Abstract: The present invention provides methods to prevent photoreceptor death. In particular, the present invention provides peptides which prevent FAS-mediated photoreceptor apoptosis.

Abstract: A back-propagating intersection collision avoidance system is provided. The system can include a first vehicle and a second vehicle, the first and second vehicles each operable to approach an intersection at a definable velocity and acceleration. In addition, the intersection can have a collision zone in which the first and second vehicles will collide if they are present there at the same time. The first vehicle can have a processing unit with a controller and a microprocessor, the microprocessor having an algorithm with a disturbance model. The processing unit is operable to back-propagate from the collision zone a capture set as a function of a disturbance for the first and second vehicles.

Abstract: An electrode array, having application as a cochlear implant, includes a tube formed of Parylene defining a hollow channel. A substrate formed primarily of Parylene is supported by the tube. In turn, a plurality of metallic electrodes and feed lines are supported by the substrate. Numerous voids are defined by the tube which opens into the hollow channel. The size and spacing of the voids regulate stiffness and curl of the tube to provide excellent fit within the cochlea.

Abstract: A method of treating side effects of antibiotic treatment includes the step of internally administering an antibiotic that is capable of inducing hearing loss in a mammal. The method further includes the step of internally administering a composition to the mammal in conjunction with administration of the antibiotic. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, vitamin E, vitamin C, and a vasodilator comprising magnesium. The combination of vitamins and the vasodilator comprising magnesium, in the biologically effective amounts, provides an effective treatment for treating side effects of antibiotic treatment.

Abstract: A microprocessor has a silicon area comprising a plurality of transistors implemented on the silicon area and a fault detection circuit occupying less than 20% of the silicon area and configured to detect faults at runtime in at least 80% of the plurality of transistors.

Abstract: A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.

Abstract: A composition for hydrogen storage includes a source of hydrogen atoms, a receptor, and a chemical bridge formed between the source and the receptor. The chemical bridge is formed from a precursor material. The receptor is adapted to receive hydrogen spillover from the source.

Abstract: Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases.

Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

Abstract: A dynamically reconfigurable battery framework for management of a large-scale battery system systems is provided. The framework monitors, reconfigures, and controls large-scale battery systems online. The framework is built upon a topology-based bypassing mechanism that provides a set of rules for changing the battery-pack configuration, and a semantic bypassing mechanism by which the battery-cell connectivity is reconfigured to recover from a battery-cell failure. More specifically, the semantic bypassing mechanism implements a constant-voltage-keeping policy and a dynamic-voltage-allowing policy. The former policy is effective in preventing unavoidable voltage drops during the battery lifetime, while the latter policy is effective in supplying different amounts of power to meet a wide-range of application requirements.

Abstract: A computer implemented method of identifying potential micoRNA targets and biomarkers comprises receiving data identifying a first set of mRNA sequences into computer accessible memory. Each mRNA sequence in the first set has a region that is upstream of a translation start site, a region that is downstream of a translation stop site, and an open reading frame. The method further comprises receiving data identifying a second set of microRNA (miRNA) sequences into the computer accessible memory. Each microRNA sequence has a 5? miRNA section and a 3? miRNA section. Each mRNA sequence is characterized by an expression pattern in the first set as being up-regulated, down-regulated, or uncharged as compared to a control sample and each miRNA sequence in the second set as being up-regulated, down-regulated, or uncharged as compared to the control sample. It is then determined which mRNA sequences from the first set are susceptible to being regulated by microRNA from the second set.

Abstract: A data processing apparatus is provided having a cache memory comprising a data storage array and a tag array and a cache controller coupled to the cache memory responsive to a cache access request from processing circuitry to perform cache look ups. The cache memory is arranged such that it has a first memory cell group configured to operate in a first voltage domain and a second memory cell group configured to operate in a second voltage domain that is different from the first voltage domain. A corresponding data processing method is also provided.

Abstract: Porous electrodes in which the porosity has a low tortuosity are generally provided. In some embodiments, the porous electrodes can be designed to be filled with electrolyte and used in batteries, and can include low tortuosity in the primary direction of ion transport during charge and discharge of the battery. In some embodiments, the electrodes can have a high volume fraction of electrode active material (i.e., low porosity). The attributes outlined above can allow the electrodes to be fabricated with a higher energy density, higher capacity per unit area of electrode (mAh/cm2), and greater thickness than comparable electrodes while still providing high utilization of the active material in the battery during use. Accordingly, the electrodes can be used to produce batteries with high energy densities, high power, or both compared to batteries using electrodes of conventional design with relatively highly tortuous pores.

Abstract: The present invention provides systems and methods for monitoring tissue regions. In particular, the present invention provides systems and methods for detecting changes in tissue regions over a period of time. In some embodiments, the systems and methods of the present invention are used to evaluate the effectiveness of a particular treatment of a tissue region. In some embodiments, the systems and methods employ functional diffusion map algorithms for imaging changes in tissue regions over time and/or in response to therapeutic interventions.

Abstract: The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, and treatment of solid tumor stem cells.

Abstract: The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

Abstract: A system is presented for detecting malware applications residing on a mobile device powered by a battery. The system includes a power monitoring module, a data analysis module and a data store that stores a plurality of known power signatures signifying a power consumption anomaly. The power monitoring module measures power drawn from the battery and the data analysis module extracts a power history signature from the power measures. The data analysis module then compares the power history signature with the plurality of known power signatures and initiates a protective operation if the power history signature is closely correlated to one or more of the known power signatures.

Abstract: A dynamically reconfigurable battery framework for management of a large-scale battery system systems is provided. The framework monitors, reconfigures, and controls large-scale battery systems online. The framework is built upon a topology-based bypassing mechanism that provides a set of rules for changing the battery-pack configuration, and a semantic bypassing mechanism by which the battery-cell connectivity is reconfigured to recover from a battery-cell failure. More specifically, the semantic bypassing mechanism implements a constant-voltage-keeping policy and a dynamic-voltage-allowing policy. The former policy is effective in preventing unavoidable voltage drops during the battery lifetime, while the latter policy is effective in supplying different amounts of power to meet a wide-range of application requirements.

Abstract: A dynamically reconfigurable framework is provided for a large-scale battery system. The framework is comprised of a plurality of battery circuits arranged adjacent to each other to form a battery-cell array that is coupled to an application load. A given battery circuit includes: a battery cell with an input terminal and an output terminal; a first switch connected between the load and an input terminal of the battery cell; a second switch is connected between an input terminal of the battery cell and an output terminal of a battery cell in an immediately adjacent battery circuit; and a third switch connected between the output terminal of the battery cell and the output terminal of the battery cell in the adjacent battery circuit. The battery-cell array also includes a local controller that selectively controls the switches in the plurality of battery circuits.