Abstract: The purpose of the present invention is to provide, for translation in a cell-free translation system, a novel translation system capable of synthesizing a peptide having therein consecutive non-proteinogenic amino acids. The present invention provides a tRNA containing the base sequence represented by SEQ ID NO: 1 and encoding a non-proteinogenic amino acid.

Abstract: A joined article including: a resin (1) having a linear expansion coefficient at 30° C. to 200° C. of 17 ppm/° C. or higher and a thickness of 5 to 100 ?m; and a metal joined to a surface of the resin (1) and having a thickness of 5 to 50 ?m. The resin (1) includes a heat-affected layer that is close to the metal and that occupies 80% or less of the thickness of the resin (1), and the joined article is a dielectric material for a substrate. Also disclosed is a substrate including the joined article and a resin (2) stacked on the joined article.

Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Abstract: In one embodiment, the present disclosure provides pharmaceutical compositions for suppressing the progression of fibrosis in systemic sclerosis, which contain an antibody against IL-31 receptor A as an active ingredient. In another embodiment, the present disclosure provides pharmaceutical compositions for suppressing Th2 polarization to suppress the progression of fibrosis in systemic sclerosis, which comprise an antibody against IL-31 receptor A as an active ingredient. In a certain embodiment, the above-mentioned antibody is an antibody having a neutralizing activity against IL-31 receptor A.

Abstract: An image processing device includes a determination unit configured to determine a type of autophagy induced in a cell, based on information indicative of autophagic activity in the cell present in a cell image in which the cell is image captured and based on information indicative of congestion of molecules in the cell present in the cell image.

Abstract: An object is to prevent eavesdropping in quantum key distribution. A photon detector outputs an output current indicating a result of detecting a quantum signal. A current-voltage conversion unit converts the output current into an output voltage signal. An analog-to-digital converter outputs an output voltage signal obtained by analog-digital conversion of the output voltage signal. A signal processing unit performs predetermined signal processing on the output voltage signal, and outputs a photon detection signal indicating a result of detecting the quantum signal. When a time difference between a timing at which the quantum signal is incident into the photon detector and a reference timing determined based on a clock signal is not within a determination range, the photon detection signal is not output from the signal processing unit.

Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.

Abstract: In a method for designing a mirror when any point on a reflecting surface is represented by M, coordinates of an intersection point between a sagittal light source ray and an incoming light ray to the M point and an intersection point between a meridional light source ray and the incoming light ray to the M point are expressed by using L1s and L1m, and coordinates of an intersection point between an outgoing light ray from the M point and a sagittal collected light ray and an intersection point between the outgoing light ray from the M point and a meridional collected light ray are expressed by using L2s and L2m. A mirror is designed using design formulas of a reflecting surface derived based on the coordinates and a condition that an optical path length from a light source position to a light collection position is constant with respect to any point on the reflecting surface for both the light collection in the sagittal direction and the light collection in the meridional direction.

Abstract: An olefin production device for producing an olefin from a raw material gas containing methane and oxygen includes a reactor containing: a first catalyst; and a second catalyst disposed downstream of the first catalyst in a flow direction of the raw material gas. The first catalyst is a catalyst in which a zirconium salt or carbonate of an alkali metal, an oxide of an alkaline earth metal, an oxide of one kind of lanthanoid element, a composite oxide containing a lanthanoid element, or a combination thereof is supported on a support. The second catalyst is a catalyst containing a tungsten oxide, phosphate, or carbonate of an alkali metal.

Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.

Abstract: A challenge is to provide an art to identify mice as individuals from captured images of one or more mice that are doing activity in a predetermined activity range. An image processing device includes an image acquisition unit, a part extraction unit, and an individual identification unit. The image acquisition unit acquires a captured video of a state in which one or more animals are doing activity in a predetermined activity range. An outline detection unit extracts the outlines of the bodies of the one or more animals from each of multiple unit images included in the video. The individual identification unit analyzes the multiple outlines detected from each of the multiple unit images by the outline detection unit, in a time-series manner and identifies the one or more animals as individuals in each of the unit images on the basis of the analysis results. Thus, the challenge is solved.

Abstract: A method for producing a ligated DNA formed by ligating DNA fragments is disclosed. The method includes (a1) preparing (1) a first vector containing structure 5?-R1-D(i)-R2-M1-R2?-D(ii)-R1?-3? and (2) a second vector containing structure 5?-R1-D(iii)-R2-M2-R2?-D(iv)-R1?-3?, which each contain recognition sequences of restriction enzymes R1, R1?, R2, and R2; selectable marker genes M1 and M2 different from each other; and DNA fragments for ligation D(i) to D(iv); (b1) treating the first vector with first restriction enzyme and second restriction enzyme to obtain a first vector fragment composed of structure 5?-D(i)-R2-M1-R2?-D(ii)-3; (c1) treating the second vector with third restriction enzyme and fourth restriction enzyme to obtain a second vector fragment with removed structure 5?-R2-M2-R2?-3?; and (d1) ligating the first vector fragment obtained in b1 and the second vector fragment obtained in cl by a ligation reaction to generate a third vector containing structure (3) 5?-R1-D(i)1-R2-M1-R2?-D(ii)1-R1?-3?.

Abstract: The present invention provides an antibody recognizing a v9 fragment of the cell adhesion molecule CADM1.

Abstract: A method of producing a resin modifier, the method comprising a process of polymerizing an ethylene unsaturated monomer in the presence of a cellulose nanofiber, the cellulose nanofiber being reacted with an amine or a quaternary ammonium salt compound.

Abstract: An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.

Abstract: In a Fourier-transform spectroscopy apparatus, a scanning mirror is arranged on a light path of scanning light. The scanning mirror delays or advances the scanning light with respect to reference light according to the rotational angle of the scanning mirror from its initial position. A spectroscopic spectrum generating unit generates an interferogram based on the intensity of the detection target light obtained from the detection target, and Fourier transforms the interferogram thus generated. The spectroscopic spectrum generating unit corrects the nonlinearity of the group delay between an envelope of the reference light and an envelope of the scanning light, and corrects the nonlinearity of the phase shift between the respective envelopes.

Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.

Abstract: Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: [Problem] To develop novel therapeutic agents for viral diseases such as coronavirus infections. [Solution] The present invention provides a therapeutic or prophylactic agent for viral diseases containing a compound with inhibitory activity against the function of Pin1 or a pharmaceutically acceptable salt thereof as an active ingredient.