Patents Assigned to The University of Florida Research Foundation, Inc.
  • Method of manufacturing stable emulsions and compositions containing the same
    Patent number: 11219606
    Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: January 11, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Anuj Chauhan, Robert A. Damitz
  • Neural proteins as biomarkers for nervous system injury and other neural disorders
    Patent number: 11221342
    Abstract: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: January 11, 2022
    Assignees: University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
    Inventors: Kevin Ka-Wang Wang, Monika Oli, Ming-Cheng Liu
  • Methods and compositions for antibody-evading virus vectors
    Patent number: 11208438
    Abstract: The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: December 28, 2021
    Assignees: The University of North Carolina at Chapel Hill, University of Florida Research Foundation, Inc.
    Inventors: Aravind Asokan, Mavis Agbandje-McKenna, Long Ping Victor Tse, Brittney Gurda
  • Compositions and methods relating to molecular cerium-oxide nanoclusters
    Patent number: 11207663
    Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. In an aspect, described herein are methods of synthesizing molecular cerium-oxide nanocluster compositions and compositions thereof. In an aspect, described herein are methods of scavenging reactive oxygen species utilizing molecular cerium-oxide nanoclusters as described herein. Also described herein are pharmaceutical compositions and methods of use. Pharmaceutical compositions as described herein can comprise a therapeutically effective amount of a compound (such as a composition comprising one or more molecular cerium-oxide nanoclusters), or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier. Methods of treating oxidative stress are also described herein, comprising administering pharmaceutical compositions as described herein to a subject in need thereof.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: December 28, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: George Christou, Kylie J. Mitchell
  • Conversion of ethane to ethylene
    Patent number: 11208366
    Abstract: Methods of converting ethane to ethylene at relatively low temperatures are described. Ir02-based catalysts are used in the conversion. Methods of converting a base gas to a first gas by exposing the base gas to an IrO2-based catalyst and forming the first gas are described. The base gas can be an alkane. The first gas can include an alkene, an alkyne, an alcohol, an aldehyde, or combinations thereof.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: December 28, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Jason F. Weaver, Yingxue Bian
  • Fabrication of autologous bone
    Patent number: 11197946
    Abstract: Described herein are methods and apparatus for constructing tissue replacements, such as bone replacements that may be used to repair damaged or missing segments of bone, such as may occur in wound repair or as a repair of a congenital anomaly. These methods involve a three-dimensional (3D) cell growth medium made from a yield stress material that allows cells and structures to be easily deposited and positioned.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: December 14, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Wallace Gregory Sawyer, Thomas Ettor Angelini, Steven C. Ghivizzani, C. Parker Gibbs
  • Biaryl ligands, methods of making biarlyl ligands, and methods of use thereof
    Patent number: 11198701
    Abstract: Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as “biaryl compound”), biaryl complexes, methods of making biaryl compounds, methods of making single enantiomers of these biaryl compounds, methods of use (e.g., catalysis), and the like.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: December 14, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Aaron Aponick, Flavio S. P. Cardoso
  • Medication adherence monitoring device
    Patent number: 11193925
    Abstract: A Self Monitoring And Reporting Therapeutics, SMART® composition, method apparatus and system are provided which flexibly provide options, by combining different embodiments of the device with different embodiments of the composition, the ability to conduct definitive medication adherence monitoring over the short term (Acute Medication Adherence Monitoring, immediately up to an hour or so after taking a medication), intermediate term (Intermediate Medication Adherence Monitoring, IMAM, an hour or so to a day or so after taking a medication), and longer term (Chronic Medication Adherence Monitoring, CMAM, a day to several days after taking a medication).
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: December 7, 2021
    Assignees: University of Florida Research Foundation, Inc., Xhale, Inc.
    Inventors: Donn Dennis, Matthew Booth, Scott Wasdo, Chris Batich, Hank Wohltjen, Douglas Crumb, Mark Tanner, Susan Baumgartner, Poonam Kaul
  • 3D printing using phase changing matertials as support
    Patent number: 11192292
    Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: December 7, 2021
    Assignees: University of Florida Research Foundation, Inc., Georigia Tech Research Corporation
    Inventors: Alberto Fernandez-Nieves, Thomas Ettor Angelini, Ya-Wen Chang, Samantha M. Marquez
  • 3D printing mechanical hold build plate
    Patent number: 11186038
    Abstract: The present disclosure provides a build plate for physically adhering or holding a three-dimensional (3D) object to a build surface and methods for mechanically anchoring the 3D object to the build surface using printing or building materials. In one embodiment, a build plate comprises a plurality of anchor holes spaced throughout a top surface of the first build plate, in which an individual anchor hole comprises a top hole portion and a bottom chamfer hole portion that is larger in size than the top portion.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: November 30, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John Michael Loeffler, Brandon Rosenthal
  • Microfluidic trap
    Patent number: 11179721
    Abstract: Provided herein are microfluidic devices that can be configured to generate an electrophoretic flow that is in opposition to a fluid flow through a microcapillary of a microfluidic device provided herein. Also provided herein are methods that include adding an amount of particle to the inlet area of a microfluidic device as provided herein, generating a first fluid flow through a microcapillary of a microfluidic device provided herein; and applying a uniform electric field to the microfluidic device, where the uniform electric field generates an electrophoretic flow that is in opposition to the fluid flow.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: November 23, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Jason E. Butler, Anthony J. Ladd, Mert Arca
  • Methods and compositions for minimizing x-ray scattering artifacts
    Patent number: 11183314
    Abstract: Disclosed are methods for minimizing x-ray scattering artifacts, the method comprising: contacting an object with an x-ray scattering mitigation material. The contacting can comprise coating the x-ray scattering material on the object, including spraying a solution of suspension of an x-ray scattering mitigation material onto the object or dry powder coating the object with a x-ray scattering mitigation material. Alternatively, the contacting can comprise immersing the object in a fluid comprising the x-ray scattering material. The fluid can be a gas, a liquid, or a gel. The disclosed x-ray scattering mitigation material can be optimized for mitigating Compton radiation scattering or for mitigating Rayleigh radiation scattering. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: November 23, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Gary W. Scheiffele, Edward L. Stanley
  • Sunlight harvesting transparent windows
    Patent number: 11177766
    Abstract: A photovoltaic system is formed as a window that is constructed of at least one polymer layer that is filled or decorated with metal nanoparticles and a window frame that includes one or more photovoltaic cells. The metal nanoparticles have a shape and size such that they display surface plasmon resonance frequencies in the near-infrared and/or the near-ultraviolet. The near-infrared and/or the near-ultraviolet radiations are scattered such that they are transmitted parallel to the face of the window to the photovoltaic cells, where an electrical current is generated.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: November 16, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Jiangeng Xue, Wei David Wei
  • Materials and methods for respiratory disease control in canines
    Patent number: 11160859
    Abstract: The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: November 2, 2021
    Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., CORNELL RESEARCH FOUNDATION, INC., THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION
    Inventors: Patti Cynthia Crawford, Paul J. Gibbs, Edward J. Dubovi, Ruben Omar Donis, Jacqueline Katz, Alexander I. Klimov, Nallakannu P. Lakshmanan, Melissa Anne Lum, Daniel Ghislena Emiel Goovaerts, Mark William Mellencamp, Nancy J. Cox, William L. Castleman
  • Cyclic polyolefins derived from hexyne, octyne, nonyne, pentadecyne and their copolymers with acetylene
    Patent number: 11155653
    Abstract: Disclosed are saturated cyclic monopolymers derived from hexyne, octyne, nonyne, pentadecyne and saturated cyclic copolymers derived from acetylene and a second alkyne monomer that is hexyne, octyne, nonyne, or pentadecyne.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: October 26, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Adam S. Veige
  • Immunogenic compositions comprising FIV and HIV gag antigens
    Patent number: 11154610
    Abstract: The subject invention pertains to materials and methods for detecting, preventing and treating retroviral infections in humans and other animals susceptible to infection by retrovirus. It has been discovered that FIV can be transmitted from cats to humans and that the FIV can infect human cells in vivo and that antibodies generated by the infected person cross-react with HIV antigens. Thus, the methods and compositions of the subject invention can be used to detect, prevent and treat FIV infection in humans and other non-feline animals that are susceptible to FIV infection. The methods and compositions of the invention can also be used to prevent and treat infection by HIV in humans.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: October 26, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventor: Janet K. Yamamoto
  • Nicotinic acetylcholine receptor silent agonists
    Patent number: 11155551
    Abstract: Derivatives of N,N-diethyl-N?-phenyl-piperazine, a silent agonist of the mammalian ?7 nicotinic acetylcholine receptor, are provided. These silent agonists control the desensitization state of the receptor. Further provided are pharmaceutical compositions that allow the administration of the silent agonists of the disclosure to a subject animal or human in need of treatment for a pathological condition arising from such as inflammation. The novel silent agonists also may be co-administered to a patient simultaneously or consecutively with a type II positive allosteric modulator to modulate the activity of the receptor.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: October 26, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Nicole Alana Horenstein, Roger Lee Papke, Marta Quadri
  • DOSING REGIMENS FOR TREATING METAL-MEDIATED CONDITIONS
    Publication number: 20210322301
    Abstract: The present disclosure provides safe and effective dosing regimens of metal chelators as treatment for metal overload disorders and, in particular, iron overload and associated conditions.
    Type: Application
    Filed: December 17, 2020
    Publication date: October 21, 2021
    Applicants: Abfero Pharmaceuticals, Inc., University of Florida Research Foundation, Inc.
    Inventors: Steven Keith BURKE, Raymond J. BERGERON
  • Trojan insertion tool
    Patent number: 11144648
    Abstract: A method and system for evaluating software tools that detect malicious hardware modifications is provided. In one embodiment, among others, a system comprises a computing device and an application. The application causes the computing device to at least receive hardware description language code that represents a circuit design and calculate a signal probability for one or more nodes in the circuit design. The application also causes the computing device to identify one or more rare nodes in the circuit design and generate a Trojan sample population. The application further causes the computing device to generate a feasible Trojan population and generate a Trojan test instance based at least in part on a random selection from the Trojan feasible population. Additionally, the application causes the computing device to generate modified hardware description code from the Trojan test instance.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: October 12, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Swarup Bhunia, Jonathan William Cruz, Prabhat Kumar Mishra
  • Insect toxin delivery mediated by a densovirus coat protein
    Patent number: 11140902
    Abstract: A coat protein of Junonia coenia densovirus (JcDNV) is used to deliver attached peptide insect toxin across the gut epithelium of a fall armyworm, Spodoptera frugiperda. A fusion protein comprising VP4 attached to an insect toxin via a peptide linker is developed. A composition comprising a JcDNV coat protein attached to an insect toxin via a peptide linker can be used for insect pest control.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: October 12, 2021
    Assignees: University of Florida Research Foundation, Inc., Iowa State University Research Foundation, Inc.
    Inventors: Bryony C. Bonning, Mariah Kemmerer