Abstract: An inverted battery device has a pair of electrodes, first and second volumes, and an electrical conductor. One of the pair of electrodes is configured as an anode and the other is configured as a cathode. A first electrolyte solution and the anode are disposed in the first volume, while a second electrolyte solution and the cathode are disposed in the second volume. The electrical conductor extends between the first and second volumes to couple the pair of electrodes to each other such that electrons travel between the pair of electrodes. The device is constructed to produce ions rather than electrons such that an ionic current can be generated in a separate system, such as a biological system or other ionic system, when coupled between the anode and cathode.
Abstract: Aspects of the present disclosure describe techniques for controlling coherent crosstalk errors that occur in multi-channel acousto-optic modulators (AOMs) by applying cancellation tones to reduce or eliminate the crosstalk errors. For example, a method and systems are described that include applying a first radio frequency (RF) tone to generate a first acoustic wave in a first channel of the multi-channel AOM, wherein a portion of the first acoustic wave interacts with a second channel to cause a crosstalk effect, and applying a second RF tone to generate a second acoustic wave in the second channel, wherein the second acoustic wave reduces or eliminates the crosstalk effect caused by the portion of the first acoustic wave.
Type:
Application
Filed:
November 11, 2022
Publication date:
August 10, 2023
Applicant:
University of Maryland, College Park
Inventors:
Kristin M BECK, Marko CETINA, Michael Lurie GOLDMAN
Abstract: Compounds that inhibit p38? MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.
Type:
Grant
Filed:
June 16, 2021
Date of Patent:
August 8, 2023
Assignee:
University of Maryland, Baltimore
Inventors:
Paul S. Shapiro, Alexander D. Mackerell, Jr., Jeffrey D. Hasday, Steven Fletcher
Abstract: The present disclosure provides methods of treating patients having decreased bone mineral density, methods of identifying subjects having increased risk of developing decreased bone mineral density, methods of detecting human Zinc And Ring Finger 3 (ZNRF3) variant nucleic acid molecules and variant polypeptides, and ZNRF3 variant nucleic acid molecules and variant polypeptides.
Type:
Grant
Filed:
June 22, 2020
Date of Patent:
August 1, 2023
Assignees:
Regeneran Pharmaceuticals, Inc., University of Maryland, Baltimore
Inventors:
Da-Wei Gong, Nehal Gosalia, Alan Shuldiner, Cristopher Van Hout, James Perry
Abstract: The disclosure describes various aspects of optical control of atomic quantum bits (qubits) for phase control operations. More specifically, the disclosure describes methods for coherently controlling quantum phases on atomic qubits mediated by optical control fields, applying to quantum logic gates, and generalized interactions between qubits. Various attributes and settings of optical/qubit interactions (e.g., atomic energy structure, laser beam geometry, polarization, spectrum, phase, background magnetic field) are identified for imprinting and storing phase in qubits. The disclosure further describes how these control attributes are best matched in order to control and stabilize qubit interactions and allow extended phase-stable quantum gate sequences.
Type:
Grant
Filed:
May 6, 2021
Date of Patent:
July 25, 2023
Assignee:
UNIVERSITY OF MARYLAND, COLLEGE PARK
Inventors:
Christopher Monroe, Marko Cetina, Norbert Linke, Shantanu Debnath
Abstract: The disclosure describes various aspects related to enabling effective multi-qubit operations, and more specifically, to techniques for enabling parallel multi-qubit operations on a universal ion trap quantum computer. In an aspect, a method of performing quantum operations in an ion trap quantum computer or trapped-ion quantum system includes implementing at least two parallel gates of a quantum circuit, each of the at least two parallel gates is a multi-qubit gate, each of the at least two parallel gates is implemented using a different set of ions of a plurality of ions in a ion trap, and the plurality of ions includes four or more ions. The method further includes simultaneously performing operations on the at least two parallel gates as part of the quantum operations. A trapped-ion quantum system and a computer-readable storage medium corresponding to the method described above are also disclosed.
Type:
Grant
Filed:
September 23, 2021
Date of Patent:
July 25, 2023
Assignees:
UNIVERSITY OF MARYLAND, COLLEGE PARK, IONQ, INC.
Inventors:
Caroline Figgatt, Aaron Ostrander, Norbert M. Linke, Kevin A. Landsman, Daiwei Zhu, Dmitri Maslov, Christopher Monroe
Abstract: Described herein are methods and compositions for the treatment of pancreatic cancer in a subject in need thereof. The pancreatic cancer may be resistant to other therapeutic regimens. The methods may comprise administering ARDA compounds to the subject.
Type:
Grant
Filed:
April 29, 2020
Date of Patent:
July 25, 2023
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE
Inventors:
Vincent C. O. Njar, Purushottamachar Puranik, Andrew K. Kwegyir-Afful
Abstract: An electrochemical module (EM) transfers a fluid across a membrane thereof using oxygen as a carrier gas. The EM has an anion exchange membrane (AEM) disposed between a first and second electrodes, each of which includes a catalyst. At an inlet side, the catalyst facilitates reaction of the fluid with carrier gas, such that an anion is formed. The anion is transported across the AEM in the presence of an electric field applied to the electrodes. At an outlet side, the catalyst facilitates dissociation of the anion back to the fluid and carrier gas. In some embodiments, the fluid comprises carbon dioxide, and the transporting by the EM is part of a heating/cooling cycle or a power generation cycle, or is used to capture carbon dioxide for storage or regeneration of stale air. In some embodiments, the fluid comprises water vapor, and the transporting by the EM dehumidifies air.
Type:
Grant
Filed:
November 27, 2018
Date of Patent:
July 25, 2023
Assignee:
UNIVERSITY OF MARYLAND, COLLEGE PARK
Inventors:
Chunsheng Wang, Ye Tao, K. Reinhard Radermacher, Yunho Hwang, Joseph Patrick Baker, Zhenyuan Mei
Abstract: The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.
Type:
Grant
Filed:
June 7, 2018
Date of Patent:
July 25, 2023
Assignee:
University of Maryland, Baltimore County
Inventors:
Govind Rao, Yordan Kostov, Abhay Andar, Mustafa Al-Adhami, Sevda Deldari, Douglas D. Frey
Abstract: The invention relates to selective small molecule human constitutive androstane receptor (hCAR) activators of Formula (I) or (II), pharmaceutical compositions thereof, and use thereof for the treatment of hematologic malignancies and other cancers. The small molecule hCAR activator in combination with CPA based chemotherapy regimen provides a synergistic effect to help promote cytoxicity of the cyclophosphamide (CPA) based anticancer treatments including CHOP regimen (CPA, doxorubicin, vincristine, and prednisone) by preferential induction of CYP2B6 over CYP3A4 and promoting the formation of therapeutically active CPA metabolite 4-OH-CPA.
Abstract: An implantable acellular polymeric scaffold device functionalized with aggrecan is provided. Also provided are methods of fabricating a polymeric scaffold device, including methods of fabricating the scaffold device via 3D printing. Methods of treating a cartilage defect in a subject in need thereof comprise application of the disclosed scaffold device in combination with microfracture procedures. A specialized lid for a centrifugation well plate is also provided.
Type:
Grant
Filed:
January 15, 2020
Date of Patent:
July 18, 2023
Assignee:
University of Maryland, College Park
Inventors:
Ting Guo, John Patrick Fisher, Hannah Baker, Max Jonah Lerman, Robert Choe
Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
Type:
Grant
Filed:
July 15, 2021
Date of Patent:
July 18, 2023
Assignee:
University of Maryland, Baltimore County
Abstract: A MEM-based device and method of fabrication, the device comprising a biochip substrate comprising one or more compliant materials, a plurality of mechanical and electrical micro-sensors configured in an array to simultaneously measure electrical and mechanical properties of a sample, wherein a first mechanical micro-sensor is formed as a patterned layer of at least one of the compliant materials, wherein the patterned layer is coupled to a first pillar comprising a dielectric material formed onto the compliant materials, the first pillar being coated with a metal film at a contact surface with the sample and along a side of the first pillar to act as a conductive probe for the first electrical micro-sensor, and wherein the first pillar is formed on the first mechanical micro-sensor to transfer a force to the first mechanical micro-sensor.
Type:
Grant
Filed:
September 3, 2020
Date of Patent:
July 18, 2023
Assignee:
University of Maryland
Inventors:
Jaydev P. Desai, Hardik Jeetendra Pandya, Kihan Park
Abstract: Electrodes containing lithium phosphate derivative materials and batteries with such electrodes are provided. The lithium phosphate derivative compounds contain an anionic framework capable of conducting lithium ions and have an activation energy from 0.2 to 0.45 eV and conductivities from 0.01 to 10 mS/cm at 300K. Materials of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
July 18, 2023
Assignees:
UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
Abstract: Disclosed herein are systems and methods for synthesizing a diamond using a diamond synthesis machine. A processor receives a plurality of images of a diamond during synthesis within a diamond synthesis machine, each of the plurality of images captured within a time period. The processor executes a diamond state prediction machine learning model using the plurality of images to obtain a predicted data object, the predicted data object indicating a predicted state of the diamond within the diamond synthesis machine at a time subsequent to the time period. The processor detects a predicted defect, a number of defects, defect types, and/or sub-features of such defects and/or other characteristics (e.g., a predicted shape, size, and/or other properties of predicted contours for the diamond and/or pocket holder) of the predicted state of the diamond. The processor adjusts operation of the diamond synthesis machine.
Type:
Grant
Filed:
May 21, 2021
Date of Patent:
July 11, 2023
Assignees:
FRAUNHOFER USA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
Inventors:
Rohan Reddy Mekala, Matthias Muehle, Adam Porter, Mikael Lindvall, Michael Becker
Abstract: The present invention provides for nutrient extraction and recovery devices that use the Donnan Membrane Principle (DMP) to cause spontaneous separation of dissolved ions along electrochemical potential gradients, wherein anions and cations such as H2PO4?, HPO42?, PO43?, Mg2+, Ca2+, NH4+, and K+ are moved from manure containing waste streams through cation and anion exchange membranes into a recovery stream thereby precipitating target compounds including but not limited to struvite, potassium struvite and hydroxyapatite.
Type:
Grant
Filed:
May 22, 2019
Date of Patent:
July 11, 2023
Assignee:
University of Maryland, Baltimore County
Abstract: The present invention relates to cell free protein manufacturing, and more particularly, for integrating machine learning into a portable cell-free bioprocessing system for producing proteins with increased and consistent purity, potency and quality wherein such proteins are prepared on-demand and for point-of-care delivery.
Type:
Grant
Filed:
May 15, 2019
Date of Patent:
June 27, 2023
Assignee:
University of Maryland, Baltimore County
Inventors:
Govind Rao, Yordan Kostov, Benjamin Punshon-Smith, Rajani Adiga
Abstract: Systems, methods, apparatuses, and computer program products for providing an anti-piracy framework for Deep Neural Networks (DNN). A method may include receiving authorized raw input at a protective transform module. The method may also include receiving unauthorized raw input at a restrictive deep neural network. The method may further include processing the authorized raw input at the protective transform module to generate a processed input. In addition, the method may include feeding the processed input into the restrictive deep neural network. The method may also include generating a result based on the processed input and the unauthorized raw input. Further, the result may include a different learning performance between the authorized raw input and the unauthorized raw input.
Abstract: A method for beam therapy is provided. The method includes receiving first data indicating a plurality of target volumes within a target region inside a subject for particle beam therapy relative to a particle beam outlet on a gantry for directing a particle beam from a particle beam source. The method further includes moving automatically, one or more energy modulator components to reduce an energy of the particle beam and deliver the particle beam to the target region such that a Bragg Peak is delivered to at least one target volume of the plurality of target volumes. The method further includes repeating the moving automatically as the particle beam source rotates with the gantry around the subject, without changing the energy of the particle beam at the particle beam outlet, until every target volume is subjected to a Bragg Peak.
Type:
Grant
Filed:
March 8, 2018
Date of Patent:
June 27, 2023
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE
Inventors:
Byong Yong Yi, Warren D. D'Souza, Ulrich Langner
Abstract: A nonlinear closed-loop control combined with an integral time-delay feedback control is disclosed to adjust a speed ratio of an infinitely variable transmission (IVT) system. A speed ratio control for an IVT system involves a forward speed controller and a crank length controller for different speed ranges. The time-delay control is designed to reduce speed fluctuations of the output speed of an IVT with an accurate speed ratio. The speed ratio of an IVT with the disclosed control strategy can achieve an excellent tracking response for the desired constant output speed and reduce speed fluctuations of the output speed of an IVT by the time-delay feedback control.
Type:
Grant
Filed:
March 2, 2022
Date of Patent:
June 27, 2023
Assignee:
University of Maryland, Baltimore County