Patents Assigned to The University of Michigan
  • Publication number: 20220142936
    Abstract: Protein-based nanoparticles for treating cancer, such as those characterized by intracranial tumors, and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water-soluble protein having an average molecular weight of ?about 8 kDa and ?about 700 kDa. In certain variations, the water-soluble protein is cross-linked (e.g., with an optional crosslinking agent) and defines a mesh structure having an average linear mesh size of ?about 1 nm to ?about 4 nm. The nanoparticle may have a transcription factor such as a therapeutic nucleic acid in the mesh structure. Methods of making such nanoparticles may include jetting a liquid comprising the water-soluble protein through a nozzle, followed by exposing the liquid to an electric field sufficient to solidify the liquid and form the protein-based nanoparticles described above.
    Type: Application
    Filed: November 8, 2021
    Publication date: May 12, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joerg LAHANN, Nahal HABIBI, Jason V. GREGORY, Maria CASTRO, Pedro LOWENSTEIN, Ava MAUSER, Padma KADIYALA, Daniel F. QUEVEDO, Felipe NUNEZ
  • Patent number: 11327018
    Abstract: An image reconstruction method includes capturing a reference image of the specimen and capturing a set of original images based on the reference image. The method includes generating a set of analyzed images based on the set of original images by determining an intensity distribution for each pixel of each original image of the set of original images and combining the intensity distribution at each pixel location across the set of original images into an intermediate image. The method includes, identifying an object in the intermediate image. In response to identifying the object in the intermediate image, determining an intensity value of the object in each original image of the set of original images and generating an improved image of the object based on the determined intensity value of the object. The method includes generating a final image including the improved image of the object and displaying the final image.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: May 10, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Somin Eunice Lee, Yunbo Liu, Yipei Wang
  • Patent number: 11325727
    Abstract: A magnetic nozzle having a converging/diverging contour shape that converts the thermal energy of a propellant into directed kinetic energy, but uses magnetic fields instead of a physical boundary to direct the flow of particles.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: May 10, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Benjamin Longmier, John Patrick Sheehan
  • Patent number: 11329241
    Abstract: Disclosed herein are exciton-blocking treatments for buffer layers used in organic photosensitive optoelectronic devices. More specifically, the organic photosensitive optoelectronic devices described herein include at least one self-assembled monolayer disposed on the surface of an anode buffer layer. Methods of preparing these devices are also disclosed. The present disclosure further relates to methods of forming at least one self-assembled monolayer on a substrate.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: May 10, 2022
    Assignee: The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Byeongseop Song, Jeramy D. Zimmerman
  • Patent number: 11319302
    Abstract: Provided herein are small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) activity, and methods of use thereof for the treatment of disease, including leukemia and other cancers, as well as other diseases dependent on the activity of PRC1.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: May 3, 2022
    Assignee: The Regents of the University of Michigan
    Inventors: Tomasz Cierpicki, Jolanta Grembecka, Weijiang Ying, Yiwu Yao, Felicia Gray, Qingjie Zhao
  • Patent number: 11323423
    Abstract: Aspects of the subject disclosure may include, for example, a method in which a processing system parses a network trace to collect packet information for an encrypted adaptive bite rate (ABR) video stream encoded into a plurality of tracks; detects request packets corresponding to a sequence of requests for video segments to be downloaded at a network client; and determines a traffic volume downloaded at the network client to obtain a sequence of traffic volumes. The processing system identifies, for each of the sequence of traffic volumes, a set of candidate segments each having a size meeting a size-matching criterion; selects a segment from the set of candidate segments to determine a segment sequence meeting an index-matching criterion; and infers characteristics of the sequence of traffic volumes based on the segment sequence. Other embodiments are disclosed.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: May 3, 2022
    Assignees: AT&T Intellectual Property I, L.P., The Regents of the University of Michigan
    Inventors: Subhabrata Sen, Shichang Xu, Zhuoqing Morley Mao
  • Patent number: 11321604
    Abstract: Subject matter disclosed herein may relate to storage and/or processing of signals and/or states representative of neural network parameters in a computing device, and may relate more particularly to compressing signals and/or states representative of neural network nodes in a computing device.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: May 3, 2022
    Assignees: ARM Ltd., The Regents of the University of Michigan
    Inventors: Jiecao Yu, Andrew Lukefahr, David Palframan, Ganesh Dasika, Reetuparnda Das, Scott Mahlke
  • Publication number: 20220126014
    Abstract: A device for wound irrigation and debridement includes a body extending along a longitudinal axis. The body comprises an interior region and an opening such that that the interior region and the first opening are configured to transfer an irrigation fluid. The body comprises a compliant region having a first stiffness and a debridement region having a different second stiffness. The compliant region defines a distal surface. In a first configuration, the compliant region defines a first axial dimension, the distal surface engages a target body region, and the debridement region is axially offset from the distal surface and disengaged from the target body region. In a second configuration, the compliant region is compressed to define a second axial dimension less than the first axial dimension, thereby engaging the debridement region with the target body region, and the distal surface engages the target body region.
    Type: Application
    Filed: February 4, 2020
    Publication date: April 28, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Paul Stephen CEDERNA, Nishant GANESH KUMAR, Jeffrey Stephen PLOTT
  • Patent number: 11313001
    Abstract: Provided herein are compositions, systems, and methods for detecting microorganisms. In particular, provided herein are compositions, systems, and methods for rapid, multiplex detection of microorganism in unpurified biological samples.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: April 26, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Nicholas Kotov, Jeremy Scott VanEpps, Kevin Ward
  • Patent number: 11311624
    Abstract: Inhibitors of mTOR, MEK, JAK and PI3K and compositions containing the same are disclosed. Methods of using the inhibitors in the treatment of a variety of diseases and conditions wherein inhibition of one or more of mTOR, MEK, JAK and PI3K provides a benefit also are disclosed. Methods of using chemical attachment moieties and linkers for the purposes of modifying compound solubility and/or lymphatic absorption are also disclosed.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: April 26, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brian D. Ross, Marcian Van Dort
  • Publication number: 20220117919
    Abstract: Methods for enhancing the bioavailability of N-(2,6-bis(1-methylethyl)phenyl)-N?-((1-(4-(dimethylamino)phenyl)cyclopentyl)-methyl)urea hydrochloride (ATR-101) through administration with food, and compositions and kits related thereto.
    Type: Application
    Filed: October 29, 2021
    Publication date: April 21, 2022
    Applicant: The Regents of the University of Michigan
    Inventor: Pharis MOHIDEEN
  • Patent number: 11307203
    Abstract: The present disclosure provides compositions and methods for using one or more polypeptide probes to profile an immune response. The polypeptide probe can be used to detect one or more antibodies from a sample. Furthermore, the present disclosure provides methods and compositions for characterizing a cancer based on the detection of one or more antibodies, such as autoantibodies.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: April 19, 2022
    Assignees: The Regents of the University of Michigan, Exact Sciences Development Company, LLC
    Inventors: Arul M. Chinnaiyan, Xiaoju Wang, Alex Tsodikov, Jeanne Ohrnberger
  • Patent number: 11297828
    Abstract: Methods and devices for lyo-processing biological materials are provided. The methods include submerging the biological molecules or cells in a buffer solution comprising trehalose, withdrawing the biological molecules or cells from the buffer solution in an environment that does not include oxygen to generate lyo-stabilized biological molecules or cells, and storing the lyo-stabilized biological molecules or cells. The devices include a motor that lowers a horizontal member having a clamp for receiving a substrate toward a solvent reservoir and raises the horizontal member having the clamp up and away from the solvent reservoir.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: April 12, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Nilay Chakraborty
  • Patent number: 11299084
    Abstract: A selectively rigidizable membrane for cargo management comprises a vacuum bladder, and a first architectural layer and a second architectural layer, each of the first and second architectural layers including a plurality of tiles interconnected by flexural elements, each of the tiles of the first and second architectural layers including at least one constraining element extending therefrom, wherein, when atmospheric pressure is present within the vacuum bladder, the first and second architectural layers are slidably moveable relative to one another and the membrane is flexible, and further wherein, when negative pressure is applied to the vacuum bladder, the first and second architectural layers are forced into engagement with one another, the constraining elements of the first and second architectural layers providing mechanical interference and preventing sliding movement of the first and second architectural layers relative to one another, causing the membrane to become substantially rigid.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: April 12, 2022
    Assignees: GM GLOBAL TECHNOLOGY OPERATIONS LLC, REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Paul W. Alexander, Wonhee M. Kim, Jonathan E. Luntz, Diann Brei, Koray Benli, Sarah M. Sober, Laura Alejandra Giner Munoz, Nancy L. Johnson
  • Patent number: 11302839
    Abstract: A design for a micro-lens (i.e., a lens on the scale of micrometers) incorporates existing nanofabrication techniques and can be incorporated into High Concentrating Photovoltaic (HCPV), solar thermal collectors, and traditional flat PV systems. Using the theory of wave optics, the design is able to achieve a high numerical aperture, i.e., it can receive light over a wider range of angles. The design also reduces the distance the focal point shifts as the light source shifts; this eliminates the need for a tracking system in CPV and PV applications. Reducing the lens size also facilitates smaller, lightweight CPV systems, which makes CPV attractive for additional applications. Finally, these concentrators reduce the exchanging area of a typical flat solar thermal system where heat is received, which improves the overall system's efficiency and allows its use also during rigid winter time.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: April 12, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, DEMETRA ENERGIA SRL
    Inventors: Ya Sha Yi, Mao Ye, Roberto Santinelli
  • Patent number: 11302881
    Abstract: The present disclosure generally relates to organic photosensitive optoelectronic devices and polaron pair recombination dynamics to impact efficiency and open circuit voltages of organic solar cells. The present disclosure also relates, in part, to methods of making organic photosensitive optoelectronic devices comprising the same.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: April 12, 2022
    Assignee: The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Noel C. Giebink
  • Patent number: 11292245
    Abstract: A device includes a nozzle including a discharge end for discharging a fluid, a shutter plate including an aperture, the shutter plate positioned at the discharge end of the nozzle, a plurality of tethers coupled to the shutter plate, and a plurality of electrostatic actuators. Each of the plurality of electrostatic actuators are coupled to one or more of the plurality of tethers. The plurality of electrostatic actuators are configured to move the shutter plate between an open position and a closed position relative the discharge end of the nozzle. In the open position, the aperture is in fluid communication with the discharge end of the nozzle to permit fluid from the discharge end of the nozzle to flow through the aperture. In the closed position, at least a portion of the shutter plate inhibits fluid from the discharge end of the nozzle from flowing through the aperture.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: April 5, 2022
    Assignees: Trustees of Boston University, The Regents of the University of Michigan
    Inventors: David J. Bishop, Lawrence Barrett, Stephen Forrest
  • Publication number: 20220099573
    Abstract: A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultra-sound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultra-sound waves, is used for imaging Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.
    Type: Application
    Filed: January 9, 2020
    Publication date: March 31, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Xudong FAN, Xueding WANG, Xuzhou LI, Yu QIN, Xiaotian TAN, Yu-Cheng CHEN, Qiushu CHEN
  • Patent number: 11286671
    Abstract: A water tower system having a catchment system to collect climatically-produced water and route the water to an output; a water mattress system fluidly coupled below to the catchment system to collect the water from the catchment system; an elevated water tower storage system fluidly coupled to the water mattress system to receive and store water from the water mattress system, the elevated water tower storage system is located at or below the water mattress system; and a water distribution system fluidly coupled to the elevated water tower storage system to receive water from the elevated water tower storage system and distribute the water to a predetermined location.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: March 29, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Anya Sirota, Jean Louis M. Farges
  • Patent number: 11288445
    Abstract: A method is presented for assigning billing codes for medical procedures. For each string in an input record describing a medical procedure in the input text description, comparing the string to entries in a dictionary of common misspelling and, in response to the string matching an entry in the dictionary, replacing the string with proper spelling; for each string in the input record, comparing the string to entries in another dictionary of abbreviations and, in response to the string matching an entry in the dictionary, replacing the string with expanded text for the abbreviation; constructing a feature vector by extracting features from the input record; for each billing code in a listing of possible billing codes, computing a classifier score for the feature vector using machine learning; and assigning a billing code to the input record from the listing of possible billing codes based on the classifier scores.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: March 29, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Michael L. Burns, John Vandervest, Sachin Kheterpal, Nirav Jitendra Shah, Leif Saager, Jay Jeong, Anik Sinha