Abstract: As a technique that can be used for cancer immunotherapy of adult T-cell leukemia (ATL), provided is a pharmaceutical composition for treatment or prevention of adult T-cell leukemia, the pharmaceutical composition containing a peptide consisting of an amino acid sequence of any one of SEQ ID NOs: 1 to 68.

Abstract: Modified influenza virus neuraminidases are described herein that have stabilized NA tetramers which may improve vaccine production efficiency, thus improving the yield of vaccine viruses.

Abstract: Provided is a robot system comprising: a robot mechanism provided with fingers for grasping a workpiece; a detection unit that detects a grasping state of the workpiece by the fingers; a recognition unit that recognizes the number of workpieces being grasped by the fingers on the basis of a detection result from the detection unit; and a control unit that, after causing the robot mechanism to perform a motion of grasping the workpieces from a placing area where a plurality of workpieces are placed, if the number of the workpieces recognized by the recognition unit is different from a specified number specified in advance, controls the motion of the robot mechanism such that the number of the grasped workpieces is equal to the specified number.

Abstract: The present invention provides a method for producing a compound library comprising two or more cyclic compounds represented by the formula (I), comprising a step of allowing a macrocyclase in vitro to act on two or more peptides represented by the formula (II): LP-X-(Xa)m-Y-Z (II) wherein X represents a group represented by the formula (1), Y is a peptide residue consisting of four amino acids and/or analogs thereof and contains a group represented by the formula (2) (wherein R1 and B1 are as defined above, and R3 represents a hydrogen or a hydrocarbon group), and LP is present or absent and, when present, represents a peptide residue consisting of 1 to 100 amino acids and/or analogs thereof, and forming the nitrogen-containing 6-membered ring A while eliminating LP, if present, to form the two or more cyclic compounds represented by the formula (I).

Abstract: A photonic spin register includes: a shift register unit including a magnetic material layer having a shape extending in one direction; and a write unit configured to write spin information into a magnetic domain in the magnetic material layer by transferring information included in an optical signal that is a pulse amplitude-modulated and serial input signal, to a spin state of the magnetic domain in the magnetic material layer by means of a photocurrent corresponding to the optical signal or by irradiation with the optical signal. When a shift current flows through the shift register unit in the one direction, a domain wall is configured to move in the magnetic material layer, thereby allowing the spin information to move and be buffered in the magnetic material layer.

Abstract: This flow cytometer includes a flow path through which an observation object flows with a fluid; an optical illumination system including a spatial optical modulation device, and a first optical element; and an optical detection system including a first light detector, wherein the optical illumination system further includes a first spatial filter disposed in a first optical path between a light source and an image position of light imaged in the flow path by the first optical element and having a first region which hinders traveling of light emitted from the light source towards the observation object, the optical detection system further includes a second light detector disposed in a second optical path between the first light detector and the image position and having a second region which directs the light modulated by the observation object towards the first light detector, and the position of the first region and the position of the second region are in a substantially optically conjugate relationship.

Abstract: An object of the present invention is to develop gene-modified measles viruses (rMV-SLAMblind and rMV-V(?)-SLAMblind) that do not recognize SLAM as a tool for a medical treatment for tumors. The present invention provides a pharmaceutical composition for inducing cell-mediated immunity against a tumor cell to subject the tumor cell to medical treatment, the pharmaceutical composition containing an oncolytic gene-modified measles virus, and also provides a method of inducing cell-mediated immunity against a tumor cell remaining in a living body that could not be eliminated even by direct introduction of an oncolytic gene-modified measles virus, or against a tumor cell that has metastasized or recurred, the method including directly introducing an oncolytic gene-modified measles virus into a tumor cell as a medical treatment target to cause cell death.

Abstract: It is an object of the present invention to provide a method for producing a virus, for use in obtaining viral particles with high purity, and the present method is more efficient than conventional methods. Specifically, the present invention relates to a method for obtaining a virus, comprising a step of treating a virus-containing sample with a surfactant. The surfactant may be one or more selected from the group consisting of an amphoteric surfactant, an anionic surfactant, a cationic surfactant, and a nonionic surfactant. In addition, the method for obtaining a virus according to the present invention may comprise a step of performing tangential flow filtration (TFF) to purify the virus.

Abstract: Uniform light irradiation to the measurement object is realized, and it is possible to obtain high resolution image information, to provide a reflective optical sensor. An optical sensor comprises a light irradiation unit for performing uniform light irradiation with respect to the measurement object, the viewing angle control plate for limiting the direction of the reflected light in the measurement object to the predetermined direction, a light detecting unit for acquiring image information showing the distribution of the reflected light obtained through the viewing angle control plate. The viewing angle control plate is a louver array film or a fiber optic plate.

Abstract: A laser light source for a photoemission electron microscope for emitting a coherent light includes: a first laser light source configured to emit a continuous wave coherent light; an optical resonator including an optical path in which the continuous wave coherent light is configured to circulate and including a non-linear optical element disposed on the optical path; and a quasi-continuous wave light source configured to emit a quasi-continuous wave coherent light having a wavelength shorter than that of the continuous wave coherent light and having a near rectangular output waveform. When the quasi-continuous wave coherent light is incident on the non-linear optical element from outside the optical resonator while the continuous wave coherent light is entering the optical resonator to circulate in the optical path, the coherent light having a wavelength shorter than that of the quasi-continuous wave coherent light is emitted from the non-linear optical element.

Abstract: The present invention is a copolymer having a structure represented by a general formula (1) [in the formula, R1 is a fluorine atom, or a perfluoroalkyl group or perfluoroalkoxy group having 1 to 10 carbon atoms which may have —O— between carbon atoms; R2 and R3 each independently represent a hydrogen atom, a halogen atom, an aliphatic hydrocarbon group having 1 to 30 carbon atoms which may have a substituent, or an aryl group which may have a substituent; the R2 and R3 may be linked with each other to form a ring; the aliphatic hydrocarbon group may contain one or more selected from the group consisting of —O—, —Si(CH3)2—, —CO—, and —NH— between carbon atoms; x and y are positive numbers satisfying a relationship of x+y=1; and a filled circle represents a bond].

Abstract: According to an aspect, a detection device includes: a first detection circuit including a first photodiode sensitive to first light and a second photodiode sensitive to second light; and a second detection circuit including a third photodiode sensitive to third light. The first photodiode and the second photodiode are coupled in series and in opposite directions to form a first detection element. One end side of the first detection element is coupled to a first signal line via a first transistor. Another end side of the first detection element is configured to be supplied with a first drive signal. A cathode of the third photodiode is coupled to a second signal line via a second transistor. An anode of the third photodiode is configured to be supplied with a second drive signal.

Abstract: There are provided a state determination device, a state determination method, and a state determination program capable of determining a state of an object to be inspected. A state determination device 10 includes an irradiation unit 12 which irradiates an object to be inspected with excitation light under a predetermined irradiation condition, a measurement unit 13 which measures light emission data of light emission from the object to be inspected, which is generated with a delay with respect to the irradiation with the excitation light, and a determination unit 15 which determines a state of the object to be inspected by checking the light emission data against light emission data of light emission from the object to be inspected, which is measured in the case where the excitation light is emitted under an irradiation condition common to the light emission data for each state of a substance constituting the object to be inspected.

Abstract: Provided is a novel compound that is promising as a probe for nuclear medical examination. The compound is represented by the following general formula (I) or a salt thereof.

Abstract: A zinc recovery method includes an alkali fusion step (102) of, at a temperature equal to or higher than a melting point of sodium hydroxide, bringing a material (1) and molten sodium hydroxide being sodium hydroxide (5) or (14) in a molten state into contact with each other to decompose the zinc ferrite contained in the material (1) into zinc oxide components and iron oxide components in the molten sodium hydroxide, a water leaching step (103) of, at a temperature lower than a boiling point of water, bringing water into contact with sodium hydroxide being the molten sodium hydroxide with a decreased temperature, the zinc oxide components, and the iron oxide components and leaching the zinc oxide components in a sodium hydroxide aqueous solution.

Abstract: An observation device includes an illumination optical system and an observation optical system. The illumination optical system includes a light source and an aperture member. The observation optical system includes an objective lens, an optical structure, and a detector. The optical structure is disposed at a first position which is the position conjugate with the aperture member. The optical structure includes a blocking portion that blocks light and a transmitting portion that transmits light, the blocking portion having a shape including the shape of an image of an aperture of the aperture member which is formed on the optical structure. The detector detects dark-field light passing through the optical structure.

Abstract: A detection device includes a plurality of optical sensors arranged in a detection area, a light source configured to emit light that is emitted to an object to be detected and is detected by the optical sensors, and a processor configured to perform processing based on outputs from the optical sensors. The processor is configured to determine, based on the outputs of the respective optical sensors obtained at a cycle of a predetermined period, an optical sensor an output of which is to be employed from among the optical sensors.

Abstract: [Problem] To provide an electronic functional member having high stretch-resistance. [Solution] An electronic functional member provided with: fibers formed in web-like shape and configuring a fiber web; a coating film coating the fibers and having a Young's modulus smaller than that of the fibers; and an electrically conductive film formed on the surface of the coating film.

Abstract: To accurately perform movement control of a moving body, a machine tool includes a feed driver that moves a moving body in the machine tool, a feedback controller that feedback-controls the feed driver in accordance with a state variable, a friction compensator that, to compensate for rolling friction that occurs in the feed driver, adds, in advance, a friction compensation value obtained from measurement data of rolling friction or a friction compensation value calculated using a rolling friction model to a command value to be input to the feed driver, and a reverse response reducer that reduces, using the state variable of the feedback controller, a reverse response that occurs due to addition of the friction compensation value.

Abstract: [Object] To suppress a decrease in the adsorption performance of an adsorbent containing diatomaceous earth and a basic compound. [Solution] An adsorbent for adsorbing an acid gas contains diatomaceous earth, a basic compound, and a saccharide.