Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

Abstract: A personal laboratory includes a self-contained, miniaturized, portable kit that provides for design, testing, and automated assembling, dissembling, and reassembling of a physical system (rather than a simulation) with flexibility as to the variety of configurations of components that may be designed and assembled, and easy integration of complex components. The personal laboratory includes a reconfigurable system, the reconfigurable system includes a plurality of functional components, and a plurality of connectors configured for operatively connect respective functional components to other functional components; a stimulus generator configured to apply a stimulus to the reconfigurable system; and a measurement system configured to measure a response to the applied stimulus generated by the reconfigurable system. In the context of electronic circuits, the reconfigurable system is a reconfigurable circuit, the functional components are circuit elements and the connectors are electrical connectors.

Abstract: A passive tag transponder circuit comprising a receive antenna, reflect antenna, and rectifier network. The receive antenna can be configured to receive an ambient RF signal having a frequency of fc, or, a backscattered RF signal having a frequency of 2fc. The reflect antenna can be configured to receive a rectified output signal from the rectifier network, the rectified output signal having a frequency of 2fc. The reflect antenna can be configured to send a backscattered signal at the frequency of 2fc. The rectifier network can be connected to receive an input corresponding to the ambient RF from the receive antenna and send the rectified output to the reflect antenna.

Abstract: Disclosed herein are optical near-field systems and methods that provide a noninvasive and fast approach to detect and characterize dislocation defects in semiconductors films caused by a mismatched film-substrate, such as found in GaAs—Si. The embodiments disclosed utilize optical cavities formed by the dislocation defects. The optical cavities act to localize a beam excitation light, which elicits second harmonic generated (SHG) light from the same region. The SHG light can be probed and mapped to provide information regarding the defects. The information derived from the map includes defect location, defect density, and defect orientation.

Abstract: A well monitoring system particularly useful in detecting kicks in the well includes a well, a well system, and a computing apparatus. The well defines a wellbore and the well system includes at least one sensor measuring at least one well condition. The computing apparatus hosts a well monitoring software component that performs a method to detect a kick in a well. The method includes: storing a set of real-time data from a measurement of a well condition by the sensor, the measurements being correlative to an unplanned fluid influx into the well; modeling the operation of the well with a physics-based, state space model of the well system to obtain an estimate of the well condition; and applying the real-time data set and the estimate to a probabilistic estimator to yield a probability of an occurrence of a kick and a confidence measure for the probability.

Abstract: Methods for the treatment of spinal cord injury or traumatic brain injury are provided. In certain embodiments, the methods include the use of a molecular tweezers and/or nucleobase oligomer capable of inhibiting the accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins. Examples of treatments that may inhibit accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins include treatment with a synuclein antisense nucleobase oligomer or treatment with the molecular tweezers CLR01. These treatments may improve outcomes of spinal cord surgery or traumatic brain injury, including, without limitation, neuronal survival, neuronal regeneration, and recovery of neuronal functions.

Abstract: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.

Abstract: The techniques described herein may provide deadlock detection and prevention with improved performance and reduced overhead over existing systems. For example, in an embodiment, a method for improving performance of software code by preventing deadlocks may comprise executing software code in a computer system comprising a processor, memory accessible by the processor, and program instructions and data for the software code stored in the memory, the program instructions executable by the processor to execute the software code, logging information relating to occurrence of deadlock conditions among threads in the executing software code, detecting occurrence of deadlock conditions in the software code based on the logged information, and modifying the software code or data used by the software code so as to prevent occurrence of at least one detected deadlock condition.

Abstract: Methods, systems, and devices for the manufacture of 3D printed components with structurally integrated metal objects using an additive manufacturing system enhanced with a range of possible secondary embedding processes. One or more layers of a three-dimensional substrate can be created by depositing a substrate, and then one or more 3D printed components can be configured on the substrate with one or more metal objects using additive manufacturing enhanced by one or more secondary embedding processes.

Abstract: Systems and methods for simulating subterranean regions having multi-scale, complex fracture geometries. Non-intrusive embedded discrete fracture modeling formulations are applied in conjunction with commercial simulators to efficiently and accurately model subsurface characteristics in regions having complex hydraulic fractures, complex natural fractures, or a combination of both.

Abstract: Provided are antisense morpholino oligomers targeted against bacterial virulence factors such as genes that contribute to antibiotic resistance or biofilm formation, or essential genes, and related compositions and methods of using the oligomers and compositions, for instance, in the treatment of an infected mammalian subject.

Abstract: The present invention includes compositions and methods for treating an autoimmune disorder or a cancer in a subject in need thereof, the method comprising: administering an effective amount of a composition comprising an oligonucleotide that specifically binds a complementary sequence of the Interleukin-7 receptor (IL7R) pre-mRNA that influences splicing of exon 6, wherein the SM-ASO increases or decreases inclusion of exon 6 in IL7R pre-mRNAs and respectively decreases or increases expression of the soluble isoform of IL7R (sIL7R). In certain embodiments, the oligonucleotide is an antisense oligonucleotide (ASO), or a splice-modulating antisense oligonucleotide (SM-ASO).

Abstract: Described are flexible electronics incorporating a bacterial cellulose paper substrate and methods of making and using the flexible electronics. Example devices disclosed include photovoltaic cells constructed over bacterial cellulose paper substrates.

Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Abstract: Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Provided in some aspects are methods and compositions for preserving platelets or other cells. In some embodiments, a platelet storage media or cell storage media may comprise a low molecular weight polyethylene glycol (e.g. PEG-400) to allow for extended storage and/or refrigeration of the platelets or cells.

Abstract: A semi-crystalline thiourethane polymer. The semi-crystalline thiourethane polymer comprises a sequential chain of a first type of monomer covalently bonded to a second type of monomer via thiourethane linkages. Each of the first type of monomer includes two or more thiol functional groups and each of the second type of monomer includes two or more isocyanate functional groups. The first and second types of monomers are polymerized together in an anionic step-growth polymerization reaction that is catalyzed by a non-nucleophillic base having a pKa greater than 7, produced by photo-initiated decomposition of a photolatent base. A method of synthesizing, and polymer jetting and stereolithography methods of manufacturing a polymer part, are also disclosed.

Abstract: The techniques described herein may include memory allocation techniques that provide improved security and performance. In embodiments, a method implemented in a computer system may include a processor and a memory, the method may comprise mapping a block of memory, dividing the block of memory into a plurality of heaps, dividing each heap into a plurality of sub-heaps, wherein each sub-heap is associated with one thread of software executing in the computer system, dividing each sub-heap into a plurality of bags, wherein each bag is associated with one size class of objects, and storing a plurality of objects in at least some of the bags, wherein each object is stored in a bag having size class corresponding to a size of the object.

Abstract: In one embodiment, an adjustable surface stiffness treadmill includes a treadmill unit, a scissor mechanism that supports the treadmill unit, a stiffness adjustment mechanism configured to adjust a vertical stiffness of the treadmill unit, and an input link having a first end and a second end, the first end being connected to the scissor mechanism and the second end being connected to the stiffness adjustment mechanism, wherein the input link translates downward vertical forces imposed upon the treadmill unit into horizontal forces imposed upon the stiffness adjustment mechanism.

Abstract: A high torque density permanent magnet switched reluctance apparatus with a structure similar to a switched reluctance motor. The apparatus has an inner stator having a plurality of poles, and a rotor disposed radially outward of the inner stator and having a plurality of segments serving as poles. A respective winding is disposed between every pair of adjacent poles of the stator. The apparatus operates with a plurality of separately excitable phases, a given phase being excited by energizing the windings corresponding to the given phase. Excitation of a given phase causes induction of magnetic fluxes traversing a region substantially confined to the region of the stators and rotor segments corresponding to the given phase, and causes a substantial amount of flux to enter rotor segments not in the radial direction but perpendicular to the radial direction.