Abstract: The present disclosure generally relates to pharmaceutical compositions and combinations comprising an androgen receptor N-terminal domain inhibitor or an inhibitor and a second therapeutically active agent, such as an CDK4/6 inhibitor, a Pin1 inhibitor (inhibitor of peptidyl-prolyl cis/trans isomerases), or an antiandrogen. In particular, the present disclosure relates to pharmaceutical compositions and combinations useful for treatment of various cancers, for example breast cancer and prostate cancer. Further, the present disclosure relates administering an androgen receptor N-terminal domain inhibitor in combination with radiation therapy for treatment of various cancers.

Abstract: A surgical cutting tool for keyhole surgery comprises: a handle 2 at a proximal end of the tool; an elongate member 4 extending from the handle to a distal end of the tool; and a saw 6 at the distal end of the tool, the saw being supported by the elongate member 4. The elongate member 4 has a length allowing for insertion of the saw 6 into the body by a distance of at least 150 mm. The tool is arranged for insertion of the saw 6 into the body during keyhole surgery; and the saw 6 is able to cut bone when pressed against the bone.

Abstract: A surface emitting laser element formed of a group III nitride semiconductor, comprising: a first clad layer of a first conductivity type; a first guide layer of the first conductivity type having a photonic crystal layer formed on the first clad layer including voids disposed having two-dimensional periodicity in a surface parallel to the layer and a first embedding layer formed on the photonic crystal layer; a second embedding layer formed on the first embedding layer by crystal growth; an active layer formed on the second embedding layer; a second guide layer formed on the active layer; and a second clad layer of a second conductivity type formed on the second guide layer, the second conductivity type being a conductivity type opposite to the first conductivity type. The first embedding layer has a surface including pits disposed at surface positions corresponding to the voids.

Abstract: Methods of inducing or controlling particle motion in suspensions and colloids are described. In one aspect, a method of inducing particle motion in a suspension comprises contacting the suspension with a gas phase to establish at least one interface between the gas phase and continuous phase of the suspension. One or more gases of the gas phase are transferred across the interface to provide a solute gradient in the continuous phase, the solute gradient inducing motion of the suspended particles.

Abstract: Provided is a two-stage reverse-torque bent screw orientation tool. An existing bent screw orientation technology has the technical problems of large friction resistance, difficult control of a borehole track, a low drilling speed and the like, and restricts economic, safe and long-acting development of oil and gas. In order to solve the above problems, the two-stage reverse-torque bent screw orientation tool is invented and composed of a first-stage clutch mechanism and a second-stage clutch mechanism, and the first-stage clutch mechanism and the second-stage clutch mechanism are both composed of a battery, a battery compartment, a pressure sensor, an electromagnetic valve, a body, a plug, a piston, an outer tooth cylinder, an inner tooth cylinder, a transmission cylinder, a connecting cylinder, a bearing, a limiting cylinder, a lower joint, a thrust bearing, a battery compartment, a circuit board, a cover plate and the like.

Abstract: The invention provides methods for identifying biomarkers in a patient's microbiota to predict a patient's response to a predetermined diet to promote weight loss and methods of promoting weight loss in the patient by optimizing the patient's diet in accordance with the biomarkers identified in the patient's gut microbiota. The methods of the invention can also be used to manage or maintain weight, i.e., prevent or inhibit weight gain, in a patient who is of normal weight or is overweight or obese.

Abstract: A LUS robotic surgical system is trainable by a surgeon to automatically move a LUS probe in a desired fashion upon command so that the surgeon does not have to do so manually during a minimally invasive surgical procedure. A sequence of 2D ultrasound image slices captured by the LUS probe according to stored instructions are processable into a 3D ultrasound computer model of an anatomic structure, which may be displayed as a 3D or 2D overlay to a camera view or in a PIP as selected by the surgeon or programmed to assist the surgeon in inspecting an anatomic structure for abnormalities. Virtual fixtures are definable so as to assist the surgeon in accurately guiding a tool to a target on the displayed ultrasound image.

Abstract: Methods for creating a conductive feature in a dielectric material are provided. In an embodiment, such a method comprises irradiating a region of a dielectric material having a resistivity of at least 108 W cm with a focused ion beam, the irradiated region corresponding to a conductive feature embedded in the dielectric material, the conductive feature having a conductivity greater than that of the dielectric material; and forming one or more contact pads of a conductive material in electrical communication with the conductive feature, the one or more contact pads configured to apply a voltage across the conductive feature using a voltage source.

Abstract: The invention includes methods and compositions for the treatment and prevention of a disease or condition resulting from dysregulation of USB1 and resulting expression of downstream miRNAs. In one preferred embodiment, the invention may include inhibiting the expression or activity of USB1 resulting in the downregulation of downstream miRNA expression. In alternative embodiments, the invention includes methods and compositions for the treatment and prevention of a disease or condition resulting from dysregulation of miRNAs downstream of USB1, namely through the inhibition of PAPD5 and/or PAPD7, resulting in the upregulation of said downstream miRNA expression.

Abstract: Provided herein are sequences of Plasmodium spp. liver stage exported proteins as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against malaria using the expression constructs provided herein.

Abstract: An agricultural management system includes an array of IoT sensors located across an area, and a set of wireless portal devices located across the area. The wireless portal devices are in communication with the IoT sensors. A drone, which includes an imaging device, is in communication with the wireless portal devices. A monitoring device gathers and analyzes information from the wireless portal devices using generative adversarial networks (GANs). The monitoring device communicates results of the analysis to an agricultural resource such as the drone to improve productivity.

Abstract: The present disclosure relates generally to an osteo-tissue graft capable of promoting bone tissue growth and regeneration, comprising at least one self-assemble peptide and mesenchymal stem cells (MSCs) in accordance with the present invention and a method of preparing such an osteo-tissue graft. The grafts are suitable for treatment of bone disorder or damages through tissue engineering, cellular replacement therapies as well as other applications.

Abstract: A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

Abstract: The present disclosure provides an apparatus for cylindrical convolutional neural network operation, and an apparatus and method for object recognition and viewpoint estimation using the same. The present disclosure uses a cylindrical convolutional network to recognize objects in the image and to determine the viewpoint, which cylindrical convolutional network performs a convolution operation while sliding the input image in the direction of rotation of the cylindrical kernel and extracts a plurality of view-specific feature vectors according to angular unit intervals, to identify and recognize objects, as well as to determine the viewpoint from which the objects were photographed.

Abstract: Disclosed is a fast self-adaptive rotary plug-in underwater force-bearing connector, which comprises a plug part and a socket part, wherein the plug part comprises a plug housing, a pin arranged in the plug housing, and a push-pull sleeve, a rotary sleeve, a front retaining ring, a ratchet lock nut and a rear retaining ring arranged outside the plug housing; the socket part comprises a socket housing and a jack arranged in the socket housing; the pin and the jack cooperate to connect the plug part and the socket part. The fast self-adaptive rotary plug-in underwater force-bearing connector of the present application can work under the working condition of a large tensile force and has a high reliability.

Abstract: A soil-climate intelligent type determination method for rice target yield and nitrogen fertilizer amount includes steps: construct a basic database; obtain historical weather data from the region where the rice planting area is to be determined over the past few years, and obtain real-time GFS weather data of the region in a predicted year; obtain 100 m×100 m grid sampling point soil data and a rice field vector layer of rice planting area to be determined; obtain at least three years of nitrogen fertilizer gradient test data of the rice planting area to be determined, rice variety information and management data of each farmer in each year; obtain accurate weather data of the prediction year; prepare soil data of 100 m×100 m plot-scale; localize genetic parameters of the rice growth model DSSAT; and run the localized DSSAT model to predict the plot-scale target yield and recommend the nitrogen application amount.

Abstract: The present invention relates to the technical field of train power supply and operation control, and provides a three-rail power supply control system for an electrical railway train. Power supply rails in the system are divided into a first power supply rail, a second power supply rail, and a third power supply rail, wherein the first power supply rail, the second power supply rail, and a running rail constitute a three-phase AC power supply loop, and the third power supply rail and the running rail constitute a DC power supply loop. An AC-DC-AC variable voltage variable frequency device supplies power to a train traction motor by means of the three-phase AC power supply loop and current collectors. Frequency modulation and voltage regulation power supply is conducted by means of the AC-DC-AC variable voltage variable frequency device on the ground to achieve train driving and operation control.

Abstract: A functional structure which can suppress functional degradation of a functional material to achieve longer life, which can save resources without complicated replacement operations, and which, used for example as a catalyst, exhibits excellent catalytic activity. The functional structure includes supports each having a porous structure and including a zeolite-type compound, and at least one functional material present in the supports and including a metal element (M), in which each of the supports has channels communicating with one another, the functional material is present at least in the channel of each of the supports, and the metal element (M) having constituted the functional material is partially substituted with an element having constituted the supports.

Abstract: The present disclosure relates to the structure of a micro light-emitting device and an alignment substrate. The light-emitting device according to one embodiment includes an inclined side surface having a three-dimensional shape. The inclined side surface is formed to protrude from one surface of the micro light-emitting device, has magnetism, and includes two different electrodes formed in one direction. In this case, among the two electrodes, one electrode may be formed on a mesa portion, and the other electrode may be formed on the inclined side surface.