Patents Assigned to The University of Texas Systems
  • SMALL MOLECULE GRB2 STABILIZERS FOR RAS MAP KINASE INHIBITION
    Publication number: 20220151991
    Abstract: The present disclosure compounds of the formula (I-A) or (I), wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer. The present disclosure also provides methods for the use of compounds of the formula (III), wherein the variables are defined herein.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 19, 2022
    Applicants: Board of Regents, The University of Texas System, Board of Trustees of the University of Arkansas
    Inventors: Zamal AHMED, John A. TAINER, Darin E. JONES
  • Treatment of aberrant fibroblast proliferation
    Patent number: 11331333
    Abstract: Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: May 17, 2022
    Assignees: Georg-August-Universität Göttingen Stiftung Öffentichen Rechts, Universitätsmadizin, Board of Regents, The University of Texas System
    Inventors: Michael Zeisberg, Elisabeth Zeisberg, Bjoern Tampe, Gerhard Anton Mueller, Xu Xingbo, Desiree Tampe, Raghu Kalluri
  • Microbubble and nanobubble expansion using perfluorocarbon nanodroplets for enhanced ultrasound imaging and therapy
    Patent number: 11334993
    Abstract: The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: May 17, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Robert F. Mattrey, Caroline De Gracia Lux, Jacques Lux, Zhenghong Gao, Carlos J. Brambila
  • COMPOUNDS WITH ANTI-TUMOR ACTIVITY AGAINST CANCER CELLS BEARING EGFR OR HER2 EXON 20 INSERTIONS
    Publication number: 20220143023
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have an EGFR and/or HER2 exon 20 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib or afatinib.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacqulyne ROBICHAUX, Monique NILSSON, John V. HEYMACH
  • LILRB4-BINDING ANTIBODY AND METHODS OF USE THEREOF
    Publication number: 20220144944
    Abstract: Provided herein are LILRB4-binding antibodies and methods of treating cancer by administering the LILRB4-binding antibodies alone or in combination with other therapies. Recombinant polypeptides comprising the CDRs of LILRB4-binding antibodies are also provided.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Naveen SHARMA, James P. ALLISON
  • METHODS OF USING IMIPRIDONES
    Publication number: 20220143024
    Abstract: Provided herein are methods of using ClpP levels and mutation status as a marker for the selection and treatment of cancer patients who will respond to the administration of imipridones. Also provided are methods of treating patients having Perrault syndrome. Also provided are methods of killing bacterial cells and treating bacterial infections using imipridones.
    Type: Application
    Filed: February 21, 2020
    Publication date: May 12, 2022
    Applicants: Board of Regents, The University of Texas System, University Health Network
    Inventors: Michael ANDREEFF, Jo ISHIZAWA, David SCHIMMER, Sara ZARABI
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF PKR-ASSOCIATED DISEASES
    Publication number: 20220143030
    Abstract: Provided herein are RNA-dependent protein kinase (PKR)-associated compounds for the treatment of PKR-associated disorders including cancer, neurodegenerative diseases, and inflammatory conditions.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Apar PATAER, Bulent OZPOLAT, Stephen G. SWISHER, Ruping SHAO
  • Atmospheric water harvesting system
    Patent number: 11326327
    Abstract: Disclosed herein are water harvesting networks. The harvesters allow extraction and collection of moisture from the atmosphere without requiring electrical energy inputs.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Guihua Yu, Fei Zhao, Xingyi Zhou
  • Method for fabricating a hyperbolic metamaterial having a near-zero refractive index in the optical regime
    Patent number: 11329389
    Abstract: A method for fabricating a hyperbolic metamaterial coating having a near-zero refractive index is disclosed. The direction of propagating light changes by means of generating subwavelength structures that alter the coatings permittivity and permeability. The coating can be deposited on lenses or incorporated into optical devices. This type of metamaterial can be utilized to direct light towards sensors or to collect light efficiently.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: May 10, 2022
    Assignee: Board Of Regents, The University of Texas System
    Inventors: Nantakan Wongkasem, Andres Ochoa
  • Method and system for using logarithm of power feedback for extremum seeking control
    Patent number: 11327448
    Abstract: The present disclosure provides a method and system for optimizing a control process. The method and system comprise using a sensor to generate a feedback signal that represents a measured performance index for an extremum seeking control (ESC) method and sending the feedback signal to an ESC conditioning circuit that applies a logarithmic transformation to the feedback signal to obtain a modified feedback signal. An ESC controller applies the modified feedback signal to the ESC method to generate an output value that is used to control an actuator to maximize the performance of a machine or process.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Mario A. Rotea
  • Small molecule inducers of autophagy
    Patent number: 11325898
    Abstract: Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang
  • ISOLATION AND DETECTION OF EXOSOME-ASSOCIATED MICROBIOME FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
    Publication number: 20220137056
    Abstract: The present invention provides methods of predicting, diagnosing, and prognosing disease in a patient by analyzing the microbiome signature present in isolated exosomes. In one embodiment, provided herein are methods of detecting a microbiome in a patient, the method comprising: (a) obtaining a body fluid sample from a patient; (b) isolating an exosomes fraction of the body fluid sample; and (c) detecting a microbial macromolecule present in the exosomes fraction.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 5, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventor: Raghu KALLURI
  • ANTISENSE ANTIBACTERIAL COMPOUNDS AND METHODS
    Publication number: 20220135973
    Abstract: Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials.
    Type: Application
    Filed: October 12, 2021
    Publication date: May 5, 2022
    Applicants: Board of Regents, The University of Texas System, Oregon State University
    Inventors: David GREENBERG, Bruce L. GELLER
  • COMPOSITIONS AND METHODS FOR ORGAN SPECIFIC DELIVERY OF NUCLEIC ACIDS
    Publication number: 20220133637
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: January 10, 2022
    Publication date: May 5, 2022
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • TELOMERASE-CONTAINING EXOSOMES FOR TREATMENT OF DISEASES ASSOCIATED WITH AGING AND AGE-RELATED ORGAN DYSFUNCTION
    Publication number: 20220136011
    Abstract: Provided herein are compositions of lipid-based nanoparticles, such as exosomes, that comprise a therapeutic anti-aging agent. Also provided are methods of using such compositions to treat a patient having an age-associated disorder. In particular, exosomes comprising a telomerase-encoding RNA are provided along with methods of their use in treating age-associated disorders.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 5, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventor: Raghu KALLURI
  • Use of FGF21 in methods of increasing exocrine pancreatic secretion
    Patent number: 11318186
    Abstract: The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 3, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: David J. Mangelsdorf, Steven A. Kliewer, Katie C. Coate, Genaro Hernandez
  • ASPERGILLUS ANTIGEN CHIMERIC RECEPTORS AND USE THEREOF
    Publication number: 20220127340
    Abstract: Provided herein is an antibody as well as chimeric antigen receptor (CAR) to the Aspergillus antigen p60-binding domain. Further provided herein are immune cells expressing the CARs as well as methods of their use in the treatment of fungal infections and cancer.
    Type: Application
    Filed: February 7, 2020
    Publication date: April 28, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Pappanaicken KUMAR, Thiago APARECIDO DA SILVA, Paul J. HAUSER
  • Methods of making and bioelectronic applications of metalized graphene fibers
    Patent number: 11311720
    Abstract: The present disclosure provides methods of making and applying metallized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: April 26, 2022
    Assignees: University of Wollongong, Board of Regents, The University of Texas System
    Inventors: Mario Romero-Ortega, Gordon Wallace, Maria Gonzalez Gonzalez, Rouhollah Ali Jalili
  • Wire embedding system with a curved delivery path
    Patent number: 11317515
    Abstract: A method for embedding a line in a substrate. A line embedding head in positioned relative to a surface of the substrate. The line from an output port in the line embedding head is output at an angle relative to the embedding head such that the line is embedded in the substrate.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: April 26, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: David Espalin, Ryan Wicker, Alfonso Fernandez, Jorge Ramirez, Jose Motta
  • Methods of detecting anti-folic acid antibodies and uses thereof
    Patent number: 11313868
    Abstract: The invention relates to devices and methods for detecting the presence of antibodies to folic acid in a sample.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: April 26, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Robert M. Cabrera, Richard H. Finnell