Abstract: The present invention provides compositions and methods to prevent apoptosis. In particular, provided herein are compositions and methods which prevent FAS-mediated photoreceptor apoptosis.

Abstract: Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid lipid walls. The fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.

Abstract: A liquid delivery apparatus for the intrathecal delivery of one or more medications to a patient is disclosed. The liquid delivery apparatus generally includes a liquid reservoir, a liquid metering unit fluidly connected to the liquid reservoir, and a catheter delivery tube fluidly connected to the liquid metering unit. Preferably, the liquid delivery apparatus includes two or more liquid reservoirs. In various embodiments, the liquid reservoir includes a deformable balloon and a compressive sleeve spring as a pressure source, the liquid metering unit is a piezoelectrically actuated microvalve, and/or diagnostic sensors are included in the apparatus. The disclosed apparatus are compact, volume-efficient, energy-efficient, capable of delivering accurate fluid volumes, and address problems associated with multi-medication therapies. Methods of operating the liquid delivery apparatus are also disclosed.

Abstract: An integrated vascular delivery system having a frame configured to receive a catheter insertable in a patient to deliver fluid at an insertion site. The frame includes a first hub, a second hub, and a pair of flexible lateral members extending between the hubs and including a tubular lateral member. The system also includes a fluidic channel that fluidically communicates with the catheter, wherein the fluidic channel passes through the tubular lateral member and at least one of the hubs, and includes a fixed turnabout portion in which fluid flows in a direction different from that within the catheter. The first and second hubs provide anchoring points on the patient distributed around the insertion site and on opposite ends of the catheter, thereby anchoring the frame to the patient and stabilizing the catheter. A method is provided for using an integrated vascular delivery system.

Abstract: The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48? HSCs, and CD244? HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs, CD48? HSCs, and CD244? HSCs populations, as well as methods of treating subjects with such compositions.

Abstract: A linking ligand compound includes three bidentate chemical moieties distributed about a central chemical moiety. Another linking ligand compound includes a bidentate linking ligand and a monodentate chemical moiety. Coordination polymers include a plurality of metal clusters linked together by residues of the linking ligand compounds.

Abstract: A method of treating an LCN13-related condition is provided comprising administering to a patient in need thereof a therapeutically effective amount of a lipocalin or a physiologically active fragment thereof.

Abstract: A hybrid energy storage system suitable for use in a vehicle having an electrified drivetrain includes a first energy storage module and a second energy storage module that is different than the first energy storage module. The first energy storage module may have a cell configuration, a cell chemistry, a cell number, a controller or another characteristic different than a like characteristic of the second energy storage module.

Abstract: A catalyst composition contains an active metal on a support including a high surface area substrate and an interstitial compound, for example molybdenum carbide. Pt—Mo2C/Al2O3 catalysts are described. The catalyst systems and compositions are useful for carrying out reactions generally related to the water gas shift reaction (WGS) and to the Fischer-Tropsch Synthesis (FTS) process.

Abstract: A system and method is provided for automatically generating explanations for individual records in an access log.

Abstract: A method of generating valid vertical interconnect positions for a multiple layer integrated circuit including multiple layers stacked vertically above one another and having a bonding interface between at least one pair of layers. The interface is formed by the coupling of a pair of conductive bond patterns formed on facing surfaces of the pair of layers. The method includes defining a candidate transformation origin, defining a sub-region which tessellates across the patterns, applying a predetermined transformation to the patterns at the bonding interface, determining the validity of the candidate transformation origin in dependence on coincidence of at least a subset of the patterns with the transformed patterns, selecting a valid transformation origin, and defining a set of valid vertical interconnect positions associated with the valid transformation origin at positions in the bonding interface where the original and transformed patterns coincided with each other.

Abstract: There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse.

Abstract: The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening.

Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.

Abstract: One aspect of the invention provides a theft detection node including: a power source; an accelerometer; a gyroscope; a transmitter; and a microcontroller in communication with the power source, the motion detector, and the transmitter. The microcontroller is programmed to determine whether the theft detection node is being transported and, if the theft detection node is being transported: estimate the distance traveled between successive stops and transmit the estimated distance to a server. Another aspect of the invention provides a method of determining a path traveled by a node. The method includes: generating a Hidden Markov Model having a plurality of hidden states, each hidden state corresponding to a road segment; receiving information from the node about one or more turns and the distance traveled between successive stops; and determining the most likely path for the distance between successive stops and a distance between successive turns.

Abstract: A computer-implemented method is provided for generating patient models from multiple imaging contrast sources which may be, for example from magnetic resonance imaging without computed tomography. The method includes: acquiring multiple sets of image data representing a volume of a patient using magnetic resonance imaging, wherein each set of image data is acquired in a different manner so as to create contrast amongst tissue types of the patient; classifying tissue in each voxel in the volume using the multiple sets of image data as input to a classification algorithm; and generating a patient model for the volume from probability distributions of the classes of tissue as derived from the classification algorithm.

Abstract: Methods of making a photovoltaic device with an organic liquid precursor having electron donor, electron acceptor, and liquid carrier are provided. The liquid precursor is applied to an electrode. A gas permeable layer/stamp contacts and applies pressure to the organic liquid precursor removing liquid carrier to form a solid active material with uniform interpenetrating network domains of electron donor/acceptor materials. A two-step process is also contemplated. A liquid precursor with either electron donor or acceptor is applied to an electrode, contacted under pressure with a first stamp having a nanoscale pattern, thus forming a solid with a patterned surface. Then, a second liquid precursor with the other of the electron donor or acceptor is applied to the patterned surface, contacted with a second stamp under pressure to form the active material. A transparent conducting electrode with material nanograting can be formed. The methods also include continuous processing, like roll-to-roll manufacturing.

Abstract: The present invention relates to compositions and methods for treating and preventing cocaine addiction. In particular, the present invention provides mutated cocaine esterase proteins for use in treating and preventing cocaine addiction.

Abstract: Methods for enhancing hydrogen spillover and storage are disclosed. One embodiment of the method includes doping a hydrogen receptor with metal particles, and exposing the hydrogen receptor to ultrasonication as doping occurs. Another embodiment of the method includes doping a hydrogen receptor with metal particles, and exposing the doped hydrogen receptor to a plasma treatment.

Abstract: A data processing apparatus is provided comprising a processing device, and an N-way set associative cache for access by the processing device, each way comprising a plurality of cache lines for temporarily storing data for a subset of memory addresses of a memory device, and a plurality of dirty fields, each dirty field being associated with a way portion and being set when the data stored in that way portion is dirty data. Dirty way indication circuitry is configured to generate an indication of the degree of dirty data stored in each way. Further, staged way power down circuitry is responsive to at least one predetermined condition, to power down at least a subset of the ways of the N-way set associative cache in a plurality of stages, the staged way power down circuitry being configured to reference the dirty way indication circuitry in order to seek to power down ways with less dirty data before ways with more dirty data.