Abstract: A system for producing a three-dimensional object from a fluid medium includes image processing units. The fluid medium is configured to solidify when subjected to a prescribed light stimulation. Each image processing unit includes at least one light emitting source configured to emit light, and at least one minor system configured to reflect the light emitted by the light emitting source. The minor system includes a manipulating system for adjusting the direction of the emitted light, a control system for controlling the manipulating system, and at least one optical element configured to manipulate the emitted light and to project the emitted light onto an area of a surface of the fluid medium to form an image on the surface. The image processing units are configured to form corresponding images on the surface, and are configured to be movable at least in a lateral direction relative to the surface.
Type:
Application
Filed:
January 24, 2020
Publication date:
March 24, 2022
Applicants:
Adaptive 3D Technologies, LLC, Board of Regents, The University of Texas System
Inventors:
Walter VOIT, Benjamin LUND, Daniel ZAMORANO, Caleb LUND, Stephen KAY, Eric PARKER
Abstract: In some aspects, provided herein are antimicrobial compositions comprising partially esterified polygalacturonic acid and certain fatty acids (e.g., caprylic acid). In some embodiments, the antimicrobial composition may be administered (e.g., topically or orally) to a subject, such as a human patient to treat an infection (e.g., an infection comprising a biofilm). In some aspects, improved catheters are provided.
Type:
Application
Filed:
June 28, 2021
Publication date:
March 24, 2022
Applicant:
Board of Regents, The University of Texas System
Abstract: A computer-implemented method for indexing a database of human body shapes, wherein the human body shapes are represented in terms of coefficient vectors in a geometric body space. The method includes predicting, for human body shapes in the database, a vector of word ratings, based on parameters of the human body shape, using a mapping between the geometric body space and a linguistic body space, wherein the linguistic body space is represented in terms of body descriptor words; and storing the body descriptor words and their predicted rating values in the database with each human body shape.
Type:
Grant
Filed:
October 16, 2020
Date of Patent:
March 22, 2022
Assignees:
Max-Planck-Gesellschaft zur Förderung D. Wissenschaften e.V., Board Of Regents, The University of Texas System
Inventors:
Stephan Streuber, Maria Alejandra Quirós Ramírez, Michael Black, Silvia Zuffi, Alice O'Toole, Matthew Q. Hill, Carina A. Hahn
Abstract: A method of treating a subject having a cancer comprising administering a tumor suppressor therapy, such as a TUSC2 therapy, in conjunction with an immune checkpoint inhibitor. Kits and reagents for use in cancer therapy are also provided.
Type:
Grant
Filed:
October 12, 2017
Date of Patent:
March 22, 2022
Assignee:
Board of Regents, The University of Texas System
Abstract: The invention relates generally to devices, systems, compositions, and methods for the detection of oligonucleotides, nucleic acids, antigens, antibodies, peptides, proteins, and non-biological molecules.
Type:
Grant
Filed:
January 13, 2017
Date of Patent:
March 22, 2022
Assignee:
Board of Regents, The University of Texas System
Abstract: Certain embodiments are directed generally to compositions and methods related to recombinant vesicular stomatitis virus vectors (?GrVSV) encoding Crimean-Congo Hemorrhagic Fever glycoprotein precursor (CCHFV-GPC) and forming a recombinant vesicular stomatitis virus vector encoding Crimean-Congo Hemorrhagic Fever glycoprotein precursor (?GrVSV-CCHFV-GPC).
Type:
Grant
Filed:
May 15, 2020
Date of Patent:
March 15, 2022
Assignee:
Board of Regents, The University of Texas System
Inventors:
Sergio E. Rodriguez, Robert W. Cross, Chad E. Mire, Thomas W. Geisbert
Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Type:
Application
Filed:
November 17, 2021
Publication date:
March 10, 2022
Applicant:
The Board of Regents of The University of Texas System
Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are defined herein. In some aspects, the present disclosure provides methods of preparing imaging agents, compositions thereof, and methods of imaging using said imaging agents or compositions thereof.
Type:
Grant
Filed:
October 21, 2019
Date of Patent:
March 8, 2022
Assignee:
The Board of Regents of The University of Texas System
Inventors:
Sara Chirayil, Veronica Clavijo Jordan, Andre F. Martins, A. Dean Sherry
Abstract: Embodiments of the present disclosure pertain to methods of sorption of H2O from an environment by associating the environment with a porous material such that the association results in the sorption of H2O to the porous material. The porous material includes a (M)-2,4-pyridinedicarboxylic acid coordination polymer, where M is a divalent metal ion selected from the group consisting of Mn, Fe, Co, Ni, Mg, and combinations thereof. The coordination polymer has a one-dimensional pore structure and shows reversible soft-crystal behavior. The porous material may be a Mg(II) 2,4-pyridinedicarboxylic acid coordination polymer (i.e., Mg-CUK-1). The methods of the present disclosure may also include one or more steps of releasing the sorbed H2O from the porous material and reusing the porous material after the releasing step for sorption of additional H2O from the environment.
Type:
Grant
Filed:
August 14, 2019
Date of Patent:
March 8, 2022
Assignees:
Board of Regents, The University of Texas System
Inventors:
Simon M. Humphrey, Jong-San Chang, Young Kyu Hwang
Abstract: Provided are methods for sequential radiotherapies, such as XRT. In some embodiments, a higher dosage of an XRT may first be administered to a subject, optionally in combination with an immunotherapy, and subsequently a lower dosage XRT is administered to the subject to treat a cancer. Separating the dosage and intensity of the radiotherapies can be used to achieve improved therapeutic responses, such as improved anti-cancer responses, survival times, and/or abscopal effects.
Type:
Application
Filed:
December 9, 2019
Publication date:
March 3, 2022
Applicant:
Board of Regents, The University of Texas System
Inventors:
James WELSH, Maria Angelica CORTEZ, David HONG, Hampartsoum Berj BARSOUMIAN
Abstract: A thiol-ene shape memory polymer including a sequential chain of a first type of monomer covalently bonded to a second type of monomer via thiol-ene linkages that form a backbone of the polymer. The first type of monomer includes two or more thiol functional groups and the second type of monomer includes two or more alkene functional groups. The sequential chain of the covalently bonded first and second types of monomers forming the polymer backbone is free of ester groups. Also disclosed in a method of synthesizing the thiol-ene shape memory polymer, a bio-electronic device including a substrate layer composed of the thiol-ene shape memory polymer, and a method of manufacturing the bio-electronic device.
Type:
Grant
Filed:
November 7, 2019
Date of Patent:
March 1, 2022
Assignee:
Board of Regents, The University of Texas System
Inventors:
Walter Voit, Melanie Ecker, Seyed Mahmoud Hosseini
Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.
Type:
Grant
Filed:
May 11, 2020
Date of Patent:
March 1, 2022
Assignee:
Board of Regents, The University of Texas System
Inventors:
Mario I. Romero-Ortega, Parisa Lotfi, Benjamin R Johnston, Swarupnarayan Dash, Joselito Razal, Gordon Wallace
Abstract: Apparatus and methods for controlling a radiotherapy electron beam. Exemplary embodiments provide for focusing the electron beam at different depths by altering parameters of a plurality of magnets. Exemplary embodiments can also provide for focusing the electron beam at different depths while maintaining the energy level of the electron beam at a consistent level.
Type:
Grant
Filed:
December 3, 2020
Date of Patent:
March 1, 2022
Assignees:
Board of Regents, The University of Texas System, Tel-Hashomer Medical Research Infrastructure and Services Ltd. at the Chaim Sheba Medical Center
Inventors:
Dirk Bartkoski, Dror Alezra, Mohammad Salehpour, Thomas Buchholz
Abstract: A method of forming a crack-free aluminum alloy structure using additive manufacturing is presented. A powder bed of precursor aluminum alloy powder is heated. The crack-free aluminum alloy structure is formed within a laser powder bed fusion system encompassing the powder bed during heating.
Type:
Grant
Filed:
August 7, 2018
Date of Patent:
March 1, 2022
Assignee:
Board of Regents, The University of Texas System
Inventors:
Philip Alexander Morton, Syed Zia Uddin, Ryan B. Wicker, David Espalin, Lawrence Eugene Murr
Abstract: Provided herein are phosphorylated Dicer 1 (pDicer1) antibodies, including those that selectively bind Serine 1728 and/or Serine 1852. Further provided herein are methods of treating cancer by administering the pDicer1 antibodies alone or in combination with other therapies.
Type:
Application
Filed:
December 23, 2019
Publication date:
February 24, 2022
Applicant:
Board of Regents, The University of Texas System
Abstract: Provided herein are mice that are heterozygous knock outs for Ctla4 and homozygous knockouts for Pdcd1 (Ctla4+/? Pdcd1?/? mice), which may suffer from autoimmunity, including myocarditis and insulin-dependent diabetes mellitus. Also provided are methods of using such mice to screen for therapeutic agents that mitigate immune-related adverse events.
Type:
Application
Filed:
September 11, 2019
Publication date:
February 24, 2022
Applicant:
Board of Regents, The University of Texas System
Abstract: Provided herein are methods of treating cancer comprising administering a PARP inhibitor which may be combined with a BRD4 inhibitor. In one embodiment, the present disclosure provides a method for treating cancer in a subject comprising administering an effective amount of a poly-ADP-ribose polymerase (PARP) inhibitor in combination with a bromodomain-containing protein 4 (BRD4) inhibitor to the subject. In some aspects, the administration of the PARP inhibitor and BRD4 inhibitor results in greater reduction in tumor growth or greater reduction in tumor mass relative to administration of PARP inhibitor or BRD4 inhibitor alone.
Type:
Application
Filed:
September 12, 2019
Publication date:
February 17, 2022
Applicant:
Board of Regents, The University of Texas System
Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
Type:
Grant
Filed:
September 14, 2016
Date of Patent:
February 15, 2022
Assignee:
The Board of Regents of The University of Texas System
Abstract: In one aspect, wireless gastrointestinal stimulations are described herein. In some embodiments, a system described herein comprises at least one transmitter and at least one stimulation device. The transmitter can include a signal generator operable to generate an electromagnetic signal, a first antenna operable to broadcast the electromagnetic signal, and an energy source. The at least one stimulation device is operable to deliver a pattern of electrical pulses to a gastrointestinal tissue comprising a muscle, and the stimulation device includes a circuit board having a circumference, at least one second antenna wrapped around the circumference of the circuit board, the at least one second antenna being configured to receive the electromagnetic signal and to generate an electrical current from the electromagnetic signal, and at least one electrode operable to deliver the electrical current to the muscle.
Type:
Grant
Filed:
December 13, 2018
Date of Patent:
February 15, 2022
Assignee:
Board of Regents, The University of Texas System
Abstract: Systems and methods for quantum clock synchronization are provided. Various embodiments can use time-energy and polarization entangled photons to securely extract the absolute time difference between two remote clocks. In some embodiments, two parties can each have a source of entangled photons. Each party can detect one member of the pair locally and time stamp the detection time, while the other photon gets sent over a common channel (single optical mode) to the other party where the transmitted photon is detected and time stamped. The time stamp values can be shared over an open authenticated channel and each receiver can run a cross-correlation of the detection times. The authenticity and non-spoofability of the timing signal are ensured if each party does not just perform a simple time of arrival measurement but also incorporate polarization measurements whose joint values constitute a Bell test.
Type:
Grant
Filed:
September 12, 2019
Date of Patent:
February 15, 2022
Assignee:
Board of Regents, The University of Texas System