Patents Assigned to The University of Guelph
  • VACCINES FOR INCLUSION BODY HEPATITIS
    Publication number: 20110165224
    Abstract: A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its progeny.
    Type: Application
    Filed: December 15, 2010
    Publication date: July 7, 2011
    Applicants: UNIVERSITY OF SASKATCHEWAN, UNIVERSITY OF GUELPH
    Inventors: Susantha Gomis, Suresh Tikoo, Davor Ojkic
  • DNA JOINING METHOD
    Publication number: 20110143399
    Abstract: The present invention provides a method to directionally clone any linear template DNA molecule into any linearized vector. The vector ends may be generated from any restriction enzyme cleavage. The method does not require a ligation step nor the use of carefully controlled conditions as is required with methods involving specific exonucleases alone. It has been determined that specific DNA polymerases are able to efficiently join one or more linear DNA molecules sharing ends with appropriate complementation.
    Type: Application
    Filed: July 15, 2009
    Publication date: June 16, 2011
    Applicant: University of Guelph
    Inventors: David Evans, David O. Willer, Xiao-Dan Yao
  • Modified leukotoxin gene and protein
    Patent number: 7932085
    Abstract: The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: April 26, 2011
    Assignee: University of Guelph
    Inventors: Reggie Y. C. Lo, Patricia E. Shewen, Raymond W. H. Lee, Doug Hodgins, Judith N. Strommer
  • NITROGEN-REGULATED SUGAR SENSING GENE AND PROTEIN AND MODULATION THEREOF
    Publication number: 20110055975
    Abstract: The present invention relates to a nitrogen-regulated GATA transcription factor gene required for sugar sensing and the modulation of the expression of this gene to modulate a characteristic in a plant. The GATA transcription factor of the present invention is involved in regulating sugar sensing in plants and its expression is influenced by nitrogen status. Increased expression of this or substantially similar genes can produce plants with improved nitrogen utilization and increased yield.
    Type: Application
    Filed: May 6, 2010
    Publication date: March 3, 2011
    Applicant: UNIVERSITY OF GUELPH
    Inventors: Steven ROTHSTEIN, Yong-Mei Bi
  • Modified Leukotoxin Gene and Protein
    Publication number: 20110002951
    Abstract: The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.
    Type: Application
    Filed: July 9, 2010
    Publication date: January 6, 2011
    Applicant: University of Guelph
    Inventors: Reggie Y. Lo, Patricia E. Shewen, Raymond W.H. Lee, Doug Hodgins, Judith N. Strommer
  • NOVEL POLYSACCHARIDE IMMUNOGENS FROM CLOSTRIDIUM DIFFICILE
    Publication number: 20100330125
    Abstract: The application relates to Clostridium difficile cell surface polysaccharides, compositions comprising Clostridium difficile cell surface polysaccharides, and includes kits, methods and uses thereof.
    Type: Application
    Filed: September 11, 2008
    Publication date: December 30, 2010
    Applicant: UNIVERSITY OF GUELPH
    Inventors: Mario Artur Monteiro, Jeyabarathy Ganeshapillai
  • VACCINE AGAINST CLOSTRIDIUM PERFRINGENS
    Publication number: 20100255022
    Abstract: There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or variant thereof, a nucleic acid encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or variant thereof.
    Type: Application
    Filed: May 30, 2008
    Publication date: October 7, 2010
    Applicant: UNIVERSITY OF GUELPH
    Inventors: John Prescott, Raveendra Kulkarni, Valeria Parreira, Shayan Sharif
  • Modified leukotoxin protein
    Patent number: 7790170
    Abstract: The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: September 7, 2010
    Assignee: University of Guelph
    Inventors: Reggie Y. C. Lo, Patricia E. Shewen, Raymond W. H. Lee, Doug Hodgins, Judith N. Strommer
  • SYNTHETIC LUNG SURFACTANT AND USE THEREOF
    Publication number: 20100055164
    Abstract: The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
    Type: Application
    Filed: July 20, 2007
    Publication date: March 4, 2010
    Applicants: UNIVERSITY OF ROCHESTER, UNIVERSITY OF GUELPH
    Inventors: Robert H. Notter, Zhengdong Wang, Adrian L. Schwan, Zhongyi Wang, Jason A. Davy, Alan J. Waring, Frans Walther, Larry M. Gordon
  • Bovine CAST gene SNP and meat tenderness
    Patent number: 7655776
    Abstract: The present invention relates to the identification of a single nucleotide polymorphism (SNP) within the bovine CAST locus encoding the calpastatin protein, wherein the allelic variation of the SNP is a G/C transversion associated with post-mortem muscle tenderness. The invention further relates to oligonucleotides useful in identifying the genotype of bovines as it relates to the CAST locus polymorphic site. The invention also encompasses computer-assisted methods and systems for improving the production efficiency for livestock having marketably tender meat using multiple data, and in particular the genotype of the animals as it relates to the CAST SNP.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: February 2, 2010
    Assignee: University of Guelph
    Inventors: Flavio Schramm Schenkel, Stephen Paul Miller, Zhihua Jiang
  • NITROGEN-REGULATED SUGAR SENSING GENE AND PROTEIN AND MODULATION THEREOF
    Publication number: 20090276919
    Abstract: The present invention relates to a nitrogen-regulated GATA transcription factor gene required for sugar sensing and the modulation of the expression of this gene to modulate a characteristic in a plant. The GATA transcription factor of the present invention is involved in regulating sugar sensing in plants and its expression is influenced by nitrogen status. Increased expression of this or substantially similar genes can produce plants with improved nitrogen utilization and increased yield.
    Type: Application
    Filed: June 29, 2009
    Publication date: November 5, 2009
    Applicant: UNIVERSITY OF GUELPH
    Inventors: Steven Rothstein, Yong-Mei Bi
  • METHOD OF DETECTING AND REDUCING BOAR TAINT USING NUCLEAR RECEPTORS
    Publication number: 20090221539
    Abstract: A method for preventing or reducing boar taint, a method of screening pigs to determine those more likely to have reduced boar taint and a method for screening substances that enhance skatole metabolism or androstenone in a pig, are disclosed These methods involve the use of the nuclear receptors constitutive androstane receptor, pregnane X receptor and farnesoid X receptor, which have been found to modulate the activity of the enzymes involved in skatole and/or androsterone metabolism
    Type: Application
    Filed: December 13, 2006
    Publication date: September 3, 2009
    Applicant: UNIVERSITY OF GUELPH
    Inventors: E. James Squires, John Peacock, James Gilmore, Philip Sinclair, Michael Terner
  • Nitrogen-regulated sugar sensing gene and protein and modulation thereof
    Patent number: 7554018
    Abstract: The present invention relates to a nitrogen-regulated GATA transcription factor gene required for sugar sensing and the modulation of the expression of this gene to modulate a characteristic in a plant. The GATA transcription factor of the present invention is involved in regulating sugar sensing in plants and its expression is influenced by nitrogen status. Increased expression of this or substantially similar genes can produce plants with improved nitrogen utilization and increased yield.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: June 30, 2009
    Assignee: University of Guelph
    Inventors: Steven Rothstein, Yong-Mei Bi
  • METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR LEVINTHAL PROCESS INDUCTION FROM KNOWN STRUCTURE USING MACHINE LEARNING
    Publication number: 20090024375
    Abstract: A method is provided for predicting the structure of a macromolecule by modeling the folding process from the unfolded to the folded state based on machine learning a training set of known structures.
    Type: Application
    Filed: May 7, 2008
    Publication date: January 22, 2009
    Applicant: University of Guelph
    Inventors: Stefan Kremer, Hao Lac
  • Prion Sensors for Diagnosis of Transmissible Spongiform Encephalopathy or for Detection of Prions, and Use Thereof
    Publication number: 20080254486
    Abstract: Disclosed are prion sensors that may be used as a diagnostic tool to diagnose TSE, or to detect PrPSc molecules, in biological and environmental samples, and methods for using these sensors. The prion sensor may comprise an acoustic sensor, such as a TSM sensor, coated with PrPC molecules, whose resonance characteristics change when contacted with a sample from an animal with TSE, or a sample comprising PrPSc molecules. Alternatively the prion sensor may comprise an optical sensor, such as an SPR sensor, coated with PrPC molecules, whose optical characteristics change when contacted with a sample from an animal with TSE, or a sample comprising PrPSc molecules. These changes provide both rapid detection and a quantitative assay for diagnosing TSE or for detecting PrPSc molecules.
    Type: Application
    Filed: December 9, 2005
    Publication date: October 16, 2008
    Applicant: UNIVERSITY OF GUELPH
    Inventors: Gordon Hayward, Warren Stiver, John Ellis, Vicky Wong
  • Harvest-inducible genes from alfalfa () and methods of use thereof
    Patent number: 7388091
    Abstract: The present invention relates to novel inducible genes from alfalfa. These genes are highly induced following mechanical harvesting or wounding of alfalfa. The genes are useful for inducible production of heterologous proteins following harvesting.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: June 17, 2008
    Assignee: University of Guelph
    Inventors: Larry Erickson, Jian Zhang
  • Harvest-inducible regulatory elements and methods of using same
    Patent number: 7329798
    Abstract: The present invention relates to a method for the production of a heterologous protein or peptide in a plant or a plant cell. The method involves providing a plant or a plant cell comprising construct comprising a harvest-inducible regulatory element that is operably linked with a heterologous coding sequence of interest, growing the plant or plant cell, and applying ABA or an analog thereof to the plant or plant cell, thereby inducing expression of the heterologous protein or peptide. If a plant is used, then following the application of ABA or an analogue thereof, the plant may be harvested.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: February 12, 2008
    Assignee: University of Guelph
    Inventors: Larry Erickson, Jian Zhang
  • Modified leukotoxin gene and protein
    Patent number: 7304151
    Abstract: The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: December 4, 2007
    Assignee: University of Guelph
    Inventors: Reggie Y. Lo, Patricia E. Shewen, Raymond W. H. Lee, Doug Hodgins, Judith N. Strommer
  • Nitrogen-Regulated Sugar Sensing Gene and Protein and Modulation Thereof
    Publication number: 20070250956
    Abstract: The present invention relates to a nitrogen-regulated GATA transcription factor gene required for sugar sensing and the modulation of the expression of this gene to modulate a characteristic in a plant. The GATA transcription factor of the present invention is involved in regulating sugar sensing in plants and its expression is influenced by nitrogen status. Increased expression of this or substantially similar genes can produce plants with improved nitrogen utilization and increased yield.
    Type: Application
    Filed: April 17, 2007
    Publication date: October 25, 2007
    Applicant: University of Guelph
    Inventors: Steven Rothstein, Yong-Mei Bi
  • Method of identifying high immune response animals
    Patent number: 7258858
    Abstract: The invention relates to a method and use of a method of identifying high immune response animals under stress. The animals are identified by a ranking procedure that classifies the animal's immune response to an antigen over a period of time that spans the stress.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: August 21, 2007
    Assignee: University of Guelph
    Inventors: Lauraine Wagter-Lesperance, Bonnie Mallard