Patents Assigned to The University
  • Microbubble and nanobubble expansion using perfluorocarbon nanodroplets for enhanced ultrasound imaging and therapy
    Patent number: 11334993
    Abstract: The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: May 17, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Robert F. Mattrey, Caroline De Gracia Lux, Jacques Lux, Zhenghong Gao, Carlos J. Brambila
  • DYNAMIC WIRELESS POWER TRANSFER SYSTEM
    Publication number: 20220149666
    Abstract: A dynamic wireless power transfer system includes a power transmission coil, a power transmission circuit, a power reception coil, a power reception circuit, and a relay circuit. The power transmission coil is provided in a road. The power transmission circuit supplies electric power to the power transmission coil. The power reception coil is provided in a vehicle. The power reception circuit is connected to the power reception coil. The relay circuit transfers electric power between the power transmission coil and the power reception coil in a contactless manner.
    Type: Application
    Filed: January 26, 2022
    Publication date: May 12, 2022
    Applicants: DENSO CORPORATION, The University of Tokyo
    Inventors: Hayato SUMIYA, Eisuke TAKAHASHI, Nobuhisa YAMAGUCHI, Masaya TAKAHASHI, Hiroshi FUJIMOTO, Osamu SHIMIZU
  • COMPOUNDS WITH ANTI-TUMOR ACTIVITY AGAINST CANCER CELLS BEARING EGFR OR HER2 EXON 20 INSERTIONS
    Publication number: 20220143023
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have an EGFR and/or HER2 exon 20 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib or afatinib.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacqulyne ROBICHAUX, Monique NILSSON, John V. HEYMACH
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF PKR-ASSOCIATED DISEASES
    Publication number: 20220143030
    Abstract: Provided herein are RNA-dependent protein kinase (PKR)-associated compounds for the treatment of PKR-associated disorders including cancer, neurodegenerative diseases, and inflammatory conditions.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Apar PATAER, Bulent OZPOLAT, Stephen G. SWISHER, Ruping SHAO
  • LILRB4-BINDING ANTIBODY AND METHODS OF USE THEREOF
    Publication number: 20220144944
    Abstract: Provided herein are LILRB4-binding antibodies and methods of treating cancer by administering the LILRB4-binding antibodies alone or in combination with other therapies. Recombinant polypeptides comprising the CDRs of LILRB4-binding antibodies are also provided.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 12, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Naveen SHARMA, James P. ALLISON
  • NOVEL BIOMOLECULE CONJUGATES AND USES THEREFOR
    Publication number: 20220143203
    Abstract: Provided herein are biomolecule conjugates, and methods of use thereof, wherein the conjugate comprises a cytokine, typically an immunopotentiating cytokine, and a peptide comprising or consisting of the sequence CSGRRSSKC (SEQ ID NO:1). Biomolecule conjugates of the invention find application, inter alia, in the treatment of tumours, atherosclerosis and fibrosis, and the degradation of ECM associated therewith. Also provided herein are uses of a peptide comprising or consisting of the sequence of SEQ ID NO:1, optionally linked to a detectable agent and/or a carrier, in the detection and/or localisation of tumour, atherosclerotic and fibrotic tissue.
    Type: Application
    Filed: October 26, 2021
    Publication date: May 12, 2022
    Applicants: The University of Western Australia, Sanford Burnham Prebys Medical Discovery Institute
    Inventors: Juliana Binti HAMZAH, Ruth Annelore GANSS, Erkki RUOSLAHTI, Hector R. BILIRAN, JR.
  • COMPOSITIONS AND METHODS RELATED TO TETHERED KETHOXAL DERIVATIVES
    Publication number: 20220143198
    Abstract: Embodiments are directed to therapeutic, diagnostic, or functional complexes comprising a kethoxal derivative.
    Type: Application
    Filed: May 22, 2020
    Publication date: May 12, 2022
    Applicant: The University of Chicago
    Inventors: Chuan HE, Tong WU, Pingluan WANG
  • IMAGE DATA PROCESSING APPARATUS AND METHOD, A MODEL TRAINING APPARATUS AND A TRAINING METHOD
    Publication number: 20220147768
    Abstract: An image data processing apparatus comprises processing circuitry configured to: receive first medical image data; obtain a first image feature data set from the first medical image data; obtain a second image feature data set from second medical image data and/or from stored image feature data; obtain style data; and generate synthesized image data based on the first image feature data set, the second image feature data set, and the style data.
    Type: Application
    Filed: November 11, 2021
    Publication date: May 12, 2022
    Applicants: The University Court of the University of Edinburgh, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Spyridon THERMOS, Sotirios TSAFTARIS, Alison O'NEIL
  • PEGYLATED BILIRUBIN FOR THE TREATMENT OF HYPERLIPIDEMIA, OBESITY, FATTY LIVER DISEASE, CARDIOVASCULAR DISEASES AND TYPE II DIABETES
    Publication number: 20220142980
    Abstract: Compositions and methods for the treatment of obesity, hyperlipidemia, fatty liver disease, cardiovascular disease and type II diabetes are described. Also described are compositions and methods for decreasing one or more of body weight, total fat, percent fat mass, visceral fat, epididymal fat, hepatic fat content, fasting blood glucose, decreasing white adipose fat (WAT) adipocyte size, or increasing percent lean mass. The compositions and methods involve PEGylated bilirubin.
    Type: Application
    Filed: February 18, 2020
    Publication date: May 12, 2022
    Applicant: The University of Toledo
    Inventors: Terry D. Hinds, Jr., David E. Stec
  • COMPOSITIONS AND METHODS FOR PROMOTING MINERALIZATION
    Publication number: 20220142881
    Abstract: The present invention relates to compositions for uses including mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by various means including dental caries, dental corrosion and fluorosis are also provided. In one aspect, the present invention provides a method of mineralizing a dental surface or sub-surface comprising contacting the dental surface or subsurface with stabilized amorphous calcium phosphate (ACP) and/or amorphous calcium fluoride phosphate (ACFP), and simultaneously or subsequently, heating the dental surface or subsurface to which the stabilized ACP and/or ACFP has been, or is being, applied to a temperature greater than 37° C.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 12, 2022
    Applicant: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • METHODS OF USING IMIPRIDONES
    Publication number: 20220143024
    Abstract: Provided herein are methods of using ClpP levels and mutation status as a marker for the selection and treatment of cancer patients who will respond to the administration of imipridones. Also provided are methods of treating patients having Perrault syndrome. Also provided are methods of killing bacterial cells and treating bacterial infections using imipridones.
    Type: Application
    Filed: February 21, 2020
    Publication date: May 12, 2022
    Applicants: Board of Regents, The University of Texas System, University Health Network
    Inventors: Michael ANDREEFF, Jo ISHIZAWA, David SCHIMMER, Sara ZARABI
  • Polymers comprising 1,3-cyclobutane dimethanol (CBDO-1)
    Patent number: 11326054
    Abstract: A polymer includes a plurality of repeated polymerized units according to scheme (2):
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: May 10, 2022
    Assignee: The University of North Dakota
    Inventors: Qianli Chu, Rahul Shahni
  • Compounds, compositions and methods for inhibiting a pathogen and/or modifying mucus
    Patent number: 11324773
    Abstract: Provided herein are compounds, compositions, and methods for modifying mucus, including modifying mucus using nitric oxide-releasing biopolymers (e.g., NO-releasing chitosan oligosaccharides). In some embodiments, a compound, composition, and/or method of the present invention modifies one or more properties of mucus to increase mucus clearance in a subject and/or prevents the growth or kills one or more pathogens present in mucus of a subject.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: May 10, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Katelyn Reighard
  • Method and system for using logarithm of power feedback for extremum seeking control
    Patent number: 11327448
    Abstract: The present disclosure provides a method and system for optimizing a control process. The method and system comprise using a sensor to generate a feedback signal that represents a measured performance index for an extremum seeking control (ESC) method and sending the feedback signal to an ESC conditioning circuit that applies a logarithmic transformation to the feedback signal to obtain a modified feedback signal. An ESC controller applies the modified feedback signal to the ESC method to generate an output value that is used to control an actuator to maximize the performance of a machine or process.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Mario A. Rotea
  • Atmospheric water harvesting system
    Patent number: 11326327
    Abstract: Disclosed herein are water harvesting networks. The harvesters allow extraction and collection of moisture from the atmosphere without requiring electrical energy inputs.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Guihua Yu, Fei Zhao, Xingyi Zhou
  • Object trapping device and object trapping device unit
    Patent number: 11325072
    Abstract: An object trapping device enables efficiently trapping a plurality of objects in a specific combination. Each of a first electrode pair (13), a second electrode pair (14), and a third electrode pair (15) in an electrode pair group (3) is applied with an individual AC voltage and traps an object by dielectrophoresis generated in accordance with the AC voltage that is applied.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 10, 2022
    Assignees: SHARP KABUSHIKI KAISHA, The University of Tokyo
    Inventors: Kunihiko Iizuka, Takeshi Mitsunaka, Yoshihisa Fujimoto, Teruo Fujii, Soo-Hyeon Kim
  • Small molecule inducers of autophagy
    Patent number: 11325898
    Abstract: Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 10, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang
  • Method for fabricating a hyperbolic metamaterial having a near-zero refractive index in the optical regime
    Patent number: 11329389
    Abstract: A method for fabricating a hyperbolic metamaterial coating having a near-zero refractive index is disclosed. The direction of propagating light changes by means of generating subwavelength structures that alter the coatings permittivity and permeability. The coating can be deposited on lenses or incorporated into optical devices. This type of metamaterial can be utilized to direct light towards sensors or to collect light efficiently.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: May 10, 2022
    Assignee: Board Of Regents, The University of Texas System
    Inventors: Nantakan Wongkasem, Andres Ochoa
  • Face mask
    Patent number: 11324974
    Abstract: Face mask devices, systems, and methods of use include a frame that holds a suitable filter material, including a face mask, over the user's face to form a seal and prevent unfiltered air from being inhaled through the nose or mouth of the user without first passing through the filter material. The frame is removably attached over the users face by, for example, adjustable straps. The frame may be adjustable in size to be suitable for use on user's having different facial sizes, shapes, and/or geometries.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: May 10, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Devin Kerry Hubbard, Nicole Lewis Wiley, Ethan John Smith
  • TELOMERASE-CONTAINING EXOSOMES FOR TREATMENT OF DISEASES ASSOCIATED WITH AGING AND AGE-RELATED ORGAN DYSFUNCTION
    Publication number: 20220136011
    Abstract: Provided herein are compositions of lipid-based nanoparticles, such as exosomes, that comprise a therapeutic anti-aging agent. Also provided are methods of using such compositions to treat a patient having an age-associated disorder. In particular, exosomes comprising a telomerase-encoding RNA are provided along with methods of their use in treating age-associated disorders.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 5, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventor: Raghu KALLURI