Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.

Abstract: A method of multi-material 3D printing is performed by an apparatus comprising at least one printhead device; a build platform; a light source; and a computing unit comprising a non-transitory computer-readable medium encoded with program instructions for controlling the at least one printhead device; the build platform; and the light source to perform the method of multi-material 3D printing. In various embodiments, each printhead device comprises a coating section, a curing section, a cleaning section, and optionally, a post-curing section. Each printhead device is configured to perform each of these steps, with the multiple printheads engaged in fabricating a multi-material part layer-by-layer.

Abstract: A system, computer-readable medium, method and apparatus, and/or device for real-time searching and object validation is provided in connection with quantum computing. In various instances, a digital object may be received and may be compared to a library of many digital objects to determine correspondence between the objects according to various factors. Moreover, fixity of objects may be validated.

Abstract: Organic light emitting devices incorporating a film of metal complex emitters that are oriented with their transition dipole moment vectors oriented parallel to the device substrate enhances the outcoupling and eliminate the need for micro-lens arrays, gratings, or other physical extraneous outcoupling methods.

Abstract: Disclosed herein are methods of regional gene-therapy with growth-factor transduced cells, in bone graft scenarios. In embodiments, the methods comprise use of 3D printed scaffolds.

Abstract: Provided are organometallic compounds comprising as metal at least one of the coin metals Au, Ag, and Cu and further a ligand comprising a 5-membered heterocyclic ring which is fused to a 6-membered aromatic ring and also fused to a 5- or 6-membered carbocyclic or heterocyclic ring or fused ring system. Also provided are formulations comprising these organometallic compounds. Further provided are organic light emitting devices (OLEDs) and related consumer products that utilize these organometallic compounds.

Abstract: A system includes a housing, sensors, actuators, and a processing device. The housing is formed of material that is soft, flexible, stretchable, deformable, or any combination of thereof. Each sensor is disposed on a surface of the housing, disposed at least partially inside the housing, or positioned spaced apart from the housing, and are configured to generate data associated with physical properties of the housing an environment external to the housing. The processing device is configured to implement a neural network having one or more inputs and one or more outputs. The inputs include the data associated with the physical properties of the housing and the data associated with the environment external to the housing. The outputs are based on the data associated the physical properties of the housing and the data associated with the environment external to the housing.

Abstract: A method for forming a composite substrate containing layers of dissimilar materials is provided. The method includes a step of disposing a release layer over a base substrate where the base substrate is composed of a first material. A template layer is attached to the release layer. Characteristically, the template layer is composed of a second material and adapted to form a compound semiconductor device thereon.

Abstract: We report human cerebellar organoids which recapitulate the major milestones of cerebellar development including generating bona fide Purkinje cells, as well as methods of making and using these human cerebellar organoids such as uses in drug target identification and drug screening. In various embodiments, we report a human organoid model (human cerebellar organoids [hCerOs]) capable of developing the complex cellular diversity of the fetal cerebellum, including a human-specific rhombic lip progenitor population that have never been generated in vitro prior to our study. 2-month-old hCerOs form distinct cytoarchitectural features, including laminar organized layering, and create functional connections between inhibitory and excitatory neurons that display coordinated network activity. Long-term culture of hCerOs allows healthy survival and maturation of Purkinje cells that display molecular and electrophysiological hallmarks of their in vivo counterparts, addressing a long-standing challenge in the field.

Abstract: Systems, computer-readable medium, methods and apparatus, and/or devices to causally quantify the potentially heterogeneous direct effect of a marketing program on focal individuals (e.g., egos) and the indirect effect on those connected to the focal ones (e.g., alters). A primary data structure (focal individual or ego) may be connected to multiple secondary data structures (alters) by a primary-to-secondary linkage net. Moreover, different secondary data structures may be connected together by a secondary-to-secondary linkage net, and some secondary data structures maybe connected to multiple primary data structures. Thus, in a complicated arrangement of connections, an input change directed at a single primary data structure may have both direct effects thereon, and complex indirect effects on secondary data structures. The systems, computer-readable medium, methods and apparatus, and/or devices provide mechanisms to evaluate these effects.

Abstract: A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.

Abstract: A method for decoding mood or other neuropsychiatric states from large-scale brain activity includes receiving, by a processor, large-scale brain activity signals from an electrode assembly coupled to a subject. The method includes continuously and automatically decoding a neuropsychiatric state of the subject from the large-scale brain activity signals received from a predictive network subset of brain sites coupled to the electrode assembly, contemporaneously with the receiving. The method includes providing a signal indicative of the neuropsychiatric state. A method for adaptive tracking of large-scale brain network activity includes characterizing, by one or more computers, a time-variant linear state-space model predictive of a brain state, at least in part by updating estimates of time-varying covariance matrices at time steps.

Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.

Abstract: A semiconductor-based sensor with enhanced light absorption, and in particular, enhanced infrared light absorption includes a semiconductor light sensor element and a patterned spatially inhomogeneous dielectric layer disposed over the semiconductor light sensor element. Characteristically, spatial inhomogeneity of the patterned spatially inhomogeneous dielectric layer is optimized to provide a maximized electric field in the semiconductor light sensor element such light absorption is enhanced.

Abstract: A method for fabricating low defective non-planar bipolar heterostructure transistors includes a steps of providing a substrate that is coated with a first dielectric layer when the substrate is not composed of a dielectric material. A layer of a first semiconductor material is formed by template liquid phase (TLP) crystal growth wherein a second dielectric layer is disposed over the first semiconductor material. A trench is patterned into the second dielectric layer. An intermediate heterostructure is formed by epitaxially growing second semiconductor material in the trench to form a fin structure therein. Various power transistor structures can be formed from the intermediate heterostructure.

Abstract: A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.

Abstract: A method assessing tissue morphology using machine learning includes a step of training a machine learnable device to predict the status of a diagnostic feature in stained tissue samples. The machine learnable device is trained with a characterized set of digital images of stained tissue samples. Each digital image of the characterized set has a known status for the diagnostic feature and an extracted feature map provides values for a extracted feature over an associated 2-dimensional grid of spatial locations. A step of inputting the set of extracted feature maps is inputted into the machine learnable device to form associations therein between the set of extracted feature maps to and the known status for the diagnostic feature to form a trained machine learnable device. The status for the diagnostic feature of a stained tissue sample of unknown status for the diagnostic feature is predicted from the trained machine learnable device.

Abstract: The disclosure provides methods for the long-term expansion of granulocyte-macrophage progenitors, the granulocyte-macrophage progenitors generated therefrom, and uses of the granulocyte-macrophage progenitors thereof.

Abstract: Examples are described for dynamically applying a digital watermark to a file, such as a dataset of genomic sequencing data. In one example, a method of dynamically applying a watermark to at least a portion of a file includes generating, using a secret key, a first random seed, generating, using the first random seed, an ordered pseudorandom set of integers, generating, using entity information and timing information, a second random seed, selecting, using the second random seed, a subset of the ordered pseudorandom set of integers, and modifying data at data locations in the file corresponding to at least a portion of the identifiers included in the subset to generate a watermarked file. The method may further include performing a check to determine whether the watermark is present in a file using a sequence of watermark elements that are generated based on the secret key.

Abstract: Described herein is a novel, mitochondrial encoded, open reading frame that leads to the production of a new mitochondrial peptide called SHMOOSE. SHMOOSE is a 58-amino-acid peptide and, within its open reading frame, contains a genome-wide significant small nucleotide polymorphism (SNP) that markedly increased risk for Alzheimer's disease, brain structure, brain gene expression, and cognition. SHMOOSE increased neuronal-type cell survival and protected against amyloid beta toxicity. Metabolomic studies revealed a role for the peptide in energy optimization, whose dysfunction and dysregulation leads to cell death in physiologically notable regions of the brain in neurodegenerative diseases such as Alzheimer's and Parkinson's. Methods and compositions, including peptide analogues and derivatives, are described for treatment and diagnostics.