Patents Assigned to The University of Southern California
  • Patent number: 10434197
    Abstract: A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: October 8, 2019
    Assignees: University of Delaware, University of Southern California
    Inventors: Joseph M. Fox, Matthew Hassink, Melissa Blackman, Zibo Li, Peter S. Conti, Ramajeyam Selvaraj
  • Patent number: 10433576
    Abstract: A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: October 8, 2019
    Assignee: University of Southern California
    Inventors: Valter D. Longo, Chia-Wei Cheng
  • Patent number: 10418890
    Abstract: A vibration energy harvester that converts kinetic energy to electrical energy. The vibration energy harvester includes an electrically conductive coil array, a magnetic array and a self-assembled liquid bearing. The magnetic array is levitated above the electrically conductive coil array. The magnetic array and the electrically conductive coil array are configured to generate the electrical energy from a relative movement between the magnetic array and the electrically conductive coil array. The self-assembled liquid bearing separates the magnetic array from the electrically conductive coil array and levitates the magnetic array over the electrically conductive coil array.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: September 17, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Eun Sok Kim, Yufeng Wang
  • Patent number: 10416453
    Abstract: A head mounted display (HMD) for viewing a virtual environment generally include a flat display (FD), lenses for focusing on the FD, and a housing to enclose the FD and lenses. The housing is generally opaque to block out all external light, so the viewer only sees light from the FD. By making a portion or all of the housing translucent or transparent, ambient light and other external light can be seen by the viewer, providing additional visual cues and a larger perceived field of view. Additionally, other people can see light from the FD. The lenses are configured to view the FD and parts of the translucent housing.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: September 17, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark Bolas, J. Adam Jones, David M. Krum
  • Patent number: 10411811
    Abstract: A system includes a transmitter with multiple transmit devices each having an OAM multiplexer that converts multiple input signals into an OAM beam. Each transmit device outputs a coaxial group of orthogonal OAM beams. The system also includes a receiver that has multiple receive devices each having an OAM demultiplexer that receives the group of OAM beams from a corresponding transmit device. The OAM demultiplexer also converts the coaxial group of mutually orthogonal OAM beams into a plurality of received signals corresponding to input signals represented by the OAM beams. The receiver also includes a MIMO processor that has an equalizer that determines a transfer function corresponding to crosstalk of each of the plurality of received signals. The MIMO processor also reduces the crosstalk of each of the plurality of received signals based on the transfer function and updates the transfer function.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: September 10, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Alan E. Willner, Yongxiong Ren, Long Li, Guodong Xie, Yinwen Cao, Zhe Wang, Cong Liu, Asher J. Willner
  • Publication number: 20190270762
    Abstract: An antiviral compound of the following formula (I) is provided or a salt or a pharmaceutically acceptable salt thereof, where B is a naturally occurring or non-naturally occurring base; R1 is a C2-C14 alkyl group; X is O, S, CH?CH (cis) or CH?CH (trans); and R2 is a C2-C14 alkyl group. In some embodiments, B can be adenine or cytosine. Compositions containing the compound, and methods of using and preparing the compound, are also provided.
    Type: Application
    Filed: October 31, 2017
    Publication date: September 5, 2019
    Applicant: University of Southern California
    Inventors: Charles E. McKenna, Boris A. Kashemirov, Jaijun Fan, Jinglei Lyu
  • Patent number: 10398755
    Abstract: Disclosed are pharmaceutical compositions comprising clusterin and polypeptides substantially the same as clusterin and treatment methods for inflammatory diseases and dry eye disease. The pharmaceutical compositions include an isolated clusterin or an isolated polypeptide substantially the same as clusterin. The clusterin is preferably secreted clusterin. The method of treating dry eye disease includes administering to a patient in need an effective amount of a pharmaceutical composition comprising an isolated clusterin or an isolated polypeptide substantially the same as clusterin. The method of treating a disease state characterized by inflammation includes administering to a patient having the disease state an amount of isolated clusterin or a protein substantially the same as clusterin effective to decrease the activity of a matrix metallproteinase selected from the group consisting of MMP-9, MMP-2 and MMP-7.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: September 3, 2019
    Assignee: University of Southern California
    Inventors: M. Elizabeth Fini, Shinwu Jeong
  • Patent number: 10403484
    Abstract: A photonic electron emission device includes an emitter, a photonic energy conduit evanescently coupled to the emitter, and an anode. The emitter includes a component selected from the group consisting of a metal, a semimetal, a semiconductor having a bandgap that is less than about 3.5 eV. The anode is positively biased with respect to the emitter, the anode directing electrons emitted from the emitter.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: September 3, 2019
    Assignee: University of Southern California
    Inventors: Fatemeh Rezaeifar Bayat, Rehan Rashid Kapadia
  • Publication number: 20190266748
    Abstract: Systems and method are provided for controlling an autonomous vehicle. In one embodiment, a method includes: receiving sensor data from a sensor of the vehicle; determining a three dimensional point cloud map segment from the sensor data; determining a vehicle pose associated with the three-dimensional point cloud map segment; determining a pose difference based on the vehicle pose, another vehicle pose, and a two-step process, wherein the two-step process includes computing a coarse-granularity pose difference, and computing a fine-granularity pose difference; aligning the three dimensional point cloud map segment with another three dimensional point cloud map segment associated with the other vehicle pose based on the pose difference; and controlling the vehicle based on the aligned three dimensional point cloud map segments.
    Type: Application
    Filed: February 23, 2018
    Publication date: August 29, 2019
    Applicants: GM GLOBAL TECHNOLOGY OPERATIONS LLC, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Fawad Ahmad, Hang Qiu, Fan Bai, Ramesh Govindan
  • Publication number: 20190254705
    Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.
    Type: Application
    Filed: February 20, 2019
    Publication date: August 22, 2019
    Applicant: University of Southern California
    Inventor: Mark S. Humayun
  • Publication number: 20190255787
    Abstract: Presented are manufacturing control systems for composite-material structures, methods for assembling/operating such systems, and transfer molding techniques for predicting and ameliorating void conditions in fiber-reinforced polymer panels. A method for forming a composite-material construction includes receiving a start signal indicating a fiber-based preform is inside a mold cavity, and transmitting a command signal to inject pressurized resin into the mold to induce resin flow within the mold cavity and impregnate the fiber-based preform. An electronic controller receives, from a distributed array of sensors attached to the mold, signals indicative of pressure and/or temperature at discrete locations on an interior face of the mold cavity. The controller determines a measurement deviation between a calibrated baseline value and the pressure and/or temperature values for each of the discrete locations.
    Type: Application
    Filed: February 20, 2018
    Publication date: August 22, 2019
    Applicants: GM GLOBAL TECHNOLOGY OPERATIONS LLC, University of Southern California
    Inventors: Roger G. Ghanem, Venkateshwar R. Aitharaju, Hamid G. Kia
  • Patent number: 10386395
    Abstract: Methods and systems, include, in one aspect, a system including: receiving a total static power indicating a static power dissipation from a complete circuit, wherein the circuit comprises a plurality of components; receiving dynamic power weights indicating changes in the static power dissipation from the complete circuit over time; applying an algorithm including the dynamic power weights to partition the total static power, based on the changes in the static power, into a summation of individual per-component static power values, wherein the per-component static power values indicate a decomposition of the static power dissipation from the complete circuit into separate amounts of per-component static power dissipation corresponding to each of the plurality of components; and processing the per-component static power to evaluate a performance of the circuit, the plurality of components, or both.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: August 20, 2019
    Assignee: University of Southern California
    Inventors: Young H. Cho, Siddharth S. Bhargav
  • Publication number: 20190246986
    Abstract: A portable apparatus for imaging an eye in a patient includes a housing with a front portion and a rear portion, the front portion including an adapter sized to be placed over the eye of the patient. A lens is mounted within the housing, and a light source is provided within the housing to illuminate the eye. The rear portion of the housing is arranged to be mounted on a mobile device such that the lens is aligned with a camera associated with the mobile device for obtaining an image of the eye.
    Type: Application
    Filed: September 8, 2017
    Publication date: August 15, 2019
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Damien C. RODGER, Mark S. HUMAYUN, Peiyu WANG
  • Publication number: 20190240232
    Abstract: The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.
    Type: Application
    Filed: July 26, 2017
    Publication date: August 8, 2019
    Applicants: University of Southern California, CNRS, Universite Grenoble Alpes, INSERM
    Inventors: Charles E. MCKENNA, Carlo PETOSA, Jerome GOVIN, Boris A. KASHEMIROV, Elena FERRI, Flore MIETTON
  • Publication number: 20190240359
    Abstract: A method of preparing a 64Cu-BaBaSar-RGD2 solution is provided. The method includes lyophilizing a solution of BaBaSar-RGD2 and adding a 64Cu solution to the lyophilized BaBaSar-RGD2.
    Type: Application
    Filed: November 30, 2018
    Publication date: August 8, 2019
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Shuanglong Liu, Peter Conti
  • Patent number: 10370664
    Abstract: Disclosed herein are compositions and methods of activating nuclear factor of activated T cells (NFAT) and T cell response by inhibiting IKK?.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: August 6, 2019
    Assignee: University of Southern California
    Inventors: Pinghui Feng, Junjie Zhang, Hao Feng
  • Patent number: 10374261
    Abstract: An iron electrode and a method of manufacturing an iron electrode for use in an iron-based rechargeable battery are disclosed. In one embodiment, the iron electrode includes carbonyl iron powder and one of a metal sulfide additive or metal oxide additive selected from the group of metals consisting of bismuth, lead, mercury, indium, gallium, and tin for suppressing hydrogen evolution at the iron electrode during charging of the iron-based rechargeable battery. An iron-air rechargeable battery including an iron electrode comprising carbonyl iron is also disclosed, as is an iron-air battery wherein at least one of the iron electrode and the electrolyte includes an organosulfur additive.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: August 6, 2019
    Assignee: University of Southern California
    Inventors: Sri R. Narayan, G. K. Surya Prakash, Robert Aniszfeld, Aswin Manohar, Souradip Malkhandi, Bo Yang
  • Patent number: 10375264
    Abstract: Systems and techniques for multispectral lighting reproduction, in one aspect, include: one or more light sources having different lighting spectra; and one or more computers comprising at least one processor and at least one memory device, the one or more computers programmed to drive the one or more light sources directly using intensity coefficients that have been determined by comparing first data for a multi-color reference object photographed by a camera in a scene with second data for the multi-color reference object photographed when lit by respective ones of the different lighting spectra of the one or more light sources.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: August 6, 2019
    Assignee: University of Southern California
    Inventors: Paul E. Debevec, Chloe Legendre, Sumanta Pattanaik
  • Patent number: 10367157
    Abstract: Disclosed herein are organic photosensitive optoelectronic devices comprising acceptor and/or donor sensitizers to increase absorption and photoresponse of the photoactive layers of the devices. In particular, devices herein include at least one acceptor layer and at least one donor layer, wherein the acceptor layer may comprise a mixture of an acceptor material and at least one sensitizer, and the donor layer may comprise a mixture of a donor material and at least one sensitizer. Methods of fabricating the organic photosensitive optoelectronic devices are also disclosed.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: July 30, 2019
    Assignee: University of Southern California
    Inventors: Mark E. Thompson, Cong Trinh, Peter I. Djurovich, Sarah M. Conron
  • Publication number: 20190227014
    Abstract: A sensor for measuring electrochemical impedance includes a primary circuit that includes a primary electrically conducting coil and a secondary circuit that includes a secondary electrically conducting coil. The primary electrically conducting coil is inductively coupled to the secondary circuit. During operation, the secondary electrically conductive couple has contact electrodes that contact a medium for which the impedance is to be measured. An alternating current source energizes the primary electrically conducting coil during impedance measurements.
    Type: Application
    Filed: June 5, 2017
    Publication date: July 25, 2019
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Ellis F. MENG, Lawrence YU