Patents Assigned to The University of Maryland
  • Publication number: 20210324365
    Abstract: A method of system of forming a biopolymer hydrogel structure includes a mold loaded with a cation. At least a portion of the surface of the mold is exposed to a solution comprising a gellable polymer such as alginate. An electric potential is applied to the mold so that the cation therein and the gellable polymer migrate via electrophoresis toward the surface portion, thereby interacting and forming a hydrogel structure adjacent to the surface portion.
    Type: Application
    Filed: April 20, 2021
    Publication date: October 21, 2021
    Applicant: University of Maryland, College Park
    Inventors: Srinivasa R. Raghavan, So Hyun Ahn, Ankit Gargava
  • Patent number: 11152640
    Abstract: Solid-state lithium ion electrolytes of lithium potassium bismuth oxide based compounds are provided which contain an anionic framework capable of conducting lithium ions. Materials of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are provided. Electrodes containing the lithium borate based materials coated on the active material and batteries containing the electrodes are also provided.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: October 19, 2021
    Assignees: UNIVERSITY OF MARYLAND, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Yifei Mo, Xingfeng He, Qiang Bai, Chen Ling, Ying Zhang
  • Patent number: 11149082
    Abstract: The present disclosure relates to multispecific antibodies targeting the human immunodeficiency virus-1 (HIV-1) envelope, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof in treatment and prevention of HIV infection.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 19, 2021
    Assignees: University of Maryland, College Park, The United States of America, As Represented By, International AIDS Vaccine Initiative
    Inventors: Javier Guenaga, Yuxing Li, James Steinhardt, John R. Mascola
  • Patent number: 11152756
    Abstract: The disclosure describes aspects of laser cavity repetition rate tuning and high-bandwidth stabilization of pulsed lasers. In one aspect, an output optical coupler is described that includes a cavity output coupler mirror, a piezoelectric actuator coupled to the cavity output coupler mirror, a locking assembly within which the cavity output coupler mirror and the piezoelectric actuator are positioned, and one or more components coupled to the locking assembly. The components are configured to provide multiple positional degrees of freedom for tuning a frequency comb spectrum of the pulsed laser (e.g., tuning a repetition rate) by adjusting at least one position of the locking assembly with the cavity output coupler mirror. A method of adjusting an output optical coupler in a pulsed laser is also described. These techniques may be used in different applications, including quantum information processing.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: October 19, 2021
    Assignees: UNIVERSITY OF MARYLAND, COLLEGE PARK, IONQ, INC.
    Inventors: Christopher Monroe, Kai Hudek, Jonathan Mizrahi, Marko Cetina, Sarah Margaret Kreikemeier, Michael Goldman, Kristin Beck
  • Patent number: 11143555
    Abstract: In a spectrometry setup where a first spectral component dominates a second spectral component having a different wavelength, diffraction of the first spectral component as it passes through the optical train of the spectrometer can produce spectral noise that obscures detection of the second spectral component. To reduce the spectral noise, the light from the spectrometer is subject to spatial filtering or interference such that effects of the first spectral component are removed, or at least reduced. The second spectral component can then be more readily detected by a detector after the spatial filtering or interference. In embodiments, the spatial filtering or interference may be provided by a filtering module, which may be installed in existing spectrometry setups or form part of a unitary spectrometry system.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: October 12, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Giuliano Scarcelli, Eitan Edrei
  • Patent number: 11142746
    Abstract: Described herein is a novel, highly efficient system to remove erythrocytes and purify leukocytes would raise the quality of UCB and other transplant grafts, thereby significantly improving patient outcomes.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: October 12, 2021
    Assignees: University of Maryland, Baltimore, The Trustees of Princeton University
    Inventors: Curt I. Civin, James C. Sturm, Robert H. Austin
  • Patent number: 11145896
    Abstract: Solid-state lithium ion electrolytes of lithium potassium tantalate based compounds are provided which contain an anionic framework capable of conducting lithium ions. An activation energy of the lithium metal silicate composites is from 0.12 to 0.45 eV and conductivities are from 10?3 to 40 mS/cm at 300K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are also provided. Electrodes containing the lithium potassium tantalate based materials and batteries with such electrodes are also provided.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: October 12, 2021
    Assignees: UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Yifei Mo, Qiang Bai, Xingfeng He, Chen Ling
  • Patent number: 11131029
    Abstract: Hydrofluoroolefin (HFO) fluid can be transported through an electrochemical device, which has a proton exchange membrane (PEM) disposed between a pair of gas-permeable electrodes that include respective catalysts. At an inlet side, the catalyst facilitates reaction of HFO with hydrogen carrier gas. The resulting cation is transported across PEM in the presence of an electric field applied to the electrodes. At an outlet side, the catalyst of the opposing electrode facilitates dissociation of the cation back into HFO and hydrogen. In some embodiments, the transported HFO has a higher pressure than that before the electrochemical device. In some embodiments, the electrochemical device can be operated in reverse to expand HFO fluid and/or to recapture power. The electrochemical device can thus be used as a compressor or expander for vapor-phase HFO or as a pump or expander for liquid-phase HFO, for example, in power generation or heating/cooling cycles.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: September 28, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Chunsheng Wang, Ye Tao, K. Reinhard Radermacher, Yunho Hwang
  • Patent number: 11130256
    Abstract: A super strong and tough densified wood structure is formed by subjecting a cellulose-based natural wood material to a chemical treatment that partially removes lignin therefrom. The treated wood retains lumina of the natural wood, with cellulose nanofibers of cell walls being aligned. The treated wood is then pressed in a direction crossing the direction in which the lumina extend, such that the lumina collapse and any residual fluid within the wood is removed. As a result, the cell walls become entangled and hydrogen bonds are formed between adjacent cellulose nanofibers, thereby improving the strength and toughness of the wood among other mechanical properties. By further modifying, manipulating, or machining the densified wood, it can be adapted to various applications.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: September 28, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Liangbing Hu, Mingwei Zhu, Jianwei Song
  • Publication number: 20210296698
    Abstract: Solid-state lithium ion electrolytes of lithium phosphate derivative compounds are provided which contain an anionic framework capable of conducting lithium ions. The activation energy of the lithium phosphate deravitive compounds is from 0.18 to 0.34 eV and conductivities are from 10?3 to 12 mS/cm at 300K. Materials of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are also provided. Electrodes containing the lithium phosphate derivative materials and batteries with such electrodes are also provided.
    Type: Application
    Filed: June 9, 2021
    Publication date: September 23, 2021
    Applicants: UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Yifei MO, Qiang BAI, Xingfeng HE, Chen LING
  • Publication number: 20210296697
    Abstract: Electrodes containing lithium phosphate derivative materials and batteries with such electrodes are provided. The lithium phosphate derivative compounds contain an anionic framework capable of conducting lithium ions and have an activation energy from 0.2 to 0.45 eV and conductivities from 0.01 to 10 mS/cm at 300K. Materials of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown.
    Type: Application
    Filed: June 9, 2021
    Publication date: September 23, 2021
    Applicants: UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Yifei MO, Qiang BAI, Xingfeng HE, Chen LING
  • Publication number: 20210290727
    Abstract: Provided herein are compositions and methods for down-regulating mTORC1 signaling in a subject, comprising administering to the subject an effective amount of one or more compositions that promote increased levels or activity of CIB32 or a biologically active fragment or variant thereof in the subject.
    Type: Application
    Filed: August 1, 2019
    Publication date: September 23, 2021
    Applicant: University of Maryland, Baltimore
    Inventors: Zubair M. Ahmed, Saumil Sethna, Saima Riazuddin
  • Patent number: 11124815
    Abstract: Embodiments of the disclosure provide for unique lipooligosaccharide/lipid A-based mimetics for use as adjuvants. Methods of generating lipooligosaccharide/lipid A-based mimetics are provided that utilize recombinantly engineered bacteria to produce the mimetics, including, for example, addition of one or more particular enzymes such as acyltransferases, deacylases, phosphatases, or glycosyltransferases.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: September 21, 2021
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, UNIVERSITY OF WASHINGTON
    Inventors: Robert K. Ernst, Mark Pelletier, Adeline Hajjar
  • Patent number: 11119061
    Abstract: The present invention generally relates to a method of using NMR relaxation rates (R2) of water molecules as an indicator of the extent of aggregation of biopharmaceutical formulations. The biopharmaceutical can be evaluated nondestructively without the vial or container being opened or protective seal compromised (i.e., broken). The method is applicable to all biopharmaceuticals and the water signal obtained by magnetic resonance relaxometry is very strong and sensitive because water is used as the solvent and is present in high (>90%) concentrations in every biopharmaceutical formulation.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: September 14, 2021
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Yihua Bruce Yu, Marc Taraban, Yue Feng
  • Patent number: 11116659
    Abstract: Disclosed are devices and methods for body temperature management using a heat transfer catheter carrying a heat transfer fluid to heat or cool a desired, focused portion of a patient's body. In accordance with certain aspects of the invention, the heat transfer catheter may include hollow nodes that have greater rigidity than the remainder of the catheter to aid in placement of the heat transfer catheter within and navigation of the desired portion of the patient's body. Methods of using such heat transfer catheter to effect temperature management of the patient's body are also disclosed.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: September 14, 2021
    Assignee: University of Maryland, Baltimore
    Inventors: Bingren Hu, Chunli Liu
  • Patent number: 11111306
    Abstract: Antibodies and antigen binding fragments that specifically bind to IL-7R? are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R? using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R?, such as acute lymphoblastic leukemia.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: September 7, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Maryland, College Park
    Inventors: Scott Durum, Julie Hixon, Wen Qing Li, Scott Walsh, Lila Kashi
  • Patent number: 11115010
    Abstract: A dielectric structure is loaded with energy (e.g., charge), which is retained therein until a trigger causes rapid discharge of the loaded energy and generation of an accompanying electromagnetic pulse (EMP). By appropriate design of the dielectric structure and/or trigger, the waveform of the EMP resulting from the rapid discharge can be tailored. Features of the dielectric structure can be modified and/or other devices can be coupled to the dielectric structure to also tailor the EMP, for example, to provide directionality. A modeling unit can predict the discharge in the dielectric structure and/or resulting EMP. The modeling unit can be used to determine charge density spatial distribution within the dielectric structure, shape of the dielectric structure, and/or actuation timing/location necessary to yield a desired waveform for the EMP emanating from the dielectric structure upon discharge.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: September 7, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Timothy W. Koeth, George Hine
  • Publication number: 20210268061
    Abstract: The present invention relates to the use of a CD24 protein for preventing or treating relapse of a cancer in a subject. The present invention also relates to the use of a CD24 protein for reducing cancer stem cell activity.
    Type: Application
    Filed: June 3, 2019
    Publication date: September 2, 2021
    Applicants: ONCOIMMUNE, INC, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Yang Liu, Pan Zheng, Martin Devenport
  • Patent number: 11104617
    Abstract: Separation methods and systems for converting high concentrations of animal wastes into nutrients and other useful products such as struvite and potassium struvite. Advantageously, the system and methods do not require the addition of external chemicals other than an acid and a base.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: August 31, 2021
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Lee Blaney, Utsav Shashvatt
  • Publication number: 20210259738
    Abstract: In some embodiments, a method includes a shaft having a side catheter guide attached thereto via a guide coupler into an inferior vena cava and a superior vena cava such that the guide coupler is disposed in a right atrium, and applying a distal force to a proximal portion of the side catheter guide such that a distal end of the side catheter guide deflects laterally about the guide coupler towards a septum. The method further includes extending a side catheter that is disposed within the side catheter guide distally from the side catheter guide towards and into contact with the septum. The method further includes, with the side catheter in contact with the septum, extending a septum penetrator that is slidably disposed within the side catheter distally from the side catheter such that the septum penetrator pierces the septum.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 26, 2021
    Applicants: University of Maryland, Baltimore, University of Maryland Medical System LLC, Protaryx Medical Inc.
    Inventors: James S. GAMMIE, Philip J. HAARSTAD, David BLAESER, Ryan BAUER, Stephen ROLLER, Rachael QUINN, Chetan PASRIJA, Edwin HLAVKA