Abstract: The invention provides an ultrasound imaging and medical instrument guiding apparatus, a system for acquiring and displaying ultrasound medical images and methods of using the apparatus and system in epidural anesthetic procedure. The apparatus comprises a hand-held ultrasound probe, configured to acquire a volumetric dataset representing a 3-D depiction of a volume; a mount to which the probe is mounted; and a medical instrument guide positionable relative to the ultrasound probe and configured to receive and guide a medical instrument along a propagation axis to a target in a body such that the target and the propagation axis intersect in the volume. The volumetric dataset acquired by the hand-held ultrasound probe comprises information about the medical instrument's position relative to the target in three dimensions and the medical instrument guide has a visible mark from which the depth of the medical instrument insertion along the propagation axis can be referenced.

Abstract: The object of the present invention is to provide a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme. The present invention provides a compound represented by formula (I) and a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme, which comprises the compound.

Abstract: The invention relates to perhexiline, or a pharmaceutically acceptable salt thereof, for use in the treatment of hypertrophic cardiomyopathy, as well as to a method of treating HCM, which comprises administering to an animal in need thereof an effective amount of perhexiline, or a pharmaceutically acceptable salt thereof, to treat said HCM. The invention further relates to a treatment programme for treating HCM, which involves the co-use or co-administration of perhexiline with one or more other compounds that are advantageous in treating HCM or the symptoms thereof.

Abstract: The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity.

Abstract: Provided are analysis cassettes that include removable sealing layers and deformable connector layers that place various channels, chambers, and reservoirs on the cassettes into fluid communication with one another. The cassettes are suitable for use in self-contained, immunoassay devices that may be operated in an automated fashion. Also disclosed are methods for analyzing samples by use of the disclosed cassettes.

Abstract: The present invention relates to the preparation of hyperpolarized 89Y. Hyperpolarized 89Y may be used as nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) agents for sensitive detection and imaging.

Abstract: An electromagnetic system having a reaction mass with a field winding embedded therein, a base plate having an inner annular surface and an outer annular surface, and an armature winding coupled to at least a portion of the inner annular surface and at least a portion of the outer annular surface of an upper end portion of the base plate. In operation, directing an electric current in at least one of the field winding and the armature winding causes at least one of the base plate and the reaction mass to move relative to each other. The electromagnetic system can be used for seismic exploration and vibroseis applications, among other uses.

Abstract: A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.

Abstract: During lung injury, p53 expression increases, inducing plasminogen activator inhibitor-1 (PAI-1) while inhibiting expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR), resulting in apoptosis of lung epithelial cells (LECs). In the bleomycin lung injury model, p53 and PAI-1 are induced while uPA and uPAR are inhibited. A 20 residue peptide DGIWKASFTTFTVTKYWFYR termed PP-1 (the Cav-1 scaffolding domain) or peptide NYHYLESSMTALYTLGH, termed PP-2, protected LECs from bleomycin-induced apoptosis in vitro and in vivo and prevented subsequent pulmonary fibrosis by attenuating lung epitheilial damage. Pharmaceutical compositions, peptide multimers and deliverable polypeptides comprising the above peptides are dislcosed.

Abstract: A method of optimizing parametric gain in a nonlinear optical crystal that in response to application of a pump beam generates through a parametric generation process signal and idler beams, wherein the signal beam is non-collinear with the pump beam and the signal beam is subject to absorption due to the nonlinear material, the method involving shaping the pump beam to have an elliptical cross section, wherein the method further involves determining the width w of the pump beam depending on the absorption co-efficient of the optical crystal.

Abstract: There is provided a mesh system (2) comprising a mesh sheet (4) and a reinforcing member in the form of a cable (6) coupled to one side of the sheet (4). The cable (6) is coupled to the mesh by wire ties (7). Two lengths (6a) and (6b) of the cable (6) may overlap or be disposed in a mutually adjacent manner. The lengths (6a) and (6b) may be coupled together by U-bolts or crimped bands (9), which may also engage the underlying sheet (4).

Abstract: The present invention includes compositions and methods for using an anionic surfactant composition for treating a hydrocarbon-bearing formation or a reservoir, of formula (I): wherein R1 and R2 are identical or different and may independently be alkyl, alkenyl, alkynyl, alkylene, aryl, propylene oxide, ethylene oxide or hydrogen groups in a straight or branched chain with 16 or more carbon atoms, X1 and X2 are identical or different and are selected from the group consisting of phosphate, sulfate, carboxylate, sulfonate or other suitable anionic groups, S is a spacer group selected from short or long arkyl, alkenyl, alkynyl, alkylene, stilbene, polyethers, and other suitable aliphatic or aromatic groups comprising 2 to 12 carbon atoms.

Abstract: Display units which can be arranged to form a single arrayed display system, thereby allowing the display of much larger images than can be shown on a single display. Each display unit can include an image display, a communication mechanism, such as a network interface card or wireless interface card, and an image display module, such as a video card and an image processor. Each display module can be configured to selectively process and display portions of large digital images.

Abstract: A method and device are disclosed for inducing mechanical stress in a cellular sample to evaluate mechanotransduction in the cellular sample. In one embodiment, the mechanical stress is induced by generating a microcavitation bubble in the cellular sample using a pulsed energy. The microcavitation bubble creates a microtsunami, which provides a transient, impulsive mechanical stress on the cellular sample, forming a gradient of effects at distances away from the microcavitation bubble.

Abstract: The resolution of conventional imaging devices is restricted by the diffraction limit ‘Perfect’ imaging devices which can achieve a resolution beyond the diffraction limit have been considered impossible to implement. However, the present disclosure provides an imaging device which can achieve improved resolution beyond the diffraction limit and which can be implemented in practice. Said imaging device comprises: a. a lens having a refractive index that varies according to a predetermined refractive index profile; b. a source; c. an outlet for decoupling waves from the device; and d. a reflector provided around the lens, the source and the outlet, wherein the reflector and the refractive index profile of the lens are together arranged to direct waves transmitted in any of a plurality of directions from the source to the outlet.

Abstract: The present application is related to compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders associated with p75 expression, such as degradation or dysfunction of cells expressing p75 in a mammal by administering an effective amount of such compounds.

Abstract: An electronic device includes a silicon carbide layer having a first conductivity type and a main junction adjacent a surface of the silicon carbide layer, and a junction termination region at the surface of the silicon carbide layer adjacent the main junction. Charge in the junction termination region decreases with lateral distance from the main junction, and a maximum charge in the junction termination region may be less than about 2×1014 cm?2.

Abstract: A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample.

Abstract: Compositions and methods for the diagnosis and prevention of B. abortus infection are provided.