Abstract: Methods to form a surface coating and surface pattern, which are based on adsorption of hydrocarbon chains that can be used with imaging optics to visualize macrophage fusion and multinucleated giant cell formation with living specimens are described.

Abstract: Mid-infrared photothermal heterodyne imaging (MIR-PHI) techniques described herein overcome the diffraction limit of traditional MIR imaging and uses visible photodiodes as detectors. MIR-PHI experiments are shown that achieve high sensitivity, sub-diffraction limit spatial resolution, and high acquisition speed. Sensitive, affordable, and widely applicable, photothermal imaging techniques described herein can serve as a useful imaging tool for biological systems and other submicron-scale applications.

Abstract: Systems and methods for maintaining the safety of a software-based system. One method includes automatically generating a first artifact tree for a hazard for a first version of the system and automatically transforming the first artifact tree into a first augmented tree using a set of heuristics. The method also includes automatically generating a second artifact tree for the hazard for a second version of the system and automatically transforming the second artifact tree for the hazard into a second augmented tree using the set of heuristics. The method further includes automatically comparing the first augmented tree and the second augmented tree to generate a delta view, and automatically generating, based on the delta view, at least one selected from a group consisting of a safety warning for the second version of the software-based system and an actionable recommendation to maintain safety of the second version of the software-based system.

Abstract: The present disclosure encompasses antibacterial compositions and methods of treating bacterial infections caused by resistant bacteria.

Abstract: Products, systems, and methods for classifying human colorectal cancer into a consensus molecular subtype (CMS) and for assessing risk of recurrence based on CMS scores and based on risk scores derived from abbreviated gene expression profiles, for determining suitable treatment protocols for human colorectal cancer patients based on the determined CMS classification and based on the determined risk of recurrence, and for administering the suitable treatment protocols.

Abstract: Aspects of the subject disclosure may include, a non-linear energy detector that obtains baseband information from a mixed signal that corresponds to an information component of a received radio frequency (RF) signal, wherein the mixed signal comprises a local oscillator signal combined, without multiplication, with the received RF signal, wherein the received RF signal comprises a carrier wave component operating at a carrier frequency within a millimeter wave spectrum, wherein the non-linear energy detector is associated with a non-linear current-voltage (I-V) characteristic curve, and wherein the baseband information is obtained by applying the mixed signal to the non-linear I-V characteristic curve. Other embodiments are disclosed.

Abstract: An N-bit non-volatile multi-level memory cell (MLC) can include a lower electrode and an upper electrode spaced above the lower electrode. N ferroelectric material layers can be vertically spaced apart from one another between the lower electrode and the upper electrode, wherein N is at least 2 and at least one dielectric material layer having a thickness of less than 20 nm can be located between the N ferroelectric material layers.

Abstract: Infections caused by multidrug-resistant (MDR) bacteria, particularly Gram-negative bacteria, are an escalating global t health threat. Often clinicians are forced to administer the last resort antibiotic colistin, however colistin resistance is becoming increasingly prevalent, giving rise to the potential for a situation in which there are no treatment options for MDR Gram-negative infections. The development of adjuvants that circumvent bacterial resistance mechanisms is a promising orthogonal approach to the development of new antibiotics. We recently disclosed that the known IKK-13 inhibitor IMD-0354 potently suppresses colistin resistance in several Gram-negative strains. In this disclosure, we explore the structure activity relationship (SAR) between the IMD-0354 scaffold and colistin resistance suppression, and identify several compounds with more potent activity than the parent against highly colistin resistant strains of Acinetobacter baumannii and Klebsiella pneumoniae.

Abstract: The present invention provides a novel class of insecticides for control of disease vector insects, particularly mosquitoes. These insecticides prevent maturation or development of larvae into adult insects using interfering RNA (iRNA). The present invention further includes compositions comprising iRNA and methods of controlling, reducing, or treating an insect infestation with the iRNA or compositions described herein.

Abstract: In a method computer storage element operation, first and second rising (or falling) clock edges are applied to first and second power inputs of the computer storage element having a transistor array between the first and second power inputs over time T1 whereupon a logic value applied to an input of the transistor array is stored therein. Thereafter, first and second falling (or rising) clock edges are applied to the first and second power inputs over time T2, whereupon part of an electrical charge or energy associated with the logic value stored in the transistor array is provided to circuitry that generates the first and/or second clock edge(s), wherein the value(s) of time T1 and/or time T2 is/are greater than a product of RC, where R is resistance associated with the computer storage element, and C is a load capacitance associated with the computer storage element.

Abstract: A thermoacoustic device includes a stage coupled to a bar, wherein the stage includes a first heating component on a first terminus of the stage. The stage further includes a first cooling component on a second terminus of the stage. A thermal conductivity of the stage is higher than a thermal conductivity of the bar. A heat capacity of the stage is higher than a heat capacity of the bar.

Abstract: Aspects of the subject disclosure may include, a non-linear energy detector that obtains baseband information from a mixed signal that corresponds to an information component of a received radio frequency (RF) signal, wherein the mixed signal comprises a local oscillator signal combined, without multiplication, with the received RF signal, wherein the received RF signal comprises a carrier wave component operating at a carrier frequency within a millimeter wave spectrum, wherein the non-linear energy detector is associated with a non-linear current-voltage (I-V) characteristic curve, and wherein the baseband information is obtained by applying the mixed signal to the non-linear I-V characteristic curve. Other embodiments are disclosed.

Abstract: Bromine induced lactamization of vinyl acetohydroxamates facilitated syntheses of monocyclic ?-lactams suitable for incorporation of a thiomethyl and extended functionality at the C(4) position. Elaboration of the resulting substituted N-hydroxy-2-azetidinones allowed incorporation of functionalized ?-amino substituents appropriate for enhancement of antibiotic activity. Evaluation of antibacterial activity against a panel of Gram-positive and Gram-negative bacteria revealed structure-activity-relationships (SAR) and identification of potent new monobactam antibiotics. The corresponding bis-catechol conjugate, 42, has excellent activity against Gram-negative bacteria including carbapenemase and carbacephalosporinase producing strains of Acinetobacter baumannii which have been listed by the WHO as being of critical concern worldwide.

Abstract: A method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group where the non-photo reactive group is coupled to an effector molecule and the photo reactive group is coupled to the nucleotide binding site of an immunoglobulin. Alternatively, the photo crosslinker contains an orthogonal reactive group such as a thiol, which can be coupled to an effector molecule or functionalized ligand.

Abstract: Substituted nitrobenzothiazinones (BTZs) are potent antituberculosis prodrugs that are reductively activated to produce nitroso moieties that form covalent adducts with a cysteine residue of decaprenylphospholyl-?-D-ribose-2?-oxi-dase (DprE1) of Mycobacterium tuberculosis (Mtb). The resulting cell wall synthesis inhibition is lethal to Mtb, leading to consideration of development of BTZs for clinical use. The hydride-induced reduction of the nitroaromatic proceeds by reversible formation of the corresponding Meisenheimer complex. Herein we demonstrate that chemical reduction of BTZ043 with NaBD4 followed by reoxidation incorporates deuterium into the core nitro aromatic warhead. Subsequent reduction of the deuterated species is not affected, but, as expected, reoxidation is slowed by the deuterium isotope effect, thus prolonging the lifetime of the active nitroso oxidation state.

Abstract: Described is a method for the preparation of a reforming catalyst. The method comprises: (a) depositing a metal precursor on a porous support by wet impregnation, wherein the porous support is selected from the group consisting of a fumed silica, a fumed metal oxide, and combinations thereof; (b) drying the porous support after depositing the metal precursor to form a powder; (c) adding additional porous support to the powder to form a diluted powder; and (d) pressing the diluted powder to form pellets.

Abstract: Aspects of the subject disclosure may include, for example, receiving, by a first radio module at a first location, a wireless signal, to obtain a first received RF signal. The wireless signal includes information originating at a remote transmitter and conveyed via a wireless channel. An envelope of the first received RF signal is detected by the first radio module without requiring a local oscillator, to obtain a first baseband signal. The first baseband signal may be filtered and/or amplified, after which it is provided to a processor. The processor also obtains a second digital signal from a second radio module receiving the wireless signal at a second location and determines an estimate of the information originating at the remote transmitter according to the first and second signals. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, receiving a radio frequency (RF) signal having a carrier wave component that operates at a carrier frequency within a millimeter wave spectrum. The RF signal also includes an information component based on a phase shift keying (PSK) modulation of the carrier wave component. A local oscillator (LO) signal is obtained, which includes an LO frequency that approximates the carrier frequency. The received RF signal and the LO signal are combined without using signal multiplication to obtain a first combined output signal. The first combined output signal being detected via a non-linear energy detector to obtain a first detected signal. The first output signal includes information of the information component. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, generating multiple digital reference pulses synchronously to a master oscillator, selectively switching the multiple digital reference pulses, and providing the switched pulses to multiple radio modules operating within a millimeter wave spectrum. For each radio module, counting cycles of an adjustable LO output signal occurring between consecutive pulses of the switched digital reference pulses, determining a difference between the count value and a reference value, and adjusting the adjustable LO according to the difference. A resulting corrected LO signal is synchronized to the master oscillator. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, receiving an RF signal having a carrier wave component operating at a carrier frequency within a millimeter wave spectrum and an information component based on a phase modulation of the carrier wave component. The received RF signal is divided into first and second signal portions that remain in phase with respect to each other. The first signal portion is delayed by one symbol period of the phase modulation and combined with the second signal portion to obtain a combined output signal. An in-phase portion of the combined output signal is detected via a non-linear energy detector, wherein an amplitude of the first detected signal corresponds to the in-phase portion of the received RF signal. The first combined output signal includes information of the information component. Other embodiments are disclosed.