Abstract: A method of treating Alzheimer's associated pathology includes a step of identifying subject having a pathology that is associated with Alzheimer's disease. A fasting mimicking diet (FMD) is then administered to the subject for a first time period. Methods for treating amyloid plaque formation and/or elevated levels of tau protein as well as neuroinflammation are also provided.

Abstract: A system, method, and device (“system”) is provided for conducting anatomically interpretable deep learning of brain age that captures domain-specific cognitive impairment. By performing personalized profiling of future brain trajectories using generative artificial intelligence, the system facilitates early identification of neuroanatomy changes to screen individuals according to risk of neurocognitive impairments. A system may implement a generative AI model and may receive a plurality of brain data sets, extract various maps of a subject brain, and determine a salience probability map of future brain trajectory or future brain disease biomarkers based thereon. Moreover, the generative AI model may compute a training objective and the model may update based on the training objective.

Abstract: This invention relates to methods and systems for reducing the concentration of SOx and/or NOx in gas streams.

Abstract: A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. The fasting mimicking diet provides the subject with at most 50% to 75% of the subject's normal caloric intake. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.

Abstract: A control system includes a target spacecraft and a swarm of chaser spacecraft. Each chaser spacecraft is controlled to follow a corresponding computed trajectory. The system also includes at least one computing device that executes a nested genetic algorithm. The nested genetic algorithm includes multiple guidance genetic algorithms and an outer genetic algorithm. Characteristically, each chaser spacecraft has an associated guidance genetic algorithm that determines a computed trajectory for the chaser spacecraft associated therewith. Advantageously, the outer genetic algorithm checks for collisions and is configured to alter one or more computed trajectories to avoid collisions.

Abstract: The disclosure provides for an engineered extracelluar vesicle and methods of using the same where the engineered extracellular vesicle comprises a first fusion protein having the formula A-B-C, wherein A is a first antibody moiety, B is a second antibody moiety, and C is a first exosomal protein transmembrane domain; and a second fusion protein comprising the formula D-E-F, wherein D is a first protein binding moiety, E is a second exosomal membrane protein transmembrane domain, and F is a second protein binding moiety; wherein both the first fusion protein and the second fusion protein are displayed on a surface of the engineered extracellular vesicle, and the first antibody moiety and the second antibody moiety separately bind to a an immune cell marker protein and a cancer cell surface-marker protein, and the first binding protein moiety and the second protein binding moiety separately bind to a second immune cell marker protein and a second cancer cell surface-marker protein.

Abstract: An ultrafast non-volatile memory cell for wafer-scale integration includes a voltage divider that outputs an output voltage. The voltage divider includes a reference resistive device that is a reference magnetic tunnel junction or another reference resistive component and a switchable magnetic tunnel junction that includes a free magnet and a fixed magnet. The switchable magnetic tunnel junction configured such that the free magnet is light switchable between a high impedance state and a low impedance state upon application of an electric signal and incident light. A transistor switch is configured to activate the voltage divider for memory write and read operations. A light modulator is in electrical communication with the output voltage from the voltage divider. The light modulator is configured to modulate a guided light beam for memory read operations. Arrays of the memory cells are also provided.

Abstract: Systems and methods are disclosed for a 3D microfluidic channel manufacturing device comprising: a main build platform and an auxiliary build platform, for printing microfluidic channels in a 3D printed product.

Abstract: A control signal may be modulated on an optical wave. A transmitter may transmit the control signal to a switch/processor location. At the remote node, the control signal is received and converted from an optical signal to an electrical signal to drive the switch/processor. To provide electrical power at the switch/processor location, optical power is transmitted from a distance and converted to electrical power using a series of PDs. Monitoring tones may be sent to the remote node and fed back to the transmitter to realize an operation state and detect a bias drift. Accordingly, an OSP function at a remote node is enabled without using any local electrical power supply.

Abstract: A system for exhaust gas remediation includes an engine, a plasma reactor, and a pulse source. The engine emits exhaust gas that includes NO molecules and NOx molecules. The plasma reactor includes an internal chamber that is fluidly connected to the engine such that the exhaust gas flows into the internal chamber. An electrode is disposed within the internal chamber of the plasma reactor. The electrode is electrically coupled to an electrical pulse source. The electrical pulse source delivers electrical pulse to the electrode to form a plasma from the exhaust gas, which removes at least a portion of the NO molecules and at least a portion of the NOx molecules.

Abstract: The invention provides a series of GMPS enzyme inhibitors. The invention includes potent GMPS inhibitors that specifically and covalently bind to GMPS, exhibit broad anti-cancer activity, block the infection efficiency of viruses, and have the potentials to suppress undesired immune responses. These novel inhibitors of GMPS, and their derivatives, have tremendous potentials to be used as therapeutic agents for the treatment of cancers, viral infection and immune disorders.

Abstract: Disclosed herein are organic photosensitive optoelectronic devices comprising acceptor and/or donor sensitizers to increase absorption and photoresponse of the photoactive layers of the devices. In particular, devices herein include at least one acceptor layer and at least one donor layer, wherein the acceptor layer may comprise a mixture of an acceptor material and at least one sensitizer, and the donor layer may comprise a mixture of a donor material and at least one sensitizer. Methods of fabricating the organic photosensitive optoelectronic devices are also disclosed.

Abstract: A method for detecting and/or localizing keyboard accessibility failures (KAFs) in a web page is disclosed. A document object model of a web page is read. A keyboard navigation flow model is generated from the document object model of the web page based on interactions of a user with the web page. The model includes states representing user interfaces displayed by the web page, nodes representing keyboard inputs in the states, and edges representing transitions that occur in the web page between the nodes. KAFs are detected based on an analysis of the keyboard navigation flow model. A report of the detected one or more KAFs on the web page is produced. The KAFs include unintuitive navigation failures, reflow related failures, and dialog related failures.

Abstract: Systems, methods and devices are provided for evaluating changes in the human cerebral cortex from computed tomography. These may include regional segmentation and parcellation of the human cerebral cortex. Such a method may include receiving a plurality of brain images, segmenting aspects of the imaging, and performing other processing, such as correcting a radiodensity gradient, performing linear translations, and/or other steps. The system, methods, and devices may characterize brain volumes from the aggregated brain data. In this manner, changes in the brain may be determined.

Abstract: Systems and methods are provided for learning control policies that are safe, robust, and interpretable in developing robotic systems. In one example, a signal temporal logic is used to evaluate and rank the quality of demonstrations. The temporal logic based specifications allow generation of non-Markovian rewards, and also define causal dependencies between tasks such as sequential task specifications.

Abstract: The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.

Abstract: Systems and methods for software defined radar are disclosed. Exemplary systems utilize a frequency stacking bandwidth reconstruction technique for a stepped frequency signal to create a synthetic wideband waveform. The methods enable low-cost, reconfigurable applications such as ground penetrating radar or small unmanned aerial vehicle synthetic aperture radar platforms.

Abstract: A method for assuring that integrated circuits are free of malicious circuit insertions and/or IC design modifications through mask swapping/addition is provided. The method includes a step of comparing 3D tomographic images constructed from design GDS to the 3D tomographic images constructed from in-line fab metrology data.

Abstract: Herbal compositions comprising dihydromyricetin (DHM) and methods of use. The herbal compositions include DHM in combination with other ingredients to form compositions that can significantly improve the quality and duration of sleep, reduce the time for onset of improved sleep quality and duration, and treat or alleviate the symptoms of sleep-related disorders and neurological conditions. The composition is a therapeutic alternative to drugs to alleviate sleep disorders and related symptoms and ailments.

Abstract: A filtering device for incorporation into an architectural façade panel includes a tubular channel having an inlet section, an outlet section, and a constricted section interposed between and in fluid communication with the inlet section and outlet section. A filtering component is attached to the tubular channel or integrated into a material forming the tubular channel. The filtering device also includes an attachment component for attachment of the filtering device to an architectural structure. The attachment component is adapted to orient the tubular channel with the inlet section positioned to face predetermined prevailing winds when the filtering device is attached to the architectural structure.