Abstract: Provided herein are methods and compositions for the delivery of bioactive compounds to a cell, tissue, or physiological site. The compositions comprise delivery system complexes comprising liposomes encapsulating a biodegradable ionic precipitate having incorporated therein a bioactive compound and delivery system complexes comprising a biodegradable ionic precipitate ionically bound to a surrounding lipid bilayer, wherein the biodegradable ionic precipitate comprises a bioactive compound. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering the delivery system complexes comprising bioactive compounds that have therapeutic activity against the disease or unwanted condition to the subject.
Type:
Grant
Filed:
August 3, 2010
Date of Patent:
April 10, 2018
Assignee:
The University of North Carolina at Chapel Hill
Abstract: The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the oocyte. The methods of the invention may additionally comprise a preceding step of increasing the intracellular concentration of Ca2+ in the oocyte prior to reduction of the intracellular Zn2+ concentration. The invention further provides unfertilized oocytes activated by the disclosed methods and viable mammalian animals produced from unfertilized oocytes activated by the disclosed methods.
Type:
Application
Filed:
October 6, 2017
Publication date:
April 5, 2018
Applicant:
The Curators of The University of Missouri
Abstract: Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (“DVBM”). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.
Type:
Application
Filed:
August 24, 2016
Publication date:
April 5, 2018
Applicant:
The University of British Columbia
Inventors:
Andre Wild, Timothy Leaver, Robert James Taylor
Abstract: The present disclosure relates to a microdevice for capturing particles from a sample, a method for capturing particles from a sample, and a method for concentrating or separating particles using the same.
Type:
Application
Filed:
September 29, 2017
Publication date:
April 5, 2018
Applicants:
The University of Tokyo, ARKRAY, Inc.
Inventors:
Teruo Fujii, Soo Hyeon Kim, Hiroshi Ito
Abstract: A linear predictive coding apparatus includes: a linear predictive analysis part performing linear predictive analysis using a pseudo correlation function signal sequence obtained by performing inverse Fourier transform regarding the ?1-th power of absolute values of the frequency domain sample sequence corresponding to the time-series signal as a power spectrum to obtain coefficients transformable to linear predictive coefficients; an adaptation part adapting values ? for a plurality of plural candidates for coefficients transformable to linear predictive coefficients stored in a code book in a code book storing part and the coefficients transformable to linear predictive coefficients obtained by the linear predictive analysis part; and a coding part obtaining a linear predictive coefficient code corresponding to the coefficients transformable to linear predictive coefficients, using the plurality of candidates for coefficients transformable to linear predictive coefficients and the coefficients transformabl
Type:
Application
Filed:
April 11, 2016
Publication date:
April 5, 2018
Applicants:
NIPPON TELEGRAPH AND TELEPHONE CORPORATION, The University of Tokyo
Abstract: Biodegradable antimicrobial films are provided that are solid at room temperature and substantially liquefy in situ after implantation into a mammal, such as a human patient. Methods of using the films to cover a medical device, such as a breast implant, prior to insertion into a subject are also provided.
Type:
Application
Filed:
November 21, 2017
Publication date:
April 5, 2018
Applicant:
Board of Regents, The University of Texas System
Inventors:
Joel ROSENBLATT, Issam RAAD, Andrew P. DENNIS
Abstract: The invention relates to the use of microRNA 29 and precursors and mimics thereof for the modulation of tendon injury and the biomechanical properties of tendon. In particular, the invention derives from the finding that synthesis of type 1 collagen in tenocytes is less sensitive to miR-29 than is synthesis of type 3 collagen, thus enabling the balance between the collagen subtypes to be modulated in favor of type 1 collagen, mitigating reduction in biomechanical properties during healing.
Type:
Grant
Filed:
January 14, 2015
Date of Patent:
April 3, 2018
Assignee:
The University Court of the University of Glasgow
Inventors:
Derek Stewart Gilchrist, Neal Lindsay Millar
Abstract: An apparatus for the production of electrospun fibers using an electrospinning solution comprising: at least one threaded rod having an exterior surface and having a longitudinal axis oriented vertically, a grounded collector, an electrospinning solution dispenser feeding electrospinning solution to the exterior surface of the threaded rod, and a high voltage power supply.
Type:
Grant
Filed:
December 10, 2014
Date of Patent:
April 3, 2018
Assignee:
The University of Akron
Inventors:
George G. Chase, Kitchaporn Nartetamrongsutt, Hyeon Ung Shin
Abstract: The invention relates to the identification of antigens, including Mycobacterium sulphate assimilation pathway components such as CysD, for preventing and treating Mycobacterium infection, especially but not exclusively Mycobacterium tuberculosis infection; to expression systems including live Mycobacterium for expression of said antigens for prevention and treatment of said infection; and to use of said antigens and expression systems for prevention and treatment of said infection.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
April 3, 2018
Assignees:
The University of Sydney, Centenary Institute of Cancer Medicine and Cell Biology
Inventors:
James Anthony Triccas, Rachel Pinto-Nadanachandran, Warwick John Britton
Abstract: Novel devices and methods of capturing, controlling and preventing infestation of insects using microfabricated surfaces are provided. In particular, a mechanism of insect capture inspired by the microstructures of the leaf surfaces of plants and the key features of those surfaces with respect to the capture and control of pests have been determined and engineered into a variety of microfabricated surfaces capable of reproducing the effectiveness of these physical capture methods.
Type:
Grant
Filed:
September 19, 2016
Date of Patent:
April 3, 2018
Assignees:
The Regents of the University of California, The University of Kentucky Research Foundation
Inventors:
Catherine Loudon, Robert Corn, Megan Szyndler, Kenneth F. Haynes, Michael F. Potter
Abstract: An apparatus including an array of wells including a number of well channels, each well channel including a plurality of wells in the well channel, the wells containing a substance in use, one or more inlets for receiving respective fluids and channels coupled to the one or more inlets for selectively supplying one or more fluids to each well channel to thereby expose the substance to different conditions allowing a response of the substance to the conditions to be determined.
Type:
Grant
Filed:
September 13, 2012
Date of Patent:
April 3, 2018
Assignee:
The University of Queensland
Inventors:
Justin John Cooper-White, Drew Murray Titmarsh
Abstract: In one aspect, apparatuses for providing chemical gradients are described herein. In some embodiments, an apparatus described herein comprises a conduit having a first end and a second end, one or more microchannels disposed in the conduit and extending from the first end toward the second end, and a fiber coiled around the exterior of at least one microchannel, wherein the fiber comprises an active agent that is operable to diffuse into the interior of the microchannel.
Type:
Grant
Filed:
February 18, 2014
Date of Patent:
April 3, 2018
Assignee:
Board of Regents, The University of Texas System
Inventors:
Mario I. Romero-Ortega, Parisa Lotfi, Benjamin R. Johnston, Swarupnarayan Dash, Joselito Razal, Gordon Wallace
Abstract: Nucleic acid agents for reducing or removing infestations of the Varroa destructor mite are described. Compositions comprising the nucleic acid agents and methods for controlling mite infestations using the nucleic acid agents and compositions are also disclosed.
Type:
Grant
Filed:
July 2, 2014
Date of Patent:
April 3, 2018
Assignees:
The University Court of the University of Aberdeen, The Secretary of State for Enviroment Food and Rural Affairs
Inventors:
Alan Stuart Bowman, Ewan McInnes Campbell, Giles Elliott Budge
Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.
Type:
Grant
Filed:
October 24, 2016
Date of Patent:
April 3, 2018
Assignee:
Board of Regents, The University of Texas System
Abstract: Methods, systems, and computer readable media for detecting a compromised computing host are disclosed. According to one method, the method includes receiving one or more domain name system (DNS) non-existent domain (NX) messages associated with a computing host. The method also includes determining, using a host score associated with one or more unique DNS zones or domain names included in the one or more DNS NX messages, whether the computing host is compromised. The method further includes performing, in response to determining that the computing host is compromised, a mitigation action.
Type:
Grant
Filed:
March 5, 2014
Date of Patent:
April 3, 2018
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
Fabian Monrose, Teryl Taylor, Srinivas Krishnan, John McHugh
Abstract: Disclosed are microfluidic devices and systems for the desalination of water. The devices and systems can include an electrode configured to generate an electric field gradient in proximity to an intersection formed by the divergence of two microfluidic channels from an inlet channel. Under an applied bias and in the presence of a pressure driven flow of saltwater, the electric field gradient can preferentially direct ions in saltwater into one of the diverging microfluidic channels, while desalted water flows into second diverging channel. Also provided are methods of using the devices and systems described herein to decrease the salinity of water.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
April 3, 2018
Assignee:
Board of Regents, The University of Texas System
Inventors:
Richard A. Crooks, Kyle N. Knust, Robbyn K. Perdue
Abstract: A system and method for creating a controlled geyser well with sustained periodical production includes a cap (16) which prevents gas from entering a well tubing (14) while allowing liquid to enter and accumulate in the tubing, means for compressing the gas, and means for injecting the gas in the annulus so that the gas enters the bottom end of the well tubing (14), thereby creating a controlled geyser effect which blows out most of the liquid residing in the well tubing (14). The gas being compressed can be a produced gas or a supplied gas.
Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.
Type:
Grant
Filed:
September 19, 2017
Date of Patent:
April 3, 2018
Assignees:
The University of Nottingham, NewSouth Innovations PTY Limited
Abstract: A matching device includes a matching unit that judges, based on a first sequence of parameters ? corresponding to each of at least one time-series signal of a predetermined time length which makes up a first signal and a second sequence of the parameters ? corresponding to each of at least one time-series signal of the predetermined time length which makes up a second signal, the degree of match between the first signal and the second signal and/or whether or not the first signal and the second signal match with each other.
Type:
Application
Filed:
April 11, 2016
Publication date:
March 29, 2018
Applicants:
NIPPON TELEGRAPH AND TELEPHONE CORPORATION, The University of Tokyo