Abstract: Electrosynthesis of oxirane can include contacting a halide electrolyte with an anode that includes an electrocatalyst comprising iridium oxide loaded with a period-6 metal oxide and provided on a metal substrate. The cathode can be operated under ORR conditions. The electrochemical system can also be provided as an integrated system that includes CO2 electroreduction to produce ethylene and formation of hypochlorous acid using the electrocatalyst, followed by contact of the ethylene and the hypochlorous acid to form ethylene chlorohydrin which is, in turn, contacted with OH? ions to produce oxirane.

Abstract: This technology relates to polynucleotides comprising optimized FMR1 open reading frame (ORF) sequences, viral vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of FMR1, such as Fragile X syndrome (“FXS”).

Abstract: A linear double stranded deoxyribonucleic acid (dsDNA) molecule comprising operatively linked in 5? to 3? direction: a) one or more Ter sites at 5? terminus (“5? Ter”); b) a segment comprising a DNA sequence of interest; and c) one or more Ter sites at 3? terminus (“3? Ter). Also methods of protecting DNA sequences of interest from exonuclease degradation using the DNA constructs of the present disclosure, cells transformed with the DNA construct of the present disclosure and cell-free synthetic biology system comprising a linear dsDNA molecule of the present disclosure.

Abstract: An adhesive device for biomedical applications is provided comprising a support and one or more water insoluble compounds of structure 1 wherein B is an oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW<10,000 g/mol, Linker L is a urethane, urea bond, or amide bond; Linker L? is a urethane or urea bond, A is a chain extender of Mw?3000 g/mol comprising substituted or unsubstituted alkyl, cycloalkyl and/or aromatic groups, W is a terminal adhesive benzene-1,2-diol derivative or a terminal adhesive benzene-1,2,3-triol derivative, m is 0 or 1; and n is 0, 1, 2, 3 or 4 or a cross-linked polymer formed from said compounds. The compound(s) have a Tg lower than 25° C.

Abstract: The present description relates to metal alloy electrocatalysts, preferably composed of Ni and Co as transition metals and Se as a chalcogen. The electrocatalysts can take the form of nanochalcogenides that can be made using cryogenic milling followed by surfactant-assistant milling. The electrocatalysts can be used in the context of water electrolysis or electroreduction of CO2 gas into carbon based products.

Abstract: A storage unit stores one of flow and distance matrices for an assignment problem having an evaluation function represented by a matrix operation of the flow and distance matrices, and a processing unit selects first and second entities from entities to be assigned to destinations, reads at least one first matrix element corresponding to the first and second entities from the stored flow or distance matrix, generates at least one second matrix element for the other of the flow and distance matrices, which is a patterned matrix, based on the first and second entities, calculates a change in the value of the evaluation function resulting from an assignment change of changing the destination of the first or second entity, using the first and second matrix elements, determines based on the change whether to allow the assignment change, and updates an assignment state when determining to allow the assignment change.

Abstract: A fusion protein comprises a nanocage monomer; and an antibody or fragment thereof linked to the nanocage monomer, the antibody or fragment thereof comprising a first member of a binding pair; wherein a plurality of the fusion proteins self-assemble to form a nanocage in which a plurality of the antibodies or fragments thereof decorate the exterior surface of the nanocage, whereby the first member of the binding pair is exposed for interacting with a second member of a binding pair.

Abstract: Described are methods for generating a reporter molecule in response to a target analyte in a cell-free system. A synthetic biological circuit is used to modify the level of the reporter molecule in response to the presence of the target analyte. The reporter molecule may be glucose or another molecule readily detected using a device such as glucose monitor or other portable sensor. Also provided are kits comprising a cell-free system with a synthetic biological circuit that generates or consumes a reporter molecule in response to a target analyte.

Abstract: A method to obtain a cache miss ratio curve where a memory blocks of a cache have variable block sizes. By stacking sets of counters, each set being for a different block size, a stack distance for variable block sizes can be obtained and used to determine a miss ratio curve. Such curve can then be used to select a cache size that is appropriate for an application without requiring excessive memory. Methods can be used for batches of request, can apply limits to block sizes, and rounding for intermediary block sizes, they can be used with pruning, and their space complexity can be held constant.

Abstract: A co-formulation comprising: (i) an ionizable colloid forming active substance; (ii) a nucleic acid molecule; and (iii) an amphiphilic molecule. Also, a method of treating a disease or disorder comprising administering the co-formulation to a subject in need, wherein the ionizable colloid-forming active substance and the nucleic acid molecule included in the co-formulation act together in the treatment of the disease or disorder; and a method of manufacturing the co-formulation.

Abstract: There is provided a system and method for traffic signal control of a traffic network with a learned model. The method including: receiving sensor readings from the traffic network, the sensor readings including positions and speeds of vehicles approaching each intersection; using a learned dynamics model that takes the sensor readings as input, predicting a plurality of possibilities for position and velocity of the vehicles approaching each intersection in a future timestep; determining a action for the one or more intersections by performing a tree search on the plurality of possibilities and selecting the possibility with a highest action value; and outputting the action to the traffic network for implementation as a traffic control action at the one or more intersections.

Abstract: A system and method for using sparsity to accelerate deep learning networks. The method includes: communicating a bit vector to a scheduler identifying which values in an input tensor are non-zero; for each lane of the input tensor, determining which values are to be communicated for multiply-accumulate (MAC) operations, the determination including directing performance of one of: communicating the current value in the lane; communicating the next value in the same lane where such value is non-zero; communicating a value from a step ahead in time where such value is non-zero; and communicating a value from a neighboring lane where such value is non-zero; and outputting the values of the MAC operations.

Abstract: An innovative power electronic control system suitable for various applications, such as for electric vehicles is provided. The system, in some embodiments, is configured for the purposes of on-board AC fast charging (e.g., single phase or multi-phase) when an object is not in use (e.g., a vehicle is stationary) and use as a drive (e.g., for a vehicle, an EV drivetrain) when in motion. The innovative power electronic control system enables, among others, the ability to obtain fast-charging from existing grid infrastructure.

Abstract: The present application relates to compounds (e.g. Formulae III, V, VII, IX, and XII) having a negative singlet-triplet gap and a positive oscillator strength. The present application also relates to use of the compounds of the present application in photocatalysis and in OLEDs as emitters and/or dopants.

Abstract: An azide-containing cross-linker and method of preparing the same are provided. Such cross-linker can be used as an intermediate in a scalable production of a cross-linked hemoglobin protein having its beta subunits covalently linked to the azide-containing cross-linker. The present disclosure also pertains to a hemoglobin-based oxygen carrier (HBOC) comprising a pair of azide cross-linked hemoglobin proteins coupled by a copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) and a method for preparing the same. The HBOC may be used in a method for increasing oxygen transport or for use in transfusions or perfusions.

Abstract: Perovskites have high density of vacancies which absorb oxygen molecules and upon illumination, transform them into superoxide species which react with perovskites to decompose them, preventing use of these materials in many photo-applications. The present disclosure provides ways for improving the stability of perovskites in air ambient by doping perovskites with metals such as lead, cadmium, zinc, manganese, iron, cobalt, nickel, copper and tin which decreases the density of vacancies in perovskites and significantly increases the lifetime of perovskites. Perovskite solar cells containing inorganic and organic ions such as Cs+, formamidinium and methylammonium cations, Pb2+, Br— and I— with these metal dopants exhibit stable efficiency within a month of storage in air ambient with the relative humidity of 50%.

Abstract: The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (III) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection.

Abstract: Systems and methods for key generation between a first user computing device and a second user computing device without requiring direct communication during key generation. The method using a plurality of third-party providers and a first private table and a second private table. The method including: performing by the second user computing device: receiving indexes each associated with a value in the second private table, each index received from the respective third-party provider sharing those values, each index associated with a value that matches an indexed value in the first private table received by the respective third-party provider from the first user computing device; and generating a common key by combining the indexed values of the second private table.

Abstract: The disclosure discloses a membrane electrode assembly (MEA) for electrochemically converting carbon monoxide (CO) into ethylene (C2H4) under applied current density, the MEA comprising: a cathode; an anode; an anion-exchange membrane (AEM) to separate the cathode from the anode; an anolyte; a reactant inlet in fluid communication with the cathode to provide a CO-enriched gas component; and a product outlet in fluid communication with the cathode to release a product mixture comprising C2H4; wherein the cathode comprises: a first layer including adsorption sites to adsorb CO as CO* intermediates; a second layer that facilitates stabilization of the CO* intermediates for adsorption onto the adsorption sites of the first layer; and a third layer that facilitates diffusion of CO to the adsorption sites of the first layer.

Abstract: The present disclosure relates to an electrode for CO2 electroreduction in an acidic electrolyte comprising cation species, the electrode comprising: a substrate, a metal-based catalyst material, and a cation-augmenting material; wherein the cation-augmenting material comprises an acidic group exchanging protons with the cation species of the acidic electrolyte so as to increase a concentration of the cation species at a surface of the electrode.