Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: A first method includes detecting, based on sensor data, an environment state; selecting an action based on the environment state; determining an autonomy level associated with the environment state and the action; and performing the action according to the autonomy level. The autonomy level can be selected based at least on an autonomy model and a feedback model. A second method includes calculating, by solving an extended Stochastic Shortest Path (SSP) problem, a policy for solving a task. The policy can map environment states and autonomy levels to actions and autonomy levels. Calculating the policy can include generating plans that operate across multiple levels of autonomy.

Abstract: There is provided a flight management system for managing a flight plan of flying objects that fly among ports.

Abstract: In this disclosure, collaborative multi-agent-based TST is presented with dedicated intersection controllers that include software agents which read local and remote detection systems and then collaboratively optimize signal timing phases by considering the feedback of all controller agents that may be affected by a change. The disclosure also presents an augmented system which considers network input from handheld remote devices to update certain traffic light phase information and adapt to emerging emergency situations.

Abstract: The present disclosure provides a method of preventing, treating, or inhibiting migraine in a subject, by administering to the subject an amount of first therapeutic selected from cercosporamide, eFT508, or 4EGI-1 sufficient to prevent, treat, or inhibit said migraine. The present disclosure further provides a composition including at least two of cercosporamide. eFT508, or 4EGI-1, both in an amount sufficient to prevent, treat, or inhibit migraine in a subject and a pharmaceutically acceptable carrier. The present disclosure further provides a composition including at least one of cercosporamide, eFT508, or 4EGI-1 and at least one additional migraine therapeutic, both in an amount sufficient to prevent, treat, or inhibit migraine in a subject, and a pharmaceutically acceptable carrier.

Abstract: In a neural network (NN) based wireless communication system, a BS determines, for an one-round latency T and an overall model size L of the NN model, i) Tu that makes {circumflex over (L)}*(Tu) larger than L and ii) Tl that makes {circumflex over (L)}*(Tl)<L; repeats determining {circumflex over (L)}*(Tm), {R*k,n}, {{circumflex over (L)}*k}, and {C*k,n} by using Tm=(Tu+Tl)/2 for k=1, K, and n=1, . . . N, while Tu is different from Tl; allocates NN model parameters to user equipments 1 to K based on {R*k,n}, {L*k}, and {C*k,n} determined based on Tm when Tu=Tl; and updates the NN model based on update results of the NN model parameters received from user equipments 1 to K.

Abstract: This present disclosure provides devices, systems, and methods relating to the management of a subject's medical needs involving safely accessing a body cavity. In particular, the present disclosure is directed to body cavity conduit devices and systems that facilitate repeated access to a subject's body cavity for removing fluid or performing a procedure in a manner that provides enhanced comfort, safety, and efficacy.

Abstract: Provided herein is a radiation powered device comprising a semiconductor comprising a diamond material.

Abstract: The present disclosure relates to a bicycle frame and associated bicycle components, and to reducing the aerodynamic drag of these. In one aspect, there is provided an elongate structural member of a bicycle frame, the member comprising a lengthwise extending leading edge, the leading edge comprising at least a pair of forwardly extending protrusions spaced apart lengthwise therealong. In one form, the protrusions comprise tubercles, a series of which are spaced apart lengthwise along the leading edge, and which further extend to at least one side of the leading edge so as to transition into a chordwise extending rib.

Abstract: A hollow light-weight, low-cost, and high-performance 3D Luneburg lens structure using partially-metalized thin film, string, threads, fiber or wire base metamaterial to implement the continuously varying relative permittivity profile, characteristic of Luneburg lens structures, is disclosed. The hollow light-weight lens structure is based on the effective medium approach and may be implemented by a number of means. Further, most of the volume of the lens structure is free-space, thus the weight of the lens is significantly less than conventional 3D Luneburg lens structures of the same dimensions.

Abstract: An electrochemical reactor for use with a liquid electrolyte is capable of generating gaseous products. An electrically conducting porous layer that is hydrophilic on the catalyst side and hydrophobic on the gas side are utilized. These different surface properties promote the transport of product gases formed at the catalyst through the porous layer to the gas side. The catalyst is formed from a hybrid Cu2O—CuBr film that has a high selectivity for ethylene gas from reacting CO2 and water in an electrochemical cell.

Abstract: The present disclosure relates to methods and products for reducing the viability of microorganisms, and to methods and products for preventing and/or treating microorganism infections. Certain embodiments of the present disclosure provide a method for reducing viability of a microorganism. The method comprises exposing the microorganism to an effective amount of an iron chelator and subsequently exposing the microorganism to an effective amount of a non-iron porphyrin, thereby reducing the viability of the microorganism.

Abstract: A vehicle traversing a vehicle transportation network may use a scenario-specific operational control evaluation model instance. A multi-objective policy for the model is received, wherein the policy includes at least a first objective, a second objective, and a priority of the first objective relative to the second objective. A representation of the policy (e.g., the first objective, the second objective, and the priority) is generated using a user interface. Based on feedback to the user interface, a change to the multi-objective policy for the scenario-specific operational control evaluation model is received. The change is to the first objective, the second objective, the priority, of some combination thereof. Then, for determining a vehicle control action for traversing the vehicle transportation network, an updated multi-objective policy for the scenario-specific operational control evaluation model is generated to include the change to the policy.

Abstract: Disclosed herein are methods, apparatus and computer program product for radar-based communication and interpretation of sign languages such as American Sign language (ASL) comprising detecting, using a radar system comprising a computing device, sign language gestures, wherein said detected sign language gestures comprise radar data; analyzing the radar data using a trained neural network executing on the computing device to determine word or phrases intended by the sign language gestures; and outputting the determined words or phrases in a visible or audible format.

Abstract: Provided herein are chimeric antigen receptors (CARs) comprising a glucuronoxylomannan receptor antigen-binding domain. Further provided herein are immune cells expressing the GXMR-CARs as well as methods of their use in the treatment of cryptococcosis.

Abstract: There is a photovoltaic (PV) panel 10 including an array of photovoltaic (PV) elements (12). Each PV element (12) is stand alone and can be electronically addressed individually. The PV panel (10) also includes a number of spectral filters (14), in this example, a red filter (14r), a green filter (14g) and a blue filter (14b) arranged over some of the PV elements (12) to filter out the red, green and blue spectral components from white (combined red, green and blue) light emitted from a red-green-blue (RGB) transmitter. Data can be transmitted by modulating the spectral components of the RGB transmitter such that the data in each of the spectral components can be recovered from the electrical signal generated by the PV elements (12).

Abstract: Provided are antisense oligonucleotides targeted against bacterial genes involved in biochemical pathways and/or cellular processes, and related compositions and methods of using the oligonucleotides and compositions, alone or in combination with other antimicrobial agents, for instance, in the treatment of an infected mammalian subject.

Abstract: The techniques described herein may provide techniques to detect, categorize, and diagnose synchronization issues that provide improved performance and issue resolution. For example, in an embodiment, a method may comprise detecting occurrence of synchronization performance problems in software code, when at least some detected synchronization performance problems occur when a contention rate for software locks is low, determining a cause of the synchronization performance problems, and modifying the software code to remedy the cause of the synchronization performance problems so as to improve synchronization performance of the software code.

Abstract: A single stack transverse flux machine includes a rotor assembly having an internal rotor disc with a rotor shaft extending from and rotating with the internal rotor disc, and a rotor ring having a plurality of stator poles interleaved with a plurality of interpoles. The plurality of stator poles and the plurality of interpoles are radially disposed around the internal rotor disc. Each stator pole has a plurality of core components spaced apart from one another. Primary magnets are interposed between the plurality of core components. The machine also includes a stator assembly with a plurality of shaped cores, each shaped core having a base with a plurality of legs with a corresponding gap therebetween. Each leg has a winding, and the shaped cores are positioned so that each leg is juxtaposed with a corresponding one of the plurality of core components and has an air gap therebetween.

Abstract: An alternative polyurethane composition is provided which comprises a reaction product of an azidated polyol and a poly(alkynyl carbamate) prepolymer, wherein reaction occurs at a temperature of from 20° C. to 200° C., optionally in the presence of a CuI-containing catalyst and wherein the poly(alkynyl carbamate) prepolymer comprises a reaction product of a polyisocyanate, an alkynol, and a glycol ether, wherein from 1 mol % to 33 mol % of isocyanate groups are reacted with glycol ether and the remaining isocyanate groups are reacted with the alkynol. The inclusion of glycol ethers into the polyisocyanate chain of the poly(alkynyl carbamate) prepolymer at a level of from 1 mol % to 33 mol %, is efficient in reducing the viscosity of the composition without compromising its performance in coatings, adhesives, sealants, films, elastomers, castings, foams, and composites made with the inventive alternative polyurethane compositions.