Patents Assigned to The University of Florida Research Foundation, Inc.
  • Magnetic particle conjugates, micelles, and methods of delivering agents
    Patent number: 11311630
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MCNC)), methods of making micelles, methods of using micelles, and the like.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: April 26, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Carlos Rinaldi, Sun Hao, Brent S. Sumerlin
  • Tagging of materials and objects and analysis for authentication thereof
    Patent number: 11314953
    Abstract: This disclosure relates to tagging of materials and objects and analysis for authentication thereof. An example method includes analyzing separately a number of locations distributed across a given surface of a solid object according to one or more analysis technologies to determine feature data for each of the locations. The feature data are indicative of a respective chemical property and/or mechanical property of the solid object at each of the locations, corresponding to a feature tag, and the feature data depend on the one or more analysis technologies. The method also includes determining a tag signature for the solid object based on the feature data determined for each of the locations.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: April 26, 2022
    Assignees: CASE WESTERN RESERVE UNIVERSITY, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Swarup Bhunia, Naren Vikram Masna, Soumyajit Mandal
  • Light-driven synthesis of plasmonic nanoparticles and nanomaterials
    Patent number: 11311940
    Abstract: In one aspect, the present disclosure pertains to methods of making various noble metal nanoprisms, e.g., gold nanoprisms. In various aspects, the methods can comprise incubating, under dark conditions, a growth solution comprising: (a) a plurality of gold seed structures; (b) a gold precursor, and (c) a photocatalytic intermediary, such that during the incubating step multiply-twinned gold seed structures in the growth solution are preferentially enlarged. The disclosed methods can comprise separating the multiply-twinned gold seed structures from the growth solution based upon the size of the gold seed structures to produce an enriched growth solution. In some aspects, the methods comprise irradiating the enriched growth solution to produce the gold nanoprisms. In some aspects, the disclosed nanoprisms comprise silver.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: April 26, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Wei David Wei, Yueming Zhai
  • Magnetic nanoparticles and methods of making magnetic nanoparticles
    Patent number: 11305351
    Abstract: The present disclosure provides for compositions of magnetic nanoparticles and methods of making magnetic nano-particles with large magnetic diameters.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: April 19, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Carlos Rinaldi, Mythreyi Unni
  • Wireless power transfer via electrodynamic coupling
    Patent number: 11309736
    Abstract: Wireless power transmission (WPT) systems are provided. For example, the WPT system can use one or more power transmitting coils and a receiver for electromagnetically coupled wireless power transfer. The electrodynamic receiver can be in the form of an electrodynamic transducer where a magnet is allowed to oscillate near a receiving coil to induce a voltage in the receiving coil, a piezoelectric transducer where the magnet causes a vibrating structure with a piezoelectric layer to move, an electrostatic transducer where movement of the magnet causes a capacitor plate to move, or a combination thereof. An alternating magnetic field from the transmitting coil(s) excites the magnet in the receiver into mechanical resonance. The vibrating magnet then functions similar to an energy harvester to induce voltage/current on an internal coil, piezoelectric material, or variable capacitor.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: April 19, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: David Patrick Arnold, Shuo Cheng, Vinod Reddy Challa
  • NEURAL PROTEINS AS BIOMARKERS FOR NERVOUS SYSTEM INJURY AND OTHER NEURAL DISORDERS
    Publication number: 20220113321
    Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 14, 2022
    Applicants: University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
    Inventors: Kevin Ka-Wang WANG, Monika OLI, Ming-Cheng LIU
  • Ligands for alpha-7 nicotinic acetylcholine receptors and methods of treating neurological and inflammatory conditions
    Patent number: 11299496
    Abstract: Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: April 12, 2022
    Assignees: Northeastern University, University of Florida Research Foundation, Inc.
    Inventors: Ganeshsingh A. Thakur, Abhijit R. Kulkarni, Roger Lee Papke
  • Nanofibrous carbon microstructures
    Patent number: 11280034
    Abstract: Various examples of methods and systems related to nanofibrous microstructures including carbon nanofibrous microelectrode arrays are provided. In one example, a method includes electrospinning photosensitive nanofibers on a patterned substrate; immersing the photosensitive nanofibers in a refractive index matching medium; and exposing the immersed photosensitive nanofibers to ultraviolet (UV) light through the patterned substrate or through a front side photomask. In another example, a microelectrode array includes a carbon thin film (CTF) trace pattern including a plurality of CTF electrode pads; and a plurality of carbon nanofiber (CNF) pillars disposed on the plurality of CTF electrode pads.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: March 22, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Yong-Kyu Yoon, Pit Fee Jao
  • Single-atom-based catalyst systems
    Patent number: 11273433
    Abstract: The disclosure relates to a single-atom-based catalyst system with total-length control of single-atom catalytic sites. The single-atom-based catalyst system comprises at least one catalyst structure comprising a first assembly of a plurality of single-atom-catalyst superparticles. The single-atom-catalyst superparticles comprise a second assembly of a plurality of single-atom-catalyst nanoparticles. The single-atom-based catalyst system has controlled porosity and spatial distribution of active single-atom catalysts from the atomic scale to the macroscopic scale. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: March 15, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Yunwei Charles Cao
  • Enhanced threshold voltage defined logic family
    Patent number: 11271569
    Abstract: The present disclosure describes systems, apparatuses, and methods for implementing a logic gate circuit structure for operating one or more Boolean functions. Instead of stacking transistors in series to accommodate an increased number of inputs, a parallel configuration is presented that significantly reduces the cascaded number of transistors and the total number of transistors for the same functionality.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: March 8, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Beomsoo Park, Nima Maghari
  • Hardware trojan detection through information flow security verification
    Patent number: 11270002
    Abstract: Disclosed are various embodiments for detecting hardware Trojans through information flow security verification. A file comprising register transfer level (HDL) code for an intellectual property core is loaded from memory. An asset within the intellectual property core is identified. An integrity verification or confidentiality verification of the HDL code that represents the asset is performed. An integrity violation or confidentiality violation within the HDL code as a result of performance of the integrity verification or confidentiality violation on the HDL code that represents the asset is detected. A malicious control point or a malicious observation point linked to the asset is identified. Finally, a trigger circuit for a hardware Trojan is identified in response to identification of the malicious control point or malicious observation point.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: March 8, 2022
    Assignee: University Of Florida Research Foundation, Inc.
    Inventors: Mark M. Tehranipoor, Adib Nahiyan, Domenic J. Forte
  • Detecting SS7 redirection attacks with audio-based distance bounding
    Patent number: 11265717
    Abstract: Disclosed are various embodiments for detecting Signaling System 7 (SS7) redirection attacks by measuring call audio round trip times between phones. Such redirection attacks force calls to travel longer physical distances than usual, thereby causing longer end-to-end delay. Accordingly, various embodiments implement a distance bounding-inspired protocol that allows for securely characterizing the round trip time between two call endpoints. As a result, telephone users can reliably detect SS7 redirection attacks and protect the information contained in their calls.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: March 1, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Patrick G. Traynor, Christian Peeters, Bradley G. Reaves, Hadi Abdullah, Kevin Butler, Jasmine Bowers, Walter N. Scaife
  • COMBINATORIAL TEMPORAL BIOMARKERS AND PRECISION MEDICINES WITH DETECTION AND TREATMENT METHODS FOR USE IN NEURO INJURY, NEURO DISEASE, AND NEURO REPAIR
    Publication number: 20220057409
    Abstract: A method, device, and kit are provided for temporal diagnostics and clinical treatment of neuro injury, neuro disease, or neuro repair, particularly including clinical treatment with precision medicines for the same therapeutic targets as a subset of the temporal biomarkers. Through the measurement of biomarkers in a biological sample from a subject, with at least one biomarker from each of the early, intermediate, and late phases of suspected injury, disease, or repair from a subject, a determination of a subject's injury, disease, or repair is provided with greater sensitivity and/or specificity than previously attainable. As many clinical inventions such an anti-inflammatories and clot disruptors are effective only during certain phases injury, disease, or repair, this knowledge can be used to clinical effect in mitigating secondary injuries and/or diseases.
    Type: Application
    Filed: December 13, 2019
    Publication date: February 24, 2022
    Applicants: GRYPHON BIO, INC., University of Florida Research Foundation, Inc.
    Inventors: William E. Haskins, Kevin Ka-wang Wang
  • Chimeric antigen receptors and uses thereof
    Patent number: 11248058
    Abstract: Provided herein are chimeric antigen receptors (CARs) comprising an antigen binding domain (e.g., CD19, CD30, GD2, etc.), transmembrane domain (e.g., CD28), and a cytoplasmic domain (e.g., CD27, 4-1BB, etc.). In some aspects, the disclosure relates to use of the CARs in T cells, compositions, kits and methods.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: February 15, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Lung-Ji Chang
  • Augmented tune/match circuits for high performance dual nuclear transmission line resonators
    Patent number: 11243280
    Abstract: A dual nuclear MR transmission line resonator is capable of operating on 1X pairs, with X being 31P, 23Na, 3He, or 129Xe. The resonator avoids many of the problems inherent in conventional dual nuclear designs. No LC trap is used, and the coil has substantially the same spatial profile on both nuclei. In the resonator, an augmented MR tune/match circuit, includes a conventional capacitive L circuit, with the L circuit shunted at a match point by a notch filter tuned to a frequency of a companion nucleus. Also disclosed is a method for simultaneously resonating conductive loops of surface coils or conductive elements of volume coils simultaneously on both 1H and X with hybrid transmission line termination elements bonded to the resonator loop or conductive elements in shunt with respect to one another.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: February 8, 2022
    Assignee: University Of Florida Research Foundation, Inc.
    Inventor: Matthew G. Erickson
  • Compositions and methods for stereoregular ring expansion metathesis polymerization
    Patent number: 11242363
    Abstract: Disclosed are to metallocyclopropene complexes, methods of making same, methods for ring expansion metathesis polymerization, and polymers prepared by the methods for ring expansion metathesis polymerization.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: February 8, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Adam S. Veige, Vineet K. Jakhar, Muhammad Tariq Jan
  • Catalyst for ring expansion metathesis polymerization of cyclic monomers
    Patent number: 11241681
    Abstract: A tetraanionic OCO pincer ligand metal-oxo-alkylidene complex is prepared from a trianionic pincer ligand supported metal-alkylidyne. The metal can be tungsten or other group 5-7 transition metal. The tetraanionic pincer ligand metal-oxo-alkylidene complex, a trianionic OCO pincer ligand metal complex, or a trianionic ONO pincer ligand metal complex can be used to polymerize cycloalkenes. The poly(cycloalkene)s are predominantly cis-alkene macrocyclics.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: February 8, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Adam S. Veige, Stella Almeida Gonsales
  • Oral delivery of angiotensin converting enzyme 2 (ACE2) or angiotensin-(1-7)-bioencapsulated in plant cells attenuates pulmonary hypertension, cardiac dysfunction and development of autoimmune and experimentally induced ocular disorders
    Patent number: 11241487
    Abstract: Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to pulmonary hypertension (PH). However, clinical success for long-term delivery of ACE2 or Ang-(1-7) would require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastric enzymes; fusion to a transmucosal carrier facilitates effective systemic absorption. Oral feeding of rats with bioencapsulated ACE2 or Ang-(1-7) attenuated monocrotaline (MCT)-induced increase in right ventricular systolic pressure, decreased pulmonary vessel wall thickness and improved right heart function in both prevention and reversal protocols.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: February 8, 2022
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Henry Daniell, Qiuhong Li, Mohan K. Raizada
  • Surface plasmon-mediated chemical deposition and plasmonic structures
    Patent number: 11231372
    Abstract: Embodiments of the present disclosure provide plasmonic structures, methods of making plasmonic structures, and the like.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: January 25, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Wei David Wei, Jingjing Qiu
  • Rollable metamaterial screen for magnetic resonance coupling based high efficiency wireless power transfer
    Patent number: 11228212
    Abstract: The present disclosure describes wireless power transfer systems and methods. One such system comprises a transmitter coil coupled to a power source; a receiver coil coupled to a load; and a metamaterial screen disposed between the transmitter coil and the receiver coil and configured to amplify and focus a magnetic field generated by the transmitter coil towards the receiver coil in a non-contact manner. Other systems and methods are also disclosed.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: January 18, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Yong-Kyu Yoon, Woosol Lee