Patents Assigned to The University of Southern California
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Publication number: 20240025959Abstract: Disclosed herein are recombinant proteins and/or polypeptides comprising a Beclin 2 polypeptide and/or a targeting moiety and methods relating to treating, preventing, reducing, and/or inhibiting a cancer, metastasis, and/or a neurodegenerative disease comprising administering said recombinant protein or polypeptides.Type: ApplicationFiled: August 24, 2021Publication date: January 25, 2024Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, THE METHODIST HOSPITAL SYSTEMInventors: Rongfu Wang, Yicheng Wang, Motao Zhu
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Publication number: 20240018199Abstract: Described herein is a novel, mitochondrial encoded, open reading frame, that leads to the production of a new mitochondrial peptide. Residing within the ND-Two subunit, a specific small nucleotide polymorphism disrupts expression of this mitochondrial peptide, and is correlated with an increase in obesity and diabetes, particularly in certain ethnic populations. In vitro administration of the peptide increases insulin secretion, decreases fat accumulation and improves glucose uptake in muscle cell. Antibodies generated against the peptide can be used for detecting peptide deficiency, in addition to SNP detection, supporting diagnostic approaches. In vivo studies further revealed that administration of the peptide improves glucose tolerance, thereby providing a new therapeutic avenue for a novel diabetes therapy and decreases bodyweight, thus serving as a novel obesity therapy. Generation of synthetic analogs further enhance or abrogated activity relative to the natural peptide.Type: ApplicationFiled: August 1, 2023Publication date: January 18, 2024Applicant: University of Southern CaliforniaInventors: Pinchas COHEN, Kelvin YEN
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Publication number: 20240021231Abstract: An ultrafast non-volatile memory cell for wafer-scale integration includes a voltage divider that outputs an output voltage. The voltage divider includes a reference resistive device that is a reference magnetic tunnel junction or another reference resistive component and a switchable magnetic tunnel junction that includes a free magnet and a fixed magnet. The switchable magnetic tunnel junction configured such that the free magnet is light switchable between a high impedance state and a low impedance state upon application of an electric signal and incident light. A transistor switch is configured to activate the voltage divider for memory write and read operations. A light modulator is in electrical communication with the output voltage from the voltage divider. The light modulator is configured to modulate a guided light beam for memory read operations. Arrays of the memory cells are also provided.Type: ApplicationFiled: October 5, 2021Publication date: January 18, 2024Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Ajey JACOB, Akhilesh JAISWAL
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Publication number: 20240021428Abstract: A method for processing a surface, comprising obtaining a substrate comprising an epitaxially grown semiconductor; reacting a surface of the semiconductor and/or a surface of a dielectric layer on the semiconductor, with a reactant comprising a gas or a plasma, to form a reactive layer on the dielectric layer and/or the semiconductor, wherein the reactive layer comprises a chemical compound including the reactant and elements of the dielectric layer or the semiconductor; and processing (e.g.Type: ApplicationFiled: July 13, 2023Publication date: January 18, 2024Applicants: California Institute of Technology, University of Southern CaliforniaInventors: Harold Frank Greer, Rehan Kapadia, Debargyha Sarkar
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Publication number: 20240019404Abstract: A system and method for imaging biological material is disclosed. The imaging system may comprise: a multi-well assay plate having a plurality of wells, each well of the plurality of wells defining a cavity that is configured to hold a biological material; an imaging module having a plurality of transducers; and a processor coupled to the imaging module. The processor may be configured to: activate the plurality of transducers to emit energy within the plurality of wells to stimulate the biological material, and generate an image of or analyze the biological material within each well. The method may comprise: adding a thin layer of acoustic coupling material; inserting the microwell plate into a support frame of an enclosure; mechanically translating the support frame; interrogating each of the wells of the microwell plate with ultrasound; and outputting results of the interrogation to an output device.Type: ApplicationFiled: October 15, 2021Publication date: January 18, 2024Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Robert G. Wodnicki, Haochen Kang
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Publication number: 20240009205Abstract: A therapeutic combination of a compound having antiestrogenic activity and a CDK4/6 inhibitor is used in a method for the treatment of BC or other estrogen-responsive tumors in a human patient, wherein the method comprises subjecting the patient to a fasting mimicking diet for a period of 24-190 hours while the patient is being treated with the therapeutic combination, in which the compound having antiestrogenic activity can be a selective estrogen receptor modulator (SERM), a selective estrogen receptor degrader (SERD) or an aromatase inhibitor (AI).Type: ApplicationFiled: April 21, 2021Publication date: January 11, 2024Applicants: IFOM -FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (37%), UNIVERSITY OF SOUTHERN CALIFORNIA (37%), UNIVERSITA' DEGLI STUDI DI GENOVA (26%)Inventors: Alessio Nencioni, Irene Caffa, Valter Longo, Vanessa Spagnolo
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Patent number: 11869176Abstract: This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.Type: GrantFiled: January 31, 2020Date of Patent: January 9, 2024Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Wen Shi, Eun Sang Koo, Scott E. Fraser, Francesco Cutrale
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Publication number: 20240007186Abstract: Atmospheric turbulence degrades decoding and data recovery from optically transmitted signals. For example, atmospheric turbulence can induce power coupling from the transmitted Gaussian mode to higher-order modes, resulting in significantly degraded mixing efficiency and system performance. Systems and methods are provided to generate a signal that is a conjugate of the atmospheric noise which is combined with a received data signal to ameliorate atmospheric noise. An optical pilot beam may be transmitted with an optical data beam and received by a receiver which utilizes the optical pilot beam to generate the signal that is a conjugate of the atmospheric noise.Type: ApplicationFiled: January 20, 2022Publication date: January 4, 2024Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Runzhou Zhang, Nanzhe Hu, Alan E. Willner, Huibin Zhou, Haoqian Song, Hao Song, Xinzhou Su, Kaiheng Zou
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Publication number: 20240004969Abstract: Examples are described for dynamically applying a digital watermark to a file, such as a dataset of genomic sequencing data. In one example, a method of dynamically applying a watermark to at least a portion of a file includes generating a first random seed, generating an ordered pseudorandom set of integers, generating a second random seed, selecting, using the second random seed, a subset of the ordered pseudorandom set of integers, the subset corresponding to identifiers of data locations in the file, and modifying data at data locations in the file corresponding to at least a portion of the identifiers included in the subset to generate a watermarked file. The genomic data file may be an ordered Binary Alignment Map (BAM) file storing sequencing data or a Variant Call Format (VCF) file or a list of variants storing genomic variation data.Type: ApplicationFiled: April 21, 2021Publication date: January 4, 2024Applicants: Children's Hospital Los Angeles, University of Southern CaliforniaInventors: Xiaowu Gai, Alex Ryutov, Tatyana Ryutov
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Patent number: 11858888Abstract: This disclosure provides compounds, pharmaceutical compositions, and methods of use for the prevention and treatment of inflammatory diseases or degenerative diseases including neurodegenerative diseases. Embodiments of the present disclosure provide compounds related to very long chain polyunsaturated fatty acids, pharmaceutical compositions containing the provided compounds, and methods of treating a subject with a condition or disease using provided compounds or pharmaceutical compositions.Type: GrantFiled: April 27, 2020Date of Patent: January 2, 2024Assignees: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE, UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Nicolas G. Bazan, Nicos A. Petasis
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Patent number: 11858213Abstract: A system for additively manufacturing a build part. The system includes a build platform configured for disposition within a resin tank, and a light source configured to cure a layer of resin. The layer of resin is disposed adjacent to a pre-cure build surface of the build part. The system also includes a constrained surface located between the build platform and the light source and configured to form a boundary for the layer of resin disposed between the constrained surface and the pre-cure build surface. The constrained surface is configured to vibrate to reduce a separation force required to separate the constrained surface from a post-cure build surface of the build part. The system also includes a vibratory source configured to vibrate the constrained surface.Type: GrantFiled: June 13, 2019Date of Patent: January 2, 2024Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Yong Chen, Jie Jin
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Publication number: 20230416293Abstract: Thymidine analogues, 5-substituted 2?-deoxy-2?-[18F]fluoro-arabinofuranosyluracil derivatives, are promising positron emission tomography (PET) tracers being evaluated for noninvasively imaging cancer cell proliferation and/or reporter gene expression. We report the radiosynthesis of 2?-deoxy-2?-[18F]fluoro-5-methyl-1-?-d-arabinofuranosyluracil ([18F]FMAU) and other 2?-deoxy-2?-[18F]fluoro-5-substituted-1-?-d-arabinofuranosyluracil analogues using 1,4-dioxane to replace the currently used 1,2-dichloroethane. Compared to 1,2-dichloroethane, 1,4-dioxane is analyzed as a better solvent in terms of radiosynthetic yield and toxicity concern. The use of a less toxic solvent allows for the translation of the improved approach to clinical production. The new radiolabeling method can be applied to an extensive range of uses for 18F-labeling of other nucleoside analogues.Type: ApplicationFiled: November 19, 2021Publication date: December 28, 2023Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Kai CHEN, Peter S. CONTI
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Patent number: 11845792Abstract: This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.Type: GrantFiled: October 22, 2020Date of Patent: December 19, 2023Assignee: University of Southern CaliforniaInventors: Parkash Gill, Ren Liu, Amy Lee
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Patent number: 11839449Abstract: Methods and systems of monitoring and controlling thermal therapy treatments. One method includes determining, with an electronic processor, a propagation constant for a plurality of waveports. The method also includes modeling an object within an imaging cavity using a sparse mesh model. The method also includes determining a simulated impedance of the object based on the model of the object. The method also includes calibrating the simulated impedance with a theoretical impedance numerically calculated for the object. The method also includes determining a distribution of an electric field and a distribution of a magnetic field for a mode in a conformal modeled waveport based on the calibrated impedance and the model of the object. The method also includes exciting the plurality of waveports to generate the determined distribution of the electric field and the distribution of the magnetic field.Type: GrantFiled: July 15, 2022Date of Patent: December 12, 2023Assignee: University of Southern CaliforniaInventors: John P. Stang, Mark S. Haynes, Mahta Moghaddam, Guanbo Chen
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Patent number: 11840549Abstract: Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.Type: GrantFiled: December 11, 2020Date of Patent: December 12, 2023Assignees: BIOVINC, LLC, UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Frank H. Ebetino, Shuting Sun, Mark W. Lundy, Charles E. McKenna, Eric Richard, Parish Sedghizadeh, Keivan Sadrerafi, Philip T. Cherian
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Publication number: 20230394516Abstract: A federated learning environment includes a central coordinator that is responsible to orchestrate execution of the federated learning environment, and a plurality of clients jointly that trains machine learning and deep learning models on client computing devices without sharing their local private datasets. The clients only share their locally trained model parameters with the central coordinator. Model parameters are encrypted before sharing with the controller. The central coordinator aggregates local models and computes a new global model in encrypted space. This process repeats for a number of synchronization periods or asynchronously until specific convergence criteria are met. A federated learning marketplace is established to incentivize data providers to join federations through a revenue-sharing model, and to facilitate the use of machine-learning models to organizations outside of the federation.Type: ApplicationFiled: April 7, 2023Publication date: December 7, 2023Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Jose Luis AMBITE MOLINA, Dimitrios STRIPELIS
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Patent number: 11835524Abstract: A method assessing tissue morphology using machine learning includes a step of training a machine learnable device to predict the status of a diagnostic feature in stained tissue samples. The machine learnable device is trained with a characterized set of digital images of stained tissue samples. Each digital image of the characterized set has a known status for the diagnostic feature and an extracted feature map provides values for a extracted feature over an associated 2-dimensional grid of spatial locations. A step of inputting the set of extracted feature maps is inputted into the machine learnable device to form associations therein between the set of extracted feature maps to and the known status for the diagnostic feature to form a trained machine learnable device. The status for the diagnostic feature of a stained tissue sample of unknown status for the diagnostic feature is predicted from the trained machine learnable device.Type: GrantFiled: March 6, 2018Date of Patent: December 5, 2023Assignee: University of Southern CaliforniaInventors: David B. Agus, Paul Thomas Macklin, Rishi Raghav Rawat, Daniel Lee Ruderman
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Patent number: 11834657Abstract: The disclosure provides for single amplification and double amplification methods for preparing nucleic acid samples for sequencing.Type: GrantFiled: June 12, 2018Date of Patent: December 5, 2023Assignees: University of Southern California, SeqOnce Biosciences Inc.Inventor: Joseph Dunham
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Patent number: 11832953Abstract: A method for preferential system identification (PSID) for modeling neural dynamics of a brain includes extracting behaviorally relevant latent brain states via a projection of future behavior onto past neural activity. The method further includes identifying, based on the extracted latent brain states, model parameters for a linear state space dynamic model of neural activity. An extension of PSID includes accounting for an effect of external inputs to the brain by using oblique projections along the external inputs instead of orthogonal projections. PSID may be extended to apply to any primary signals and secondary signals in place of the neural activity and the behavior. In some embodiments, the extracting and the identifying may be performed using a numerical optimization of recurrent neural networks (RNN) instead of the projection.Type: GrantFiled: October 13, 2020Date of Patent: December 5, 2023Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Maryam M. Shanechi, Omid Ghasem Sani
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Patent number: 11834470Abstract: This disclosure provides a method of synthesis of 4?-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4?-thioribose NAD+ and compounds related thereto.Type: GrantFiled: October 4, 2019Date of Patent: December 5, 2023Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Yong Zhang, Zhefu Dai, Xiao-Nan Zhang