Patents Assigned to The University of Notre Dame
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Patent number: 11219608Abstract: The disclosure relates to use of a triple formulation comprising a histone deacetylase, a cyclodextrin and polyethylene glycol or propylene glycol, and in the treatment and management of chronic pain.Type: GrantFiled: December 4, 2018Date of Patent: January 11, 2022Assignees: Northwestern University, The University of Notre Dame Du LacInventors: A. Vania Apkarian, Kasturi Haldar, Suhail Alam, Maria Virginia Centeno
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Patent number: 10976282Abstract: Herein are described an instrument and a method for using the same. The instrument comprises a fluid channel fluidly connected to at least a first fluid reservoir and a second fluid reservoir; a counter electrode (CE), a reference electrode (RE), and a working electrode (WE); and a potentiostat. The CE, RE, and WE are all disposed within the fluid channel; the potentiostat is isolated from earth ground by at least one isolator and is powered by a floating power supply; and the CE, RE, and WE are each electrically connected to the potentiostat.Type: GrantFiled: March 16, 2017Date of Patent: April 13, 2021Assignee: The University of Notre Dame du LacInventors: Paul Bohn, Lawrence Zaino, III
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Patent number: 10910573Abstract: A diode and logic gate comprising cells is disclosed. A method of making the diode and logic gate comprising cells is disclosed.Type: GrantFiled: September 8, 2016Date of Patent: February 2, 2021Assignee: The University of Notre Dame du LacInventor: Pinar Zorlutuna
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Patent number: 10526391Abstract: Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and other cells transformed with the molecular contracts express a modified TCR that imparts a reduction, in non-specific binding, -an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed (wild-type, native) T-cells, are described. The modified TCRs possess an affinity enhancing motif and an affinity weakening motif. Methods of transforming cells and methods of using enriched populations of transformed cells, in the treatment of cancer and infections arid T-cell mediated pathologies are provided. The affinity weakening motif imparts a weakened interaction, of a TCR with major histocompatibility complex proteins, such as HLA proteins in humans.Type: GrantFiled: July 22, 2015Date of Patent: January 7, 2020Assignees: The University of Notre Dame du Lac, University of MassachusettsInventors: Brian Baker, Lance Hellman, Brian Pierce, Zhiping Weng
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Patent number: 10287578Abstract: The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic acids. One aspect of the invention relates to compounds comprising DNAzymes conjugated to nanoparticles (DZ-NP), such as metallic or gold nanoparticles, and methods for their synthesis. Another aspect of the invention relates to methods of using the conjugated compounds to detect nucleic acids, such as genomic material or transcripts of infectious agents, such as viruses, exemplified by applications demonstrating visual detection of Flavivirus RNA molecules, such as dengue virus, or Alphavirus RNA molecules, such as chikungunya virus, in short time periods, using compositions comprising stable components.Type: GrantFiled: June 16, 2014Date of Patent: May 14, 2019Assignee: The University of Notre DameInventors: James Carter, Malcolm J. Fraser, Jr.
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Patent number: 10100889Abstract: A brake disc rotor or stator is manufactured with slots in the interior face of the disc. A paste comprised of a fine powder of a carbide-forming metal along with fine carbon powder, suspended in an organic binder, is applied to the force-bearing areas in the rotor slot faces or the stator slot faces. The disc is then placed into a furnace in a nitrogen atmosphere and heated to the ignition temperature. When the furnace reaches the ignition temperature, a combustion reaction begins that creates a molten liquid ceramic material on the slot face. Upon cooling, the resulting brake disc has a tough, hard, abrasion-resistant ceramic surface on the portion of the brake disc slot that bears pressure.Type: GrantFiled: May 10, 2013Date of Patent: October 16, 2018Assignees: Honeywell International Inc., The University of Notre Dame Du LacInventors: Allen H. Simpson, Mark L. La Forest, Gregory Vanderheyden, Alexander Mukasyan
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Patent number: 10087489Abstract: Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression values of the biomarkers are also presented. Computer implemented methods employing the biomarkers, and as well as for determining relapse-free survival probability in a patient having RCC or LCC are provided. A genetic method for classifying a colon cancer tissue as a RCC or as a LCC is also disclosed.Type: GrantFiled: September 26, 2016Date of Patent: October 2, 2018Assignee: The University of Notre DameInventors: Steven Buechler, Amanda B. Hummon
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Publication number: 20170312066Abstract: A small animal bed for use with small animal subjects for sedatation during experimental procedures. In some embodiments, the bed uses flow of heated air through the bed to keep the small animal warm during the imaging process. The imaging bed can also incorporate an integrated anesthesia delivery system and exhaust to remove the unused anesthesia from the small animal bed. Various embodiments include a table platform, as well as a nose cone adapter for fitting multiple subjects simultaneously.Type: ApplicationFiled: November 30, 2016Publication date: November 2, 2017Applicant: The University of Notre Dame du LacInventor: Warren Matthew Leevy
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Publication number: 20170269035Abstract: Herein are described an instrument and a method for using the same. The instrument comprises a fluid channel fluidly connected to at least a first fluid reservoir and a second fluid reservoir; a counter electrode (CE), a reference electrode (RE), and a working electrode (WE); and a potentiostat. The CE, RE, and WE are all disposed within the fluid channel; the potentiostat is isolated from earth ground by at least one isolator and is powered by a floating power supply; and the CE, RE, and WE are each electrically connected to the potentiostat.Type: ApplicationFiled: March 16, 2017Publication date: September 21, 2017Applicant: The University of Notre Dame du LacInventors: Paul Bohn, Lawrence Zaino, III
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Publication number: 20170247766Abstract: A method for determining the likelihood of late ER? breast cancer disease relapse/recurrence is disclosed. Late ER+ breast cancer disease onset and/or recurrence is determined for a period of 5 to 20 years after an initial ER+ breast cancer disease onset in a patient. An ER+ breast cancer patient is assigned a risk score that is compared to a defined threshold value, and identifies the risk score as low risk or high risk for late breast cancer recurrence. A late ER+ breast cancer gene panel of 8 to 15 genes is provided. Subjects having a risk score greater than or equal to that of the threshold value are at a relatively high risk of recurrent disease, and are determined to benefit from aggressive therapeutic intervention, whereas subjects having a risk score less than the threshold value are at a relatively low risk of recurrent disease, and could forego treatment.Type: ApplicationFiled: August 26, 2015Publication date: August 31, 2017Applicant: The University of Notre Dame du LacInventors: Steven Buechler, Sunil Badve
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Patent number: 9707257Abstract: Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting the immune system with cells expressing these antivirals prevents re-establishment of HIV infection from reservoirs in the re-established lymphocyte and macrophage populations. Over time, reservoirs will be depleted entirely, effectively eliminating the virus. In effect, this new type of antiviral can be used to cure HIV infections.Type: GrantFiled: April 28, 2011Date of Patent: July 18, 2017Assignee: The University of Notre DameInventor: Malcolm James Fraser, Jr.
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Publication number: 20170069860Abstract: A diode and logic gate comprising cells is disclosed. A method of making the diode and logic gate comprising cells is disclosed.Type: ApplicationFiled: September 8, 2016Publication date: March 9, 2017Applicant: The University of Notre Dame du LacInventor: Pinar Zorlutuna
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Publication number: 20170021339Abstract: A method of making LDO-Co nanoparticles is described herein. A method of using LDO-Co nanoparticles, particularly in the treatment of wastewater, is described herein.Type: ApplicationFiled: July 5, 2016Publication date: January 26, 2017Applicant: The University of Notre Dame du LacInventors: Chongzheng Na, Hanyu Ma, Haitao Wang
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Patent number: 9541106Abstract: The present invention relates to a method of designing or optimizing a control surface for use with plasma actuators for controlling an aircraft, missile, munition or automobile, and more particularly to controlling fluid flow across their surfaces or other surfaces using plasma actuators, which would benefit from such a method. The various embodiments provide the steps to increase the efficiency of aircraft, missiles, munitions and automobiles. The method of flow control also provides a means for reducing aircraft, missile's, munition's and automobile's power requirements. These methods also provide alternate means for aerodynamic control using low-power hingeless plasma actuator devices.Type: GrantFiled: February 26, 2007Date of Patent: January 10, 2017Assignees: Orbitel Research Inc., The University of Notre Dame du LacInventors: Mehul Patel, Thomas Corke, Alan B. Cain
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Patent number: 9538974Abstract: Various methods and systems are provided for estimating and compensating for table deflection in reconstructed images. In one embodiment, a method for computed tomography (CT) imaging comprises reconstructing images from data acquired during a helical CT scan where table deflection parameters are estimated and the reconstruction is adjusted based on the table deflection parameters. In this way, images may be reconstructed without artifacts caused by table deflection.Type: GrantFiled: November 20, 2014Date of Patent: January 10, 2017Assignees: General Electric Company, The University of Notre Dame du LacInventors: Guangzhi Cao, Jiang Hsieh, Jean-Baptiste Thibault, Jiahua Fan, Ken D. Sauer
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Patent number: 9321692Abstract: Production of pore-free carbon/carbon-silicon carbide composite materials with mechanical properties making them suitable for use in such applications as the production of aircraft landing system brake components including brake discs. The method includes: providing a porous carbon-carbon composite preform; surrounding the porous carbon-carbon composite preform with silicon powder to form an intermediate construct; applying a uniaxial load to the construct; applying direct electrical current to an assembly containing the loaded construct of porous carbon-carbon preform surrounded by silicon powder, thereby melting the silicon powder and infiltrating the pores of the carbon-carbon preform with liquid silicon; and initiating a combustion-type reaction between the silicon and carbon in the preform, thereby forming silicon carbide in the preform.Type: GrantFiled: July 31, 2009Date of Patent: April 26, 2016Assignees: Honeywell International Inc., The University of Notre Dame du LacInventors: Manuel Koucouthakis, Douglas J. Steinke, Alexander Mukasyan, Jeremiah D. E. White
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Patent number: 9220770Abstract: Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvant may also be described as a heterologous acellular collagenous tissue preparation. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.Type: GrantFiled: August 26, 2010Date of Patent: December 29, 2015Assignees: The University of Notre Dame, Cook Biotech, Inc.Inventors: Mark A. Suckow, William R. Wolter, Paul J. Hall
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Patent number: 9020230Abstract: A method for reconstructing an image of an object that includes a plurality of image elements. The method includes accessing image data associated with a plurality of image elements, and reconstructing an image of the object by optimizing an objective function, where the objective function is optimized by iteratively solving a nested sequence of approximate optimization problems. The algorithm is composed of nested iterative loops, in which an inner loop iteratively optimizes an objective function approximating the outer loop objective function, and an outer loop that utilizes the solution of the inner loop to optimize the original objective function.Type: GrantFiled: November 2, 2011Date of Patent: April 28, 2015Assignees: General Electric Company, The University of Notre Dame Du Lac, Purdue Research FoundationInventors: Zhou Yu, Evgeny Drapkin, Bruno Kristiaan Bernard De Man, Jean-Baptiste Thibault, Kai Zeng, Jiang Hsieh, Brian Edward Nett, Debashish Pal, Lin Fu, Guangzhi Cao, Charles A. Bouman, Jr., Ken David Sauer
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Patent number: 8880380Abstract: Crashworthiness designing of a structure using a Hybrid Cellular Automata (HCA) algorithm where field states are computed using finite element analysis (FEA) and the material distribution of the structure is updated at each iteration using cellular automata method. The HCA algorithm optimizes the topology of the structures to achieve certain performance within the limits of various constraints applied to ensure crashworthiness of the structures. The HCA algorithm may also be applied to designing of structures to be fabricated by an extrusion method having the same cross section along the direction of extrusion or stamped structures having thickness varying across the structure.Type: GrantFiled: December 19, 2008Date of Patent: November 4, 2014Assignees: Honda Motor Co., Ltd., The University of Notre Dame Du LacInventors: Kishore K. Pydimarry, Duane T. Detwiler, John E. Renaud, Neal M. Patel, Byungsoo Kang, Chandan K. Mozumder
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Patent number: 8865761Abstract: The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.Type: GrantFiled: August 7, 2013Date of Patent: October 21, 2014Assignee: The University of Notre Dame du LacInventor: Richard Taylor