Patents Assigned to The University of Michigan
  • Publication number: 20250146987
    Abstract: A first-dimension-guided differential scaling algorithm of the contour plot in comprehensive two-dimensional gas chromatography (2D GC) system is developed by incorporating both 1D and 2D chromatograms obtained by first and second detectors. This differential scaling method is shown to significantly improve 2D GC results in terms of retention time accuracy and consistency, peak width and hence peak capacity, and analyte quantification accuracy, which are inevitably affected by the modulation period and phase shift in modulation when the conventional contour plot reconstruction methods. Furthermore, the differential scaling method is shown to better handle the coelution and missing peak issues often encountered in the conventional methods. Finally, the differential scaling method exhibits high versatility in detector selection, which greatly broadens the 2D GC utility and can be easily adapted to other 2D chromatography systems.
    Type: Application
    Filed: November 5, 2024
    Publication date: May 8, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Xudong FAN, Wenzhe Zang, Xiaheng Huang, Ruchi Sharma
  • Publication number: 20250145852
    Abstract: A durable solid and liquid repellant material is provided having an elastomeric matrix with a plurality of lubricating domains distributed therein formed by a partial crosslinking reaction between an elastomeric precursor having a first reactive functional group and a polyol having a second reactive functional group. The polyol has a limited solubility circle. The first reactive functional group is selected from the group consisting of: alkene, amine, carboxylic acid, hydroxyl, isocyanate, and combinations thereof and the second reactive group is selected from the group consisting of: amine, carboxylic acid, hydroxyl group, and combinations thereof. The partially crosslinked elastomeric matrix has a crosslink density of greater than or equal to about 200 mol/m3 and less than or equal to about 2,000 mol/m3. Methods for forming the durable solid and liquid repellant material are also provided.
    Type: Application
    Filed: February 10, 2023
    Publication date: May 8, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Anish TUTEJA, Jing WANG, Neil P. DASGUPTA
  • Patent number: 12287352
    Abstract: A motion sensing system uses high-voltage biasing to achieve high resolution with ultra-low power. The motion sensing system consists of a motion sensor, a readout circuit, and a high-voltage bias circuit to generate the optimized bias voltage for the motion sensor. By using the high-voltage bias, the signal from the motion sensor is raised above the readout circuit's noise floor, eliminating the power-hungry amplifier and signal-chopping used in conventional motion sensing systems. The bias circuit, while producing the programmable bias voltages for the motion sensor, also compensates for the process mismatch raised by the high voltage biases.
    Type: Grant
    Filed: November 9, 2022
    Date of Patent: April 29, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Yimai Peng, David Blaauw, Dennis Sylvester, David Kyojin Choo
  • Patent number: 12280159
    Abstract: Protein-based nanoparticles for treating cancer, such as those characterized by intracranial tumors, and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water-soluble protein having an average molecular weight of ?about 8 kDa and ?about 700 kDa. In certain variations, the water-soluble protein is cross-linked (e.g., with an optional crosslinking agent) and defines a mesh structure having an average linear mesh size of ?about 1 nm to ?about 4 nm. The nanoparticle may have a transcription factor such as a therapeutic nucleic acid in the mesh structure. Methods of making such nanoparticles may include jetting a liquid comprising the water-soluble protein through a nozzle, followed by exposing the liquid to an electric field sufficient to solidify the liquid and form the protein-based nanoparticles described above.
    Type: Grant
    Filed: November 8, 2021
    Date of Patent: April 22, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Joerg Lahann, Nahal Habibi, Jason V. Gregory, Maria Castro, Pedro Lowenstein, Ava Mauser, Padma Kadiyala, Daniel F. Quevedo, Felipe Nunez
  • Publication number: 20250108677
    Abstract: A stochastic Model Predictive Control approach is developed to efficiently optimize the thermal management of electric vehicles and accommodate scenarios with multiple routes. To account for the uncertainties, the cost function is constructed to minimize the expected cost across all possible routes over the prediction horizon. Thermal constraints are treated as soft constraints using slack variables. This approach allows for flexibility in satisfying the constraints while optimizing the performance. Through simulations, the performance of the proposed method is evaluated using a fleet of vehicles. In this way, the proposed method achieves a good trade-off between multiple competing performance metrics. Furthermore, an adaptation strategy is introduced, which dynamically adjusts the penalty weight value. This adaptive approach eliminates the need for offline calibration and further enhances performance.
    Type: Application
    Filed: September 26, 2024
    Publication date: April 3, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Mohammad Reza AMINI, Quihao Hu, Ilya Kolmanovsky, Jing Sun
  • Patent number: 12265285
    Abstract: Traveling-wave modulation is a form of space-time modulation which has been shown to enable unique electromagnetic phenomena such as non-reciprocity, beam-steering, frequency conversion, and amplification. The capability to accurately simulate spatially-discrete traveling-wave modulated structures is critical to design. However, simulating these structures is challenging due to the complex space-time dependence of the constituent unit cells. Thus, an interpath relation is derived for spatially-discrete traveling-wave modulated structures. The interpath relation reveals that the field within a single time-modulated unit cell (rather than an entire spatial period) is sufficient to determine the field solution throughout space. It is shown that the interpath relation can be incorporated into existing periodic method of moments solvers simply by modifying the source basis functions.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: April 1, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Anthony Grbic, Cody Scarborough
  • Publication number: 20250077068
    Abstract: Touchscreen devices, designed with an assumed range of user abilities and interaction patterns, often present challenges for individuals with diverse abilities to operate independently. Prior efforts to improve accessibility through tools or algorithms necessitated alterations to touchscreen hardware or software, making them inapplicable for the large number of existing legacy devices. This disclosure introduces a hardware interaction proxy that performs physical interactions on behalf of users while allowing them to continue utilizing accessible interfaces, such as screen readers and assistive touch on smartphones, for interface exploration and command input. The proxy maintains an interface model for accurate target localization and utilizes exchangeable actuators for physical actuation across a variety of device types, effectively reducing user workload and minimizing the risk of mistouch.
    Type: Application
    Filed: August 27, 2024
    Publication date: March 6, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Anhong GUO, Alanson SAMPLE, Ruijie GENG, Thomas KROLIKOWSKI, Yasha IRAVANTCHI, Chen LIANG
  • Patent number: 12233189
    Abstract: An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase CO2 sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas CO2 (EGCO2) level and/or an blood oxygen saturation sensor disposed upstream of the blood inlet of the membrane lung system and monitoring a blood oxygen saturation level; and a feedback controller receiving the CO2 signal and/or blood oxygen saturation signal and outputting a control signal to control gas flow and/or blood flow.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: February 25, 2025
    Assignees: The Regents of The University of Michigan, United States Government As Represented by the Department of Veterans Affairs
    Inventors: Joseph Potkay, Robert H. Bartlett, Alvaro Rojas-Pena
  • Patent number: 12227190
    Abstract: A grip force sensing and shape-changing steering wheel configured to serve as an intuitive means of communication between a human driver and automatic driving system or driver assist system.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: February 18, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Brent Gillespie, Akshay Bhardwaj
  • Patent number: 12220244
    Abstract: A short wave infrared (SWIR) imaging system and method of using the same is provided for assessing a tissue damage depth and/or readiness for reconstruction and/or debridement. The SWIR imaging system includes a light source for illuminating the wound or burn, an image light-registering camera system having at least one narrow-band SWIR filter to image the wound or burn and output imaging information, and a detection system for receiving the imaging information and processing the imaging information to determine a tissue damage depth and/or readiness for reconstruction and/or debridement assessment.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: February 11, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Benjamin Levi, Omer Berenfeld, Michael D. Morris
  • Patent number: 12225044
    Abstract: One commonality among most vehicular security attacks reported to date is that they ultimately require write access to the CAN bus. In order to cause targeted and intentional changes in the vehicle behavior, malicious CAN injection attacks require knowledge of the CAN message format. However, since this format is proprietary to OEMs and can differ even among different models of a single make of vehicle, one must manually reverse-engineer the CAN message format of each vehicle they target. To mitigate this difficulty, an automated CAN message translator is presented.
    Type: Grant
    Filed: September 26, 2020
    Date of Patent: February 11, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Kang G. Shin, Mert Dieter Pese
  • Patent number: 12216043
    Abstract: Methods and devices for detecting chiral properties from a sample are provided. Light may be directed towards a sample in contact with a chiral nanoparticle. Third harmonic Mie scattering (THMS) optical activity generated by the chiral nanoparticle in contact with the sample can then be detected. A device for detecting chiral properties of a sample is also contemplated that includes Nat least one microwell having a volume of ?about 1 microliter configured to hold a chiral nanoparticle capable of generating third harmonic Mie scattering (THMS) optical activity and a sample to be analyzed. The device includes a source of light configured to generate and direct light toward the at least one microwell containing the chiral nanoparticle and the sample and at least one detector configured to detect third harmonic Mie scattering (THMS) generated by the chiral nanoparticle in the microwell.
    Type: Grant
    Filed: December 1, 2022
    Date of Patent: February 4, 2025
    Assignees: The Regents of The University of Michigan, University of Bath
    Inventors: Nicholas A. Kotov, Ventsislav Valev, Lukas Ohnoutek, Ji-Young Kim
  • Publication number: 20250028563
    Abstract: An accelerator architecture is presented for a Transformer machine learning model. The accelerator is comprised of: one or more memory devices, each memory device has a random access memory and is configured for processing in memory, where a key matrix, a value matrix, a query weight matrix, a key weight matrix, and a value weight matrix for an attention mechanism of the Transformer machine learning model are stored in the one or more memory devices; and a control device interfaced with each of the one or more memory devices, the control device is used to coordinate the vector matrix multiplication operations performed on the memory devices, perform other arithmetic and logic operations used in attention blocks that are not suited for the memory devices, and coordinate the updates of the key and value matrices in the one or more memory devices.
    Type: Application
    Filed: July 19, 2024
    Publication date: January 23, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Wei Lu, Yuting Wu, Ziyu Wang
  • Patent number: 12206388
    Abstract: Bulk acoustic wave resonators are presented. Such resonators typically operate based on a dynamic nonuniform effective piezoelectricity in composite multilayer ferroelectrics with large electrostriction coefficients, like barium strontium titanate (BST). Harmonic resonance modes of a multilayer bulk acoustic wave resonator can be selectively excited with an electromechanical coupling coefficient equal to the fundament mode, which is contrary to the trend K2?1/n2 exhibited by conventional piezoelectric bulk acoustic resonators. Such a resonator allows for the design of a new class of band-switching filters.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: January 21, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Amir Mortazawi, Milad Zolfagharloo Koohi
  • Publication number: 20250012757
    Abstract: Nearly all existing direct current (DC) chemical vapor sensing methodologies are based on charge transfer between sensor and adsorbed molecules. However, the high binding energy at the charge-trapped sites, which is critical for high sensitivity, significantly slows sensors' response and makes the detection of non-polar molecules difficult. By exploiting the incomplete screening effect of graphene, this disclosure demonstrates a DC graphene electronic sensor for rapid (sub-second) and sensitive (ppb) detection of a broad range of vapor analytes, including polar, non-polar, organic and inorganic molecules. Molecular adsorption induced capacitance change in the graphene transistor is revealed to be the main sensing mechanism. This work provides an avenue for a broad spectrum real-time gas sensing technology and serves as an ideal testbed for probing molecular physisorption on graphene.
    Type: Application
    Filed: November 15, 2022
    Publication date: January 9, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Zhaohui ZHONG, Xudong FAN, Wenzhe ZANG, Zhe LIU, Girish S. KULKARNI, Hongbo ZHU, You WU
  • Patent number: 12190533
    Abstract: Image security is becoming an increasingly important issue with the progress of deep learning based image manipulations, such as deep image inpainting and deep fakes. There has been considerable work to date on detecting such image manipulations using better and better algorithms, with little attention being paid to the possible role hardware advances may have for more powerful algorithms. This disclosure proposes to use a focal stack camera as a novel secure imaging device for localizing inpainted regions in manipulated images. Applying convolutional neural network (CNN) methods to focal stack images achieves significantly better detection accuracy compared to single image based detection.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: January 7, 2025
    Assignee: The Regents of The University of Michigan
    Inventors: Theodore Norris, Zhengyu Huang, Jeffrey Fessler, Zhaohui Zhong
  • Patent number: 12184292
    Abstract: A phase locked loop (PLL) includes a phase detector configured to receive a reference signal and a feedback signal, wherein the reference signal has a reference frequency, sample the feedback signal, and output a phase detection signal indicative of a phase of the feedback signal. A voltage controlled oscillator is configured to generate an output signal based on the phase detection signal. The output signal has an output frequency greater than the reference frequency. Feedback circuitry is configured to detect a signal edge of the output signal and selectively supply, once per cycle of the reference signal, the detected signal edge of the output signal as the feedback signal.
    Type: Grant
    Filed: July 19, 2023
    Date of Patent: December 31, 2024
    Assignee: The Regents of The University of Michigan
    Inventors: Matthew R. Belz, Lu Jie, Seungheun Song, Michael P. Flynn
  • Publication number: 20240425414
    Abstract: An engineered cementitious composite (ECC) that forms extremely durable concrete (EDC) is provide that includes Portland cement binder, a tire-derived rubber granular component (e.g., crumb rubber), a calcined clay component comprising a calcined clay, Portland cement component, and limestone, water, a superplasticizer, a polymeric or natural fiber, and optionally further including silica sand, microsilica, fly ash, a cellulose-based viscosity modifier, microsilica, or combinations thereof. Such an engineered cementitious composite has a tensile strain capacity of greater than or equal to about 3% and an ultimate tensile strength of greater than or equal to about 2.2 MPa. Such an ECC has high toughness and can be loaded in both tension and compression having a built-in capability of crack width control without the need for steel reinforcement.
    Type: Application
    Filed: June 21, 2024
    Publication date: December 26, 2024
    Applicants: The Regents of The University of Michigan, Georgia Tech Research Corporation
    Inventors: Victor C. LI, Duo ZHANG, Kimberly KURTIS
  • Publication number: 20240418632
    Abstract: Methods and devices for detecting chiral properties from a sample are provided. Light may be directed towards a sample in contact with a chiral nanoparticle. Third harmonic Mie scattering (THMS) optical activity generated by the chiral nanoparticle in contact with the sample can then be detected. A device for detecting chiral properties of a sample is also contemplated that includes at least one microwell having a volume of ?about 1 microliter configured to hold a chiral nanoparticle capable of generating third harmonic Mie scattering (THMS) optical activity and a sample to be analyzed. The device includes a source of light configured to generate and direct light toward the at least one microwell containing the chiral nanoparticle and the sample and at least one detector configured to detect third harmonic Mie scattering (THMS) generated by the chiral nanoparticle in the microwell.
    Type: Application
    Filed: December 1, 2022
    Publication date: December 19, 2024
    Applicants: The Regents of The University of Michigan, University of Bath
    Inventors: Nicholas A. KOTOV, Ventsislav VALEV, Lukas OHNOUTEK, Ji-Young KIM
  • Publication number: 20240398552
    Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.
    Type: Application
    Filed: August 15, 2024
    Publication date: December 5, 2024
    Applicants: The Regents of The University of Michigan, Georgia Tech Research Corporation
    Inventors: David A. ZOPF, Scott J. Hollister