Abstract: Described herein are method, compositions and kits for prognosis of prostate cancer. The methods include determining the ratio of PCA3 and of a prostate-specific marker expression in a urine sample and correlating the value of the PCA3/prostate-specific marker ratio with the aggressiveness and mortality risk of prostate cancer in the subject. The method for prognosing prostate cancer in a sample of a patient includes assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of prostate-specific marker in the sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of prostate-specific marker; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value.
Type:
Grant
Filed:
April 13, 2016
Date of Patent:
April 24, 2018
Assignee:
Stichting Katholieke Universiteit, The University Medical Centre Nijmegen
Inventors:
Daphne Hessels, Gerald Verhaegh, Jack A. Schalken, J. Alfred Witjes
Abstract: This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed.
Type:
Grant
Filed:
December 18, 2015
Date of Patent:
April 24, 2018
Assignees:
Roche Molecular Systems, Inc., The University of North Carolina Chapel Hill
Inventors:
George Martin, Steven Soper, Makgorzata Witek, Jen Jen Yeh
Abstract: There is presented an optical apparatus comprising first and second photon pair sources configured to convert at least one pump light photon into a first and second correlated signal and idler photon pairs. In one example, the apparatus is configured to use one of the signal and idler photons from the first correlated photon pair for controlling the conversion of the pump light photon in the second photon pair source. The apparatus may configured such that, at least one of the signal and idler photons from the first correlated photon pair is output from the first photon pair source onto an optical path wherein at least one of the signal and idler photons from the second correlated photon pair is output from the second photon pair source onto the optical path. A method is also provided for outputting one or more photons using the optical apparatus.
Type:
Grant
Filed:
September 9, 2016
Date of Patent:
April 24, 2018
Assignee:
The University of Bristol
Inventors:
Terence Rudolph, Mark Thompson, Jonathan Matthews, Damien Bonneau
Abstract: A spatial distribution of cells or sub-cellular structures of a subject is quantified by receiving image data that includes a plurality of biomarkers and processing the image data to obtain a set of coordinates. Each coordinate denotes the location of a cell or sub-cellular structure represented by a biomarker or combination of biomarkers. The set of coordinates is processed into a two-dimensional symmetric matrix. Each element of the matrix indicates the frequency of a cell or sub-cellular structure represented by a first biomarker or combination of biomarkers being observed within an interaction distance of a cell or sub-cellular structure represented by a second biomarker or combination of biomarkers. A classifier assigns the subject to a group or category based on the matrix. A toxicity and/or efficacy of one or more interventions is assessed based on a comparison of the spatial distribution to one or more predetermined reference or control distributions.
Abstract: A method of analyzing an exosome is provided for detecting abnormality in a cell, including: (a) a step of preparing an exosome from a sample; (b) a step of bringing the exosome prepared in the step (a) into contact with a first antibody to a protein which exists on the surface of the exosome as an antigen and forming a first antibody-exosome complex; and (c) a step of measuring a zeta potential of the first antibody-exosome complex.
Type:
Grant
Filed:
February 23, 2015
Date of Patent:
April 24, 2018
Assignees:
The University of Tokyo, Nikon Corporation
Abstract: An extramedullary bone lengthener and use thereof that is an internal device that does not require nailing. The invention includes a telescoping plate that attaches to the upper and lower portions of the bone via screws; a small motor affixed on or within the plate. This motor, controlled remotely, will controllably lengthen the plate, thus lengthening the bone. The bone will be cut (osteotomy) then the plate will be applied to both ends and fixed to each end with screws. The motor will be controlled from outside by a remote control which will allow the plate to expand causing lengthening of the attached bone.
Type:
Grant
Filed:
May 29, 2015
Date of Patent:
April 24, 2018
Assignees:
Texas Tech University System, Board of Regents, The University of Texas System
Inventors:
Amr Abdelgawad, Noe Vargas-Hernandez, Khaled Emara, Mario E. Rodriguez
Abstract: In one aspect, nerve growth inhibition devices are described herein. In some embodiments, a nerve growth inhibition device described herein comprises a tube having a proximal end and a distal end. A matrix material is disposed in the tube, and the matrix material comprises one or more microchannels. The proximal end of the tube comprises an opening operable to receive nerve tissue, the distal end of the tube is sealed, and the microchannels of the matrix material extend from the proximal end of the tube toward the distal end of the tube.
Type:
Grant
Filed:
February 18, 2014
Date of Patent:
April 24, 2018
Assignee:
Board of Regents, The University of Texas System
Inventors:
Mario I. Romero-Ortega, Rafael Granja-Vasquez
Abstract: A method is provided for manipulating target tissue of a patient during a medical procedure. The method includes introducing a medical instrument system to a general site of target tissue. At least one characteristic of the target tissue is identified using an imaging device located in a working channel of the medical instrument system. The imaging device is removed from the working channel of the medical instrument system, and a medical instrument is inserted through the working channel of the medical instrument system. The target tissue is then manipulated using the medical instrument. A medical instrument system is also provided for manipulating target tissue of a patient during a medical procedure.
Type:
Grant
Filed:
November 3, 2010
Date of Patent:
April 24, 2018
Assignee:
The Trustees Of The University Of Pennsylvania
Abstract: A vertical-mode tunnel field-effect transistor (TFET) is provided with an oxide region that may be laterally positioned relative to a source region. The oxide region operates to reduce a tunneling effect in a tunnel region underlying a drain region, during an OFF-state of the TFET. The reduction in tunneling effect results in a reduction or elimination of a flow of OFF-state leakage current between the source region and the drain region. The TFET may have components made from group III-V compound materials.
Type:
Application
Filed:
December 6, 2017
Publication date:
April 19, 2018
Applicant:
The Board of Regents of The University of Texas System
Abstract: The invention provides molecule comprising: (i) a targeting moiety capable of directly or indirectly targeting to unwanted cells, and (ii) a further moiety that has a masked immune cell binding region so as to prevent binding of the further moiety to an immune cell, wherein the masked immune cell binding region is capable of being selectively unmasked when the molecule is in the vicinity of the unwanted cells so as to allow binding of the further moiety to an immune cell.
Abstract: Methods and systems are provided for managing patient or patient populations within a fully integrated captivated healthcare system, which includes creating a patient profile or a patient population profile; screening, assessing and treating a patient or patient population; reviewing, analyzing, and comparing a patient or patient population to a control group or pre-treatment patient profile or patient population profile; and prioritizing, scheduling, and care coordination for a patient or patient population as part of follow-up healthcare assessment and services included in the fully integrated healthcare delivery system. Part of the methods and system includes the ability to utilize comparative patient and patient population data to assess and control healthcare access, quality, and costs.
Type:
Application
Filed:
September 28, 2017
Publication date:
April 19, 2018
Applicant:
Board of Regents, The University of Texas System
Inventors:
Alexander H. VO, Stephen Smock, Anthony K. Williams, Ben Raimer, Owen J. Murray, Ryan S. Westberry, David L. Callender, Kelly Michael Jackson
Abstract: An object of the invention is to provide an agent for preventing or treating corneal disorders, such as corneal epithelial disorder, dry eye, and reduction in corneal sensitivity. This object is achieved by using angiopoietin-like protein 7 as an active ingredient.
Type:
Application
Filed:
April 15, 2016
Publication date:
April 19, 2018
Applicants:
The University of Tokyo, Senju Pharmaceutical Co., Ltd.
Abstract: Methods for standardized sequencing of nucleic acids and uses thereof are described. The identification of genetic information is becoming a key piece of information for the diagnosis and treatment of many diseases. In order to make such diagnostic tool readily available, it is desired that this identification be as efficient and as inexpensive as possible.
Type:
Grant
Filed:
November 25, 2013
Date of Patent:
April 17, 2018
Assignee:
The University of Toledo
Inventors:
James C. Willey, Thomas Blomquist, Erin Crawford
Abstract: The present disclosure provides wavelength discriminating imaging systems and methods that spatially separate (over different depths) the wavelength constituents of an image using a dispersive element or lens, such that this spectral information may be exploited and used. The wavelength constituents of an image are deconstructed and identified over different depths using the dispersive element or lens.
Type:
Grant
Filed:
September 15, 2015
Date of Patent:
April 17, 2018
Assignee:
The University of North Carolina at Charlotte
Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
Type:
Grant
Filed:
June 14, 2017
Date of Patent:
April 17, 2018
Assignees:
Research Triangle Institute, The University of North Carolina at Chapel Hill
Inventors:
Leah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
Abstract: A process of producing a yarn, ribbon or sheet that includes nanofibers in which the process includes forming a yarn, ribbon or sheet comprising nanofibers, and applying an enhancing agent comprising a polymer to the yarn, ribbon or sheet.
Type:
Grant
Filed:
July 7, 2016
Date of Patent:
April 17, 2018
Assignee:
Board of Regents, The University of Texas System
Inventors:
Mei Zhang, Shaoli Fang, Ray H. Baughman, Anvar A. Zakhidov, Kenneth Ross Atkinson, Ali E. Aliev, Sergey Li, Chris Williams
Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
Type:
Grant
Filed:
March 31, 2016
Date of Patent:
April 17, 2018
Assignee:
The University of British Columbia
Inventors:
Pieter R. Cullis, Igor V. Jigaltsev, James R. Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
Abstract: A narrowband transmission system includes a dielectric grating that defines a surface and includes a plurality of longitudinal members arranged along an axis. The longitudinal members are surrounded by a medium. The longitudinal members are made of a material that has an index of refraction that is greater than an index of refraction of the medium. The dielectric grating is configured to receive radiation at the surface. The system further includes a means for breaking a symmetry between the radiation and the dielectric grating such that the dielectric grating transmits a given wavelength band of the radiation through the dielectric grating while rejecting remainder of wavelengths embodied in the radiation.
Type:
Grant
Filed:
January 8, 2015
Date of Patent:
April 17, 2018
Assignee:
The Regents of The University of Michigan
Inventors:
Justin Foley, Jamie D. Phillips, Steve Young
Abstract: The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
Type:
Grant
Filed:
June 29, 2015
Date of Patent:
April 17, 2018
Assignees:
The United States of America, as represented by the Secretary, Department of Health and Human Services, The University of Dundee, Masaryk Memorial Cancer Institute
Inventors:
Curtis C. Harris, Kaori Fujita, Izumi Horikawa, Borivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane