Patents Assigned to The University of Mississippi
  • Process and apparatus for producing spherical pellets using molten solid matrices
    Patent number: 7413690
    Abstract: A method and apparatus for forming pellets, the apparatus comprising a column for housing column liquid; column liquid; temperature controlling elements engaging the column and capable of maintaining a first and second temperature in the column liquid, and an injection orifice to introduce the liquid pellet composition to the column liquid.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: August 19, 2008
    Assignee: The University of Mississippi
    Inventors: Sreekhar Cheboyina, John H. O'Haver
  • System and method for manipulating insect behavior
    Publication number: 20080192578
    Abstract: A method and system for detecting the presence of subterranean termites, involving use of a thermal imaging camera to scan the structure before installation of an acoustic sensor in order to quickly locate potential areas of subterranean termite infestation, and an acoustic sensor in the form of an accelerometer or the disclosed innovative acoustic sensors having a bandwidth of at least 100 Hz to 15 kHz to detect noises made by the subterranean termites. Information collected by the acoustic sensor may be transmitted to a portable mini-computer (pocket PC) for confirmation and to a central operations center for inclusion in a comprehensive database of termite data and information.
    Type: Application
    Filed: September 26, 2007
    Publication date: August 14, 2008
    Applicant: The University of Mississippi
    Inventor: Peng Lee
  • DNA encoding a human imidazoline receptor and ligand binding assay employing same
    Patent number: 7384752
    Abstract: A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family of receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Also, a screening method for identifying drugs that interact with the imidazoline receptor is described.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: June 10, 2008
    Assignee: University of Mississippi Medical Center
    Inventors: John E. Piletz, Tina R. Ivanov
  • Termite acoustic detection
    Patent number: 7385483
    Abstract: A method and system for detecting the presence of subterranean termites, involving use of a thermal imaging camera to scan the structure before installation of an acoustic sensor in order to quickly locate potential areas of subterranean termite infestation, and an acoustic sensor in the form of an accelerometer or the disclosed innovative acoustic sensors having a bandwidth of at least 100 Hz to 15 kHz to detect noises made by the subterranean termites. Information collected by the acoustic sensor may be transmitted to a portable mini-computer (pocket PC) for confirmation and to a central operations center for inclusion in a comprehensive database of termite data and information.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: June 10, 2008
    Assignee: The University of Mississippi
    Inventor: Peng Lee
  • Compounds and methods for inhibiting cellular responses to hypoxia
    Patent number: 7375132
    Abstract: Compounds and compositions of the following formula: and analogs and stereoisomers thereof (and pharmaceutically acceptable carriers). Additionally disclosed is a method of inhibiting hypoxia-inducible factor-1 function in a patient or sample thereof, comprising administering to the patient or sample an effective inhibiting amount of a compound or composition of the present invention.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: May 20, 2008
    Assignee: University of Mississippi
    Inventors: Yu-Dong Zhou, Dale G. Nagle, Asjad Kaleem Mohammed, Chowdhury Faiz Hossain
  • Solubilization and disposal of radioactive scale and sludge
    Patent number: 7360967
    Abstract: A process to transform solid, low-level, radioactive waste produced from oil and gas production into a form that may be safely disposed of, such as by re-injection into geologic formations in the Earth.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: April 22, 2008
    Assignee: University of Mississippi
    Inventor: John Charles Matthews
  • Design and synthesis of optimized ligands for PPAR
    Patent number: 7339065
    Abstract: This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: March 4, 2008
    Assignees: Bethesda Pharmaceuticals, Inc., The University of Mississippi
    Inventors: Mitchell A. Avery, Harrihar A. Pershadsingh
  • HIGH MOLECULAR WEIGHT POLYSACCHARIDE FRACTION FROM ALOE VERA WITH IMMUNOSTIMULATORY ACTIVITY
    Publication number: 20070286914
    Abstract: A complex, water soluble polysaccharide fraction having potent immunostimulatory activity isolated from Aloe vera. The polysaccharide fraction has an apparent molecular weight above 2 million daltons. Its major glycosyl components are glucose, galactose, mannose and arabinose. The invention further includes pharmaceutical compositions containing the instant polysaccharide fraction, optionally in combination with acceptable pharmaceutical carriers and/or excipents. These pharmaceutical compositions may be used to provide immunostimulation to an individual in need of such treatment by administering to such an individual an effective amount of the composition. The polysaccharide fraction is also useful as a component of dietary supplements and as a standardization component of commercial Aloe products.
    Type: Application
    Filed: January 12, 2007
    Publication date: December 13, 2007
    Applicant: The University of Mississippi
    Inventors: David Pasco, Nirmal Pugh, Mahmoud Elsohly, Samir Ross
  • Potent Immunostimulatory from Microalgae
    Publication number: 20070264271
    Abstract: Immunostimulatory polysaccharides can be preferentially extracted from food-grade microalgae using an aqueous ethanol extraction procedure. The resulting preparations exhibit extremely potent immunostimulatory activity. The preferential extraction of these immunostimulatory polysaccharides is dependent on the concentration of ethanol used and the extraction temperature. The most efficient conditions are 50% ethanol concentration at temperatures between 60° and 70° C. The isolated polysaccharide preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function.
    Type: Application
    Filed: April 5, 2007
    Publication date: November 15, 2007
    Applicant: The University of Mississippi
    Inventors: Mahmoud ElSohly, Samir Ross, David Pasco, Nirmal Pugh, Hala ElSohly
  • Termite acoustic detection
    Patent number: 7271706
    Abstract: A method and system for detecting the presence of subterranean termites, involving use of a thermal imaging camera to scan the structure before installation of an acoustic sensor in order to quickly locate potential areas of subterranean termite infestation, and an acoustic sensor in the form of an accelerometer or the disclosed innovative acoustic sensors having a bandwidth of at least 100 Hz to 15 kHz to detect noises made by the subterranean termites. Information collected by the acoustic sensor may be transmitted to a portable mini-computer (pocket PC) for confirmation and to a central operations center for inclusion in a comprehensive database of termite data and information.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: September 18, 2007
    Assignee: The University of Mississippi
    Inventor: Peng Lee
  • Controlling Toxicity of Aminoquinoline Compounds
    Publication number: 20070190188
    Abstract: A method of controlling toxicity to a user caused by administration to the user of an aminoquinoline compound comprising administering to the user a toxicity controlling amount of at least one inhibitor of a cytochrome P450 (CYP) enzyme.
    Type: Application
    Filed: December 13, 2006
    Publication date: August 16, 2007
    Applicant: The University of Mississippi
    Inventors: Larry Walker, Babu Tekwani, Lalit Tripathi
  • Method and device for reducing engine noise
    Patent number: 7240493
    Abstract: A method and device to reduce the noise produced by jet aircraft engines and/or other supersonic nozzles involves the use of corrugated engine seals (30) for the secondary internal divergent flaps (14) of the nozzle (10). Such corrugated seals (30) serve not only to eliminate shock-generated noise, but also generate a counter-rotating vorticity to force low speed mixing of surrounding ambient air with the high-speed jet exhaust. Lower exhaust velocities, combined with reduced levels of the turbulent Reynolds shear stress, lead to reduction of turbulence-generated noise, including Mach wave emission.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: July 10, 2007
    Assignee: The University of Mississippi
    Inventor: John M. Seiner
  • Potent immunostimulants from microalgae
    Patent number: 7205284
    Abstract: Immunostimulatory polysaccharides can be preferentially extracted from food-grade microalgae using an aqueous ethanol extraction procedure. The resulting preparations exhibit extremely potent immunostimulatory activity. The preferential extraction of these immunostimulatory polysaccharides is dependent on the concentration of ethanol used and the extraction temperature. The most efficient conditions are 50% ethanol concentration at temperatures between 60° and 70° C. The isolated polysaccharide preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: April 17, 2007
    Assignee: University of Mississippi
    Inventors: David Stanley Pasco, Nirmal Derek Pugh, Mahmoud ElSohly, Samir Ross, Nala Miazi ElSohly
  • High molecular weight polysaccharide fraction from with immunostimulatory activity
    Patent number: 7196072
    Abstract: A complex, water soluble polysaccharide fraction having potent immunostimulatory activity isolated from Aloe vera. The polysaccharide fraction has an apparent molecular weight above 2 million daltons. Its major glycosyl components are glucose, galactose, mannose and arabinose. The invention further includes pharmaceutical compositions containing the instant polysaccharide fraction, optionally in combination with acceptable pharmaceutical carriers and/or excipents. These pharmaceutical compositions may be used to provide immunostimulation to an individual in need of such treatment by administering to such an individual an effective amount of the composition. The polysaccharide fraction is also useful as a component of dietary supplements and as a standardization component of commercial Aloe products.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: March 27, 2007
    Assignee: University of Mississippi
    Inventors: David Stanley Pasco, Nirmal Derek Ceri Pugh, Mahmoud ElSohly, Samir Ross
  • Transmucosal delivery of cannabinoids
    Publication number: 20060257463
    Abstract: A method of transmucosally delivering a cannabinoid to a subject in need of such treatment comprising the steps of: administering to the subject a transmucosal preparation containing the cannabinoid wherein said transmucosal preparation is made by incorporating an effective amount of the cannabinoid via hot-melt extrusion technology, hot-melt molding, admixing or a solvent cast technique into a film matrix or a reservoir containing the cannabinoid, and attaching said transmucosal preparation to the mucosa of the subject.
    Type: Application
    Filed: May 30, 2003
    Publication date: November 16, 2006
    Applicant: UNIVERSITY OF MISSISSIPPI
    Inventors: Mahmoud Elsohly, Michael Repka
  • Cyclopentenedione antifungal compounds and methods for their use
    Patent number: 7109380
    Abstract: Compounds and methods useful in the control, treatment, and prevention of fungal activity, of the following formula: where R1-3 are independently H, alkyl, methyl, acyl, halogen, phenyl, R4 is H, alkyl, methyl, acyl, alkoxy, halogen, phenyl provided that when R3 is methyl and R4 is H, R1 and R2 are not both H; and stereoisomers, analogs, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: September 19, 2006
    Assignees: The University of Mississippi, The United States of America as represented by the Secretary of Agriculture
    Inventors: Xing-Cong Li, Melissa R. Jacob, David Wedge
  • Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents
    Patent number: 7098242
    Abstract: This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial properties. This invention also describes methods of preparation of these compositions and methods of use of such compositions for the treatment of cancer, and protozoal infections, including malaria, or leishmaniasis. The compounds of this invention represent a potential new class of anti-tumor agents, one that has shown promising activity against solid tumors, and with a pattern of selectivity that suggests a possible new mechanism of action.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: August 29, 2006
    Assignee: The University of Mississippi
    Inventors: Mahmoud A. ElSohly, Samir A. Ross, Ahmed M. Galal
  • Synthesis of epothilones and related analogs
    Patent number: 6989450
    Abstract: The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: and stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: January 24, 2006
    Assignee: The University of Mississippi
    Inventor: Mitchell A. Avery
  • Method of diagnosing and monitoring malignant breast carcinomas
    Patent number: 6972180
    Abstract: A panel of biomarkers for the diagnosis and treatment of breast cancer was examined in the saliva of a cohort of 1) healthy women, 2) women with benign lesions of the breast and 3) women with diagnosed breast cancer. Recognized tumor markers c-erbB-2 (erb), cancer antigen 15-3 (CA 15-3), and tumor suppresser oncogene protein 53 (p53) were found in the saliva of all three groups of women. The levels of erb and CA 15-3 in the cancer patients evaluated, however, were significantly higher than the salivary levels of healthy controls and benign tumor patients. Conversely, pantropic p53 levels were higher in controls as compared to those women with breast cancer and those with benign tumors.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: December 6, 2005
    Assignee: The University of Mississippi Medical Center
    Inventors: Charles F. Streckfus, Lenora G. Bigler, James Tate Thigpen
  • Plastic bag transporter
    Patent number: D530206
    Type: Grant
    Filed: July 19, 2004
    Date of Patent: October 17, 2006
    Assignee: The University of Mississippi
    Inventor: William Joseph Sumrall