Abstract: The subject invention provides compositions and methods for inhibiting the growth and/or proliferation of cancer cells. The subject invention also provides methods for treating cancer in a subject in need of such treatment by administering a composition described herein. The subject invention can be used to inhibit cancer cell growth by exposing the cells to a composition. The subject invention further provides cancer treatments that may be used in combination with surgery, chemotherapy, and/or radiation therapy.

Abstract: A device for in-situ measuring settleability of activated sludge includes a sample chamber, an ultrasonic time domain reflectometer, a magnetic stirrer, an ultrasonic probe, a sample inlet, a sample outlet, and a stagnant zone. The sample chamber is configured to hold an activated sludge sample, and the ultrasonic time domain reflectometer is configured to measure the settling characteristics of the activated sludge. The stagnant zone is disposed in the sample chamber. The sample inlet and the sample outlet communicate with the sample chamber. The stagnant zone includes a top part, a sidewall, and a bottom part. The sample inlet is connected to the top part of the stagnant zone. The sample outlet is connected to the sidewall of the stagnant zone. The magnetic stirrer is disposed at the bottom part of the stagnant zone. The ultrasonic probe is disposed on the top part of the stagnant zone.

Abstract: The present invention relates to a method for preparing a core-gap-shell nanoparticle having an average height of 0.1 nm to 10 nm, in which a Raman-active material is disposed between a core and a shell, and more specifically, to a method for preparing a core-gap-shell nanoparticle, which comprises introducing a shell made of an alloy of a second metal and a third metal, on the core particles of the first metal, the surface of which is modified with a Raman-active material; selectively removing the second metal by treating with a second metal etchant, followed by dealloying; the core-gap-shell nanoparticle prepared by the above method comprising a Raman-active material disposed in the gap, and uses of the core-gap-shell nanoparticle for biosensing and/or bioimaging.

Abstract: Disclosed herein is a method for piecewise linear scaling of a geometry atlas, the method including generating min-max normalized depth values and generating geometry atlases by scaling the depth values so as to correspond to the gradients of multiple linear intervals.

Abstract: A dependent closed pressure vessel is fluidly coupled to an independent closed pressure vessel. A pressure sensor monitors pressure in the vessels to generate raw pressure measurement data. A flow meter monitors multidirectional rate of flow of fluid between the vessels and the volume of fluid flowing from the independent closed pressure vessel to generate raw rate of flow and raw volume measurement data. A pressure/flow regulator valve adjusts pressure in the dependent closed pressure vessel in response to a pressure set point signal generated in response to the raw pressure data, adjusts the rate of flow of fluid between the vessels in response to a rate of flow set point signal generated in response to the raw rate of flow data, and adjusts the rate of flow of fluid between the vessels in response to a volume set point signal generated in response to the raw volume data.

Abstract: The present invention relates to a network transmission optimization device for a graph-type blockchain, at least comprising a transaction processing module, a node managing module, and a route managing module, wherein the transaction processing module performs compression on a transaction, and transaction data obtained through the compression are transmitted among different clusters through a routing node selected by the route managing module from at least one cluster, wherein the at least one cluster is obtained through dividing plural nodes by the node managing module. The network transmission optimization method provides a transaction coding scheme to the existing graph-type blockchain systems, and improve use efficiency of network bandwidth by means of parallelized broadcast. The structured network topology of the network transmission optimization method is made to address delay among nodes, and is adaptive to dynamic joining and exit of nodes, thereby improving network transmission efficiency.

Abstract: A tactile sensor, a surgical instrument, and a method of making the tactile sensor are provided. In one embodiment, a tactile sensor includes a first electrode, a second electrode, and an intermediate layer between the first electrode and the second electrode. The intermediate layer includes a polyurethane-zinc oxide nanocomposite. Further, one or both of the first and second electrodes may include a silver conductive paste.

Abstract: Vibration suppression handle structures for high-vibration handheld machines (e.g., jackhammers, hydraulic breakers, hammer drills, soil compactors, etc.) are provided that offer improved vibration suppression. The provided handle structures include a handle that is connected to vibration suppression systems that include an arrangement of support members and resilient members for improved vibration suppression over typical high-vibration handled machines while remaining a compact design. A portion of the support members are arranged as X-shaped support structures. In at least some embodiments, the handle structures include a system by which to adjust a stiffness, and therefore vibration suppression, of the vibration suppression systems. Jackhammers are further provided that include the provided vibration suppression handle structures.

Abstract: Disclosed herein are electrospun fibrous matrix and its production method. The method mainly includes the steps of, mixing a first polymer and a drug to form a first mixture, and sonicating the first mixture until a plurality of microparticles are formed with the drug encapsulated therein; and mixing the plurality of microparticles with a second polymer to form a second mixture, subjecting the second mixture to a wet electrospinning process to form the electrospun fibrous matrix. The thus-produced electrospun fibrous matrix is characterized by having a plurality of first and second fibrils woven together, in which each second fibril has a plurality of drug-encapsulated microparticles independently integrated and disposed along the longitudinal direction of the second fibril. Also disclosed herein is a method for treating a wound of a subject. The method includes applying the present electrospun fibrous matrix to the wound of the subject.

Abstract: The present invention provides a method of treating frontotemporal dementia, or a childhood genetic neurodegenerative disease such as Ataxia Telangiectasia (A-T), or neurodegenerative diseases such as Parkinson's disease or neuropsychiatric diseases comprising administering to a subject in need thereof an effective amount of chlorite composition, such as sodium chlorite. The present invention thereby provides a method of modulating the immune system in a subject in need thereof. Described herein are methods of administration and treatment.

Abstract: The present application discloses a self-powered sensing method and sensing device for spheroidal robot, which belongs to the technical field of robot attitude sensing. The design feature is structure of the spheroidal robot, comprises: a spheroidal object (1) and 26 electrode groups (2); the spheroidal object (1) includes 18 regular octagonal surfaces, 8 regular hexagonal surfaces and 24 quadrilateral surfaces; the electrode group (2) is arranged on each regular octagonal surface and each regular hexagonal surface; the electrode group (2) includes a first outer layer semicircular ring electrode (2-1), a second outer layer semicircular ring electrode (2-2) and an inner ring electrode (2-3). The present invention aims to provide a self-powered sensing method and sensing device for spheroidal robot to sense the posture of the spheroidal robot.

Abstract: Methods for the treatment of cutaneous vascular conditions and cutaneous proliferative conditions are provided. The methods employ topical administration of mammalian target of rapamycin (mTOR) inhibitors such as sirolimus (rapamycin) and everolimus. Conditions treatable by the disclosed methods include venolymphatic malformations, acne, acne rosacea, periorificial dermatitis, acne vulgaris, cutaneous capillary malformation-arteriovenous malformation (CM-AVM) syndrome, RASopathies, Langerhans cell histiocytosis, non-Langerhans cell histiocytosis, scars, hypertrophic or keloidal scars, Proteus syndrome, PIK3CA-related overgrowth spectrum (PROS), PTEN hamartoma tumor syndromes, cutaneous malignancies and tumors associated with PI3K/AKT/mTOR mutations, keratodermas, acanthosis nigricans, Birt-Hogg-Dube syndrome, Brooke-Speigler syndrome, cylindromas, and epidermal nevi.

Abstract: The present disclosure relates to a multiple LAMP primer set, a detection method, and a kit for simultaneously detecting multiple pathogens, belonging to the field of microbial detection. The multiple pathogens are Vibrio harveyi, Vibrio parahaemolyticus, and Singapore grouper iridovirus. The detection primer set is as shown in SEQ ID NO.: 1-18. The present disclosure further provides an application, a kit, and a detection method of multiple LAMP primer sets in simultaneously detecting multiple pathogens. The method of the present disclosure can simultaneously detect whether a sample contains the Vibrio harveyi, the Vibrio parahaemolyticus, or the Singapore grouper iridovirus, has strong specificity, convenient and simple operation, and has no need for an expensive instrument and equipment.

Abstract: A variety of superhyrdophobic porous materials are provided including a covalent organic framework having a plurality of perfluoroalkyl or perfluorheteroalkyl moieties covalently attached thereto. The materials can include a polymeric foam matrix made of a three-dimensional network of polymer fibers, and the covalent organic framework can be made encasing at least a portion of the polymer fibers. The covalent organic framework can be intertwined within the polymeric foam matrix such that the covalent organic framework encasing the portion of the polymer fibers is stable to mechanical compression of the polymeric foam matrix. Surfaces and other articles are provided including the superhyrdophobic porous materials are also provided, as are methods of making the superhyrdophobic porous materials, and methods of use for oil recovery among other things.

Abstract: A gas turbine engine with a closed loop working fluid cycle.

Abstract: The present invention relates to a vehicle data communication and interaction system and a construction method thereof. The system includes a first test vehicle placed in an environment perception test platform and a second test vehicle placed in a rotating hub test platform, an intelligent-electronic control unit (i-ECU), a vehicle control unit (VCU), and a vehicle bottom electronic control unit that are communicatively connected with each other are mounted on each of the first test vehicle and the second test vehicle, and a sensor is further mounted on the first test vehicle. The first test vehicle is communicatively connected to the second test vehicle, and specifically, the VCU or a network gateway is connected via the sensor, to implement a communication connection between the two test vehicles.

Abstract: A supercritical fluid chromatograph includes a liquid sender that supplies a mobile phase including a supercritical fluid to a supply flow path, first and second back pressure regulators that are respectively provided in first and second flow paths into which a path from the liquid sender branches and an analysis column provided at a position farther upstream than the first back pressure regulator in the first flow path. An analysis assistance device includes a storage a receiver, a first calculator, and a presenter.

Abstract: Disclosed herein are compositions and methods for treating obesity involving satiation gut peptide administration to the mouth of a subject for a predetermined dose and frequency. In other embodiments, materials and methods of treating certain psychological disorders are disclosed involving satiation gut peptides. In exemplary embodiments, the satiation gut peptide pertains to PYY.

Abstract: Chimeric antigen receptors (CARs) including an scFv binding to coronavirus spike protein (S309 scFv), nucleic acids encoding the CARs, vectors including nucleic acids encoding the CARs, and cells expressing the CARs are provided. Methods of treating a subject with coronavirus are also provided, including administering to the subject a modified immune cell expressing a disclosed CAR.

Abstract: Described herein relates to a system and method for the prevention of a malicious attack on a computing resource. In embodiments, the system may comprise the following, including but not limited to: (1) at least one processor; and (2) computer memory storing instructions that, when executed by the at least one processor, cause the at least one processor to perform operations including: (a) observing traffic flow of a network; (b) altering a SYN threshold value based on the observing of the traffic flow of the network; (c) comparing a metric of SYN messages submitted to the network; and (d) based on the comparison of the metric of SYN messages submitted, selectively engaging corrective action with the network.