Patents Assigned to The University of Memphis Research Foundation
  • Publication number: 20200191778
    Abstract: The present disclosure features compositions and methods related to the detection and molecular profiling of extracellular vesicles using fluorescent probes. These compositions and methods leverage the unique optoelectrical properties of quantum dots and fluorescently labeled nanoparticles, which allows reliable, real-time detection of extracellular vesicles and vesicle surface bound or lumenal molecules.
    Type: Application
    Filed: December 18, 2019
    Publication date: June 18, 2020
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: XIAOHUA HUANG, THANG BA HOANG
  • Publication number: 20200138753
    Abstract: Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface.
    Type: Application
    Filed: October 31, 2019
    Publication date: May 7, 2020
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Jessica Amber Jennings, Daniel Lee Baker, Rukhsana Awais, Zoe Harrison, Babatunde Raji
  • Publication number: 20190275200
    Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).
    Type: Application
    Filed: March 11, 2019
    Publication date: September 12, 2019
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: GARY L. BOWLIN, ALLISON E. FETZ, MARKO Z. RADIC
  • Patent number: 10405746
    Abstract: In one embodiment, a method is disclosed in which an analog sensor receives an electromagnetic (EM) wave (e.g., a radio frequency signal) from an interrogation device. The sensor converts a biological measurement of a subject into an electrical resistance and modulates a response to reflect the incident signal based on the electrical resistance. The sensor then provides the response to the interrogation device that corresponds to the biological measurement.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: September 10, 2019
    Assignee: The University of Memphis Research Foundation
    Inventors: Bashir I. Morshed, Sergi Consul-Pacareu
  • Publication number: 20190192666
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Application
    Filed: July 31, 2018
    Publication date: June 27, 2019
    Applicant: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: WARREN O. HAGGARD, SCOTT P. NOEL, JOEL D. BUMGARDNER
  • Patent number: 10182499
    Abstract: A multilayer printed circuit as well as printed passive and active electronic components using additive printing technology is provided. The fabrication process includes a substrate and a first conductive layer that is printed with conductive ink on the substrate. An insulation layer that has uniform thickness is printed on the first conductive layer and the substrate, less via cavities, test point cavities, and a surface mount component contact point and mounting cavities. The insulation layer is replaceable with resistive layer or semi-conductive layer to fabricate electronic components. The vias are printed with conductive ink inside of the via cavities. Additionally, a second conductive layer is printed on the vias and over the insulation layer. The insulation, resistive, or semi-conducting layer, the vias, and the conductive layers are repeatedly printed in sequence to thus form the multilayer printed circuit.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: January 15, 2019
    Assignee: The University of Memphis Research Foundation
    Inventor: Bashir I. Morshed
  • Patent number: 10052388
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: August 21, 2018
    Assignee: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Warren O. Haggard, Scott P. Noel, Joel D. Bumgardner
  • Patent number: 9983162
    Abstract: The present invention is directed to an electrochemical sensor involving an electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode. Devices and methods for using this electrochemical sensor are also disclosed.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 29, 2018
    Assignees: THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Edward Chaum, Erno Lindner, Jidong Guo
  • Patent number: 9962468
    Abstract: This invention describes a cell growth apparatus, particularly neuronal printed circuit board apparatus comprising an aerogel base and a pre-printed cellular growth pattern. The cellular growth pattern is comprised of combinations of layers of cellular adhesion promoting materials, cellular adhesion inhibiting materials, and/or cellular signal promoting materials. The invention further describes methods of promoting cell growth using the neuronal printed circuit board apparatus of the invention. The invention is useful for regeneration and precise guidance of cells, particularly nerve cells, when used as an implant.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: May 8, 2018
    Assignee: The University of Memphis Research Foundation
    Inventor: Firouzeh Sabri
  • Patent number: 9952209
    Abstract: Magnetic-optical iron oxide-gold core-shell nanoparticles are disclosed. Methods for making and using the nanoparticles are also disclosed.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: April 24, 2018
    Assignee: The University of Memphis Research Foundation
    Inventors: Xiaohua Huang, Saheel Bhana
  • Publication number: 20170258967
    Abstract: The invention provides compositions featuring chitosan and polyethylene glycol and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the chitosan-PEG compositions can be loaded with one or more antimicrobial agents, including hydrophobic agents, and can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Application
    Filed: February 13, 2015
    Publication date: September 14, 2017
    Applicant: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Warren O. HAGGARD, Ashley C. PARKER, Jessica Amber JENNINGS
  • Patent number: 9733351
    Abstract: A system for detecting object movement including a sensory network having at least one sensory device using modulated radar for detecting an object in proximity to the sensory network. The sensory network including wireless transmission means and a base station having computer processing means located remote from the sensory network and including wireless transmission means to communicate with the sensory network. The base station having computer readable program code means for causing the computer processing means to analyze data received from the sensory network to determine motion characteristics of the object in proximity to the sensory network.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: August 15, 2017
    Assignee: The University of Memphis Research Foundation
    Inventors: Robert Kozma, Khan M. Iftekharuddin, Lan Wang, Ross Deming
  • Publication number: 20170209583
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicant: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: WARREN O. HAGGARD, SCOTT P. NOEL, JOEL D. BUMGARDNER
  • Patent number: 9700246
    Abstract: The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: July 11, 2017
    Assignees: THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Edward Chaum, Erno Lindner, Jidong Guo
  • Patent number: 9662400
    Abstract: The invention provides improved methods for generating biodegradable chitosan compositions, and therapeutic methods of using such compositions to deliver therapeutic agents.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 30, 2017
    Assignee: The University of Memphis Research Foundation
    Inventors: James Keaton Smith, Ashley C. Parker, Jessica A. Jennings, Benjamin T. Reves, Warren O. Haggard
  • Patent number: 9642948
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: May 9, 2017
    Assignee: The University of Memphis Research Foundation
    Inventors: Warren O. Haggard, Scott P. Noel, Joel D. Bumgardner
  • Patent number: 9603522
    Abstract: This document relates to methods and materials involved in detecting neurochemical signals, electrophysiological signals, ions, or combinations thereof with brain tissue. For example, methods and materials for using probes to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, or combinations thereof during deep brain stimulation are provided.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: March 28, 2017
    Assignees: Mayo Foundation for Medical Education and Research, The University of Memphis Research Foundation
    Inventors: Kendall H. Lee, Kevin E. Bennet, Charles D. Blaha
  • Patent number: 9566576
    Abstract: The invention relates to novel metal complexes useful as catalysts in redox reactions (such as, hydrogen (H2) production). In particular, the invention provides novel transition metal (e.g., cobalt (Co) or nickel (Ni)) complexes, in which the transition metal is coupled with N,N-Bis(2-pyridinylmethyl)-2,2?-Bipyridine-6-methanamine (DPA-Bpy), 6?-((bis(pyridin-2-ylmethyl)amino)methyl)-N,N-dimethyl-2,2?-bipyridin-6-amine (DPA-ABpy), N,N-bis((isoquinolin-1-yl)methyl)(6-(pyridin-2-yl)pyridin-2-yl)methanamine (DIQ-Bpy), or a derivative thereof. The invention also relates to a method of producing H2 from an aqueous solution by using the metal complex as a catalyst. In certain embodiments, the invention provides a metal complex of the formulae as described herein.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: February 14, 2017
    Assignee: The University of Memphis Research Foundation
    Inventors: Xuan Zhao, Charles E. Webster
  • Patent number: 9557413
    Abstract: A system for detecting object movement including a sensory network having at least one sensory device using modulated radar for detecting an object in proximity to the sensory network. The sensory network including a wireless transmission system and a base station having a computer processing system located remote from the sensory network and including a wireless transmission system to communicate with the sensory network. The base station having a computer readable program code for causing the computer processing system to analyze data received from the sensory network to determine motion characteristics of the object in proximity to the sensory network.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: January 31, 2017
    Assignee: The University of Memphis Research Foundation
    Inventors: Robert Kozma, Lan Wang, Khan M. Iftekharuddin, Ross Deming, Orges Furxhi, Sergi Consul
  • Patent number: 9552526
    Abstract: A method of image processing using a cellular simultaneous recurrent network (CSRN) is provided. In particular, the method includes a processor that sets initial parameters of the CSRN and generates a target image based on the initial parameters. Then, a training process is executed to learn an image processing task. The training process performs an image processing task on one of a plurality of sub-images of an input image and then the sub-image is stored after the training process. The training process is then repeated until the image processing task has been performed on each of the plurality of sub-images of the input image. Once the training process is complete, an image transformation is performed on the input image and an output image is displayed based on the transformed input image.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: January 24, 2017
    Assignee: University of Memphis Research Foundation
    Inventors: John K. Anderson, Khan M. Iftekharuddin