Abstract: Methods and compounds for treating cancer, dmg resistance and/or metastasis are described herein. These methods and compounds can inhibit the expression of aberrant TG2 expression and/or inhibit the binding of GTP to TG2, and thereby prevent the induction of epithelial to mesenchymal transition of cancer cells, and a stem cell-like phenotype.

Abstract: The present disclosure provides a method of monitoring a property of a sample, such as a nanoscopic property of the sample. The method comprises the steps of providing a quantum probe having a quantum state and exposing the quantum probe to the sample in a manner such that the property of the sample, in the proximity of the quantum probe, affects quantum coherence of the quantum probe. The method also comprises detecting a rate of quantum decoherence of the quantum probe to monitor the property of the sample. Further the present disclosure provides an apparatus for monitoring a property of a sample.

Abstract: Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility.

Abstract: A method for modelling a dataset includes a training phase, wherein the dataset is applied to a non-stationary Gaussian process kernel in order to optimize the values of a set of hyperparameters associated with the Gaussian process kernel, and an evaluation phase in which the dataset and Gaussian process kernel with optimized hyperparameters are used to generate model data. The evaluation phase includes a nearest neighbor selection step. The method may include generating a model at a selected resolution.

Abstract: The present invention relates to a biocompatible ceramic material comprising Sr, Mg or Ba doped Hardystonite (Ca2ZnSi2O7), and a method for its synthetic preparation. The present invention also relates to an implantable medical device comprising biocompatible doped Hardystonite, and a method for its production. The present invention further relates to a method for improving the long term stability of an implantable medical device and an implantable drug delivery device comprising doped Hardystonite. Further, the present invention relates to the use of comprising biocompatible doped Hardystonite in the regeneration or resurfacing of tissue.

Abstract: The present invention relates to polymer microgel beads having a polymeric matrix with nanomagnetic particles dispersed substantially uniformly therethrough, wherein a steric stabiliser is associated with the particles, the steric stabiliser being a polymeric material that (i) does not form part of the polymeric matrix of the beads, and (ii) comprises a steric stabilising polymeric segment and an anchoring polymeric segment, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the nanomagnetic particles and secures the stabiliser to the particles.

Abstract: The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin resonance (NMR) measurement sample (10), including—a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),—at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),—a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48a, 48b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically tr

Abstract: A plate puller device can include a head portion and extension rod portion. The device enables the fastener receiving member to be pulled against a bone surface before a head section of the fastener is advanced within the fastener receiving member into a locked position. The head portion can be positioned between the head section of the fastener and a surface of the fastener receiving member not adjacent to the bone surface. Also, a plate puller device can include a screwdriver, a grasper portion and a grasper sleeve. The grasper portion and grasper sleeve can be threadingly mated wherein rotation of the grasper sleeve forces a head portion of the grasper portion to grip the head section of the fastener to prevent the head section from advancing within the fastener receiving member.

Abstract: Screw driver-holder apparatuses, systems and methods are provided and can include a screw and a screwdriver. The screw can include a threaded screw body and a screw head, and the screw head can include a socket and a screw head surface surrounding the socket. The screwdriver can include a hollow sleeve with a longitudinal bore and a first end defining a screw engagement surface and a driving shaft positioned within the longitudinal bore of the hollow sleeve and rotatable relative to the hollow sleeve. The driving shaft can further include a first end extending beyond the first end of the hollow sleeve, a second end opposite the first end, and a stop restricting axial movement of the sleeve towards the second end of the driving shaft. The first end can include a protruding tip adapted for engaging the socket of the screw head.

Abstract: A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light source such that the output intensity varies as a function of a modulation signal at a modulation frequency. A detector receives light from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local oscillator receives the detector output and produces a demodulated output, insensitive to any phase difference between the modulation signal and the oscillator, indicative of blood volume as a function of time and/or blood composition. A number of demodulators may be provided to derive signals from multiple light sources of different wavelengths, or from an array of detectors. The plethysmograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part of the optical spectrum and may use polarizing filters.

Abstract: A counter-rotating axial flow fan with improved characteristics and reduced noise compared to the related art can be provided. Defining the number of front blades as N, the number of stationary blades as M, and the number of rear blades as P, and defining the maximum axial chord length of the front blades as Lf, the maximum axial chord length of the rear blades as Lr, the outside diameter of the front blades as Rf, and the outside diameter of the rear blades as Rr, the counter-rotating axial flow fan satisfies the following two relationships: N?P>M; and Lf/(Rf×?/N)?1.25 and/or Lr/(Rr×?/P)?0.83.

Abstract: This invention relates to an isolated, synthetic or recombinant peptide, wherein the peptide comprises the sequence: C K G K G A Xaa1 C R Xaa2 Xaa3 Xaa4 Y Xaa5 C C Xaa6 G Xaa7 C R Xaa8 Xaa9 R C SEQ ID NO: 1 wherein Xaa1, Xaa3, Xaa4, Xaa6, Xaa7 and Xaa8 are independently selected from serine and threonine; Xaa2 is selected from arginine and lysine; Xaa5 is selected from aspartic acid and glutamic acid; and Xaa9 is selected from glycine, alanine, valine, leucine and isoleucine.

Abstract: A wireless communication apparatus includes a wireless communication device for multiplexing communication channels according to a predetermined method for carrying out wireless communication with a terminal, and carrying out communication with the terminal; and a control device for providing a plurality of program executing environments corresponding to the respective communication channels to operate in parallel or a in multitask manner, wherein, in each of the program executing environment, a process for providing a virtual wireless communication device interface corresponding to a corresponding communication channel and for carrying out Media Access control for communication via the virtual wireless communication device interface is executed, and the control device causes only the program being executed in the program executing environment to carry out communication via a virtual wireless communication device interface provided by the program being executing in the program executing environment.

Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.

Abstract: Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may be adapted to contract from a first diameter to a second diameter that is less than the first diameter. The contraction of the cutting surface from the first diameter to the second diameter may define a tapered profile between the first diameter and the second diameter suitable for obtaining a tapered graft.

Abstract: Periodic material-based seismic isolation systems and methods are a new and innovative means to mitigate the potential damage to structures due to earthquakes or the like. The periodic materials are arranged in a periodic way in one, two and three directions, which are defined as one-dimensional (1D), two-dimensional (2D) and three dimensional (3D) periodic materials. With this periodic material, the pattern of the earthquake event energy can be completely obstructed or changed when it reaches the periodic foundation of the structural system. This may result in a total isolation of the foundation from the earthquake wave energy.

Abstract: Provided are methods of controlling the shape and surface chemistry of nanoparticles, particularly ferrite nanoparticles. Methods for preparing non-spherical ferrite nanoparticles, including nanocubes, nanobars, nanoplates, and nanoflowers, are described. Also provided are methods of functionalizing the surface of metal and metal oxide particles. The surface functionalization methods do not require the use of chemical linkers and/or additional reagents, and permit the facile conjugation of a range of molecules, including bioactive agents, to the surface of particles.

Abstract: Systems, methods, and devices relating to short range wireless communications. A host device wirelessly communicates with a user device. The transceiver on the host device is of a greater complexity than the transceiver on the user device. The host device performs a number of signal processing steps on data to be exchanged with the user device such that the complexity of the processing to be done by the user device is significantly reduced. This approach thereby reduces the complexity of the transceiver on the user device. The host device processing includes pre-channel equalization and pre-synchronization.

Abstract: Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis and uses thereof are provided.

Abstract: A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block copolymer film The method creates a well-ordered array of voids in the block copolymer film that is maintained over a large area. The nanopatterned block copolymer films can be used in a variety of different applications, including the fabrication of high density data storage media.