Abstract: Methods and compositions which include or include the administration of a hydrophobic drug, prodrug thereof, salt thereof, isoform thereof, or a combination thereof; cyclodextrin, prodrug thereof, salt thereof, or a combination thereof; polyethylene glycol, propylene glycol, or combination thereof; and optionally, a pharmaceutically acceptable carrier.

Abstract: First, second, and third integrated devices each include one or more interconnecting structure. Each interconnecting structure includes (i) one or more interconnecting nodules extending from an edge surface of the device, (ii) one or more interconnect voids formed in an edge surface of the device, or (iii) both (i) and (ii). The one or more interconnecting structures on each of the first and second device is mated with the one or more interconnecting structures on the second device. The first integrated device includes a signal output, the third integrated device includes a signal input; and the second integrated device includes a conductor for conducting a signal from the signal output to the signal input.

Abstract: Disclosed herein are ionic liquid compounds, complexes and compositions suitable for use as refrigerants. Methods and systems for heating and/or cooling, including vapor compression heating or cooling systems, including such refrigerants are also disclosed. Preferred ionic liquids include those having anions selected from pyrrolide, pyrazolide, triazolide, imidazolide, benzimidazolide, and indolide, and cations selected from phosphonium, ammonium, pyrrolidinium, imidazolium, and pyridinium.

Abstract: Systems and methods for determining an available bandwidth in a WiFi link using frame aggregation. One system includes an electronic processor configured to send a request for a probe sequence from a server to an electronic communication device. The electronic processor is configured to receive a probe sequence via the WiFi link and determine an aggregation intensity parameter, the aggregation intensity parameter associated with a number of packets assembled in an aggregated frame for the WiFi link. In response to the aggregation intensity parameter being above a threshold, the electronic processor determines an available bandwidth of the WiFi link is less than a probe rate.

Abstract: An adjustable structural connection can be used to join steel structural elements at a range of angles and is capable of adjusting in situ to accommodate additional angles or tolerances through cold bending. Pre-bent plate or plates may be loosely fitted around steel structural elements, such that holes in the plates align with holes of the steel structural elements. Placing bolts through the aligned holes and tightening those bolts can be used to cold bend the plate or plates and conform the angle of the pre-bent plates to a different angle defined by an apex joint of two steel structural elements. Specific tightening procedures may be employed.

Abstract: The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with the enzyme MMP-8, or the topical treatment of the wound with MMP-8 in combination with administration of an MMP-9 inhibitor, to accelerate the healing of the wound.

Abstract: Clostridium difficile infection (CDI) is a public health threat that results in 14,000 annual deaths in the United States. Challenges involve the production of CDI spores that can remain dormant for years and the production of toxins that damage the gut. Current therapies for CDI include vancomycin and metronidazole, but neither inhibits spore or toxin production. Thus, recurrence of infection occurs in 25% of patients and there are no antibiotics that are effective for multiple recurrences. We describe oxadiazoles with activity against C. difficile, including the highly virulent NAP1/027 strain with increased production of toxins A and B, as well as the additional binary toxin. Oxadiazole 2 is poorly absorbed, thus advantageously achieving high concentrations in the gut. The compound targets peptidoglycan synthesis and inhibits vegetative cells, spores, and toxin production.

Abstract: The invention provides pharmaceutical compositions and method of using the compositions, wherein the compositions comprise liposomes or micelles that contain one or more targeting peptides and/or anticancer drugs. In various embodiments, the components of the liposomes can include a) a phospholipid and optionally a lipid that is not a phospholipid; b) a pegylated lipid; c) a peptide-ethylene glycol (EG)-lipid conjugate wherein the peptide is a targeting ligand, and d) one or more drug-conjugated lipid, encapsulated drugs, or a combination thereof. The peptide-EG-lipid conjugate can be, for example, a compound of Formula (I) or Formula (II). The ethylene glycol (EG) segments of the peptide-EG-lipid conjugate can be, for example, EG6 to about EG36; and the EG segment can be conjugated to one or more lysine moieties.

Abstract: A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed (Formula V). Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding proteins and/or other important cellular targets. Methods for inhibiting the growth and/or replication of bacteria using the compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, including drug-resistant strains of Staphylococcus aureus.

Abstract: The described BPE-enabled device includes two separated chambers which perform detection and reporting independently. Analytical reaction of a target molecule in the analytical cell is coupled to and monitored by an electrochromic reaction in the reporting cell. The color change in the reporting cell can be determined spectrophotometrically by RGB analysis of a CCD image acquired via smartphone. This detection method provides a linear response and a low limit of detection due to the redox cycling behavior in both chambers. The BPE based electrochromic detector can be modified for sensing of multiple analytes by integrating three or more sets of detection chemistries into one single device. Multiple analytes with different concentrations can be detected within this device simultaneously.

Abstract: Disclosed are computational modeling methods employing RMS fluctuation values associated with energy functions to compute binding properties of a subject biomolecule and an identified target. An energy function (or force field) that relates the molecular structure of a biomolecule to an energy value, modified with terms calculated from sets of RMS fluctuation values of the biomolecule, the target and the complex, are used to identify a potential mutation or modification suitable for imparting a selected property to a biomolecule of interest. Uses of the method in the manufacture of non-native proteins having a selected modified property are also provided. Therapeutic agents (proteins, antibodies, TCRs) enzymes, etc., prepared according to the present methods are also provided. Non-native biomolecules having improved properties, for example, weaker or enhanced binding affinity in a modified TCR, are described. Enzymes, industrial reagents, and the like, created using the disclosed methods are also presented.

Abstract: A DUV-LED including a bottom substrate, a n-contact/injection layer formed on the bottom substrate, a p-contact region, and an emitting active region between the n-contact/injection layer and the contact region. The emitting active region includes at least one GaN quantum heterostructure. The at least one GaN quantum heterostructures is sized and shaped to determine a certain emission wavelength. Preferably, the certain emission wavelength is in a range of approximately 219-280 nm. In one embodiment, the size is controlled by precisely controlling parameters selected from the group consisting of: an epitaxial deposition time; a Ga/N ratio; a thermal annealing time; a temperature during deposition; and combinations thereof.

Abstract: Systems and methods for monitoring rotating machinery are disclosed. Transmitter and receiver antennas can be provided with access to the rotating machinery. At least one receiver signal resulting from at least one transmitter signal that has propagated through a portion of the rotating machinery can be obtained. A first signal pair can be formed from a first receiver signal and a first transmitter signal, or from first and second receiver signals obtained from spatially-separated receiver antennas, or from first and second receiver signals which are attributable to different transmitter signals. Amplitude and phase information of a plurality of frequency components for each signal in the first signal pair can be determined. A set of comparison values for the first signal pair can be determined by comparing respective frequency component phases or respective frequency component amplitudes. A characteristic of the rotating machinery can then be analyzed using the comparison values.

Abstract: A system and method for detection of complex sinusoidal signals. The method can include obtaining a set of complex-valued samples of one or more signals, in the presence of unknown noise, using a plurality of sensors. The presence of ? candidate complex sinusoids can be assumed. Then, ? candidate complex sinusoids in the set of complex-valued samples can be estimated. The method can include comparing a measurement of the energy of the ? estimated candidate complex sinusoids with a threshold value. Based on the comparison, a determination can be made whether to assume a different number of candidate complex sinusoids and repeat the estimation and the comparison steps, or to specify the estimated ? candidate complex sinusoids as detected complex sinusoids. The threshold value can be determined using a penalty value which reduces the probability of overestimating the number of complex sinusoids.

Abstract: Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein.

Abstract: Systems and methods for performing energy efficient communication. A transceiver for use in a point-to-point packet-based communication link with packet erasures is described. The transceiver can include a data source to provide bits of data for transmission to a remote device. The transceiver can map the bits of data to symbols in a constellation according to a modulation scheme and can provide the symbols on one or more subcarriers. The transceiver can include co-located orthogonally polarized antenna elements or spatially separated antenna elements or both. The symbols can be transmitted in packets via one or more of the antenna elements. The transceiver can determine a metric of average transmit energy per bit successfully decoded, and not erased, at the remote device and can adjust transmission powers at the antenna elements to reduce the average transmit energy per successfully decoded and unerased bit.

Abstract: The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

Abstract: Disclosed are methods, compositions, and devices for an integrated, heterogenerous ion-exchange membrane-based plastic microfluidic biochip platform that can be used to detect multiple diagnostic markers present in real samples. Its various components can be easily integrated in a modular fashion for different applications. Automated control allows sequential and dynamic activation of different components on the chip. The integrated platform consists of three units and is designed to execute the following functions: (i) separation of the target biomolecules from the real sample, (ii) localizing and concentrating the targeted molecules at a specific location in the microfluidic chip, and (iii) detection of the targeted molecules using hybridization/docking events against a complementary ssDNA oligoprobe sequence or a specific antibody.

Abstract: A structural plane is presented for forming a variable depth structure constructed of adjustable modules. Each module is formed of four links connected with revolute joints. The modules are connected at adjacent lateral joints and by upper and lower chords connecting the upper and lower revolute joints of the modules. The ultimate lateral joints of the modules at each end are connected to each end of the structural plane. The adjustable module and other components can form two- and three-hinged arches made of standard rolled steel sections.

Abstract: A method for fabricating nanostructured polymeric materials based on a combination of inkjet printing and template synthesis. Layer-by-layer assembled nanotubes can be synthesized in a polycarbonate track-etched (PCTE) membrane by printing poly(allylamine hydrochloride) (PAH) and poly(styrenesulfonate) (PSS) sequentially. By changing the printing conditions, polymeric nanotubes or nanowires can be prepared by printing poly(vinyl alcohol) (PVA) in a PCTE template. Inkjet printing paired with template synthesis can be used to generate patterns comprised of chemically distinct nanomaterials. Thin polymeric films of layer-by-layer assembled PAH and PSS can be printed on a PCTE membrane. Inkjet printing paired with template synthesis can also be used to prepare functional mosaic membranes, such as charge mosaic membranes comprising polyelectrolytes of different charges to pattern positively charged or negatively-charged domains, respectively, on the surface of the template.