Abstract: A method for implementing a relocatable Over-The-Horizon-Radar (OTHR) including transmitting mutually orthogonal signals on each of a plurality of antenna elements of a transmitting system, and receiving and decoding the signals at a plurality of receiving systems to synthesize beams from the orthogonal signals. Each receiving system has a plurality of antenna elements fewer in number than the plurality of antenna elements of said transmitting system. The method includes connecting as a network the transmitting system, the plurality of receiving systems, and a network controller.

Abstract: A method of processing NdFeB magnetic powder comprises: providing a source of hydrogenated NdFeB powder (101, 102, 103); feeding said powder into an inlet of a cyclone separator (104); separating the powder into an overflow enriched in Nd-rich grain boundary phase and an underflow enriched in NdxFeyBHz matrix phase particles (106); optionally feeding the underflow back into the inlet of the cyclone separator whereby to further enrich the underflow in the NdxFeyBHz matrix phase particles (108a); and collecting the underflow (108).

Abstract: A desalination system including: a partitioned container having upstream and downstream compartments divided by a movable partition, a first inlet port at an upstream end, and a second inlet port and an outlet port at the downstream end; a membrane container housing a cross-flow semipermeable membrane dividing the membrane container into saline and desalinated compartments, the saline compartment including first and second cross-flow ports, the desalinated compartment including a desalinated water outlet port; a feed pump connected to the first inlet port; a recharge pump having an inlet connected to the second cross-flow port and an outlet connected to the second inlet port; a main valve connected between the outlet port and the first cross-flow port; a bypass valve connecting the inlet port to the second cross-flow port and the recharge pump inlet; and a purge valve connecting the first cross-flow port and the main valve to a purge port.

Abstract: Disclosed is a vehicle charging station (1) comprising a first reservoir (5) arranged to contain a first charging fluid and a charging fluid delivery system (3) arranged to deliver at least part of the first charging fluid (5) into a heat exchange relationship with a vehicle thermal energy storage material (108) of a vehicle (100) selectively connected to the vehicle charging station (1), thereby charging the vehicle thermal energy storage material (108) by changing its temperature and/or phase and/or chemistry.

Abstract: The invention relates to a genetic probe, wherein the genetic probe comprises: an oligonucleotide, or an oligonucleotide analogue, with a Raman-active moiety incorporated therein, wherein the Raman-active moiety is incorporated into a base of the oligonucleotide or oligonucleotide thereof; and associated methods, uses, kits and compositions for determining a single point variant nucleotide in a target nucleic acid.

Abstract: The present disclosure relates to the treatment of neurological conditions, by inhibiting Chk2 kinase. Particular neurological conditions may be associated with neuronal damage/dysfunction or neurological degeneration, which may result from, physical trauma, chemical means, infection, inflammation, hypoxia and/or interruption in blood supply, or be due to a neurodegenerative disorder and/or autoimmune disease. The Chk2 inhibitor may be a small molecule, protein, peptide or nucleic acid. Exemplary small molecule Chk2 inhibitors include PV1019, AZD7762, CCT241533, BML-277 or prexasertib.

Abstract: The invention relates to a surgical or wound dressing comprising a sheet of gellan gum and an antifibrotic agent. Methods of producing dressings comprising gellan gums and biologically active agents area also produced.

Abstract: A stimuli-responsive surface (3) comprising a substrate (20) on which is located a switchable molecule (2) which has a functional moiety (22) associated therewith, wherein the switchable molecule (2) has a first equilibrium state (2A) in which access to the functional moiety (22) is inhibited and a second stimulated state (2B), in which access to the functional moiety (22) is permitted.

Abstract: The present invention relates to a method of preparing a molecular sensor that is specific for a target molecule having a saccharide or peptide region. The method comprises using the target molecule as a template and incubating the template with a receptor to form a template-receptor complex. A molecular scaffold is formed on a surface around the template-receptor complex such that the receptor and at least a portion of the template are embedded in the scaffold, and the template is removed to produce a cavity defined by the scaffold, such that the cavity is complementary to at least a portion of the saccharide or peptide region of the target molecule.

Abstract: Provided herein are methods to predict pain sensitivity and pain intensity to prolonged pain in a subject. Electroencephalograms are recorded in a pain-free state or, alternatively, in a pain-free state and after applying a prolonged pain stimulus in a prolonged pain state. Pain-free and prolonged pain peak alpha frequencies or ?PAF are measured. These values correlate negatively with the likelihood of increased pain sensitivity and increased pain intensity. Also provided is a method for predicting a likelihood of chronic pain in a subject after a medical procedure and designing a plan to treat the chronic pain.

Abstract: Methods and systems for measuring the intraocular pressure of an eye in a human. The methods include directing an acoustic incident wave at the surface of the eye to generate a reflected wave, measuring the coefficient of reflection of the incident and reflected waves, and determining the intraocular pressure of the eye from the coefficient of reflection. Also disclosed are methods of diagnosing glaucoma and/or intraocular hypertension.

Abstract: A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.

Abstract: Compositions that include anti-cancer, anti-tumor, and anti-microbial infection peptides are provided. In some embodiments, the compositions include 1-10 or more synthetic peptides that are between 8 and 50 amino acids long and include an amino acid sequence as disclosed herein.

Abstract: A method for controlling a wind turbine system connected to a power grid. The method comprises generating a wind turbine control signal based on a power control reference for controlling a power output of a wind turbine; monitoring an electrical frequency of the power grid; in response to detecting a change in the frequency in the power grid, activating a fast frequency support method comprising the steps of; adjusting the power control reference to cause an overproduction of power by the wind turbine; the overproduction of power causing a transfer of inertial kinetic energy from the wind turbine to electrical power; wherein the power control reference is determined by applying an adaptive gain function to a measurement of a difference in grid frequency from a nominal level.

Abstract: The present invention relates to a method for identifying whether or not it may be appropriate to administer to a subject a therapy for alleviating any potential consequences which may arise due to the subject having an atrial fibrillation (AF), the method comprising detecting, in a sample of fluid from the subject, a level of ccl21 and/or ddit4 expression and determining whether or not it may be appropriate to administer to the subject a therapy for alleviating any consequences which may arise due to the subject having AF, based upon the ccl21 and/or ddit4 expression level detected. Also provided are an anticoagulant or other AF therapy and a method of administering an anticoagulant drug or another AF therapy.

Abstract: Provided are compositions that include one or more synthetic target peptides, wherein each synthetic target peptide is about or at least 8-50 amino acids long; and has an amino acid sequence as set forth in Table 2 and/or Table 3. Also provided are in vitro populations of dendritic cells that include the disclosed compositions, in vitro population of CD8+ T cells capable of being activated upon being brought into contact with the disclosed populations of dendritic cells, antibodies or antibody-like molecules that specifically binds to a complex of an MHC class I molecule and a peptide having an amino acid sequence as set forth in Table 2 and/or Table 3, methods for treating and/or preventing cancers by administering a therapeutically effective dose of a composition that includes at least one target peptide having an amino acid sequence as set forth in Table 2 and/or Table 3.

Abstract: Provided is a method of diagnosing and/or monitoring mild traumatic brain injury (mTBI) or concussion in a subject. The method comprises determining a level of at least one miRNA in a saliva sample from the subject. Also provided is a sensor element, a detection system, composition and a kit for diagnosing and/or monitoring TBI, and a method of determining an appropriate treatment for a subject with suspected mTBI or concussion.

Abstract: The present invention relates to a drug delivery system and methods of using the delivery system, particularly a delivery system for transporting pharmaceutically active agents across, for example, the skin, the surface of the eye or mucosal membranes. The drug delivery system comprises a pharmaceutically effective moiety and a polyamine or amine moiety, wherein the polyamine or amine moiety does not comprise two or more contiguous basic amino acid residues. The drug delivery system may be provided for use as a medicament, or for use in the treatment of a disease or condition selected from eye disease, burns, infection, and trauma. The invention also provides a method comprising administering a pharmaceutically effective amount of the drug delivery system of the invention to a patient in need thereof.

Abstract: Methods and compositions are provided for increasing muscle hypertrophy, e.g., through the administration of novel combinations of natural products that inhibit SIRT1.

Abstract: An optical frequency manipulation using an optical subsystem configured to provide a modulated laser beam for interaction with an atomic sample. The optical system may include: an optical subsystem for producing a light beam, the optical subsystem having a laser source and an IQ modulator, wherein the IQ modulator is operable to modulate light from the laser source at a carrier frequency to produce modulated light having a single sideband at a sideband frequency; and a chamber for containing an atomic sample, wherein the optical subsystem is arranged to direct the light beam towards the chamber to interact with an atomic sample contained therein.