Patents Assigned to The University of Memphis Research Foundation
  • Patent number: 11124490
    Abstract: The present disclosure provides novel ATX inhibitors, and pharmaceutical compositions comprising said inhibitors, as well as methods of treatment comprising administration of said inhibitors.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: September 21, 2021
    Assignees: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, UNIVERSITY OF MEMPHIS
    Inventors: Duane D. Miller, Gabor G. Tigyi, Souvik Banerjee, Abby L. Parrill-Baker
  • Publication number: 20210275440
    Abstract: The invention provides microbeads comprising chitosan, a magnetic nanoparticle, and an agent, and methods for using such microbeads for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection or disease.
    Type: Application
    Filed: September 27, 2017
    Publication date: September 9, 2021
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: ANKITA MOHAPATRA, MICHAEL A. HARRIS, BASHIR I. MORSHED, JESSICA A. JENNINGS, JOEL BUMGARDNER, TOMOKO FUJIWARA, SANJAY R. MISHRA, DAVID A. LEVINE, GREGORY MCGRAW, WARREN O. HAGGARD
  • Publication number: 20210190774
    Abstract: The invention features compositions and methods related to the detection and molecular profiling of membrane bound vesicles using the Raman Extracellular Vesicle Assay (REVA). The method makes use of highly sensitive and specific surface enhanced Raman scattering technology to label and detect membrane bound vesicles that are captured on a miniaturized device based on the protein expression on the surface of the membrane bound vesicle.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 24, 2021
    Applicant: The University of Memphis Research Foundation
    Inventors: Xiaohua Huang, Allie Elyahb Kwizera, Vojtech Vinduska, Thang Ba Hoang
  • Publication number: 20210154264
    Abstract: Compositions of chitosan and one or more polyalcohols, such as mannitol and polyethylene glycol, and methods of use thereof, are provided. The disclosed compositions can deliver high concentrations of localized antimicrobials and metabolites to make infections more susceptible to antimicrobials. The disclosed compositions may be used to deliver biologically active agents to an infection at a site of trauma or surrounding an indwelling medical device, to treat an infection caused by persister bacterial cells, and to treat and/or prevent the formation of biofilm bacteria on an indwelling medical device or surrounding tissue.
    Type: Application
    Filed: November 23, 2020
    Publication date: May 27, 2021
    Applicant: The University of Memphis Research Foundation
    Inventors: J. Amber Jennings, Leslie Pace, Madison N. Brown
  • Publication number: 20210113699
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Application
    Filed: September 21, 2020
    Publication date: April 22, 2021
    Applicant: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: WARREN O. HAGGARD, SCOTT P. NOEL, JOEL D. BUMGARDNER
  • Publication number: 20210047653
    Abstract: The invention features compositions and methods for the inducible regulation of one or more target genes using a CRISPR-based synthetic gene regulatory network that responds to spatiotemporally-controlled agents present, for example, on a substrate (e.g., an electrospun template).
    Type: Application
    Filed: January 29, 2019
    Publication date: February 18, 2021
    Applicant: The University of Memphis Research Foundation
    Inventors: Gary L. Bowlin, Diego Augusto Velasquez Pulgarin, Alexander Espinosa
  • Patent number: 10799592
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: October 13, 2020
    Assignee: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Warren O. Haggard, Scott P. Noel, Joel D. Bumgardner
  • Publication number: 20200191778
    Abstract: The present disclosure features compositions and methods related to the detection and molecular profiling of extracellular vesicles using fluorescent probes. These compositions and methods leverage the unique optoelectrical properties of quantum dots and fluorescently labeled nanoparticles, which allows reliable, real-time detection of extracellular vesicles and vesicle surface bound or lumenal molecules.
    Type: Application
    Filed: December 18, 2019
    Publication date: June 18, 2020
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: XIAOHUA HUANG, THANG BA HOANG
  • Publication number: 20200138753
    Abstract: Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface.
    Type: Application
    Filed: October 31, 2019
    Publication date: May 7, 2020
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Jessica Amber Jennings, Daniel Lee Baker, Rukhsana Awais, Zoe Harrison, Babatunde Raji
  • Publication number: 20190275200
    Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).
    Type: Application
    Filed: March 11, 2019
    Publication date: September 12, 2019
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: GARY L. BOWLIN, ALLISON E. FETZ, MARKO Z. RADIC
  • Patent number: 10405746
    Abstract: In one embodiment, a method is disclosed in which an analog sensor receives an electromagnetic (EM) wave (e.g., a radio frequency signal) from an interrogation device. The sensor converts a biological measurement of a subject into an electrical resistance and modulates a response to reflect the incident signal based on the electrical resistance. The sensor then provides the response to the interrogation device that corresponds to the biological measurement.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: September 10, 2019
    Assignee: The University of Memphis Research Foundation
    Inventors: Bashir I. Morshed, Sergi Consul-Pacareu
  • Publication number: 20190192666
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Application
    Filed: July 31, 2018
    Publication date: June 27, 2019
    Applicant: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: WARREN O. HAGGARD, SCOTT P. NOEL, JOEL D. BUMGARDNER
  • Patent number: 10182499
    Abstract: A multilayer printed circuit as well as printed passive and active electronic components using additive printing technology is provided. The fabrication process includes a substrate and a first conductive layer that is printed with conductive ink on the substrate. An insulation layer that has uniform thickness is printed on the first conductive layer and the substrate, less via cavities, test point cavities, and a surface mount component contact point and mounting cavities. The insulation layer is replaceable with resistive layer or semi-conductive layer to fabricate electronic components. The vias are printed with conductive ink inside of the via cavities. Additionally, a second conductive layer is printed on the vias and over the insulation layer. The insulation, resistive, or semi-conducting layer, the vias, and the conductive layers are repeatedly printed in sequence to thus form the multilayer printed circuit.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: January 15, 2019
    Assignee: The University of Memphis Research Foundation
    Inventor: Bashir I. Morshed
  • Patent number: 10052388
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: August 21, 2018
    Assignee: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Warren O. Haggard, Scott P. Noel, Joel D. Bumgardner
  • Patent number: 9983162
    Abstract: The present invention is directed to an electrochemical sensor involving an electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode. Devices and methods for using this electrochemical sensor are also disclosed.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 29, 2018
    Assignees: THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Edward Chaum, Erno Lindner, Jidong Guo
  • Patent number: 9962468
    Abstract: This invention describes a cell growth apparatus, particularly neuronal printed circuit board apparatus comprising an aerogel base and a pre-printed cellular growth pattern. The cellular growth pattern is comprised of combinations of layers of cellular adhesion promoting materials, cellular adhesion inhibiting materials, and/or cellular signal promoting materials. The invention further describes methods of promoting cell growth using the neuronal printed circuit board apparatus of the invention. The invention is useful for regeneration and precise guidance of cells, particularly nerve cells, when used as an implant.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: May 8, 2018
    Assignee: The University of Memphis Research Foundation
    Inventor: Firouzeh Sabri
  • Patent number: 9952209
    Abstract: Magnetic-optical iron oxide-gold core-shell nanoparticles are disclosed. Methods for making and using the nanoparticles are also disclosed.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: April 24, 2018
    Assignee: The University of Memphis Research Foundation
    Inventors: Xiaohua Huang, Saheel Bhana
  • Publication number: 20170258967
    Abstract: The invention provides compositions featuring chitosan and polyethylene glycol and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the chitosan-PEG compositions can be loaded with one or more antimicrobial agents, including hydrophobic agents, and can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Application
    Filed: February 13, 2015
    Publication date: September 14, 2017
    Applicant: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Warren O. HAGGARD, Ashley C. PARKER, Jessica Amber JENNINGS
  • Patent number: 9733351
    Abstract: A system for detecting object movement including a sensory network having at least one sensory device using modulated radar for detecting an object in proximity to the sensory network. The sensory network including wireless transmission means and a base station having computer processing means located remote from the sensory network and including wireless transmission means to communicate with the sensory network. The base station having computer readable program code means for causing the computer processing means to analyze data received from the sensory network to determine motion characteristics of the object in proximity to the sensory network.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: August 15, 2017
    Assignee: The University of Memphis Research Foundation
    Inventors: Robert Kozma, Khan M. Iftekharuddin, Lan Wang, Ross Deming
  • Publication number: 20170209583
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicant: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: WARREN O. HAGGARD, SCOTT P. NOEL, JOEL D. BUMGARDNER