Abstract: Described herein are compositions a genetically modified comprising nucleic acids encoding a chimeric antigen receptor (CAR) and a checkpoint inhibitor and methods for using the compositions to treat cancer.

Abstract: A digital integrated circuit comprising may include a digital sensor circuit that converts binary bit patterns of wires in a sub-circuit over a given time into a single integer value that represents the total activity of a sub-circuit, and a digital data processing circuit that receives multiple activity integer values from multiple digital sensors in multiple sub-circuits and logically combines the values or uses a lookup table to output a single integer value that represents the total activity of a larger sub-circuit.

Abstract: Disclosed herein are recombinant polypeptides comprising an elastin-like peptide (ELP) and a scFv, or a biological equivalent of the scFv. Also disclosed are compositions containing scFv-ELP polypeptides and methods of use.

Abstract: Compositions of Allopregnanolone (Allo), and methods of use thereof for treating and preventing Alzheimer's Disease (AD) or dementia, have been developed. In some embodiments, the amount of Allo effective to treat AD or dementia is between about 2 mg and about 10 mg, preferably 4 mg per dose. Methods for identifying subjects for treatment of AD or dementia are also provided. The methods include selecting a subject having one or more Apo E4 gene alleles. Methods of treating a human subject having AD or at risk of AD or dementia are provided. The methods include administering a dosage of from 2 mg to 6 mg to the subject once within a 24 hour period. The dosing is repeated every seven days, or less frequently. The methods stimulate mitosis of neural progenitor cells, stimulate neurite growth and organization, protect against neural loss, or one or more of these neural processes.

Abstract: A method for extracting a set of principal time series data of dynamic latent variables. The method includes detecting, by a plurality of sensors, dynamic samples of data each corresponding to one of a plurality of original variables. The method also includes analyzing, using a controller, the dynamic samples of data to determine a plurality of latent variables that represent variation in the dynamic samples of data. The method also includes selecting, by the controller, at least one inner latent variable that corresponds to at least one of the plurality of original variables. The method also includes estimating an estimated current value of the at least one inner latent variable based on previous values of the at least one inner latent variable.

Abstract: A computer implemented method for analyzing media content includes a step of providing a plurality of narrative files formatted in human readable format. Each narrative file includes a script and/or dialogues tagged with character names along with auxiliary information. Each script includes a plurality of portrayals performed by an associated actor or character. Linguistic representations of content of the narrative files in both abstract and semantic forms is determined. The linguistic representations are connected to higher order representations and mental states. The linguistic representations are connected to behavior and action. Interplay between language constructs and demographics of content creators is analyzed. Content representations towards individuals/groups are adapted to reflect heterogeneity in preferences.

Abstract: A task allocation system for dynamically allocating computing tasks to networked computing resources with heterogeneous capabilities includes: a task library having a plurality of tasks, each task being one of a plurality of different implementations of an application, wherein the different implementations of an application provide different levels of accuracy and resource usage during execution, wherein the different implementations are configured based on a trade-off between level of accuracy and resource usage during execution; and a real-time scheduler module configured to monitor available computing resources and connectivity to the computing resources, receive a plurality of task requests, prioritize applications to be executed when performing the tasks wherein more critical applications are assigned a higher priority, allocate computing resources to the higher priority applications, allocate remaining computing resources to other applications, and select specific implementations of applications for ass

Abstract: The invention relates to regenerative, solid sorbents for adsorbing carbon dioxide from a gas mixture, including air, with the sorbent including a modified polyamine and a solid support. The modified polyamine is the reaction product of an amine and an epoxide. The sorbent provides structural integrity, as well as high selectivity and increased capacity for efficiently capturing carbon dioxide from gas mixtures, including the air. The sorbent is regenerative, and can be used through multiple cycles of adsorption-desorption.

Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.

Abstract: A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.

Abstract: The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.

Abstract: Antiviral compounds comprising prodrugs with differing side chains derived from a tyrosine substance in the form of a tyrosine amide in which the amide substituent side chain is an alkyl ether, thioether, or alkene. Embodiments of the compounds have a range of effective lipophilicity values allowing variation in aqueous solubility, oral bioavailability, cell permeability and in vivo activation properties. The embodiments have promoieties derived from a single amino acid, which are expected to have low toxicity. The features described above also make possible a novel “precision medicine” approach to treatment of viral infections, whereby the prodrug variations can be exploited to match optimal activation of the prodrug to a given patient or strain of virus.

Abstract: A system for structuring a directed energy beam includes one or more coherent light sources that emit one or more initial light beams, one or more spatial light modulators that modulate the one or more initial light beams, and a beam combiner that coherently adds orbital angular momentum beams to create a reconfigurable spatial region of localized power that forms the directed energy beam. Each spatial light modulator is loaded with a pattern that receives an incident light beam and outputs an orbital angular momentum beam. The pattern encodes one or more orthogonal orbital angular momentum functions. Characteristically, each orbital angular momentum having an associated complex weight with which each orbital angular momentum beam is weighted in forming the coherent addition.

Abstract: A robot may extrude a tower or column. The robot may include an extrusion nozzle, a positioning system, a climbing apparatus, and a controller. The extrusion nozzle may controllably extrude uncured construction material. The positioning system may controllably cause the extrusion nozzle to traverse a perimeter layer of the tower or column. A climbing apparatus may controllably cause the robot to climb. A controller may autonomously: direct the positioning system to cause the nozzle to traverse the perimeter layer of the tower or column; direct the nozzle to extrude uncured construction material during the traverse; direct the climbing apparatus to cause the robot to climb an incremental amount; and repeat each of the foregoing positioning, extrusion, and climbing steps until the extruded tower or column attains a desired height.

Abstract: A power generation system includes a plurality of energy conversion devices for generating a plurality of power signals based on one or more sensed environmental conditions. The system further includes a plurality of power conditioning circuits each coupled to one or more of the energy conversion devices for receiving the power signals and storing energy in an energy storage system. The system also includes a selection circuit coupled to at least one of the power conditioning circuits and receiving a first input power signal from one of the power conditioning circuits and a second input power signal. The selection circuit is configured to deliver an output power signal representing a selection from between the first and second input power signals based on a relative voltage level of the first and second input power signals. A method of power generation, and associated power module, are also disclosed.

Abstract: Methods, systems, and apparatus for detecting single event effects. The system includes a first-modulus digital logic unit and a second-modulus digital logic unit each configured to reduce one or more operands by a respective modulus, apply an arithmetic compute logic to the reduced operands to produce a respective compute output, and reduce the respective compute output by their respective modulus. The system includes a kernel digital logic unit configured to apply the arithmetic compute logic to the operands to produce a kernel compute output, output the kernel compute output reduced by the first modulus, and output the kernel compute output reduced by the second modulus. The system includes a detector configured to detect a single event effect based on the reduced first compute output, the kernel compute output reduced by the first modulus, the reduced second compute output, and the kernel compute output reduced by the second modulus.

Abstract: Volumetric imaging with selective volume illumination (SVI) using light field detection is provided using various systems and techniques. A volumetric imaging apparatus includes a light source configured to emit an illumination light that propagates via an illumination light path to illuminate a three-dimensional (3D) sample; and an optical system arranged with respect to the light source to receive a light field, which comes from the illuminated 3D sample. The light field propagates via a detection light path, and the light source, the optical system, or both; are configurable to perform SVI, which selects a volume of a 3D-confined illumination of the 3D sample based on the 3D sample to be illuminated and a light field detection (LFD) process to be applied. Further, the volume of the 3D-confined illumination is a selected 3D volume of the 3D sample to be particularly excited by the 3D-confined illumination for imaging.

Abstract: Methods and apparatuses for additive manufacturing using stereolithography (“SLA”) materials. The apparatus includes a platform for holding an assembly of SLA resin layers. The apparatus also includes a platform for holding an assembly of SLA resin layers. The apparatus also includes a first movable stage for depositing and curing a portion of the liquid SLA resin on the platform, forming a pattern of cured SLA resin. The apparatus also includes a second movable stage for depositing a low-viscosity non-SLA material in voids in the pattern of cured SLA resin. The apparatus also includes a cooler for cooling the low-viscosity non-SLA material below its freezing point until solidified.

Abstract: Implementations of the present disclosure include methods, systems, and computer-readable storage mediums for image reconstruction. Actions include receiving an image acquired by an endoscopic system including an optical fiber bundle with multiple optical fibers, each optical fiber being surrounded by cladding, determining in the image fiber core locations corresponding to the optical fibers, reconstructing missing information from the image using interpolation performed in accordance with the fiber core locations, the missing information corresponding to artifacts in the acquired image that result from the cladding, and providing a fiber-pattern removed image, in which the artifacts in the acquired image are removed using the missing information.

Abstract: This disclosure relates to pancreatic stromal progenitor cells. This disclosure also relates to isolation of pancreatic stromal progenitor cells. This disclosure further relates to a composition comprising pancreatic stromal progenitor cells and preparation of this composition. This disclosure also relates to a treatment comprising administering a composition comprising pancreatic stromal progenitor cells. This disclosure also relates to a treatment of diabetes mellitus comprising administering a composition comprising pancreatic stromal progenitor cells.