Patents Assigned to The University of Texas Systems
  • Systems and methods for measuring neonatal cerebral oxygenation
    Patent number: 11109782
    Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: September 7, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
  • Electrospun PNIPAAm/PCL fiber mats for aligned cell sheets
    Patent number: 11111611
    Abstract: The present invention provides compositions comprising aligned fibers of electrospun PNIPAAm and poly (?-caprolactone) (PCL) (denoted PNIPAAm/PCL fibers). The PNIPAAm/PCL compositions enable enhanced growth and detachment of intact anisotropic cell sheets. The compositions do not require chemical modification or resource-intensive techniques, thus saving time and expense, and have the potential to generate tissue-specific, aligned cell sheets for transplant studies.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: September 7, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Janeta Zoldan, Alicia Allen
  • Multi-dimensional impact detect and diagnosis in cellular networks
    Patent number: 11108620
    Abstract: A method for multi-dimensional impact detection and diagnosis of networks. The methods and systems dynamically explore only those network feature combinations that are likely to have problems by using a summary structure Sketch, for example. The method and systems capture fine-grained anomalies at a coarse level which allows for on-demand zoom into the finer-grained levels for further analysis.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: August 31, 2021
    Assignees: AT&T Intellectual Property I, L.P., Board of Regents, The University of Texas System
    Inventors: Ajay Mahimkar, Mubashir Adnan Qureshi, Lili Qiu
  • Method and system for detecting and mitigating time synchronization attacks of global positioning system (GPS) receivers
    Patent number: 11105932
    Abstract: A system and method are provided for detecting and estimating time synchronization attacks (TSAs) on Global Positioning System (GPS) receivers. The system and method can be implemented to address gaps in the known or proposed TSA detection solutions. In particular, the system and method can be implemented to provide a TSA countermeasure solution that: 1) provides a comprehensive countermeasure against different types of TSAs; 2) allows the GPS receiver to continue its normal operation, which is especially beneficial in Phasor Measurement Unit (PMU) applications where the network's normal operation cannot be interrupted; in other words, the solution not only detects TSAs, but also mitigates their effects so that the network can continue its normal operation; and 3) is relatively simple and capable of being integrated with current GPS receivers without having to alter the circuitry of the GSP receivers.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: August 31, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ali Khalajmehrabadi, Nikolaos Gatsis, David Akopian, Ahmad Fayez Taha
  • COMBINATION OF EZH2 INHIBITOR AND CHECKPOINT THERAPY FOR THE TREATMENT OF CANCER
    Publication number: 20210260051
    Abstract: Provided herein are methods of treating cancer comprising administering an EZH2 inhibitor which may be combined with an immune checkpoint inhibitor. Further provided herein are methods of depleting regulatory T cells (Tregs) in a subject comprising administering an EZH2 inhibitor to the subject. Also provided herein are pharmaceutical compositions comprising CPI-1205 and an immune checkpoint inhibitor.
    Type: Application
    Filed: June 14, 2019
    Publication date: August 26, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Padmanee SHARMA, James P. ALLISON, Sangeeta GOSWAMI
  • Coiled and twisted nanofiber yarns for electrochemically harvesting electrical energy from mechanical deformation
    Patent number: 11085422
    Abstract: Yarn energy harvesters containing conducing nanomaterials (such as carbon nanotube (CNT) yarn harvesters) that electrochemically convert tensile or torsional mechanical energy into electrical energy. Stretched coiled yarns can generate 250 W/kg of peak electrical power when cycled up to 24 Hz, and can generate up to 41.2 J/kg of electrical energy per mechanical cycle. Unlike for other harvesters, torsional rotation produces both tensile and torsional energy harvesting and no bias voltage is required, even when electrochemically operating in salt water. Since homochiral and heterochiral coiled harvester yarns provide oppositely directed potential changes when stretched, both contribute to output power in a dual-electrode yarn.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: August 10, 2021
    Assignees: Board of Regents, The University of Texas System, Industry-University Cooperation Foundation Hanyang University
    Inventors: Ray H. Baughman, Shaoli Fang, Carter S. Haines, Na Li, Jiangtao Di, Seon Jeong Kim, Shi Hyeong Kim, Keon Jung Kim, Tae Jin Mun, Changsoon Choi
  • METHODS FOR MEASURING AND STABILIZING STAT3 INHIBITORS
    Publication number: 20210235688
    Abstract: Methods for stabilizing Stat3 inhibitors in a blood sample are provided. Methods for assessing the level of such Stat3 inhibitors are also provided.
    Type: Application
    Filed: April 17, 2019
    Publication date: August 5, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: David J. TWEARDY, David KWOK
  • Metal oxide semiconductor field effect transistor with crystalline oxide layer on a III-V material
    Patent number: 11081590
    Abstract: A metal oxide semiconductor field effect transistor (MOSFET) includes a substrate having a source region, a drain region, and a channel region between the source region and the drain region, the substrate having an epitaxial III-V material that includes three elements thereon, a source electrode over the source region, a drain electrode over the drain region, and a crystalline oxide layer including an oxide formed on the epitaxial III-V material in the channel region, the epitaxial III-V material including three elements.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: August 3, 2021
    Assignees: Samsung Electronics Co., Ltd., Board of Regents, The University of Texas System
    Inventors: Wei-E Wang, Mark S. Rodder, Robert M. Wallace, Xiaoye Qin
  • MULTI-COLOR FISH TEST FOR BLADDER CANCER DETECTION
    Publication number: 20210230703
    Abstract: The present disclosure provides methods and compositions for the detection of bladder in a subject using four locus-specific probes to 6p22, 8q22, 11q13, and 20p11.2.
    Type: Application
    Filed: January 30, 2019
    Publication date: July 29, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Bogdan CZERNIAK, Keith BAGGERLY, Jolanta BONDARUK, Tadeusz MAJEWSKI, Colin DINNEY, Shizhen ZHANG, Yan WANG
  • Integrated System Design For A Mobile Manipulation Robot With Socially Expressive Abilities
    Publication number: 20210221005
    Abstract: Various embodiments of the present technology generally relate to robotics. More specifically, some embodiments of the present technology relate to an integrated system design for a mobile manipulation robot with socially expressive abilities. Some embodiments provide for a robot comprising a socially expressive head unit. The head can have at least two degrees of freedom created by a motor with a planetary gear box and a servo. The motor can be connected to a shell via a support that allows the shell to tilt up and down upon activation of the motor. The shell can include a camera housing configured to receive a camera which can be attached to the support. The motor can be mounted on a rotatable shaft controlled by a servo causing the head unit to pan.
    Type: Application
    Filed: May 14, 2019
    Publication date: July 22, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Andrea L. Thomaz, Maxwell Svetlik, Alfredo Serrato, Prashant Rao
  • Antimicrobial compositions and uses thereof
    Patent number: 11065223
    Abstract: In some aspects, provided herein are antimicrobial compositions comprising partially esterified polygalacturonic acid and certain fatty acids (e.g., caprylic acid). In some embodiments, the antimicrobial composition may be administered (e.g., topically or orally) to a subject, such as a human patient to treat an infection (e.g., an infection comprising a biofilm). In some aspects, improved catheters are provided.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: July 20, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joel Rosenblatt, Issam Raad
  • Utilization of laser interstitial thermotherapy guided with real time thermal MRI
    Patent number: 11065063
    Abstract: Methods, apparatus, and kits for applying thermal energy to tissue in a region of interest. Certain embodiments include registration of fiducial markers with an image guidance system and temperature monitoring via magnetic resonance imaging thermography.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: July 20, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Claudio E. Tatsui, R. Jason Stafford
  • Method of manufacturing a heat-shrink elastomeric element
    Patent number: 11065807
    Abstract: Provided are methods and systems for manufacturing and using heat-shrink elastomeric. An example method of manufacturing a heat-shrink elastomeric element comprises providing a thermoplastic elastomeric element having a first shape; modifying the thermoplastic elastomeric element to produce a thermoset elastomeric element having the first shape; heating the thermoset elastomeric element to a temperature of at least the glass transition temperature of the thermoset elastomeric element; adjusting the first shape of the thermoset elastomeric element to produce a second shape with at least one dimension greater than that of the first shape; and cooling the thermoset elastomeric element to a temperature below that of the glass transition temperature of the thermoset elastomeric element to produce the heat-shrink elastomeric element.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: July 20, 2021
    Assignees: The University of Texas System Board of Regents, Halliburton Energy Services, Inc.
    Inventors: Michael L. Fripp, Kejia Yang, Radu Reit, Benjamin Lund, Walter Voit
  • DUAL SPECIFICITY ANTIBODIES TO PD-L1 AND PD-L2 AND METHODS OF USE THEREFOR
    Publication number: 20210214445
    Abstract: The present disclosure is directed to dual specificity antibodies which may bind to PD-L1 or PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1 or PD-L2.
    Type: Application
    Filed: March 15, 2019
    Publication date: July 15, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Ashvin R. JAISWAL, Dongxing ZHA, Kui VOO, Carlo TONIATTI, Bianka PRINZ, Nga Rewa HOUSTON, Eric KRAULAND
  • SINGLE MOLECULE SEQUENCING IDENTIFICATION OF POST-TRANSLATIONAL MODIFICATIONS ON PROTEINS
    Publication number: 20210215706
    Abstract: The present disclosure provides methods of selectively label an amino acid residue on a peptide by replacing a post translational modification with a labeling moiety and sequencing the peptide to obtain the location of the amino acid residue and the identity of the post translational modification. In some aspects, the disclosure also provides methods of identifying the position, quantity, the identity of a post translational modification, or any combination thereof, in peptides which may be used for therapeutic purposes.
    Type: Application
    Filed: January 22, 2021
    Publication date: July 15, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Edward MARCOTTE, Eric ANSLYN, Jagannath SWAMINATHAN, Angela M. BARDO, Caroline M. HINSON, Cecil HOWARD, Brendan FLOYD
  • Device for the detection and prevention of pressure ulcers and methods of use
    Patent number: 11058347
    Abstract: Provided herein are systems, methods and devices for the Detection and Prevention of Pressure Ulcers. The system, methods, and devices generally relate to sensors and fluid systems for detecting ulcers and preventing further pain for the patient and allow healthcare providers with valuable information to reposition a patient.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: July 13, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: U-Ter Aondo Grace Jia, Meryem Bousfiha, Casey Whitney, Mario Hernandez
  • Imidazopiperazine inhibitors of transcription activating proteins
    Patent number: 11058688
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: July 13, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kang Le, Michael J. Soth, Philip Jones, Jason Bryant Cross, Christopher L. Carroll, Timothy Joseph McAfoos, Pijus Kumar Mandal
  • Systems and methods for cloud-based radiation therapy treatment planning
    Patent number: 11058891
    Abstract: A cloud-based radiation therapy treatment planning system (TPS). The TPS changes the clinical workflow of the radiotherapy treatment planning process, by increasing the mobility and computational power of the treatment planning software and hardware architecture. The system is divided into computational components. A user device includes a light and flexible user interface, while the server side entails a hospital relay server, and/or a graphics processing unit cluster server. The TPS computational architecture enables the computational power of a GPU-cluster server on a tablet, laptop, or smartphone.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: July 13, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Vasant P. Kearney, Ko-ay Timmy Siauw, Xun Jia, Steve Bin Jiang, Xuejun Gu
  • Method for Accurate Sequencing of DNA
    Publication number: 20210207210
    Abstract: DNA is sequenced by (a) independently sequencing first and second strands of a dsDNA to obtain corresponding first and second sequences; and (b) combining the first and second sequences to generate a consensus sequence of the dsDNA. By independently sequencing first and second strands the error probability of the consensus sequence approximates a multiplication of those of the first and second sequences.
    Type: Application
    Filed: November 18, 2020
    Publication date: July 8, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zbyszek Otwinowski, Dominika Borek
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER CELLS BY INDUCTION OF CYTOTOXIC OXIDATIVE STRESS
    Publication number: 20210196753
    Abstract: Provided herein are methods and compositions for the treatment of cancers with D-VC and arsenic trioxide. In some aspects, cancers for treatment according to the embodiments include cancers with increased GLUT1 expression and/or comprise KRAS mutation.
    Type: Application
    Filed: August 20, 2019
    Publication date: July 1, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Dos D. SARBASSOV, Xinggang WU, Lee ELLIS, Rajat BHATTACHARYA