Patents Assigned to The University of Washington
-
Patent number: 8664471Abstract: Nucleic acid compositions encoding rapidly maturing fluorescent proteins, as well as non-aggregating versions thereof (and mutants thereof) as well as the proteins encoding the same, are provided. The proteins of interest are proteins that are fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins are further characterized in that, in certain embodiments, they are mutants of wild type proteins that are obtained either from non-bioluminescent Cnidarian, e.g., Anthozoan, species or are obtained from Anthozoan non-Pennatulacean (sea pen) species. In certain embodiments, the subject proteins are mutants of wild type Discosoma sp. “red” fluorescent protein. Also of interest are proteins that are substantially similar to, or mutants of, the above specific proteins. Also provided are fragments of the nucleic acids and the peptides encoded thereby, as well as antibodies to the subject proteins and transgenic cells and organisms.Type: GrantFiled: May 11, 2004Date of Patent: March 4, 2014Assignees: The University of Chicago, The University of WashingtonInventors: Brooke Bevis, Benjamin Glick
-
Publication number: 20130087609Abstract: Methods and systems for accurately tracking medical devices using a two-dimensional (2D) matrix code are disclosed. Scan data, location data, and status data may be received by a processor. The scan data may comprise identification information corresponding to a medical device; the location data may comprise location information corresponding to the medical device; and the status data may comprise status information corresponding to the medical device. Once the scan data, location data, and status data has been received, the scan data, the location data and the status data may be stored. Next, at least one medical-device characteristic may be determined, based on at least the scan data and the status data, and once the medical-device characteristic is determined, the medical-device characteristic may be displayed on a graphical display.Type: ApplicationFiled: June 18, 2012Publication date: April 11, 2013Applicant: The University of Washington through its Center for Commercialization, a public Institution of HigInventors: Graham NICHOL, Adrian Todd EMERSON
-
Patent number: 8372594Abstract: The present invention relates to the use of protein expression profiles of sPLA2 isoforms with clinical relevance to osteoarthritis (OA). In particular, the invention provides methods for diagnosing OA or determining risk factors for development of OA based on expression of sPLA2-IIA.Type: GrantFiled: January 22, 2010Date of Patent: February 12, 2013Assignees: Case Western Reserve University, Brigham and Womens Hospital, The University of WashingtonInventors: David M. Lee, Eric Boilard, Michael H. Gelb, Reuben Gobezie
-
Patent number: 8293248Abstract: This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.Type: GrantFiled: October 16, 2009Date of Patent: October 23, 2012Assignees: Vical Incorporated, The University of WashingtonInventors: Adrian Vilalta, Michal Margalith, Lichun Dong, David Koelle
-
Patent number: 8263087Abstract: This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.Type: GrantFiled: October 23, 2009Date of Patent: September 11, 2012Assignees: Vical Incorporated, The University of WashingtonInventors: Adrian Vilalta, Michal Margalith, Lichun Dong, David M. Koelle
-
Patent number: 8247195Abstract: Methods for expressing recombinant polypeptides in host cells and host cells for polypeptide expression are provided.Type: GrantFiled: January 16, 2008Date of Patent: August 21, 2012Assignee: The University of WashingtonInventors: Ferric C. Fang, William Wiley Navarre, Stephen J. Libby
-
Publication number: 20110313933Abstract: Systems and methods for the decision-theoretic control and optimization of crowd-sources workflows utilize a computing device to map a workflow to complete a directive. The directive includes a utility function, and the workflow comprises an ordered task set. Decision points precede and follow each task in the task set, and each decision point may require (a) posting a call for workers to complete instances of tasks in the task set; (b) adjusting parameters of tasks in the task set; or (c) submitting an artifact generated by a worker as output. The computing device accesses a plurality of workers having capability parameters that describe the workers' respective abilities to complete tasks. The computing device implements the workflow by optimizing and/or selecting user-preferred choices at decision points according to the utility function and submits an artifact as output. The computing device may also implement a training phase to ascertain worker capability parameters.Type: ApplicationFiled: March 16, 2011Publication date: December 22, 2011Applicant: The University of Washington through its Center for CommercializationInventors: Peng Dai, Mausam, Daniel S. Weld
-
Publication number: 20110256628Abstract: The embodiments described herein include porous scaffolds formed from a stimuli-responsive polymer. The stimuli-responsive polymer of the scaffold creates a “smart” scaffold that changes properties in response to an effective stimulus applied to the stimuli-responsive polymer. In a preferred embodiment, an effective stimulus applied to the scaffold initiates a phase transition event in the stimuli-responsive polymer that results in a change in the volume of the pores of the scaffold. The scaffolds can be used to capture appropriately sized objects (e.g., cells) by using the volume-change properties of the pores. Relatedly, the scaffolds can be used as tissue-engineering scaffolds by capturing cells in the pores and introducing the cell-loaded scaffold into a cell-growth environment (e.g., in vivo).Type: ApplicationFiled: April 20, 2011Publication date: October 20, 2011Applicant: The University of Washington through its Center for CommercializationInventors: Anna Galperin, Thomas Joseph Long, Buddy D. Ratner
-
Patent number: 7972856Abstract: This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.Type: GrantFiled: April 24, 2003Date of Patent: July 5, 2011Assignee: The University of WashingtonInventors: David W. Russell, Roli K. Hirata
-
Patent number: 7935352Abstract: This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.Type: GrantFiled: October 16, 2009Date of Patent: May 3, 2011Assignees: Vical Incorporated, The University of WashingtonInventors: Adrian Vilalta, Michal Margalith, Lichun Dong, David Koelle
-
Patent number: 7910714Abstract: Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use.Type: GrantFiled: January 19, 2010Date of Patent: March 22, 2011Assignees: The University of Chicago, The University of WashingtonInventors: Benjamin S. Glick, Brooke Bevis, Daniel E. Strongin, David Baker, Michelle Scalley-Kim
-
Patent number: 7888016Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.Type: GrantFiled: March 16, 2007Date of Patent: February 15, 2011Assignee: The University of WashingtonInventors: Mark J. Rieder, Allan Rettie
-
Patent number: 7879339Abstract: This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.Type: GrantFiled: October 16, 2009Date of Patent: February 1, 2011Assignees: Vical Incorporated, The University of WashingtonInventors: Adrian Vilalta, Michal Margalith, Lichun Dong, David Koelle
-
Patent number: 7875451Abstract: The survival of cells during transplantation is enhanced. Cells to be transplanted are administered in a formulation that provides two ore more survival enhancing factors. Optionally, prior to administration, the cells are cultured in the presence of factors that enhance survival, and may be heat shocked prior to transplantation.Type: GrantFiled: January 19, 2006Date of Patent: January 25, 2011Assignee: The University of WashingtonInventors: Charles E. Murry, Michael Alan Laflamme
-
Patent number: 7851144Abstract: The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.Type: GrantFiled: August 16, 2007Date of Patent: December 14, 2010Assignees: The University of Washington, The University of North Carolina at Chapel Hill, The University of Pittsburgh, The Cleveland Clinic FoundationInventors: Teresa A. Brentnall, Ru Chen, Katherine L. Pogue-Geile, David C. Whitcomb, Mary Patricia Bronner, Carol A. Otey
-
Patent number: 7829282Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.Type: GrantFiled: March 16, 2007Date of Patent: November 9, 2010Assignee: The University of WashingtonInventors: Mark J. Rieder, Allan Rettie
-
Publication number: 20100280060Abstract: Identification of nucleic acids involved in life span diseases and disorders or related diseases and disorders, and the use of such methods for identifying candidate agents which modulate life span diseases and disorders or related diseases and disorders are provided. Compositions and methods for treating life span diseases and disorders or related diseases and disorders are provided.Type: ApplicationFiled: December 12, 2007Publication date: November 4, 2010Applicant: The University of WashingtonInventors: Ralph W. Powers, III, Matthew R. Kaeberlein, Stanley Fields
-
Patent number: 7825391Abstract: Various mechanisms are provided relating to plasma-based light source that may be used for lithography as well as other applications. For example, a device is disclosed for producing extreme ultraviolet (EUV) light based on a sheared plasma flow. The device can produce a plasma pinch that can last several orders of magnitude longer than what is typically sustained in a Z-pinch, thus enabling the device to provide more power output than what has been hitherto predicted in theory or attained in practice. Such power output may be used in a lithography system for manufacturing integrated circuits, enabling the use of EUV wavelengths on the order of about 13.5 nm. Lastly, the process of manufacturing such a plasma pinch is discussed, where the process includes providing a sheared flow of plasma in order to stabilize it for long periods of time.Type: GrantFiled: April 10, 2008Date of Patent: November 2, 2010Assignee: The University of WashingtonInventors: Uri Shumlak, Raymond Golingo, Brian A. Nelson
-
Patent number: 7811819Abstract: Primate embryonic stem cells are cryopreserved by resuspension in a freezing medium and slow cooling at a controlled rate. In some embodiments, prior to the controlled freezing step, the suspension of cells is cooled to a temperature just below freezing, and ice crystal formation is induced. The cryopreserved cell aggregates are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, and as targets for the discovery of factors or molecules that can affect them.Type: GrantFiled: May 31, 2005Date of Patent: October 12, 2010Assignee: The University of WashingtonInventors: Carol Ware, Angelique M. Nelson
-
Patent number: 7807260Abstract: The invention disclosed herein relates to relates to foamed thermoplastic material objects and articles of manufacture having an internal layered cellular structure, as well as to methods of making the same. In one embodiment, the invention is directed to a multi-layer foamed polymeric article of manufacture, comprising: a non-laminated multi-layer thermoplastic material sheet, wherein the multi-layer thermoplastic material sheet has first and second discrete outer layers sandwiching a plurality of discrete inner foamed layers, and wherein the two outer layers and plurality discrete inner foamed layers are integral with one another. The thermoplastic material may be a semi-crystalline polymer such as, for example, PET (polyethylene terephthalate), PEEK (polyetheretherketone), PEN (polyethylene napthalate), PBT (polybutylene terephthalate), PMMA (polymethyl methacrylate), PLA (polylactide), polyhydroxy acid (PHA), thermoplastic urethane (TPU), or blends thereof.Type: GrantFiled: January 17, 2008Date of Patent: October 5, 2010Assignees: MicroGREEN Polymers, Inc., The University of WashingtonInventors: Krishna Nadella, Gregory L. Branch, Vipin Kumar, Michael A. Waggoner