Abstract: A set of target peptides are presented by HLA A*0201, B*0301, B*0702 and B*2705 on the surface of disease cells. They are envisioned to, among other things, stimulate an immune response to the proliferative disease, e.g., colorectal cancer, to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, facilitate antibody recognition of tumor boundaries in surgical pathology samples, act as biomarkers for early detection and/or diagnosis of the disease, and/or act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.

Abstract: The disclosure relates to a line commutated converter, LCC, for a high-voltage direct current, HVDC, power converter. The LCC comprises at least one bridge circuit for connection to at least one terminal of a DC system. Each bridge circuit comprises at least two arms, and each arm is associated with a phase of an AC system. Each arm comprises one or more upper thyristor valves and one or more lower thyristor valves connected in series, and a branch extending from between the upper and lower thyristor valves. Each arm further comprises a parallel capacitor module comprising at least one parallel capacitor being connected in parallel between at least one pair of branches comprising a first branch and a second branch wherein during commutation of a flow of current in the first branch to a flow of current in the second branch, the at least one parallel capacitor is configured to discharge current in to the second branch in the same direction as the flow of current in the second branch.

Abstract: Oil spill detection is crucial, both from an environmental perspective and the associated economic losses. Current optical oil sensing techniques, such as underwater microscopy and light scattering methods, mainly focus on detecting the properties of particles or organisms in water and often require costly equipment and sophisticated data processing. Recent studies on graphitic foam show its extraordinary pollutant absorbing properties, with high absorption weight ratios. Here we propose to produce a graphene foam based ultra-light material that changes its optical properties on absorbing oil species. The results demonstrate clear changes in optical transmission and scattering properties of graphene foam when exposed to various oils. The effective graphene foam sorbent can be easily integrated with optic fibers systems to detect the optical property variations and also to monitor oil presence/spillages remotely. Such sensors can also be used for underground oil exploration.

Abstract: The present invention relates to inhibitors of VAP-1 and their use as medicaments in treating fibrotic conditions. Furthermore, the present invention relates to a method of diagnosing a fibrotic condition on the basis of elevated level of soluble VAP-1 or SSAO activity in a bodily fluid, and to a kit for use in said diagnostic method.

Abstract: Provided is a method of diagnosing and/or monitoring mild traumatic brain injury (mTBI) or concussion in a subject. The method comprises determining a level of at least one miRNA in a saliva sample from the subject. Also provided is a sensor element, a detection system, composition and a kit for diagnosing and/or monitoring TBI, and a method of determining an appropriate treatment for a subject with suspected mTBI or concussion.

Abstract: A line commutated converter (LCC) for a high voltage direct current power converter, the LCC comprising at least one LCC bridge circuit for connection to at least one terminal of a DC system, each bridge circuit comprising a plurality of arms, each associated with a respective phase of an AC system, each arm comprising: an upper thyristor valve or valves, and lower thyristor valve or valves connected in series; an associated branch extending from between the upper and lower thyristors; and at least one thyristor-based capacitor module for each phase, each module comprising a plurality of module thyristors, the or each capacitor module operable to insert a main capacitor into the respective arm of the bridge circuit by firing at least one or more of said module thyristors.

Abstract: A variety of targeting moiety peptide epitope complexes (TPECs) are described in different embodiments. In each of the embodiments, however, a targeting moiety may be used to deliver the TPEC to an area of unwanted cells, allowing for a therapeutic effect to be delivered locally. The TPEC also contains a plurality of T-cell epitopes. The TPEC further comprises cleavage sites that release the T-cell epitopes from the targeting agent, and in some embodiments from each other, when they are in the microenvironment of the unwanted cells. Although the arrangement and number of T-cell epitopes varies in different embodiments described herein, once cleaved from the targeting agent (and any neighboring T-cell epitopes), the T-cell epitopes function by stimulating an immune response against the unwanted cells.

Abstract: Provided is a nitrided metal surface functionalized with molecules, each molecule comprising at least one binding group and an antimicrobial moiety. The molecules are immobilized on the surface by only covalent interactions between the binding groups of the molecules and nitrogen atoms within the nitrided metal surface. Articles comprising the functionalized nitrided surface find use in inhibiting or reducing the growth of microorganisms on surfaces that are frequently touched. A method for preparing the functionalized nitrided surface comprises contacting a nitrided metal surface with molecules so as to form covalent bonds between the binding groups of the molecules and the nitrogen atoms in the surface, thereby immobilising the molecules on the metal surface.

Abstract: A set of target peptides are presented by HLA class I molecules on the surface of hepatocellular carcinoma (HCC) ceils and/or esophageal cancer cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., HCC and/or esophageal cancer, (b) function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation anti-body-like molecules which recognize the target-peptide/MHC complex.

Abstract: The invention relates to an antimicrobial surface, in particular a surface functionalised with a peptide comprising an antimicrobial moiety. The invention comprises a surface functionalised with a peptide comprising an antimicrobial moiety and a binder moiety, wherein the peptide is immobilized on the surface by electrostatic interactions between the binder moiety and the surface. Further provided is a medical device, a peptide and a method for the immobilization of a peptide.

Abstract: A variety of targeting moiety peptide epitope complexes (TPECs) are described in different embodiments. In each of the embodiments, however, a targeting moiety may be used to deliver the TPEC to an area of unwanted cells, allowing for a therapeutic effect to be delivered locally. The TPEC also contains a plurality of T-cell epitopes. The TPEC further comprises cleavage sites that release the T-cell epitopes from the targeting agent, and in some embodiments from each other, when they are in the microenvironment of the unwanted cells. Although the arrangement and number of T-cell epitopes varies in different embodiments described herein, once cleaved from the targeting agent (and any neighboring T-cell epitopes), the T-cell epitopes function by stimulating an immune response against the unwanted cells.

Abstract: The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a T cell antigen, wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.

Abstract: A method of processing NdFeB magnetic powder comprises: providing a source of hydrogenated NdFeB powder (101, 102, 103); feeding said powder into an inlet of a cyclone separator (104); separating the powder into an overflow enriched in Nd-rich grain boundary phase and an underflow enriched in NdxFeyBHz matrix phase particles (106); optionally feeding the underflow back into the inlet of the cyclone separator whereby to further enrich the underflow in the NdxFeyBHz matrix phase particles (108a); and collecting the underflow (108).

Abstract: An agent for use in a method of treating and/or preventing a viral infection, and compositions comprising said agent, are described. The agent modulates the expression of one or more circadian clock genes, or the activity of one or more circadian clock gene products. The agent may comprise or consist of an agonist of REV-ERB?.

Abstract: A method of generating at least one trapped atom of a specific species, the method comprising the steps of: positioning a sample material (18) comprising a specific species in a vacuum (14); generate an atomic vapor (20) of the specific species by irradiating the sample material with a first laser (12); trapping one or more atoms from the generated atomic vapor.

Abstract: A molecular sensor that utilizes dichroism can be used to identify the presence of a target nucleic acid molecule in a sample, for example during or after amplification reactions such as PCR/thermocyling reactions and isothermal reactions. A sensor element for use in the molecular sensor may comprise an alignable scaffold/receptor complex, the receptor of said complex comprising a nucleic acid sequence which is complementary to at least a portion of a target nucleic acid molecule.

Abstract: A line commutated converter, LCC, for a high-voltage, direct current, HVDC, power converter comprises at least one bridge circuit for connection to at least one terminal of a DC system. Each bridge circuit comprises a plurality of arms, and each arm is associated with a respective phase of an AC system. Each arm comprises an upper and lower thyristor connected in series, an associated branch extending from between the upper and lower thyristors, and at least one capacitor module for each phase. The, or each capacitor module is operable to insert a capacitor into the respective arm of the bridge circuit.

Abstract: The invention provides an agent for preventing or treating a condition characterised by the presence of unwanted cells, the agent comprising: (i) a targeting moiety that is capable of targeting to the unwanted cells; and (ii) a T cell antigen, wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent in the vicinity of the unwanted cells.

Abstract: Provided is a method of diagnosing and/or monitoring traumatic brain injury (TBI) in a subject. The method comprises determining a level of at least one miRNA in a fluid sample from the subject. The miRNA may be selected from mat-425-5p, miR-502, milt-21 and miR-335. The method may involve determining whether a subject is suffering from mild-TBI or moderate-to-severe TBI. Also provided is a sensor element, a detection system, composition and a kit for diagnosing and/or monitoring TBI, and a method of determining an appropriate treatment for a subject with a suspected TBI.

Abstract: A method for producing particulate clusters comprises passing a core through an array of matrix-supported coating particles. Particulate clusters produced by the method may find application as catalytic particles, components of novel electronic and photonic materials and sensors, and as binding sites for protein molecules in biochips.