Abstract: A first object of the present invention is to provide a method for producing a cyclic imide compound with high yield and high purity. A second object of the present invention is to provide a composition that can be used in the method for producing a cyclic imide compound with high yield and high purity. A third object of the present invention is to provide an intermediate compound that can be used in the method for producing a cyclic imide compound with high yield and high purity. The method for producing a cyclic imide compound according to the present invention includes reacting a compound represented by formula (1) below with at least one amine compound to obtain a compound represented by formula (2) below.

Abstract: [Problem] To develop novel therapeutic agents for viral diseases such as coronavirus infections. [Solution] The present invention provides a therapeutic or prophylactic agent for viral diseases containing a compound with inhibitory activity against the function of Pin1 or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: An objective of the present invention is to provide a method, or the like, for estimating the convergence of dimensional changes in a molded article over time, by utilizing the polarization intensity of terahertz waves. The present invention provides a method for estimating the convergence of changes in the dimensions of a molded article over time, the method comprising: irradiating a molded article with terahertz waves at multiple positions thereon, wherein the molded article is irradiated with the terahertz waves at each position thereon in multiple orientations about the optical axis; measuring polarization intensities of the terahertz waves transmitted through or reflected from the molded article; and determining whether the polarization intensities at the multiple positions are in a given relationship with each other.

Abstract: Provided is a method of fixing a sufficient amount of carbon dioxide contained in a carbon dioxide-containing gas (e.g., a plant exhaust gas) simply, at low cost, and efficiently. The method of fixing carbon dioxide includes a contact step of bringing a carbon dioxide-containing gas into contact with powdery or grainy particles, which are each formed of a cementitious hardened body and each have a particle size of 40 mm or less, at a temperature of from 75° C. to 110° C. to fix carbon dioxide contained in the carbon dioxide-containing gas to the powdery or grainy particles, wherein the relative humidity of the carbon dioxide-containing gas is adjusted in accordance with the particle size of the powdery or grainy particles and the state of adjustment of moisture content of the powdery or grainy particles before the contact step.

Abstract: The invention relates to automatic discovery and evaluation of a motion by treating motion recognition as an optimization problem by considering a series of basic motions obtained by segmenting a subject motion. The method comprises segmenting time series data defining a motion of a subject into a plurality of segments, classifying each segment into a class for a basic motion by using time series data of the segment, and converting the motion of the subject to a sequence of high rank symbols in which each high rank symbol is formed from a series of the basic motions, wherein a function that calculates a score based on a set of a high rank symbol and a sequence of basic motions is provided and the motion of the subject is converted to the sequence of the high rank symbols by an optimization calculation using dynamic programming.

Abstract: An object of the present disclosure is to enable behavior of a linear structure in water to be estimated. The present disclosure is an apparatus that: expresses at least one parameter in a plurality of discrete values, and forecasts behavior of a linear structure by using each of the discrete values; acquires behavior of the linear structure detected using an optical fiber; calculates a likelihood between the forecasted behavior of the linear structure and the acquired behavior of the linear structure; updates at least one of the plurality of discrete values on the basis of the likelihood; and calculates behavior of the linear structure by using the updated plurality of discrete values.

Abstract: The present invention provides a nucleic acid having excellent cell membrane permeability.

Abstract: The present invention provides an antibody to a fibrosis-related molecule and medical application thereof. The antibody of the present invention is an antibody that binds to CHL1 protein and an antibody that neutralizes the binding of the CHL1 protein to a fibroblast.

Abstract: An image processing device includes a determination unit configured to determine a type of autophagy induced in a cell, based on information indicative of autophagic activity in the cell present in a cell image in which the cell is image captured and based on information indicative of congestion of molecules in the cell present in the cell image.

Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.

Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.

Abstract: The present invention provides a method for preparing a somatic chimera by using a pluripotent cell genetically engineered not to differentiate into a predetermined type of cell. The present invention particularly provides a method for preventing a pluripotent cell from contributing to the brain and gonad in a somatic chimera animal.

Abstract: The present invention relates to a novel combination of (1) a substance that suppresses or inhibits the function of extracellular TCTP (translationally controlled tumor protein), especially released from tumor cells, and (2) a cancer immunotherapeutic agent for the treatment of cancer. Preferably, such a cancer immunotherapeutic agent is an immune checkpoint inhibitor. The substance that suppresses or inhibits the function of extracellular TCTP functions as an activator or enhancer of anti-tumor immune cells including T cells and natural killer (NK) cells and/or an antagonist of immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), in the tumor immune microenvironment (TIME). The combination according to the present invention is useful for treating or preventing cancer. The combination according to the present invention is also useful for alleviating, reverting, or preventing immune suppression in the tumor immune microenvironment.

Abstract: The present invention has found that chimeric animals suffer from noticeable inflammation after birth, though neither immune response nor inflammation in the fetal period of these animals has been reported hitherto. This is an unexpected finding since chimeric animals in the fetal period were exclusively analyzed in prior studies and thus it is deemed that immunotolerance has been theoretically established therein. The present invention provides a composition for suppressing immune response or inflammation in the fetal period of a born chimeric animal.

Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.

Abstract: A refrigeration cycle apparatus includes a refrigerant circuit and an adsorbent. The refrigerant circuit includes a compressor that compresses a refrigerant. The refrigerant circuit configures a vapor compression refrigeration cycle in which the refrigerant circulates. The adsorbent adsorbs and desorbs the refrigerant circulating in the refrigerant circuit. The adsorbent adsorbs and desorbs the refrigerant in accordance with a change in a pressure of the refrigerant circulating in the refrigerant circuit.

Abstract: A polymer represented by the following formula (I): wherein each symbol is as described in the specification, is useful as a drug carrier in effectively delivering a drug to a target site.

Abstract: A refrigerant circuit includes a compressor that compresses refrigerant and an expansion mechanism that decompresses refrigerant. The refrigerant circuit configures a vapor compression refrigeration cycle in which the refrigerant circulates. The adsorbent adsorbs and desorbs the refrigerant circulating in a first unit. The refrigerant circuit includes a high-pressure region and a low-pressure region. The refrigeration cycle apparatus is operated under at least one of a first condition and a second condition. In the first condition, the refrigerant in the high-pressure region has a pressure lower than or equal to a critical pressure of the refrigerant, and the refrigerant in the high-pressure region has a temperature exceeding a critical temperature of the refrigerant.

Abstract: The present invention provides a light-transmitting electrode which has high electrical conductivity and high electron blocking performance. The present invention also provides a solar cell which is capable of achieving high energy conversion efficiency at low cost. The present invention provides a method for producing a light-transmitting electrode that has a light-transmitting substrate, a carbon nanotube film which is formed directly or indirectly on the light-transmitting substrate, and a metal oxide film which is formed directly on the carbon nanotube film. This production method includes vapor depositing the metal oxide film, which contains oxygen and a metal element belonging to the group 4, 5 or 6 of the periodic table, on one surface or both surfaces of the carbon nanotube film. The present invention provides a light-transmitting electrode which includes a light-transmitting substrate and a conductive carbon nanotube film that is formed directly or indirectly on the light-transmitting substrate.

Abstract: A mammalian or avian cell line that expresses high levels of human influenza virus receptors is provided. In one embodiment, the cell line supports human influenza virus, e.g., human A/H3 influenza virus, isolation and growth much more effectively than corresponding conventional (unmodified) cells or in corresponding human virus receptor-overexpressing cells, and the propagated viruses may maintain higher genetic stability than in the corresponding cells.