Patents Assigned to The University of Bath
  • Publication number: 20230313258
    Abstract: Disclosed are methods and kits for producing a conformationally constrained peptide, such as a helix constrained peptide, in a cell. In some cases, the methods comprise contacting a cell comprising an intracellularly-localised recombinant peptide with a cross-linker and culturing the cell in the presence of the cross-linker, wherein the cross-linker forms thioether cross-links with at least two derivatisable amino acids located at anchoring positions in the recombinant peptide. The methods and kits and cells find application, for example, in the identification of inhibitors that can be used to disrupt protein-protein interactions.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 5, 2023
    Applicant: The University of Bath
    Inventor: Jody Michael MASON
  • Publication number: 20230234987
    Abstract: The invention relates to compounds capable of modulating the permeability of junctions between epithelial cells, and their use to facilitate delivery of substances such as therapeutic and diagnostic agents across epithelial surfaces.
    Type: Application
    Filed: June 11, 2021
    Publication date: July 27, 2023
    Applicant: The University of Bath
    Inventors: Randy MRSNY, Alistair TAVERNER, Khaled ALMANSOUR
  • Patent number: 11696676
    Abstract: A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: July 11, 2023
    Assignees: THE UNIVERSITY OF BATH, HERIOT-WATT UNIVERSITY
    Inventors: Robert R Thomson, Debaditya Choudhury, Tim Birks
  • Publication number: 20230146038
    Abstract: Disclosed are methods, kits and cells for screening an inhibitor of association between candidate binding partners, such as for screening antagonists of amyloid peptides. The methods, kits and cells employ a reporter expression cassette and hybrid proteins. The reporter expression cassette encodes a reporter and comprises at least one DNA binding site. Each hybrid protein comprises a candidate binding partner and a component of a DNA binding protein and, upon association, form a DNA-binding complex capable of binding to the at least one binding site and inhibiting expression of the reporter. The methods, kits and cells find application, for example, in the identification of inhibitors that may be useful in treating diseases associated with protein aggregation, such as Alzheimer's Disease and Parkinson's Disease.
    Type: Application
    Filed: February 3, 2021
    Publication date: May 11, 2023
    Applicant: The University of Bath
    Inventors: Jody Michael MASON, Neil Mark KAD
  • Patent number: 11278218
    Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: March 22, 2022
    Assignee: The University of Bath
    Inventors: Richard Guy, Adelina Ilie, Luca Lipani, Floriant Doungmene, Bertrand Gilbert Roger Jacques Dupont
  • Patent number: 10662222
    Abstract: A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents; and related methods.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: May 26, 2020
    Assignee: The University of Bath
    Inventor: Randall Jay Mrsny
  • Publication number: 20200008717
    Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.
    Type: Application
    Filed: April 26, 2017
    Publication date: January 9, 2020
    Applicant: The University of Bath
    Inventors: Richard GUY, Adelina ILIE, Luca LIPANI, Floriant DOUNGMENE, Bertrand Gilbert Roger Jacques DUPONT
  • Publication number: 20190282683
    Abstract: The invention relates to methods and compositions for use in stimulating an immune response against a target antigen. More specifically, it relates to use of domains III and IV of the Staphylococcal Sbi protein as an immunological adjuvant, for enhancing an immune response against a target antigen.
    Type: Application
    Filed: November 24, 2017
    Publication date: September 19, 2019
    Applicant: THE UNIVERSITY OF BATH
    Inventors: Jean VAN DEN ELSEN, Andrew Graham WATTS, Kevin James MARCHBANK
  • Patent number: 10030031
    Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: July 24, 2018
    Assignee: The University of Bath
    Inventors: John Lewis, Stephen Husbands
  • Patent number: 9969746
    Abstract: The present invention relates to opioid compounds, especially to C14 esters and ethers of naltrexone and analogs thereof. The present invention also relates to compositions, methods and medical uses that employ such compounds. More specifically, the present invention pertains to compounds of formula: and to their use in the treatment of diseases and disorders including pain, hyperalgesia, addiction, substance abuse disorders, stress, anorexia, anxiety, depression, cough, asthma, hypertension, gastrointestinal motility disorder, water retention, cognitive disorders, and locomotor disorders.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: May 15, 2018
    Assignee: The University of Bath
    Inventors: John Lewis, Stephen Husbands, Lawrence Toll
  • Patent number: 9890170
    Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: February 13, 2018
    Assignee: The University of Bath
    Inventors: John Lewis, Stephen Husbands
  • Publication number: 20180030062
    Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.
    Type: Application
    Filed: October 3, 2017
    Publication date: February 1, 2018
    Applicant: The University of Bath
    Inventors: John Lewis, Stephen Husbands
  • Publication number: 20170342025
    Abstract: The invention discloses compounds of the formula wherein A, B, X, Y and Z are defined. The compounds of the invention show activity against a range of bacteria, and are useful in the treatment or prophylaxis of a bacterial infection in an animal.
    Type: Application
    Filed: December 29, 2015
    Publication date: November 30, 2017
    Applicants: The University of Bath, Swansea University
    Inventors: Barry Victor Lloyd POTTER, Wolfgang DOHLE, Xiangdong SU, John NORMANTON, Edward DUDLEY, Yamni NIGAM
  • Patent number: 9733254
    Abstract: Methods and apparatus for the in vitro modelling of changes that occur on administration of a drug formulation are described, in particular for studying the changes that take place on administration of protein or peptide drug formulations by subcutaneous injection.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: August 15, 2017
    Assignee: The University of Bath
    Inventors: Randall Jay Mrsny, Hanne Maarit Kinnunen
  • Publication number: 20170044173
    Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.
    Type: Application
    Filed: October 27, 2016
    Publication date: February 16, 2017
    Applicant: The University of Bath
    Inventors: John LEWIS, Stephen Husbands
  • Patent number: 9563839
    Abstract: A non-biological asynchronous neural network system comprising multiple neurons to receive respective input signals representing an input stimulus for the network, supply an output signal representing a spatio-temporal sequence of rhythmic electric pulses to an external system, wherein respective ones of the multiple neurons are connected using multiple mutually inhibitory links.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: February 7, 2017
    Assignee: The University of Bath
    Inventor: Alain Nogaret
  • Patent number: 9534228
    Abstract: This invention relates to methods for altering cell proliferation in a plant by modulating the expression of an endogenous plant gene whose expression product affects cell proliferation. These methods can be used to modify plant characteristics, such as seed size. In particular, the invention provides methods for modifying cell proliferation in the integuments and/or seed coats of a plant by inhibiting expression of endogenous gene encoding Auxin response factor 2 (ARF2/MNT) or an orthologue thereof, such that the number of cells in the integuments and/or seed coat is increased, resulting in increased seed size. The plant or plant propagating material can be transformed, e.g., with a nucleic acid construct, to increase or decrease the expression of endogenous genes or the orthologues thereof that affect cell proliferation. The invention also relates to modified plants and reproducible plant material produced by the methods, and nucleic acid constructs for use in such methods.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: January 3, 2017
    Assignee: The University of Bath
    Inventor: Roderick Scott
  • Patent number: 9499852
    Abstract: The invention provides vesicles that may be used in diagnosing infection, especially with infection by bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. The vesicles can be used in wound dressings.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: November 22, 2016
    Assignee: The University of Bath
    Inventors: Andrew Tobias Jenkins, Naig Tun Thet, June Mercer-Chalmers
  • Patent number: 9480684
    Abstract: The invention provides a method of treating anxiety or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: November 1, 2016
    Assignee: The University of Bath
    Inventors: John Lewis, Stephen Husbands
  • Publication number: 20160304529
    Abstract: The present invention relates to opioid compounds, especially to C14 esters and ethers of naltrexone and analogues thereof. The present invention also relates to compositions, methods and medical uses that employ such compounds. More specifically, the present invention pertains to compounds of formula: and to their use in the treatment of diseases and disorders including pain, hyperalgesia, addiction, substance abuse disorders, stress, anorexia, anxiety, depression, cough, asthma, hypertension, gastrointestinal motility disorder, water retention, cognitive disorders, and locomotor disorders.
    Type: Application
    Filed: December 5, 2014
    Publication date: October 20, 2016
    Applicants: THE UNIVERSITY OF BATH, THE TORREY PINES INSTITUTE FOR MOLECULAR STUDIES, SRI INTERNATIONAL
    Inventors: John LEWIS, Stephen HUSBANDS, Lawrence TOLL