Abstract: A co-formulation comprising: (i) an ionizable colloid forming active substance; (ii) a nucleic acid molecule; and (iii) an amphiphilic molecule. Also, a method of treating a disease or disorder comprising administering the co-formulation to a subject in need, wherein the ionizable colloid-forming active substance and the nucleic acid molecule included in the co-formulation act together in the treatment of the disease or disorder; and a method of manufacturing the co-formulation.

Abstract: There is provided a system and method for traffic signal control of a traffic network with a learned model. The method including: receiving sensor readings from the traffic network, the sensor readings including positions and speeds of vehicles approaching each intersection; using a learned dynamics model that takes the sensor readings as input, predicting a plurality of possibilities for position and velocity of the vehicles approaching each intersection in a future timestep; determining a action for the one or more intersections by performing a tree search on the plurality of possibilities and selecting the possibility with a highest action value; and outputting the action to the traffic network for implementation as a traffic control action at the one or more intersections.

Abstract: A system and method for using sparsity to accelerate deep learning networks. The method includes: communicating a bit vector to a scheduler identifying which values in an input tensor are non-zero; for each lane of the input tensor, determining which values are to be communicated for multiply-accumulate (MAC) operations, the determination including directing performance of one of: communicating the current value in the lane; communicating the next value in the same lane where such value is non-zero; communicating a value from a step ahead in time where such value is non-zero; and communicating a value from a neighboring lane where such value is non-zero; and outputting the values of the MAC operations.

Abstract: An innovative power electronic control system suitable for various applications, such as for electric vehicles is provided. The system, in some embodiments, is configured for the purposes of on-board AC fast charging (e.g., single phase or multi-phase) when an object is not in use (e.g., a vehicle is stationary) and use as a drive (e.g., for a vehicle, an EV drivetrain) when in motion. The innovative power electronic control system enables, among others, the ability to obtain fast-charging from existing grid infrastructure.

Abstract: The present application relates to compounds (e.g. Formulae III, V, VII, IX, and XII) having a negative singlet-triplet gap and a positive oscillator strength. The present application also relates to use of the compounds of the present application in photocatalysis and in OLEDs as emitters and/or dopants.

Abstract: An azide-containing cross-linker and method of preparing the same are provided. Such cross-linker can be used as an intermediate in a scalable production of a cross-linked hemoglobin protein having its beta subunits covalently linked to the azide-containing cross-linker. The present disclosure also pertains to a hemoglobin-based oxygen carrier (HBOC) comprising a pair of azide cross-linked hemoglobin proteins coupled by a copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) and a method for preparing the same. The HBOC may be used in a method for increasing oxygen transport or for use in transfusions or perfusions.

Abstract: Perovskites have high density of vacancies which absorb oxygen molecules and upon illumination, transform them into superoxide species which react with perovskites to decompose them, preventing use of these materials in many photo-applications. The present disclosure provides ways for improving the stability of perovskites in air ambient by doping perovskites with metals such as lead, cadmium, zinc, manganese, iron, cobalt, nickel, copper and tin which decreases the density of vacancies in perovskites and significantly increases the lifetime of perovskites. Perovskite solar cells containing inorganic and organic ions such as Cs+, formamidinium and methylammonium cations, Pb2+, Br— and I— with these metal dopants exhibit stable efficiency within a month of storage in air ambient with the relative humidity of 50%.

Abstract: The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (III) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection.

Abstract: Systems and methods for key generation between a first user computing device and a second user computing device without requiring direct communication during key generation. The method using a plurality of third-party providers and a first private table and a second private table. The method including: performing by the second user computing device: receiving indexes each associated with a value in the second private table, each index received from the respective third-party provider sharing those values, each index associated with a value that matches an indexed value in the first private table received by the respective third-party provider from the first user computing device; and generating a common key by combining the indexed values of the second private table.

Abstract: The disclosure discloses a membrane electrode assembly (MEA) for electrochemically converting carbon monoxide (CO) into ethylene (C2H4) under applied current density, the MEA comprising: a cathode; an anode; an anion-exchange membrane (AEM) to separate the cathode from the anode; an anolyte; a reactant inlet in fluid communication with the cathode to provide a CO-enriched gas component; and a product outlet in fluid communication with the cathode to release a product mixture comprising C2H4; wherein the cathode comprises: a first layer including adsorption sites to adsorb CO as CO* intermediates; a second layer that facilitates stabilization of the CO* intermediates for adsorption onto the adsorption sites of the first layer; and a third layer that facilitates diffusion of CO to the adsorption sites of the first layer.

Abstract: The present disclosure relates to an electrode for CO2 electroreduction in an acidic electrolyte comprising cation species, the electrode comprising: a substrate, a metal-based catalyst material, and a cation-augmenting material; wherein the cation-augmenting material comprises an acidic group exchanging protons with the cation species of the acidic electrolyte so as to increase a concentration of the cation species at a surface of the electrode.

Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.

Abstract: A system and method for memory compression for deep learning networks. The method includes: compacting an input data stream by identifying a bit width necessary to accommodate the value from the input data stream with the highest magnitude; storing a least significant bits of the input data stream in a first memory store, the number of bits equal to the bit width, wherein if the value requires more bits than those currently left unused in the first memory store, the remaining bits are written into a second memory store; and outputting the value of the first memory store, as a consecutive part of a compressed data stream, with an associated width of the data in the first memory store when the first memory store becomes full and copying the value of the second memory store to the first memory store; and decompressing the compressed data stream.

Abstract: Systems, devices and methods are provided for fabricating anisotropic polymer materials. According to various embodiments, a fluidic device is employed to distribute a polymer solution and a flow-confining solution in order to generate a layered flow, where the layered flow is formed such that a polymer liquid sheet is sheathed on opposing sides by flow-confining liquid sheets. The fluidic device includes first and second fluid conduits, where the first fluid conduit receives the layered flow. The second fluid conduit has a reduced height relative to the first fluid conduit, such that the layered flow is constricted as it flows through the second fluid conduit. The constriction formed by the second flow conduit causes hydrodynamic focusing, reducing the thickness of the polymer liquid sheet, and inducing molecular alignment and anisotropy within the polymer liquid sheet as it is hardened and as strain is applied during extrusion of the sheet.

Abstract: The present disclosure provides a method for generating progenitor T cells from stem and/or progenitor cells comprising exposing the stem and/or progenitor cells to Notch ligand Delta-like-4 (DL4) and vascular adhesion molecule 1 (VCAM-1) under conditions suitable to generate progenitor T cells. The method provided is suitable for in vitro and in vivo pro-T cell generation. In vitro, the pro-T cells are generated under serum-free conditions. Cells produced using the method are provided as well as methods of using same.

Abstract: There is provide herein a compound of Formula (1): wherein R1, R2, R3, R4, and R5 are each independently H or an organic group.

Abstract: The present application provides an inhibitory compound, such as a peptide, and methods for using the inhibitory compound in the treatment, diagnosis or monitoring of cognitive and mood disorders that are typically associated with memory loss and/or loss of executive function. In one example, the inhibitory compound is a peptide that mimics the N-terminal sequence of the intracellular loop of ?5 subunit of ?5GABAA receptors. Also provided are compositions and methods for treating a disorder associated with memory loss or loss of executive function. The therapeutic method comprises the step of inhibiting binding of radixin to ?5GABAA receptors, for example, by administration of the presently described inhibitory compound or peptide.

Abstract: The present disclosure relates to the manufacturing and use of co-doped multi-metallic electrocatalysts for electroreduction of CO or CO2 to produce n-propanol. The co-doped multi-metallic electrocatalyst includes Cu as well as Ag and a secondary dopant, such as Ruthenium (Ru), Rhodium (Rh), Iridium (Ir), Palladium (Pd), Gold (Au) or Platinum (Pt). The co-doped multi-metallic electrocatalyst can be manufactured using a two-stage method where Cu nanoparticles are first doped with Ru and then doped with Ag. The co-doped multi-metallic electrocatalysts facilitate adsorption of CO, C1-C1 coupling, C1-C2 coupling and certain kinetics for the production of propanol by electroreduction with good selectivity at high current densities.

Abstract: Phosphorylated heptose compounds are useful in modulating an immune response in a subject. Also, the compounds are useful as adjuvants.

Abstract: A fully dilutable in aqueous phase self-microemulsifying system for the delivery of one or more polar oil active compounds having a positive characteristic curvature (Cc), comprising: a lecithin compound; a hydrophilic linker or a combination two or more hydrophilic linkers, the hydrophilic linker or the combination of two or more hydrophilic linkers having one having one hydrocarbon group with 6 to 10 carbon atoms, and the hydrophilic linker or the combination of two or more HLs having a Cc of about ?5 or more negative than about ?5; and a carrier oil.