Abstract: A substrate that is stretchable and that at least has a wiring region; wiring at least positioned in the wiring region on a first surface side of the substrate, the wiring having a meandering shape section that includes peaks and valleys aligned along a first direction that is one of planar directions of the first surface of the substrate; and a stretching control mechanism that controls extension and contraction of the substrate. The stretching control mechanism at least includes stretching control parts that are positioned in the wiring region of the substrate and that are aligned along the first direction.

Abstract: The present invention addresses the problem of providing a pregnancy-induced hypertension syndrome therapy composition having controlled placental permeability. Provided are nicotinamide-encapsulating micelles having a particle diameter of 25-100 nm. Controlling the particle diameter of the nicotinamide-encapsulating micelles enables control of placental permeability so as to make it possible to accumulate nicotinamide-encapsulating micelles in a placental while suppressing transfer to a fetus. Administering the nicotinamide-encapsulating micelles brings about a superior effect of reducing blood pressure during a pregnancy-induced hypertension syndrome.

Abstract: RNA molecules for RNA interference to target a mutant allele with a point mutation, wherein the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and when counted from the base at the 5?-end in the nucleotide sequence complementary to the sequence of the mutant allele: a base at position 5 or 6 is mismatched with a base in the mutant allele; a base at position 10 or 11 is at the position of the point mutation and is identical to the base at the position of the point mutation in the mutant allele; the group at the 2?-position of the pentose in the ribonucleotide at position 8 is modified with OCH3, halogen, or LNA; and the group at the 2?-position of the pentose in the ribonucleotide at position 7 is not modified with any of OCH3, halogen, and LNA.

Abstract: An electromagnetic wave absorbing sheet includes a metallic base and an electromagnetic wave absorption film formed on the metallic base. The electromagnetic wave absorption film contains MTC-substituted ?—Fe2O3, black titanium oxide, a conductive filler, and a resin. The MTC-substituted ?—Fe2O3 is a crystal belonging to the same space group as an ?—Fe2O3 crystal and containing Ti, Co, Fe, and at least one element selected from the group consisting of Ga, In, Al, and Rh. The proportion of the conductive filler to the electromagnetic wave absorption film is equal to or greater than 0.1% by volume and equal to or less than 10% by volume.

Abstract: A material for preventing adhesion having a high adhesion preventing effect has been desired. Provided is a sheet-like material for preventing adhesion which contains alginate, at least a portion of which is crosslinked with a curing agent, the material for preventing adhesion satisfying (1) and (2) when a dissolution test is performed in which a sample cut into a substantial circle having a diameter of 8 mm is left to stand, via a mesh, on agar of a petri dish to which a physiological saline solution is added substantially to a top surface of the agar, the petri dish is shaken at an amplitude of 25 mm and 40 shakes/min., and the weight of the sample is measured at least one arbitrary point in time. (1) The time required for the weight of the sample to be less than 0.01 g is 5-36 hours from a start of the test, and (2) the time required for the weight of the sample to reach the maximum weight is 10 hours or less from the start of the test.

Abstract: A method for producing ammonia involves producing ammonia from molecular nitrogen in a production apparatus for performing electrolysis by supplying electrons from a power source, protons from a proton source and molecular nitrogen from a device for supplying a nitrogen gas while in the presence of a solid catalyst and a complex in a cathode. For example, a molybdenum complex represented by formula (A1) or formula (B2) as the complex, and a platinum catalyst or a platinum catalyst/gold catalyst combination as the solid catalyst are used.

Abstract: Provided is a robot system comprising: a robot mechanism provided with fingers for grasping a workpiece; a detection unit that detects a grasping state of the workpiece by the fingers; a recognition unit that recognizes the number of workpieces being grasped by the fingers on the basis of a detection result from the detection unit; and a control unit that, after causing the robot mechanism to perform a motion of grasping the workpieces from a placing area where a plurality of workpieces are placed, if the number of the workpieces recognized by the recognition unit is different from a specified number specified in advance, controls the motion of the robot mechanism such that the number of the grasped workpieces is equal to the specified number. At least one of the fingers is flexible. The control unit controls the motion of the robot mechanism such that, in a state in which workpieces are being grasped by the fingers, the position of at least one of the fingers is changed.

Abstract: A multi-axial tactile sensor for detecting forces in directions of three axes and a moment about at least one axis includes at least four sensor elements including at least three shearing force detecting elements having beam structures provided with a first resistive layer and a second resistive layer at specific portions, and at least one pressing force detecting element having a beam structure provided with a third resistive layer and a fourth resistive layer at specific portions, the beam structures of the four sensor elements being arranged on a sensor substrate so that their respective longitudinal directions are radially arranged, and the moment about at least one axis is detected based on outputs of two or more sensor elements being arranged at positions of rotational symmetry around the center of the radial arrangement of the plurality of sensor elements.

Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRJSPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CR.ISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.

Abstract: To provide a novel polysaccharide derivative which can be used to form a conjugate with a drug and can be used as a medical material, and a polysaccharide derivative-drug conjugate which uses the same. A polysaccharide derivative obtained by introducing a group represented by formula (A) to a polysaccharide which is acidic, basic or both, and a polysaccharide derivative-drug conjugate of said polysaccharide derivative and a drug.

Abstract: The purpose of the present invention is to develop a virus vector, the activity of which is rendered controllable. A virus protein gene derived from an RNA virus is provided in which a gene encoding an optical switch protein is inserted into a foreign gene introducible region of the virus protein so as to enable expression of the gene. By means of this virus vector, it is possible to control, with irradiation of light, enzyme activity of the virus protein and virus vector activity based thereon.

Abstract: A mutant SaCas9 protein such as a protein having an amino acid sequence resulting from mutations of glutamic acid at the 782-position to lysine (E782K), leucine at the 800-position to arginine (L800R), asparagine at the 968-position to arginine (N968R), asparagine at the 985-position to alanine (N985A), arginine at the 991-position to alanine (R991A), alanine at the 1021-position to serine (A1021S), threonine at the 927-position to lysine (T927K), lysine at the 929-position to asparagine (K929N), and isoleucine at the 1017-position to phenylalanine (I1017F) in SEQ ID NO: 2 has relaxed restriction on target sequence while maintaining binding ability to guide RNA, and is useful as a tool for gene editing.

Abstract: A fracture caused by fatigue of a connecting portion positioned at a corner of a reinforcing frame directly secured to a frame is avoided regardless of a relative displacement that occurs in the frame upon disposing the reinforcing frame made of steel, which has an elevational shape surrounding the frame along an inner circumferential surface of the frame and a cross-sectional shape with a flange on a side of the frame, in a structure plane of the frame of a column and a beam of reinforced concrete structure, and joining the reinforcing frame to the inner circumferential surface of the frame. A reinforcing frame is constituted of a column portion along a column of a frame, a beam portion along a beam, and a connecting portion that is joined to the column portion and the beam portion, and connects the column portion to the beam portion.

Abstract: Provided is a compound capable of forming through a printing process an organic semiconductor exhibiting high charge mobility. The compound according to the present disclosure is represented by Formula (1) below. In Formula (1), X1 and X2 are the same or different and each represent —O—, —NR1—, or —PR2-. Y1 and Y2 are the same or different and each represent an oxygen atom or a sulfur atom. Z1 to Z8 are the same or different and each represent ?N— or ?CR3—. The R1, R2, and R3 are the same or different and each represent a hydrogen atom or an organic group. n represents an integer of 0 or greater.

Abstract: Modified influenza virus neuraminidases are described herein that have stabilized NA tetramers which may improve vaccine production efficiency, thus improving the yield of vaccine viruses.

Abstract: A wave receiving mechanism includes: a shaft driving a hydraulic pump; and a wave receiving member including an arm and wave receiving plate, the arm unrotatably attached to the shaft, the plate being at the arm receiving a wave force, the wave receiving member swinging about the shaft by receiving the wave force and turning the shaft turn. The arm includes first and second arm portions, and a bendable portion, the first arm portion unrotatably attached to the shaft, the second arm portion being at the plate, the bendable portion coupling the first and second arm portions. When a swing angle of the first arm portion is less than a first predetermined angle, the bendable portion makes the arm portions swing integrally. When the swing angle of the first arm portion is the predetermined angle, the bendable portion allows the second arm portion to bend relative to the first.

Abstract: An adsorbent and a granulated substance for which reduction in adsorption performance in low humidity environments is suppressed are provided. The adsorbent includes: a porous body mainly composed of silicon dioxide, including a plurality of fine pores, and having a specific surface area of not less than 1 m2/g and not more than 10 m2/g; one of an acid and a base with which inside of the fine pores of the porous body is impregnated to neutralize a target gas to generate a salt; and a hydrophilic fiber held in the porous body.

Abstract: A motor-driven vehicle includes: a motor, a first rotational shaft to be driven to rotate by the motor, a clutch, a second rotational shaft to be driven to rotate by the motor via the clutch, an arm configured to rotate in association with rotation of the second rotational shaft, and at least two wheels, wherein each of the at least two wheels being attached to the arm at a position offset from a rotation center of the arm, and each of the at least two wheels being rotatable in association with rotation of the first rotational shaft.

Abstract: Provided is a semiconductor device and a method of manufacturing the semiconductor device that is capable of improving the connection reliability between an electronic element and a substrate in a semiconductor device in which the electronic element is fixed to the substrate. The semiconductor device includes: a substrate 10 provided with wirings and wiring connection parts 12 connected to the wirings; electronic elements 20, 30, 40, and 50 electrically connected to the wiring connection parts 12 and fixed to the substrate; and a resin film 60 laminated on one surface of the substrate 10, conforming to the shapes of the electronic elements 20, 30, 40, and 50, and covering the electronic elements 20, 30, 40, and 50.

Abstract: A vibration-driven energy harvesting element includes: a pair of fixed electrode portions that have a plurality of fixed comb teeth and are arranged such that the plurality of fixed comb teeth face each other; and a movable electrode portion that is arranged between the pair of fixed electrode portions and has a pair of a plurality of movable comb teeth being inserted between the fixed comb teeth of the respective fixed electrode portions, wherein: the vibration-driven energy harvesting element has a three-terminal structure in which the fixed comb teeth and/or the movable comb teeth are electretized; a gap dimension of a clearance region between the fixed comb teeth and the movable comb teeth is smaller than 20 ?m; and an aspect ratio being a ratio of a dimension of the clearance region in a comb tooth height direction to the gap dimension of the clearance region, is 20 or more.