Patents Assigned to The University of British Columbia
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Patent number: 10835878Abstract: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.Type: GrantFiled: May 14, 2020Date of Patent: November 17, 2020Assignee: The University of British ColumbiaInventors: Andre Wild, Timothy Leaver, Robert James Taylor
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Patent number: 10831319Abstract: A sensor for detecting and distinguishing between increasing and decreasing proximity of a pointing element, touch by a pointing element, pressure applied by a pointing element, stretching (and/or other deformation) of the sensor, and any of the above while stretching and/or otherwise deforming the sensor. The sensor may comprise a cluster sensor unit having a first sensor and a second sensor wherein the first sensor has a higher ratio of distal flux to proximate flux as compared to the second sensor. With this flux characteristic, the first sensor is relatively more sensitive (as compared to the second sensor) to proximity of a pointing element, while the second sensor is relatively more sensitive (as compared to the first sensor) to force and/or pressure applied by the pointing element.Type: GrantFiled: February 9, 2018Date of Patent: November 10, 2020Assignee: The University of British ColumbiaInventors: John D. W. Madden, Mirza S. Sarwar
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Patent number: 10829394Abstract: A UV reactor irradiates a flow of fluid with UV radiation. The reactor comprises: a fluid conduit defined by a heat conducting conduit body comprising one or more heat conducting walls for permitting a flow of fluid therethrough; a UV-LED operatively connected to a PCB and oriented for directing radiation into the fluid conduit. The PCB comprises a heat conducting substrate having a first surface. The conduit body is in thermal contact with the first surface of the heat conducting substrate. Heat is dissipated from the UV-LED via the heat conducting substrate, the thermal contact between the first surface of the heat conducting substrate and the heat conducting conduit body, and from the one or more heat conducting walls of the heat conducting conduit body to the fluid flowing through the fluid conduit.Type: GrantFiled: January 19, 2017Date of Patent: November 10, 2020Assignee: The University of British ColumbiaInventor: Fariborz Taghipour
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Patent number: 10829800Abstract: Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like.Type: GrantFiled: July 17, 2019Date of Patent: November 10, 2020Assignee: The University of British ColumbiaInventors: Andrea Marziali, Joel Pel, Jason Donald Thompson, Gosuke Shibahara
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Publication number: 20200348302Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.Type: ApplicationFiled: June 25, 2020Publication date: November 5, 2020Applicant: The University of British ColumbiaInventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
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Publication number: 20200339625Abstract: This application relates to compounds of Formula (I-a) or Formula (I-b), or is salts or solvates thereof. R1 is —(CH2)5CH3 or comprises 2-4 fused benzene rings. R2 is I, Br, F, Cl, H, OH, OCH3, NH2, NO2 or CH3. R3 is a peptide-bonded glycine, aspartate or glutamate or is glutamate peptide bonded through Cdelta. L is —CH2NH—, —(CH2)2NH—, —(CH2)3NH—, or —(CH2)4NH—. R4 is a radiometal chelator optionally bound by a radiometal. Variable ‘n’ is 1-3. The compounds may be useful for imaging prostate specific membrane antigen (PSMA)-expressing tissues or for treating PSMA-expressing diseases (e.g. cancer).Type: ApplicationFiled: October 22, 2018Publication date: October 29, 2020Applicants: Provincial Health Services Authority, The University of British ColumbiaInventors: Kuo-Shyan Lin, Frangois Benard, Hsiou-Ting Kuo, Zhengxing Zhang
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Patent number: 10819205Abstract: Aspects of the invention provide methods and systems for moving a plurality of moveable stages relative to a stator. The stator comprises a plurality of coils shaped to provide pluralities of coil trace groups where each coil trace group comprises a corresponding plurality of generally linearly elongated coil traces which extend across a stator tile. Each moveable stage comprises a plurality of magnet arrays. Methods and apparatus are provided for moving the moveable stages relative to the stator, where a magnet array from a first moveable stage and a magnet array from a second moveable stage both overlap a shared group of coil traces. For at least a portion of the time that the magnet arrays from the first and second moveable stages overlap the shared group of coil traces, currents are controllably driven in the shared coil trace group based on the positions of both the first and second moveable stages. The positions of the first and second moveable stages may be ascertained by feedback.Type: GrantFiled: May 31, 2019Date of Patent: October 27, 2020Assignee: The University of British ColumbiaInventor: Xiaodong Lu
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Publication number: 20200332357Abstract: Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.Type: ApplicationFiled: April 16, 2020Publication date: October 22, 2020Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Carl Lars Genghis Hansen, Hans Zahn, Jens Huft, Marinus Theodorus Johannes Van Loenhout, Kaston Leung, Bill Kengli Lin, Anders Klaus, Samuel Alves Jana Rodrigues Aparicio, Sohrab Prakash Shah, Adi Steif
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Publication number: 20200325431Abstract: Microfluidic devices and methods for perfusing a cell with perfusion fluid are provided herein, wherein the gravitational forces acting on the cell to keep the cell at or near a retainer or a retaining position exceed the hydrodynamic forces acting on the cell to move it toward an outlet. Also provided, are methods for assaying cell products within the microfluidic device.Type: ApplicationFiled: June 10, 2020Publication date: October 15, 2020Applicant: The University of British ColumbiaInventors: Carl L. G. Hansen, Veronique LECAULT, James M. PIRET, Anupam Singhal
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Publication number: 20200326341Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.Type: ApplicationFiled: June 25, 2020Publication date: October 15, 2020Applicant: The University of British ColumbiaInventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
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Publication number: 20200326342Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.Type: ApplicationFiled: June 25, 2020Publication date: October 15, 2020Applicant: The University of British ColumbiaInventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
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Patent number: 10804988Abstract: A discrete-time delay (TD) technique in a baseband receiver array is disclosed for canceling wide modulated bandwidth spatial interference and reducing the Analog-to-Digital Conversion (ADC) dynamic range requirements. In particular, the discrete-time delay (TD) technique first aligns the interference using non-uniform sampled phases followed by uniform cancellation using a cancellation matrix, such as, for example, a Truncated Hadamard Transform implemented with antipodal binary coefficients.Type: GrantFiled: September 9, 2019Date of Patent: October 13, 2020Assignees: Washington State University, The University of British ColumbiaInventors: Subhanshu Gupta, Erfan Ghaderi, Sudip Shekhar, Shyam Venkatasubramanian, Ajith Sivadhasan Ramani
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Patent number: 10794910Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.Type: GrantFiled: June 25, 2020Date of Patent: October 6, 2020Assignee: The University of British ColumbiaInventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
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Patent number: 10780174Abstract: This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.Type: GrantFiled: December 22, 2016Date of Patent: September 22, 2020Assignee: The University of British ColumbiaInventors: Marco A. Ciufolini, Pieter R. Cullis, Yuen Yi Tam, Joshua Zaifman
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Patent number: 10781502Abstract: This application pertains to methods of recovering metals from metal sulfides that involve contacting the metal sulfide with an acidic sulfate solution containing ferric sulfate and a reagent that has a thiocarbonyl functional group, wherein the concentration of reagent in the acidic sulfate solution is sufficient to increase the rate of metal ion extraction relative to an acidic sulfate solution that does not contain the reagent, to produce a pregnant solution containing the metal ions.Type: GrantFiled: January 15, 2020Date of Patent: September 22, 2020Assignee: The University of British ColumbiaInventors: David Dixon, Oscar Olvera Olmedo, Edouard Asselin, Ahmad Ghahreman, Zihe Ren
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Patent number: 10772969Abstract: The disclosure pertains to N-terminal epitopes identified in A-beta, including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.Type: GrantFiled: November 9, 2016Date of Patent: September 15, 2020Assignee: The University of British ColumbiaInventors: Neil R. Cashman, Steven S. Plotkin
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Patent number: 10775376Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.Type: GrantFiled: January 17, 2020Date of Patent: September 15, 2020Assignee: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
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Patent number: 10775377Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.Type: GrantFiled: June 25, 2020Date of Patent: September 15, 2020Assignee: The University of British ColumbiaInventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
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Patent number: 10775378Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.Type: GrantFiled: June 25, 2020Date of Patent: September 15, 2020Assignee: The University of British ColumbiaInventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
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Patent number: 10774120Abstract: The disclosure pertains to conformational epitopes in A-beta, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.Type: GrantFiled: November 9, 2016Date of Patent: September 15, 2020Assignee: The University of British ColumbiaInventors: Neil R. Cashman, Steven S. Plotkin