Patents Assigned to The University
  • Treatment with opioid antagonists and mTOR inhibitors
    Patent number: 8685995
    Abstract: Embodiments of the invention provide methods of treating a disorder or disease characterized by cellular proliferation and migration by co-administering a synergistically effective amount of an mTOR inhibitor and a ?-opioid receptor antagonist.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: April 1, 2014
    Assignee: The University of Chicago
    Inventors: Jonathan Moss, Patrick A. Singleton
  • Compositions and methods for reducing the risk of agent-induced liver toxicity
    Patent number: 8685956
    Abstract: The present disclosure relates generally to a pharmaceutical compositions and methods of reducing acetaminophen-induced liver toxicity. The disclosure includes pharmaceutical compositions including acetaminophen and one or more components selected from S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof. The disclosure also relates to methods of reducing acetaminophen-induced liver toxicity in a subject by administering or co-administering one or more of S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof, with acetaminophen to a subject.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: April 1, 2014
    Assignees: The Board of Trustees of The University of Illinois, The Board of Trustees of The Leland Stanford Junior University
    Inventors: Hong-Hsing Liu, Gary Allen Peltz, Guochun Liao, Timothy Alan Garrow
  • Miniaturized radio repeater
    Patent number: 8686920
    Abstract: A radio repeater system is provided that utilizes miniaturized antennas and a meta-material channel isolator. The radio repeater is comprised of: a receive antenna configured to receive a signal at a desired channel frequency; a transmit antenna configured to transmit the signal at the channel frequency; an amplifier electrically connected between the receive antenna and the transmit antenna; and an array of resonating circuits disposed spatially between the receive antenna and the transmit antenna. Each resonating circuit is designed to resonant at the channel frequency and thereby suppress propagation of surface waves between the antennas.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: April 1, 2014
    Assignee: The Regents of The University of Michigan
    Inventors: Kamal Sarabandi, Young Jun Song
  • Nanoparticle fabrication methods, systems, and materials
    Patent number: 8685461
    Abstract: Nanosized particles are molded from granules of organic substances in nano-scale molds. The nano-scale molds can be fabricated from non-wetting, low surface energy polymeric materials. The nanosized particles can be virtually any shape, are typically less than 500 micrometers in a broadest dimension, and can include pharmaceutical compositions, biologic drugs, drug compositions, organic materials, and the like.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: April 1, 2014
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ginger D. Rothrock, Benjamin W. Maynor
  • Rate-compatible protograph LDPC codes
    Patent number: 8689083
    Abstract: Digital communication coding methods resulting in rate-compatible low density parity-check (LDPC) codes built from protographs. Described digital coding methods start with a desired code rate and a selection of the numbers of variable nodes and check nodes to be used in the protograph. Constraints are set to satisfy a linear minimum distance growth property for the protograph. All possible edges in the graph are searched for the minimum iterative decoding threshold and the protograph with the lowest iterative decoding threshold is selected. Protographs designed in this manner are used in decode and forward relay channels.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: April 1, 2014
    Assignees: California Institute of Technology, Board of Regents, The University of Texas System
    Inventors: Thuy V. Nguyen, Aria Nosratinia, Dariush Divsalar
  • Open-and-close controllable odor compound release device and method of manufacture
    Patent number: 8685338
    Abstract: An odor compound release device includes a support that is deformed when an external stimulus is applied, and when the external stimulus is not applied, restored to its original state. A plurality of spaces are located in the support, have upper portions closed by the support, and are to be filled with odor compounds, wherein the upper portions are opened or closed by deformation or restoration of the support due to the application of the external stimulus. A member that is located in the support or on a surface of the support and applies the external stimulus to the support.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: April 1, 2014
    Assignees: Samsung Electronics Co., Ltd., The Rgegents of The University of California
    Inventors: Jong-jin Park, Sung-ho Jin, Kyu-hyun Im, Jong-min Kim
  • Highly selective sigma receptor ligands
    Patent number: 8686008
    Abstract: Compounds having the general formula II, III, or IV wherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: April 1, 2014
    Assignees: The University of Mississippi, L'Universite Catholique de Louvain
    Inventors: Christopher R. McCurdy, Christophe Mesangeau, Rae Reiko Matsumoto, Jacques Henri Poupaert, Bonnie Ann Avery, Ahmed Hassan Amin Abdelazeem
  • Diglycidic ether derivative therapeutics and methods for their use
    Patent number: 8686050
    Abstract: This invention provides compound having a structure of Formula I or Formula II Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: April 1, 2014
    Assignees: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Marianne D. Sadar, Nasrin R. Mawji, Jun Wang, Raymond J. Andersen, David E. Williams, Mike Leblanc
  • Combinatorial multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules
    Patent number: 8685755
    Abstract: A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 ?l in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: April 1, 2014
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Mauro Ferrari, Xuewu Liu, Ennio Tasciotti, Ali Bouamrani, Ye Hu
  • FORWARD-IMAGING OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEMS AND PROBES
    Publication number: 20140083970
    Abstract: Provided are forward-imaging optical coherence tomography (OCT) systems and probes.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 27, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventors: Karthik KUMAR, Jonathan C. CONDIT, Nathaniel J. KEMP, Thomas E. MILNER, Xiaojing ZHANG
  • Methods and Compositions for Heptameric Targeting Ligands
    Publication number: 20140086835
    Abstract: The present invention provides a self assembly molecule having an affinity for one or more target molecules, for use in formation of a heptameric complex, comprising: a) a monomer comprising a multimerization domain of Archaeal Sm1 (AF-Sm1) protein or SM-like ribonucleoprotein from other organisms, able to interact with other molecules of the same monomer comprising a multimerization domain of AF-Sm1 protein or SM-like ribonucleoprotein to self-assemble into a heptamer; and b) a target binding domain or peptide attached directly or via a linker to the monomer of (a). Also provided are heptamers comprising these self assembly molecules and methods for their use in therapy, imaging and diagnostics.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 27, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventor: Rihe Liu
  • Muscarinic Agonists as Enhancers of Working Memory and Cognitive Flexibility
    Publication number: 20140088119
    Abstract: Methods and compositions for treating a mental condition in a subject in need thereof, includes administering to a subject in need thereof an effective amount of a CDD-102A compound [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine], or a pharmaceutically acceptable salt or hydrate thereof pharmaceutically acceptable salt or hydrate thereof.
    Type: Application
    Filed: April 30, 2012
    Publication date: March 27, 2014
    Applicants: The Board of Trustees of the University of Illinois, The University of Toledo
    Inventors: William S. Messer, Michael Ragozzino
  • Methods For Endoscopic Mucosal Resection And Endoscopic Submucosal Dissection
    Publication number: 20140086866
    Abstract: In one aspect, methods for separating biological tissue are described herein. In some embodiments, a method for separating tissue comprises providing a first composition comprising a polymerizable material, providing a second composition comprising a polymerization initiator, disposing the first composition at a first site beneath a first tissue layer, disposing the second composition at the first site, polymerizing the polymerizable material at the first site, and separating the first tissue layer from a second tissue layer.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 27, 2014
    Applicant: Board Of Regents, The University of Texas System
    Inventors: Jian Yang, Minh-Tuan Richard Tran, Michael W. Palmer, Shou-Jiang Tang
  • METHODS AND COMPOSITIONS FOR PRODUCING VITAMIN K DEPENDENT PROTEINS
    Publication number: 20140087458
    Abstract: The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 27, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Darrel W. Stafford, Tao Li
  • Methods and compositions for the treatment of Huntington'S disease
    Patent number: 8679750
    Abstract: Methods and compositions for reducing expression of a mutant huntingtin (mHTT) protein in a cell are provided. Such methods include contacting the cell with an effective amount of a nucleic acid silencing agent targeting a differentiating polymorphism in RNA encoding the mHTT.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: March 25, 2014
    Assignee: The University of British Columbia
    Inventors: Michael Hayden, Jeffrey Carroll, Simon Warby
  • E-cadherin as a biomarker of gastroesophageal reflux disease
    Patent number: 8679766
    Abstract: The present invention provides methods of diagnosing and identifying subjects as having GERD comprising detecting E-cadherin fragments in a biological sample from the subject. The invention further provides methods for identifying subjects as having heartburn that is responsive to proton pump inhibitor therapy and subjects having an increased likelihood of a rapid relapse of GERD after reducing the dosage of PPIs or terminating PPI therapy. In addition, the present invention provides methods for monitoring the healing of erosive and nonerosive esophagitis of GERD without the need for esophagogastroduodenoscopy or esophagogastroduodenoscopy and biopsy, respectively.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: March 25, 2014
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Roy C. Orlando, Biljana Jovov, Nelia A. Tobey, Geraldine S. Orlando, Zorka Djukic
  • 1, 4-benzoxazine compounds and derivatives thereof as therapeutic drugs for the treatment of neurodegenerative conditions
    Patent number: 8680094
    Abstract: The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: March 25, 2014
    Assignees: Board of Regents, The University of Texas System, Southern Methodist University
    Inventors: Santosh R. D'Mello, Edward R. Biehl, Haribabu Ankati, Shashidhar Kumar Akubathini
  • Nanoencapsulation of isocyanates via aqueous media
    Patent number: 8680176
    Abstract: The present invention provides a nanocapsule of a blocked isocyanate encapsulated within a polymeric nanosphere. In one aspect, the polymeric nanosphere is functionalized. Free isocyanate functionality is released upon thermal annealing or UV exposure of the nanospheres containing the blocked isocyanate. This present invention also provides a novel method for encapsulating isocyanates in aqueous media. In one aspect, the method comprises miniemulsion polymerization. The thermally or UV deblocked isocyanate can be used as an active functional group for many potential applications.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: March 25, 2014
    Assignee: The University of Southern Mississippi
    Inventors: James W. Rawlins, Huaxiang Yang, Sharathkumar K. Mendon
  • Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
    Patent number: 8679749
    Abstract: Polynucleotides encoding variant polypeptides of DsRed are provided herein. The DsRed variants have increased bacterial expression, reduced aggregation, increased solubility, shifted emission spectra or increased brightness relative to a wild-type DsRed.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: March 25, 2014
    Assignee: The University of Chicago
    Inventors: Benjamin S. Glick, Daniel E. Strongin, Robert Keenan, Rita L. Strack, Dibyendu Bhattacharyya
  • Hybrid nanostructure array
    Patent number: 8680574
    Abstract: A hybrid nanostructure array having a substrate and two types of nanostructures, including a set of first nanostructures extending from the substrate and a set of second nanostructures interspersed among the first nanostructures. The first and second nanostructures comprise structures having nanoscale proportions in two dimensions and being elongate in the third dimension. For example, the nanostructures can be nanotubes, nanowires, nanorods, nanocolumns, and/or nanofibers. Also disclosed is a hybrid nanoparticle array using two different types of nanoparticles that have all three dimensions in the nanoscale. The two types of nanostructures or nanoparticles can vary in composition, shape, or size.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: March 25, 2014
    Assignee: The Regents of The University of Michigan
    Inventor: Anastasios John Hart