Abstract: Provided herein are methods for treating or preventing myopia, or for inhibiting the development of myopia, comprising administering to a subject in need thereof an effective amount of an agent capable of increasing nitric oxide levels in one or more ocular cells or an agent capable of promoting or increasing the expression and/or activity of nNOS in one or more ocular cells. Also provided are methods for inducing or promoting nNOS expression and/or activity in one or more ocular cells, comprising exposing said cells to an effective amount of L-arginine.

Abstract: Described herein is a device, system and method for digital-to-analogue conversion. One embodiment provides a digital-to-analogue converter device including: a) a first input configured to receive a digital signal to be converted; b) a second input configured to receive a digital dither signal, the digital dither signal having a predefined amplitude; c) a signal combining module that is configured to combine the digital dither signal with the digital signal in the digital domain to define a combined digital signal; and d) a digital-to-analogue converter module that is configured to process the combined digital signal and to output an analogue signal that is an analogue representation of the combined digital signal. The digital-to-analogue converter module has a predefined output amplitude range. The predefined amplitude of the dither signal is at least 1% of the predefined output amplitude range.

Abstract: The present invention relates to hydrogels which may be used to encapsulate or entrap live cells. The invention further relates to methods for transporting live cells which are encapsulated or entrapped within hydrogels from a first location to a second location. The invention further relates to method of treating a wound, disease or tissue injury, e.g. an ocular injury or a damaged ocular surface in a subject using a hydrogel comprising corneal stem cells. The hydrogels used in such methods may be ones which have been transported from a first location to a second location.

Abstract: Provided herein are methods and compositions for the targeted delivery to myometrial tissue of one or more agents capable of regulating contractility of myometrial tissue, wherein the one or more agents are contained or encapsulated within a polymeric delivery vehicle conjugated with one or more molecules that recognizes and/or is capable of binding, directly or indirectly, to the oxytocin receptor.

Abstract: Provided herein are methods and compositions for the targeted delivery to myometrial tissue of one or more agents capable of regulating contractility of myometrial tissue, wherein the one or more agents are contained or encapsulated within a polymeric delivery vehicle conjugated with one or more molecules that recognizes and/or is capable of binding, directly or indirectly, to the oxytocin receptor.

Abstract: A process for stimulating microbial methane production in a petroleum-bearing subterranean formation, comprising: (a) analyzing one or more components of the formation to determine characteristics of the formation environment; (b) detecting the presence of a microbial consortium, comprising at least one methanogenic microorganism, within the formation; (c) assessing whether the formation microorganisms are currently active; (d) determining whether the microbial consortium comprises one or more methanotrophic microorganism; (e) characterization of one or more microorganisms of the consortium, at least one of the members of the consortium being a methanogenic microorganism, and comparing the members of the consortium with at least one known microorganism having one or more known physiological and ecological characteristics; (f) characterization of one or more methanotrophic microorganisms of the consortium (if present), and comparing the members of the consortium with at least one known microorganism having one

Abstract: The present invention relates to a variant archaeal DNA polymerase having a modified amino acid sequence of a wild-type amino acid sequence, the modified sequence being in the amino-terminal amino acids that comprise a uracil-binding pocket in the wild-type polymerase whereby the variant polymerase has reduced affinity for uracil than the wild-type polymerase. Such variant polymerases may be usefully employed in biological assay systems such as the polymerase chain reaction.

Abstract: A method of immobilising a biological molecule on a substrate comprises: (i) covalently attaching a substantially three-dimensional polysilane polymer to a substrate; and (ii) attaching a biological molecule onto and/or within the polymer. The method may additionally comprise the steps of coating the substrate (or the chemically protective layer) with a layer of radiation sensitive material, exposing the substrate to a source of radiation, and incubating the substrate in the presence of a first species of biological molecule.

Abstract: Apparatus for reducing dust emissions from particulate commodities such as wheat or coal using a curved loading spoon connected to the discharge from a loading spout. The curved loading spoon turns particulate commodities delivered at a rate above a predetermined delivery velocity against a curved outer wall causing dust arising from the particulate commodities to be re-entrained within the commodities as they are diverted from a straight path by the curvature. Also described are an optional flap designed to rest just above the surface of the commodities stream adjacent the outlet, and a converging duct located upstream of the curve loading spoon and arranged to direct commodities against the curved outer wall adjacent the inlet.

Abstract: The present invention relates to methods for the separation of materials from heterogeneous fluids and provides a means of effecting stimulant-sensitive flocculation and consolidation of solid suspensions within a liquid medium. Specifically, the present invention provides a method of controlling the state of a suspension of solid particles in a liquid, including applying to the suspension a stimulus adapted to control inter-particle forces between the solid particles. The stimulus is reversibly operable to control attraction and/or repulsion. Means of consolidating a sediment bed and of separating the resultant liquids-rich and solids-rich phases are also within the ambit of the invention.

Abstract: The present invention provides a device (10) for detecting the frothing ability of a fluid, said device including: an inlet (11) for receiving a portion of said fluid; means (12) for entraining air into said fluid portion; a mixing chamber (13) for receiving said air entrained fluid portion, said mixing chamber (13) being adapted for mixing said fluid portion and said air; and a detector (15) for detecting the amount of froth (18) generated in said mixing chamber (13). The invention also provides a method for detecting the frothing ability of a fluid.

Abstract: A scapula component (1) for a reverse shoulder prosthesis comprises a part spherical, convex, surface (3) which is less than a hemisphere. The part spherical surface does not have a rotational axis of symmetry, and may include a main circular surface portion and one or more subsidiary surface portions (5, 6, 7) depending from an edge of the main surface portion. A humerus component (200) for a reverse shoulder prosthesis comprises a cup member (202) having a part spherical, concave bearing surface (206) surrounded by an oval rim (208).

Abstract: A method of manufacturing thermosets such as epoxy resins includes adding expandable hollow microspheres, which expand with temperature as shown in the accompanying graph, to the base thermoset components in the liquid phase and applying heat treatment to the mixture so formed causing the micropsheres to expand during or after curing of the thermoset. This results in a toughening mechanism caused by compressive residual stress around the microspheres which significantly increases the specific fracture energy of the epoxy resin.

Abstract: A sensing device and method. The device includes a first element and a second element. Each of the elements includes a first electrode, and a second electrode, and a piezoelectric layer between and connected to the first and second electrode. The first electrode, second electrode and piezoelectric layer of each element form a pressure wave transducer. The first and second elements are oriented such that the second electrode of the first element faces the second electrode of the second element. The elements are displaced from one another such that the second electrodes form the plates of a capacitor.

Abstract: An overflow launder for a separation cell where particles are fluidiZEd and rise to the top of the cell, has a primary trough (1) surrounding the rim of the cell (2), and an array of secondary troughs (4) extending across the fluid surface from the side (5) of the rim to the opposite side (6). FluidiZed particles can report directly to the secondary troughs (4) without travelling across the surface of the cell, reducing the incidence configurations with radial secondary troughs and external and/or internal primary troughs are also described.

Abstract: The present invention relates to a variant archaeal DNA polymerase comprising a modified amino acid sequence of a wild-type amino acid sequence, wherein during DNA replication, the variant polymerase is adapted to mis-incorporate a greater number of incorrect bases than compared to a wild-type archaeal DNA polymerase. Such a variant DNA polymerase may be usefully employed in biological assay systems, such as PCR.

Abstract: A froth flotation process typically used to separate particulate materials such as coal, has a mixed size feed (1) separated in a sieve bend (2) into a stream of relatively fine particles (3) and a stream of relatively coarse particles (14). The fine particles are fed to a flotation cell (7) in the normal manner, while the coarse particles are mixed with wash water (16) and distributed onto or into the froth layer (10) by wash water distribution apparatus (19, 20). Alternative variations of wash water distribution apparatus able to handle coarse particles are also described.

Abstract: A semiconductor device includes: a SiC substrate; a silicide layer disposed on the SiC substrate; and a carbide layer disposed on the silicide layer. The silicide layer includes a first metal, and the carbide layer includes a second metal. The first metal is Ni or Ni alloy, and the second metal is Ti, Ta or W. The device provides excellent ohmic contact and high quality surface metallization construction.

Abstract: A method of forming an ohmic contact on a substrate composed of a wide-band gap semiconductor material includes: depositing a transition metal group metal on the substrate; annealing the substrate at a high temperature to cause a solid state chemical reaction between the substrate and the deposited metal that forms a modified layer in the substrate having modified properties different than the substrate, and by-products composed of a silicide and a nanocrystalline graphite layer; selectively etching the substrate to remove one or more of the by-products of the solid state chemical reaction from a surface of the substrate; and depositing a metal film composed of a transition group metal over the modified layer on the substrate to form the ohmic contact. The modified layer permits formation of the ohmic contact without high temperature annealing after depositing the metal film.

Abstract: The present invention relates to methods of identifying potentially therapeutic compounds for the treatment of hepatic disorders, preferably alcohol-induced hepatitis. Further, use of mammals in such methods, therapeutic compounds identified using said methods and the use of a Chinese Herb, CH-100, in the treatment of hepatic disorders, particularly alcohol-induced hepatic disorders, are described.