Abstract: Methods and systems for mRNA analysis and quantification of mRNA expression in cells are provided. An example method includes introducing a first capture probe and a second capture probe into the cells, the first capture probe and the second capture probe each configured to be complementary to a respective section of target mRNA within the cells, wherein binding of the first and second capture probes to the respective sections of the target mRNA results in tagging of the cells and causes the first and second capture probes to form clusters with each other. The first capture probe and the second capture probe are each bound to magnetic nanoparticles (MNPs) that, when trapped within the tagged cells, cause the tagged cells to be susceptible to magnetic forces. The method and system further include introducing the cells into a device configured to magnetically capture tagged cells.

Abstract: The present application relates to the treatment of nematode infections.

Abstract: A method for biosynthesis of polymer precursors, including, adipic acid, 1,6-hexanediol, 6-hydroxyhexanoic and 6-aminocaproic acids from carboxylic acids is provided. A method for biosynthesis of adipic acid from six-carbon dicarboxylic acids having ?, ?-enoate reductase activity by treatment with an enzyme is provided. The biocatalytic conversion of aliphatic and hydroxycarboxylic acids to corresponding aldehydes, alcohols, and amines using novel carboxylate reductases, aldehyde reductases, and aminotransferases is described. Also provided are genetically engineered microorganisms for use in the biosynthetic processes.

Abstract: The present application relates to the treatment of nematode infections.

Abstract: The present disclosure relates to compounds of the Formula (I), which are UBA5 inhibitors.

Abstract: A building structure in an outrigger configuration having a building core, at least one perimeter column, and at least one outrigger beam having a main body portion connected to the building core, an end portion distal from the building core in a direction of the at least one perimeter column and a vane portion extending from the end portion. At least one damper having a high-viscosity fluid container connected is connected to the at least one perimeter column and the vane portion extends into the high-viscosity fluid container to couple the building core to the at least one perimeter column, such that when the building structure is subjected to lateral loads and the building core is displaced with respect to the at least perimeter column, high-viscosity fluid within the high-viscosity fluid container is sheared by the vane to damp vibrations and provide coupling in the building structure.

Abstract: The present disclosure relates to methods and uses of C-terminal peptides for inhibiting neuronal cell death or dysfunction, such as retinal ganglion cell death or dysfunction, treating retinal degenerative disorders, stroke, CNS and PNS insults. The disclosure also relates to the C-terminal peptides, fusion proteins and compositions thereof.

Abstract: The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures.

Abstract: Systems and methods for generating a random signal, based on quantum noise in the phase of two or more input signals. The generated output random signal has random variation in its intensity based on the quantum noise in the phases of the input signals.

Abstract: A damping system including a first set of plates having one end thereof attached to a first vertically extending structural element, a second set of plates having one end thereof attached to a second vertically extending structural element spaced in a horizontal direction from the first vertically extending structural element, and arranged such that the first set of plates has a second end portion extending towards and overlapping with a second end portion of the second set of plates at an overlapping region, and further including an energy dissipating material provided in the overlapping region for connecting the first set of plates and the second set of plates.

Abstract: Systems and methods for integrating maps in which roads are represented as polylines. The main novelty of the invention is in using only the locations of the endpoints of the polylines rather than trying to match whole lines. Experiments on real-world data are given, showing that this approach of integration based on matching merely endpoints is efficient and accurate (that is, it provides high recall and precision).

Abstract: The present invention involves a quantum computing structure, comprising: one or more logical qubits, which is encoded into a plurality of superconducting qubits; and each of the logical qubits comprises at least one operating qubit and at least one ancilla qubit. Also provided is a method of quantum computing, comprising: performing encoded quantum computing operations with logical qubits that are encoded into superconducting operating qubits and superconducting ancilla qubits. The present invention further involves a method of error correction for a quantum computing structure comprising: presenting a plurality of logical qubits, each of which comprises an operating physical qubit and an ancilla physical qubit, wherein the logical states of the plurality of logical qubits are formed from a tensor product of the states of the operating and ancilla qubits; and wherein the states of the ancilla physical qubits are suppressed; and applying strong pulses to the grouping of logical qubits.

Abstract: The invention provides a method for stimulating nerve growth, which also includes nerve regeneration, by contacting nerve cells with human Neural Plakophilin Related Armadillo Protein (hNPRAP). In a specific embodiment, hNPRAP causes the development of numerous long, cellular extensions, which are similar to axonal sprouting observed during neuronal regeneration and synapse formation. The invention further relates to pharmaceutical compositions comprising an hNPRAP, or alternatively a gene therapy vector that expresses an hNPRAP. Also provided are methods for identifying substances that modulate expression of hNPRAP.

Abstract: Purified and isolated nucleic acid molecules are provided which encode a FlaC flagellin protein of a strain of Campylobacter, particularly C. jejuni, or a fragment or an analog of the FlaC flagellin protein. The nucleic acid molecules may be used to produce proteins free of contaminants derived from bacteria normally containing the FlaA or FlaB proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules, proteins encoded thereby and antibodies raised against the proteins, may be used in the diagnosis of infection.

Abstract: A method of producing Y-junction carbon nanotubes. An alumina template with branched growth channels is produced after which individual Y-junction carbon nanotubes are grown directly by pyrolysis of acetylene using cobalt catalysis. The use of a branched growth channel allows the natural simultaneous formation of a very large number of individual but well-aligned three-port Y-junction carbon nanotubes with excellent uniformity and control over the length (up to several tens &mgr;m) and diameter (15-100 nm) of the “stem” and “branches” separately. These Y-junctions offer the nanoelectronics community a new base material for molecular scale electronic devices including for example transistors and rectifiers.

Abstract: A method of producing three dimensional ordered arrays of particles. The method may be used for the preparation of nanocomposite materials with highly periodic structures. More particularly the invention provides a method of producing three dimensional arrays based on applying a controlled oscillatory motion to settling dispersions of colloid particles. The controlled oscillatory motion is characterized by G=A&ohgr;2/g, wherein g is the gravitational constant, A is the displacement and &ohgr; is angular frequency. G is maintained in the desired range by varying values of A within an effective range of displacements and &ugr; within an effective range of frequencies.

Abstract: A flash E.sup.2 PROM cell having source and drain regions disposed in a substrate, a channel region intermediate to the source and drain regions, a tunnel dielectric layer overlying the channel region, a floating gate overlying the tunnel dielectric layer, an inter-poly dielectric layer overlying the floating gate, and a control gate overlying the inter-poly dielectric layer. The flash E.sup.2 PROM cell further having a highly doped p.sup.+ pocket implant covering a portion of the cell width and adjacent to at least one of the drain and source regions. The flash E.sup.2 PROM cell is comprised of two sections butted together. The portion (width-wise) that is covered by the highly doped p.sup.+ pocket implant is referred to as a program section. The remaining portion (width-wise) not covered by the highly doped p.sup.+ pocket implant resembles a conventional flash E.sup.2 PROM cell and is referred to as a sense section. The highly doped p.sup.+ pocket implant and the n.sup.

Abstract: Methods and kits for treament of glaucoma are disclosed. In general, the methods of the invention include administering a therapeutically effective amount of a deprenyl compound to a subject such that the subject is treated for glaucoma.

Abstract: Tissue infiltrating primer formulations and methods of using such formulations, e.g., in the dental or medical fields, are described. The formulations of the invention include an effective amount of a tissue infiltrating agent and a primer. The tissue infiltrating primer formulations provide enhanced penetration of a biomaterial into a target substrate, e.g. hard tissues, when compared to their non-tissue infiltrating primer formulation counterparts.