Abstract: The present application provides novel human genes RHBDF1 whose expression is markedly elevated in CML and AML compared to normal peripheral blood cell, and lung adenocarcinoma compared to normal lung cell. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

Abstract: A semiconductor device including quantum dots comprises a barrier layer of a semiconductor crystal having a first lattice constant and a quantum dot layer including a plurality of quantum dots of a semiconductor crystal having a second lattice constant formed on the barrier layer and a side barrier layer of a semiconductor crystal having a third lattice constant, which is formed in contact with the side faces of the plurality of quantum dots, in which the barrier layer, the quantum dots and the side barrier layer are configured so that the difference between the values of the first lattice constant and the second lattice constant has a sign opposite to that of the difference between values of the first lattice constant and the third lattice constant.

Abstract: An intrinsic GaAs waveguide layer is formed on a p-type AlGaAs cladding layer, a quantum dot active layer is formed further thereon. An n-type AlGaAs cladding layer is formed on the center portion of the quantum dot active layer. Thus-configured semiconductor laser is allowed to successfully suppress the area of the p-n junction plane to a small level, and to obtain a high level of reliability, because there is no need of processing the center portion of the quantum dot active layer, contributive to laser oscillation.

Abstract: A Terminal equipment 10 has a message information accepter 12 for accepting message information from terminal program 26, an ID generator 14 for generating a thread ID for identifying the message information, a transmitter 16 for generating a message containing the message information and the thread ID and for transmitting the message to IC card 24, and a receiver 18 for receiving a message from the IC card 24. When the message received from the IC card 24 contains the thread ID inserted in the transmitted message, the message information accepter 12 returns the received message as a return value for the message information to the terminal program 26 and terminates a process attributed to the message information.

Abstract: The present invention is directed to avoidance of inconvenience arising from application program's incapability of recognizing processing executed on the IC card side, interruption of communication between IC cards, and so on on the occasion of an exchange of electronic values between the IC cards. A portable terminal 20, when receiving an exchange offer message of electronic values from a portable terminal 10, notifies an application program 21 of an exchange offer content based on a listener corresponding to the message. When the application program 21 accepts this offer content and when electronic values V1, V2 are determined as exchange objects, the portable terminal 20 returns an exchange confirmation message of the electronic values. When the portable terminal 10 receives the exchange confirmation message, it notifies an application program 11 of an exchange content based on a listener corresponding to the message.

Abstract: The invention provides objective methods for detecting and diagnosing colorectal cancers and pre-malignant lesions. For example, the methods disclosed herein can reliably detect very early-stage colorectal cancers. In one embodiment, the diagnostic method involves the scoring of gene expression profiles that discriminate between adenomas and carcinomas. The profile score calculated acts as diagnostic indicator that can objectively indicate whether a sample tissue is non-cancerous, pre-cancerous, or cancerous. The present invention further provides methods of diagnosing colorectal tumors in a subject, methods of screening for therapeutic agents useful in the treatment of colorectal tumors, methods of treating colorectal tumors and method of vaccinating a subject against colorectal tumors.

Abstract: Objective methods for detecting and diagnosing testicular seminoma (TS) arc described herein. In one embodiment, the diagnostic method involves the determining a expression level of TS -associated gene that discriminate between TS and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of TS, methods of treating TS and method of vaccinating a subject against TS.

Abstract: A hybrid type semiconductor integrated circuit includes a semiconductor active region provided in a first area of a substrate; an insulating region surrounding side surfaces of the semiconductor active region; a mechanical electrode provided in a second area adjacent to the first area and surrounded by a part of the insulating region and a trench; and a interconnection layer one end of which is connected to the mechanical electrode and of which the other end extends to the semiconductor active region via a part of the insulating region.

Abstract: The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.

Abstract: A high-speed forward dynamics computation for a link system wherein links are connected via joints, has: (1) first step for adding a joint one by one in series between the links to an initial link condition wherein all of the respective links are not connected via the joints so as to obtain a force of constraint acting at the joint between the links at that time; (2) second step for removing the joint in a reverse order as that of the first step so as to compute a final force of constraint at respective joints; (3) third step for computing an acceleration of respective links by utilizing applied forces obtained in the first step and the second step; and (4) fourth step for computing a joint acceleration by utilizing the accelerations of the links positioned at both ends of respective joints obtained at the third step.

Abstract: There is provided an electrostatic induction conversion device which is small, has high conversion efficiency between electric energy and kinetic energy, and can prevent degradation of an electret. The electret is formed by injecting an electric charge into the vicinity of the surface of an insulating material, is disposed between two conductors, and is constructed so that it moves relatively to at least one of the conductors opposite to the electret and converts between electric energy and kinetic energy. As the insulating material forming the electret, it is preferable to use a polymer having a fluorine-containing aliphatic cyclic structure.

Abstract: Disclosed are methods of detecting metastasis of colorectal cancer using differentially expressed genes. Also disclosed are methods of identifying agents for treating colorectal cancer or preventing metastasis of colorectal cancer.

Abstract: Objective methods for detecting and diagnosing intestinal-type gastric cancers are described herein. Also described is method for predicting the presence or absence of lymph node metastasis (i.e., identifying the metastatic phenotype). In one embodiment, the diagnostic method involves the scoring of gene expression profiles that discriminate between lymph node positive tumors and lymph node negative tumors. The predictive score calculated acts as diagnostic indicator that can objectively indicate whether a sample tissue has the metastatic phenotype. The present invention further provides methods of diagnosing intestinal-type gastric cancer in a subject, methods of screening for therapeutic agents useful in the treatment of intestinal-type gastric cancer, methods of treating intestinal-type gastric cancer and method of vaccinating a subject against intestinal-type gastric cancer.

Abstract: There is provided a method for a quick and easy evaluation of a substance which is an object of evaluation for its endocrine disruptive action. An evaluating method according to the present invention is a method for the evaluation of endocrine disruptive action which is characterized in comprising a step where the object substance is brought into contact with a cell group in which an electrode is arranged, a step where an agonist to a hormone receptor is brought into contact as a comparative substance with a cell group in which an electrode is arranged, and a measuring step where electrophysiological responses in the cell groups are measured via the electrode before and after contacting the object substance and before and after contacting the comparative substance, respectively.

Abstract: A method of generating poses and motions of a tree structure link system that is made by modeling of a man, animals, robots, etc., and consists of multiple links connected at joints, characterized in that by giving arbitrary numbers of constraint conditions to arbitrary numbers of arbitrary links, or by allowing adding or canceling the constraint conditions arbitrarily in the middle of the generation, the poses and the motions of the tree structure link system satisfying these constraint conditions are generated.

Abstract: A core layer contains photonic crystals formed by ferroelectric members made of a ferroelectric substance and periodically disposed along a one-dimensional direction or two-dimensional directions. Electrodes apply an electric field to the core layer. An optical function device is provided which can be made compact and can set a wavelength at high speed.

Abstract: The light emitting device comprises a substrate 10 of a p-type semiconductor; an active layer 20 formed of a plurality of quantum dot layers 18 stacked, the quantum dot layers 18 having three-dimensional grown islands self-formed by S-K mode, respectively; and an n-type semiconductor layer 22 formed over the active layer. Because of the p-type semiconductor, over which the active layer 20 is formed on, and the n-type semiconductor, which is formed over the active layer 20, lower layer regions of the active layer 20, where good quantum dots 19 are formed are nearer to regions of the active layer 20, which are nearer to the p-type semiconductor. Accordingly, the radiation recombination between the holes and electrons takes place mainly in the regions where those of the quantum dots, which are of good quality. Thus, even when a number of the quantum dot layers 18 are stacked, good device characteristics can be obtained.

Abstract: Disclosed are methods for detecting, diagnosing, treating and preventing non-small cell lung cancer using differentially expressed genes. Furthermore, novel human genes, whose expression is elevated in non-small cell lung cancer compared to non-cancerous tissues, are provided. Also disclosed are agents for treating and preventing non-small cell lung cancer as well as methods for identifying further compounds for treating and preventing non-small cell lung cancer.

Abstract: The present application provides novel human genes WDRPUH and KRZFPUH and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in response to the transduction of wild-type APC1 into colon-cancer cells. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

Abstract: A MOS transistor with a controlled threshold voltage includes a SOI which includes a substrate composed of a semi-conducting material, a single crystal layer composed of a semi-conducting material and an insulating layer interposed between the substrate and the single crystal layer. The single crystal layer is formed therein with a source region, a drain region and a surrounded region surrounded by the source region and the drain region. The surrounded region includes a depletion layer having a composition surface which is in contact with the insulating layer. The MOS transistor comprises an EIB-MOS transistor of which the substrate is adapted to be applied with a voltage of a first polarity for inducing charges of a second polarity over the composition surface of the surrounded region.