Abstract: A mammalian or avian cell line that expresses high levels of human influenza virus receptors is provided. In one embodiment, the cell line supports human influenza virus, e.g., human A/H3 influenza virus, isolation and growth much more effectively than corresponding conventional (unmodified) cells or in corresponding human virus receptor-overexpressing cells, and the propagated viruses may maintain higher genetic stability than in the corresponding cells.

Abstract: The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry.

Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.

Abstract: Modified influenza virus neuraminidases are described herein that improve viral replication, thus improving the yield of vaccine viruses. Expression of such modified. neuraminidases by influenza virus may also stabilize co-expressed hemagglutinins so that the hemagglutinins do not undergo mutation.

Abstract: The present invention provides a comprehensive assay capable of comprehensively measuring interactive factors for a variety of different types of proteins. In the present invention, provided is a system for detecting activation of a protein by integrating, with mediation of a plurality of factors, changes in the transcriptional regulatory region of a gene whose expression is changed by activation of the protein. The stimulation response ratio of transcription activity before and after stimulation by ligands possessed by individual transcriptional regulatory regions is synergistically integrated, so that a highly sensitive reporter assay system can be constructed.

Abstract: An information processing system includes a first acquisition unit, a second acquisition unit, a movement control unit, and a state evaluation unit. The first acquisition unit acquires, from a first imaging unit, image data relating to a first image of a head of a subject that is captured at a first angle of view. The second acquisition unit acquires, from a second imaging unit, image data relating to a second image of an eye region of the subject that is captured at a second angle of view narrower than the first angle of view. The movement control unit moves a visual field range of the second imaging unit. The state evaluation unit evaluates a change in state of the eye of the subject.

Abstract: A coherent light source outputs coherent light including high-order harmonics obtained by irradiating short-pulse laser light to a nonlinear medium. A spectrometer includes a grating that diffracts the coherent light and an image sensor that measures an image of the diffracted light. In a first state, a first double slit having a pair of apertures spaced apart in a first direction is arranged at a predetermined position between coherent light source and an incident slit of spectrometer. In a second state, a second double slit that is a replica of first double slit is arranged at the predetermined position as a replacement of first double slit with a sample held in one aperture. A calculation processing device calculates optical constants of the sample based on interference images measured in the first and second states.

Abstract: A power supply apparatus includes a power reception coil mounted to a moving object, a plurality of relay coils, and a power reception circuit connected with the power reception coil. The relay coils are configured to successively relay supply of electric power from a power transmission coil, which is arranged along a surface on which the moving object moves, to the power reception coil during movement of the moving object. Each of the relay coils includes a first coil and a second coil, which are configured to be magnetic-field-coupled respectively to the power transmission coil and the power reception coil, and a connection circuit that connects the first and second coils. The connection circuit includes at least one resonance capacitor involved in setting of a resonance frequency of at least one of the first and second coils. The at least one resonance capacitor has a parallel characteristic.

Abstract: [Problem] Provided is a cell-adhesive composition including an oxyethylene chain-containing polymer having excellent biocompatibility and excellent reactivity. [Solution]A cell-adhesive composition according to the present invention includes an oxyethylene chain-containing polymer represented by the following general formula (1): (wherein, in the general formula (1), R1 is —(CH2)p—SH, —(CH2)p—N3, —(CH2)p—NH2, or —(CH2)p—COOH, and p is an integer of 1 to 5; R2 to R4 are each independently hydrogen or a C1-10 alkyl group; R5 is a C1-10 alkyl group; R6 is hydrogen or a C1-5 alkyl group; R7 is a C1-10 alkyl group; n is an integer of 5 to 1000; m is an integer of 1 to 10; and q is an integer of 0 to 5).

Abstract: A method by one or more computers for learning a machine learning model classifying an input image into known classes and an unknown class by extracting a feature of the input image. The method comprises acquiring a set of features of a plurality of samples of training data each of which is with a label, calculating a loss function based on the set of the features, and learning the machine learning model to reduce the loss function. The loss function is calculated to include a first loss function and a second loss function. The first loss function is configured to become larger as first distances become smaller than a predetermined margin. The second loss function is configured to become larger as second distances become larger and as third distances become smaller.

Abstract: According to an aspect, a detection device includes a plurality of optical sensors arranged on a substrate. Each of the optical sensors includes a first photodiode and a second photodiode that is coupled in series and in an opposite direction to the first photodiode.

Abstract: The present disclosure is a shape measurement system including: a multi-core optical fiber in which four or more cores are disposed in a part other than the center of a cross section; a strain distribution measurement device configured to measure a strain distribution of each of the cores in a longitudinal direction of the multi-core optical fiber; and an analysis device configured to calculate a shape of the multi-core optical fiber by using the strain distribution of the multi-core optical fiber.

Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.

Abstract: An object of the present invention is to provide a gel material including a solvophilic polymer having a ?m-scale porous structure. A polymer gel in which solvophilic polymer units are cross-linked with each other, wherein the polymer gel contains a solvent and has a three-dimensional network structure having two regions: a first region in which the polymer units are densely present and a second region in which the polymer units are sparsely present, and a mesh size composed of the first region is from 1 to 500 ?m.

Abstract: It is an object of the present invention to provide a preventive agent, a therapeutic agent or a therapeutic composition for steatohepatitis developed by phospholipid deficiency or decreased phospholipid synthesis in the liver, and to provide a therapeutic method for the aforementioned disease. More specifically, the present invention relates to a therapeutic agent for steatohepatitis, comprising, as an active ingredient, choline or a choline metabolite, ethanolamine or an ethanolamine metabolite, a salt thereof, or a solvate thereof, wherein the therapeutic agent for steatohepatitis is characterized in that the steatohepatitis is developed by decreased phospholipid synthesis in the liver. Examples of the choline metabolite may include betaine, dimethylglycine, and phosphatidylcholine.

Abstract: A compound is represented by the following general formula (I): The compound or a salt thereof provides a fluorescent probe for detecting carboxypeptidase activity In the formula, R1 represents an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; T represents an amino acid residue or a residue of an amino acid derivative; S represents a C-terminal amino acid residue. represents a fluorophore, and the fluorophore is a fluorophore in which an absorption/fluorescence wavelength greatly changes or a quenched state changes to a fluorescent state by elimination of the —P(?O)(—R1)-T-S moiety.

Abstract: A photoelectric conversion element includes a light absorbing layer, a hole transport layer that transports holes generated by photoexcitation of the light absorbing layer, and a transparent conductive layer that is in contact with the hole transport layer and receives holes from the hole transport layer. The carrier density of the transparent conductive layer is more than 1×1016 cm?3 and 1×1020 cm?3 or less.

Abstract: It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.

Abstract: An electrostatic device includes: a fixed portion, a moveable portion, and an elastically-supporting portion that are formed in a same substrate; and a first glass package and a second glass package that are anodically bonded to each other on one and the other of front and back surfaces of the substrate with the fixed portion and the elastically-supporting portion separated from each other, the second glass package forms a sealed space in which the moveable portion is arranged between the first and second glass packages, an electret is formed at least partially in the fixed portion and the moveable portion, and a first electrode connected to the fixed portion and exposed on an outer surface of the second glass package and a second electrode connected to the elastically-supporting portion and exposed on the outer surface of the second glass package are formed in the second glass package.

Abstract: A power transfer device including an AC power source unit and a single power transfer element, and a power reception device including a single power reception element electrically coupled to the power transfer element and a power reception circuit outputting power are included. The power reception circuit includes a different potential field disposed at a position that is an electric field formed by the power transfer element and at which intensity of the electric field is different from intensity of an electric field formed at a position of the power reception element.