Patents Assigned to The University
  • Duplexed parvovirus vectors
    Patent number: 8784799
    Abstract: The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: July 22, 2014
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard Jude Samulski, Douglas M. McCarty
  • Dual-cure dental resins and adhesives with increased cure and color stability and low color
    Patent number: 8785514
    Abstract: Various embodiments of the present invention generally relate to a light-cure and dual-cure resin that have low color and is color stable over conventional light, self and dual-cured resins. Additionally, the light-cure resin has enhanced degree of cure over conventional light-cure resins. Finally, due to the low color and enhanced color stability of the dual-cure resins, their inherent property of having lower shrinkage stress as compared to light-cure resins can now be utilized in various dental applications and other resin applications.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: July 22, 2014
    Assignee: The Board of Regents of The University of Texas System
    Inventors: H. Ralph Rawls, Kyumin Whang, Nasser Barghi, Dong-Hoon Shin, Richard Plymale, Janice Plymale
  • Neural stem cells
    Patent number: 8785187
    Abstract: A homogenous, symmetrically dividing population of adherent neural stem cells is obtained from ES cells or foetal or adult brain isolates, using an activator of a signalling pathway downstream of a receptor of the EGF receptor family, optionally in combination with an activator of a signalling pathway downstream of an FGF receptor. The neural stem cell population is highly pure and retains the ability to differentiate into neurons after in excess of 100 passages.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: July 22, 2014
    Assignee: The University Court of the University of Edinburgh
    Inventors: Luciano Conti, Steven Michael Pollard, Austin Gerard Smith
  • Hierarchially porous carbon particles for electrochemical applications
    Patent number: 8784768
    Abstract: Hierarchically porous graphitic carbon particles are prepared by an aerosol process using a aqueous solution of a carbon precursor compound in which different sized particles or clusters of silicon oxide species are dispersed. The aerosol is heated to evaporate the solvent. The solid residue is carbonized and non-carbon species removed to obtain small porous particles of graphitic carbon. The interconnected, different size pores in the small carbon particles make them very useful as electrode materials in electrochemical devices, such as supercapacitors, in which efficient ion transport through the pores or the particles is required.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: July 22, 2014
    Assignees: GM Global Technology Operations LLC, The Regents of The University of California
    Inventors: Mei Cai, Yunfeng Lu, Zheng Chen
  • Low power media access control protocol
    Patent number: 8787389
    Abstract: A method of transmitting data from a transmitter to a receiver in an unsynchronized, ad-hoc, low-power, wireless network including: creating a packet including a header and data; and retransmitting the same created packet a plurality of times in succession.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: July 22, 2014
    Assignee: The University Court of the University of Edinburgh
    Inventors: Damal K. Arvind, Kai Juan Wong
  • Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same
    Patent number: 8785419
    Abstract: Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: July 22, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Ramachandran Murali, Mark I. Greene
  • Genetic diagnosis of hepatic steatosis
    Patent number: 8785128
    Abstract: Disclosed are methods of identifying a genetic variant in a person determined to have or be predisposed having a fatty liver by determining whether the person has PNPLA3-I148M. Also disclosed are methods of identifying a genetic variant in a person by determining whether the person has PNPLA3-I148M; and prescribing to the person a treatment to reduce liver fat or associated inflammation.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: July 22, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Helen H Hobbs, Jonathan C Cohen
  • Maintaining shale stability by pore plugging
    Patent number: 8783352
    Abstract: Compositions and methods for improving wellbores stability of a hydrocarbon bearing shale formation using nanoparticles to decrease swelling and plug pore throats.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: July 22, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Martin E. Chenevert, Mukul M. Sharma
  • antigenic composition
    Patent number: 8784831
    Abstract: The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: July 22, 2014
    Assignees: CSL Limited, The University of Melbourne
    Inventors: Eric Charles Reynolds, Nada Slakeski, Chao Guang Chen, Ian George Barr
  • Covered micro gel fiber
    Patent number: 8785195
    Abstract: A microfiber showing improved mechanical strength, which comprises a micro gel fiber consisting of collagen gel or the like covered with high strength hydrogel such as alginate gel.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: July 22, 2014
    Assignee: The University of Tokyo
    Inventors: Shoji Takeuchi, Hiroaki Onoe, Yukiko Matsunaga, Daisuke Kiriya, Riho Gojo, Midori Negishi
  • Water-soluble carbon nanotube compositions for drug delivery and medicinal applications
    Patent number: 8784866
    Abstract: Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 22, 2014
    Assignees: William Marsh Rice University, Board of Regents, The University of Texas System
    Inventors: James M. Tour, Rebecca Lucente-Schultz, Ashley Leonard, Dmitry V. Kosynkin, Brandi Katherine Price, Jared L. Hudson, Jodie L. Conyers, Jr., Valerie C. Moore, S. Ward Casscells, Jeffrey N. Myers, Zvonimir L. Milas, Kathy A. Mason, Luka Milas
  • Liposomal curcumin for treatment of diseases
    Patent number: 8784881
    Abstract: The present invention provides compositions and methods for the treatment of a human patient. The methods and compositions of the present invention include composition for the efficient loading of curcumin, comprising: an amount of a curcuminoid:liposome complex effective to load curcumin into the liposome, wherein the curcuminoids has between 2 to 9 weight percent of the total composition and the curcuminoids are natural or synthetic.
    Type: Grant
    Filed: December 1, 2007
    Date of Patent: July 22, 2014
    Assignees: Board of Regents, The University of Texas System, SignPath Pharma Inc.
    Inventors: Razelle Kurzrock, Lan Li, Kapil Mehta, Bharat Bhushan Aggarawal, Lawrence Helson
  • Diamond synthesis employing nanoparticle seeds
    Patent number: 8784766
    Abstract: Iron nanoparticles were employed to induce the synthesis of diamond on molybdenum, silicon, and quartz substrates. Diamond films were grown using conventional conditions for diamond synthesis by hot filament chemical vapor deposition, except that dispersed iron oxide nanoparticles replaced the seeding. This approach to diamond induction can be combined with dip pen nanolithography for the selective deposition of diamond and diamond patterning while avoiding surface damage associated to diamond-seeding methods.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: July 22, 2014
    Assignee: The University of Puerto Rico
    Inventors: Kishore Uppireddi, Gerardo Morell, Brad R. Weiner
  • Production of Cyanobacterial or Algal Biomass Using Chitin as a Nitrogen Source
    Publication number: 20140197098
    Abstract: A process of growing a culture of cyanobacteria or algae using chitin or chitosan as a source of nitrogen for photosynthetic growth is described. This process can be used to remove pollutants from nitrogen-deficient natural waters or wastewaters. Biomass that results from photosynthetic growth on chitin can be used, either as whole cells or the isolated components of the cells, for a large variety of commercial purposes.
    Type: Application
    Filed: February 14, 2014
    Publication date: July 17, 2014
    Applicant: The University of Montana
    Inventors: Carrine Blank, Nancy W. Hinman
  • METHODS OF FACILITATING NEURAL CELL SURVIVAL USING NON-PEPTIDE AND PEPTIDE BDNF NEUROTROPHIN MIMETICS
    Publication number: 20140200277
    Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
    Type: Application
    Filed: January 27, 2014
    Publication date: July 17, 2014
    Applicants: The University of North Carolina at Chapel Hill, The United States of America as represented by the Department of Veterans Affairs, The Regents of the University of California
    Inventors: Frank M. Longo, Stephen M. Massa
  • COMPOSITIONS AND METHODS FOR INHIBITING REDOX-SENSITIVE GTPASES
    Publication number: 20140200230
    Abstract: The invention provides compositions for inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, comprising an effective amount of a redox-sensitive purine compound and an effective amount of a redox agent. The invention further provides methods of inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, by administering compositions of the invention. Methods of screening for compounds that inhibit a redox-sensitive GTPase protein, including compounds that target and inhibit Rho or Rab family GTPases, are further provided.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 17, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventor: Jongyun Heo
  • Modified surfaces
    Patent number: 8778454
    Abstract: The invention provides a method for producing a modified surface (5) comprising: patterning a surface (7) by forming thereon a porous molecular network (9) defined by non-covalent interactions between constituent molecules; and depositing in said porous network (9) and on said patterned surface (11) molecules (13) so as to form a self-assembled monolayer (15), wherein both said patterning and said depositing are effected by contact with liquids.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: July 15, 2014
    Assignee: Universit Court of The University of St Andrews
    Inventors: Manfred Buck, Rafael Madueño, Christophe Silien, Minna Tuulia Räisänen
  • Molecular structure determination from NMR spectroscopy
    Patent number: 8779770
    Abstract: Methods for the determination of the molecular structures of compounds are disclosed, the methods comprising obtaining NMR spectroscopic measurements of compounds, determining internuclear distances from the NMR measurements, and inputting the distances to an algorithm to determine probable structures. Optionally, constraints may be added and the algorithm repeated. Usually, the methods do not require comparisons to databases of spectra during the generation of possible structures.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: July 15, 2014
    Assignee: The University of Bristol
    Inventors: Craig P. Butts, Jeremy Harvey
  • Procaspase 8-mediated disease targeting
    Patent number: 8778302
    Abstract: The invention provides compositions and method for delivering a therapeutic or diagnostic agent to a disease site in a mammal, the method comprising administering to the mammal a therapeutically or diagnostically effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises the therapeutic or diagnostic agent coupled to a Procaspase 8 polypeptide and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: July 15, 2014
    Assignee: The University of British Columbia
    Inventor: Isabella Tai
  • Field-effect transistor, semiconductor wafer, method for producing field-effect transistor and method for producing semiconductor wafer
    Patent number: 8779471
    Abstract: Provided is a field-effect transistor including a gate insulating layer, a first semiconductor crystal layer in contact with the gate insulating layer, and a second semiconductor crystal layer lattice-matching or pseudo lattice-matching the first semiconductor crystal layer. Here, the gate insulating layer, the first semiconductor crystal layer, and the second semiconductor crystal layer are arranged in the order of the gate insulating layer, the first semiconductor crystal layer, and the second semiconductor crystal layer, the first semiconductor crystal layer is made of Inx1Ga1-x1Asy1P1-y1 (0<x1?1, 0?y1?1), the second semiconductor crystal layer is made of Inx2Ga1-x2Asy2P1-y2 (0?x2?1, 0?y2?1, y2?y1), and the electron affinity Ea1 of the first semiconductor crystal layer is lower than the electron affinity Ea2 of the second semiconductor crystal layer.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: July 15, 2014
    Assignees: Sumitomo Chemical Company, Limited, The University of Tokyo, National Institute of Advanced Industrial Science and Technology
    Inventors: Masahiko Hata, Hisashi Yamada, Noboru Fukuhara, Shinichi Takagi, Mitsuru Takenaka, Masafumi Yokoyama, Tetsuji Yasuda, Yuji Urabe, Noriyuki Miyata, Taro Itatani, Hiroyuki Ishii