Patents Assigned to The University of Notre Dame
  • Patent number: 11219608
    Abstract: The disclosure relates to use of a triple formulation comprising a histone deacetylase, a cyclodextrin and polyethylene glycol or propylene glycol, and in the treatment and management of chronic pain.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: January 11, 2022
    Assignees: Northwestern University, The University of Notre Dame Du Lac
    Inventors: A. Vania Apkarian, Kasturi Haldar, Suhail Alam, Maria Virginia Centeno
  • Patent number: 10976282
    Abstract: Herein are described an instrument and a method for using the same. The instrument comprises a fluid channel fluidly connected to at least a first fluid reservoir and a second fluid reservoir; a counter electrode (CE), a reference electrode (RE), and a working electrode (WE); and a potentiostat. The CE, RE, and WE are all disposed within the fluid channel; the potentiostat is isolated from earth ground by at least one isolator and is powered by a floating power supply; and the CE, RE, and WE are each electrically connected to the potentiostat.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: April 13, 2021
    Assignee: The University of Notre Dame du Lac
    Inventors: Paul Bohn, Lawrence Zaino, III
  • Patent number: 10910573
    Abstract: A diode and logic gate comprising cells is disclosed. A method of making the diode and logic gate comprising cells is disclosed.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: February 2, 2021
    Assignee: The University of Notre Dame du Lac
    Inventor: Pinar Zorlutuna
  • Patent number: 10526391
    Abstract: Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and other cells transformed with the molecular contracts express a modified TCR that imparts a reduction, in non-specific binding, -an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed (wild-type, native) T-cells, are described. The modified TCRs possess an affinity enhancing motif and an affinity weakening motif. Methods of transforming cells and methods of using enriched populations of transformed cells, in the treatment of cancer and infections arid T-cell mediated pathologies are provided. The affinity weakening motif imparts a weakened interaction, of a TCR with major histocompatibility complex proteins, such as HLA proteins in humans.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: January 7, 2020
    Assignees: The University of Notre Dame du Lac, University of Massachusetts
    Inventors: Brian Baker, Lance Hellman, Brian Pierce, Zhiping Weng
  • Patent number: 10287578
    Abstract: The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic acids. One aspect of the invention relates to compounds comprising DNAzymes conjugated to nanoparticles (DZ-NP), such as metallic or gold nanoparticles, and methods for their synthesis. Another aspect of the invention relates to methods of using the conjugated compounds to detect nucleic acids, such as genomic material or transcripts of infectious agents, such as viruses, exemplified by applications demonstrating visual detection of Flavivirus RNA molecules, such as dengue virus, or Alphavirus RNA molecules, such as chikungunya virus, in short time periods, using compositions comprising stable components.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 14, 2019
    Assignee: The University of Notre Dame
    Inventors: James Carter, Malcolm J. Fraser, Jr.
  • Patent number: 10100889
    Abstract: A brake disc rotor or stator is manufactured with slots in the interior face of the disc. A paste comprised of a fine powder of a carbide-forming metal along with fine carbon powder, suspended in an organic binder, is applied to the force-bearing areas in the rotor slot faces or the stator slot faces. The disc is then placed into a furnace in a nitrogen atmosphere and heated to the ignition temperature. When the furnace reaches the ignition temperature, a combustion reaction begins that creates a molten liquid ceramic material on the slot face. Upon cooling, the resulting brake disc has a tough, hard, abrasion-resistant ceramic surface on the portion of the brake disc slot that bears pressure.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: October 16, 2018
    Assignees: Honeywell International Inc., The University of Notre Dame Du Lac
    Inventors: Allen H. Simpson, Mark L. La Forest, Gregory Vanderheyden, Alexander Mukasyan
  • Patent number: 10087489
    Abstract: Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression values of the biomarkers are also presented. Computer implemented methods employing the biomarkers, and as well as for determining relapse-free survival probability in a patient having RCC or LCC are provided. A genetic method for classifying a colon cancer tissue as a RCC or as a LCC is also disclosed.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: October 2, 2018
    Assignee: The University of Notre Dame
    Inventors: Steven Buechler, Amanda B. Hummon
  • Publication number: 20170312066
    Abstract: A small animal bed for use with small animal subjects for sedatation during experimental procedures. In some embodiments, the bed uses flow of heated air through the bed to keep the small animal warm during the imaging process. The imaging bed can also incorporate an integrated anesthesia delivery system and exhaust to remove the unused anesthesia from the small animal bed. Various embodiments include a table platform, as well as a nose cone adapter for fitting multiple subjects simultaneously.
    Type: Application
    Filed: November 30, 2016
    Publication date: November 2, 2017
    Applicant: The University of Notre Dame du Lac
    Inventor: Warren Matthew Leevy
  • Publication number: 20170269035
    Abstract: Herein are described an instrument and a method for using the same. The instrument comprises a fluid channel fluidly connected to at least a first fluid reservoir and a second fluid reservoir; a counter electrode (CE), a reference electrode (RE), and a working electrode (WE); and a potentiostat. The CE, RE, and WE are all disposed within the fluid channel; the potentiostat is isolated from earth ground by at least one isolator and is powered by a floating power supply; and the CE, RE, and WE are each electrically connected to the potentiostat.
    Type: Application
    Filed: March 16, 2017
    Publication date: September 21, 2017
    Applicant: The University of Notre Dame du Lac
    Inventors: Paul Bohn, Lawrence Zaino, III
  • Publication number: 20170247766
    Abstract: A method for determining the likelihood of late ER? breast cancer disease relapse/recurrence is disclosed. Late ER+ breast cancer disease onset and/or recurrence is determined for a period of 5 to 20 years after an initial ER+ breast cancer disease onset in a patient. An ER+ breast cancer patient is assigned a risk score that is compared to a defined threshold value, and identifies the risk score as low risk or high risk for late breast cancer recurrence. A late ER+ breast cancer gene panel of 8 to 15 genes is provided. Subjects having a risk score greater than or equal to that of the threshold value are at a relatively high risk of recurrent disease, and are determined to benefit from aggressive therapeutic intervention, whereas subjects having a risk score less than the threshold value are at a relatively low risk of recurrent disease, and could forego treatment.
    Type: Application
    Filed: August 26, 2015
    Publication date: August 31, 2017
    Applicant: The University of Notre Dame du Lac
    Inventors: Steven Buechler, Sunil Badve
  • Patent number: 9707257
    Abstract: Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting the immune system with cells expressing these antivirals prevents re-establishment of HIV infection from reservoirs in the re-established lymphocyte and macrophage populations. Over time, reservoirs will be depleted entirely, effectively eliminating the virus. In effect, this new type of antiviral can be used to cure HIV infections.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: July 18, 2017
    Assignee: The University of Notre Dame
    Inventor: Malcolm James Fraser, Jr.
  • Publication number: 20170069860
    Abstract: A diode and logic gate comprising cells is disclosed. A method of making the diode and logic gate comprising cells is disclosed.
    Type: Application
    Filed: September 8, 2016
    Publication date: March 9, 2017
    Applicant: The University of Notre Dame du Lac
    Inventor: Pinar Zorlutuna
  • Publication number: 20170021339
    Abstract: A method of making LDO-Co nanoparticles is described herein. A method of using LDO-Co nanoparticles, particularly in the treatment of wastewater, is described herein.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 26, 2017
    Applicant: The University of Notre Dame du Lac
    Inventors: Chongzheng Na, Hanyu Ma, Haitao Wang
  • Patent number: 9541106
    Abstract: The present invention relates to a method of designing or optimizing a control surface for use with plasma actuators for controlling an aircraft, missile, munition or automobile, and more particularly to controlling fluid flow across their surfaces or other surfaces using plasma actuators, which would benefit from such a method. The various embodiments provide the steps to increase the efficiency of aircraft, missiles, munitions and automobiles. The method of flow control also provides a means for reducing aircraft, missile's, munition's and automobile's power requirements. These methods also provide alternate means for aerodynamic control using low-power hingeless plasma actuator devices.
    Type: Grant
    Filed: February 26, 2007
    Date of Patent: January 10, 2017
    Assignees: Orbitel Research Inc., The University of Notre Dame du Lac
    Inventors: Mehul Patel, Thomas Corke, Alan B. Cain
  • Patent number: 9538974
    Abstract: Various methods and systems are provided for estimating and compensating for table deflection in reconstructed images. In one embodiment, a method for computed tomography (CT) imaging comprises reconstructing images from data acquired during a helical CT scan where table deflection parameters are estimated and the reconstruction is adjusted based on the table deflection parameters. In this way, images may be reconstructed without artifacts caused by table deflection.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: January 10, 2017
    Assignees: General Electric Company, The University of Notre Dame du Lac
    Inventors: Guangzhi Cao, Jiang Hsieh, Jean-Baptiste Thibault, Jiahua Fan, Ken D. Sauer
  • Patent number: 9321692
    Abstract: Production of pore-free carbon/carbon-silicon carbide composite materials with mechanical properties making them suitable for use in such applications as the production of aircraft landing system brake components including brake discs. The method includes: providing a porous carbon-carbon composite preform; surrounding the porous carbon-carbon composite preform with silicon powder to form an intermediate construct; applying a uniaxial load to the construct; applying direct electrical current to an assembly containing the loaded construct of porous carbon-carbon preform surrounded by silicon powder, thereby melting the silicon powder and infiltrating the pores of the carbon-carbon preform with liquid silicon; and initiating a combustion-type reaction between the silicon and carbon in the preform, thereby forming silicon carbide in the preform.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: April 26, 2016
    Assignees: Honeywell International Inc., The University of Notre Dame du Lac
    Inventors: Manuel Koucouthakis, Douglas J. Steinke, Alexander Mukasyan, Jeremiah D. E. White
  • Patent number: 9220770
    Abstract: Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvant may also be described as a heterologous acellular collagenous tissue preparation. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: December 29, 2015
    Assignees: The University of Notre Dame, Cook Biotech, Inc.
    Inventors: Mark A. Suckow, William R. Wolter, Paul J. Hall
  • Patent number: 9020230
    Abstract: A method for reconstructing an image of an object that includes a plurality of image elements. The method includes accessing image data associated with a plurality of image elements, and reconstructing an image of the object by optimizing an objective function, where the objective function is optimized by iteratively solving a nested sequence of approximate optimization problems. The algorithm is composed of nested iterative loops, in which an inner loop iteratively optimizes an objective function approximating the outer loop objective function, and an outer loop that utilizes the solution of the inner loop to optimize the original objective function.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: April 28, 2015
    Assignees: General Electric Company, The University of Notre Dame Du Lac, Purdue Research Foundation
    Inventors: Zhou Yu, Evgeny Drapkin, Bruno Kristiaan Bernard De Man, Jean-Baptiste Thibault, Kai Zeng, Jiang Hsieh, Brian Edward Nett, Debashish Pal, Lin Fu, Guangzhi Cao, Charles A. Bouman, Jr., Ken David Sauer
  • Patent number: 8880380
    Abstract: Crashworthiness designing of a structure using a Hybrid Cellular Automata (HCA) algorithm where field states are computed using finite element analysis (FEA) and the material distribution of the structure is updated at each iteration using cellular automata method. The HCA algorithm optimizes the topology of the structures to achieve certain performance within the limits of various constraints applied to ensure crashworthiness of the structures. The HCA algorithm may also be applied to designing of structures to be fabricated by an extrusion method having the same cross section along the direction of extrusion or stamped structures having thickness varying across the structure.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: November 4, 2014
    Assignees: Honda Motor Co., Ltd., The University of Notre Dame Du Lac
    Inventors: Kishore K. Pydimarry, Duane T. Detwiler, John E. Renaud, Neal M. Patel, Byungsoo Kang, Chandan K. Mozumder
  • Patent number: 8865761
    Abstract: The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: October 21, 2014
    Assignee: The University of Notre Dame du Lac
    Inventor: Richard Taylor