective plurality of rods comprises rods having different core sizes, the rods of different core sizes being arranged in a selected arrangement, and the rods of different core sizes being arranged such that each stack has a respective selected shape; wherein the selected shape or shapes are such that the stacks stack together in a desired arrangement; the method further comprising: drawing each of the plurality of stacks; stacking together the plurality of drawn stacks together in the desired arrangement to form a further stack; drawing the further stack; and using the drawn further stack to form an imaging fibre apparatus, wherein the selected arrangement of the rods in each stack and the selected shape or shapes of the stacks are such that the further stack comprises a repeating pattern of rods of different core sizes.

Abstract: An in vitro method for identifying, isolating and/or enriching primate naive pluripotent stem cells, the method including analyzing transcription of a type 7 long terminal repeat (LTR7) nucleic acid sequence of a type H human endogenous retrovirus (HERVH) (LTR7/HERVH-associated transcription), and identifying, isolating and/or enriching primate naive pluripotent stem cells based on LTR7/HERVH-associated transcription, wherein LTR7/HERVH-associated transcription is a marker for primate naive pluripotent stem cells. An isolated in vitro population of primate naive pluripotent stem cells is obtained by the method, wherein in the cells LTR7/HERVH-associated transcription is elevated in comparison to control cells, wherein control cells are primed pluripotent stem cells or differentiated cells.

Abstract: A method of forming an imaging fibre apparatus comprises arranging rods to form a plurality of stacks each comprising a respective plurality of rods, wherein: for each stack, the respective plurality of rods comprises rods having different core sizes, the rods of different core sizes being arranged in a selected arrangement, and the rods of different core sizes being arranged such that each stack has a respective selected shape; wherein the selected shape or shapes are such that the stacks stack together in a desired arrangement; the method further comprising: drawing each of the plurality of stacks; stacking together the plurality of drawn stacks together in the desired arrangement to form a further stack; drawing the further stack; and using the drawn further stack to form an imaging fibre apparatus, wherein the selected arrangement of the rods in each stack and the selected shape or shapes of the stacks are such that the further stack comprises a repeating pattern of rods of different core sizes.

Abstract: A method for determining a flight path for an aircraft system, for example an unmanned aircraft system (UAS) comprises analysing an intensity map relating to a three dimensional space. The intensity map comprises an array of voxels, each voxel defining a volume in the three dimensional space, and each voxel having a related traffic intensity value based on historical flight data through that voxel. The method comprises determining a probability of an encounter for a preferred flight path between a start point and an end point via one or more voxels in the three dimensional space, based on traffic intensity values of the one or more voxels along the preferred flight path. The preferred flight path is selected if the probability of encounter is less than a first threshold value.

Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.

Abstract: A method of forming an imaging fibre apparatus comprises arranging rods to form a plurality of stacks each comprising a respective plurality of rods, wherein: for each stack, the respective plurality of rods comprises rods having different core sizes, the rods of different core sizes being arranged in a selected arrangement, and the rods of different core sizes being arranged such that each stack has a respective selected shape; wherein the selected shape or shapes are such that the stacks stack together in a desired arrangement; the method further comprising: drawing each of the plurality of stacks; stacking together the plurality of drawn stacks together in the desired arrangement to form a further stack; drawing the further stack; and using the drawn further stack to form an imaging fibre apparatus, wherein the selected arrangement of the rods in each stack and the selected shape or shapes of the stacks are such that the further stack comprises a repeating pattern of rods of different core sizes.

Abstract: A protein structure analysis method includes receiving a fluorescence emission spectrum generated by a protein sample at a first excitation wavelength, evaluating, from the fluorescence emission spectrum, an indication characteristic of a fluorescence response of the protein sample at the first excitation wavelength, and repeating the receiving and evaluating steps in relation to a plurality of fluorescence emission spectra generated by the protein sample at a different excitation wavelength to the first excitation wavelength. In addition, the method includes generating a non-linear relationship between excitation wavelength and indication characteristic of fluorescence response of the protein sample that includes an indication of at least one characteristic of the conformational state of the protein sample.

Abstract: The present invention provides a way to capture a biomolecule such as a protein in one or more layers of covalently bonded amorphous silica, forming a cage or shell which preserves the shape of the protein and prevents denaturation caused by heat and/or aging and/or non-physiological conditions, through unfolding and loss of secondary and/or higher order structure.

Abstract: An apparatus for generating electrical energy comprises an oscillating heat pipe for transferring heat between a heat source and a heat sink, and a pyroelectric generator for generating electricity from thermal fluctuations generated by the oscillating heat pipe as the oscillating heat pipe transfers heat between the heat source and the heat sink.

Abstract: A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents; and related methods.

Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.