Abstract: The present disclosure includes exosomal protein biomarkers for differential diagnosis of idiopathic pulmonary fibrosis including a five-protein signature determined using mass spectrometry-based proteiomic analysis of plasma extracellular vesicles (EVs) for differential diagnosis of idiopathic pulmonary fibrosis.

Abstract: A power supply circuit that outputs an electric power input from a vibration-driven energy harvesting element to an external load includes a rectifying circuit that rectifies an alternating current power input from the vibration-driven energy harvesting element; a first capacitor that accumulates a power output from the rectifying circuit; a chopper circuit that has a switching element controlling a chopper timing and has an input terminal connected to the first capacitor; and a control signal generation unit that supplies a control signal to the switching element, wherein: the control signal generation unit generates the control signal without referring to a voltage of the first capacitor.

Abstract: In a heat exchanger, each of a plurality of heat exchange members includes: a flat pipe; and a heat transfer plate integrated with the flat pipe along a longitudinal direction of the flat pipe. A width direction of each of the flat pipes intersects with a direction in which the plurality of heat exchange members are arranged side by side. Each of the heat transfer plates includes an extending portion extending outward in the width direction of each of the flat pipes from at least one of one end of a corresponding one of the flat pipes in the width direction and another end of the corresponding one of the flat pipes in the width direction. Each of the flat pipes has one or more flat pipe bent portions, each forming a groove extending along the longitudinal direction of the flat pipes.

Abstract: Functionally graded graphene materials, methods of making and uses thereof are described.

Abstract: A dental implant adapted for implanting within a jaw bone, the implant comprising a horizontally-oriented body having a length extending in the mesial-distal direction of the jaw bone, the body having a threaded cavity dimensioned for receiving a prosthetic abutment, and wherein the cavity comprises an opening that is located wholly within a buccolingual width of the body.

Abstract: Methods for treating ovarian cancer comprising: administering to a patient and effective amount of a cannabis extract comprising CBD, wherein preferably, the cannabis extract is administered via a mucosal formulation.

Abstract: The present disclosure relates to sealed isocyanate resin compositions. The resin compositions may be used for additive manufacturing. One embodiment of the invention includes a photopolymerizable resin for additive manufacturing, the resin comprising: a blocked isocyanate; at least one monomer or oligomer; and a multifunctional nucleophile.

Abstract: The present disclosure presents aerial communication systems and methods. One such system comprises an unmanned aerial vehicle platform and a communication component integrated with the unmanned aerial vehicle platform, wherein the communication component is configured to establish an Air to Air (A2A) communication channel with a remote directional antenna that is integrated with a remote unmanned aerial vehicle platform. The system further includes a computing component integrated with the unmanned aerial vehicle platform, wherein the computing component is configured to determine an optimal heading angle for transmission of communication signals from a directional antenna to the remote directional antenna in an unknown communication environment from received signal strength indicator (RSSI) information obtained from the remote directional antenna. Other systems and methods are also disclosed.

Abstract: A method for treating a noncancerous gynecological disorder comprising: administering to a patient and effective amount of composition comprising a cannabis extract comprising cannabidiol (CBD), wherein the composition is preferably administered in a mucosal form, such as intravaginally.

Abstract: A safety management system to prevent unauthorized use, accident, resale, theft, and so forth of a flying object. The safety management system includes changing, at a motor controller, a power feeding amount to each drive unit based on an instruction from a main control unit, an authentication information storage unit which records registered identification information for performing operator authentication, an authentication accepting unit which accepts an input of input identification information, an operator authentication unit which performs operator authentication of an operator of the flying object based on the input identification information and the registered identification information, and a safety managing unit connected between a power source of the flying object and the motor controller of the flying object. The safety managing unit includes a switch which controls electrical connection between the motor controller and the power source based on the result of the operator authentication.

Abstract: An electric signal transmission device including an electrode 11, disposed to be opposed to an electrogenic cell, and for sending and receiving electric signals to and from the electrogenic cell via the electrode 11.

Abstract: The present disclosure addresses IBD from the standpoint of inhibiting or ablating pathogenic mucosal stem cells cloned from defined regions of disease in the gastrointestinal tract. In the case of Crohn's disease, for example, isolation of those stem cells according to the methods of the present disclosure reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition.

Abstract: It is an object of the present invention to provide a conjugate of a duocarmycin derivative and a biotin-modified dimer, which is useful for pretargeting methods. According to the present invention, a compound represented by the following formula (1) or formula (2) is provided: wherein R1 and R2 each independently represent a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group; one of R3, R4, and R5 represents —O-L7-(Xaa)m-L6-N3, and the remaining two each independently represent a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group; X represents a reactive group; L6 and L7 each independently represent a divalent linking group; Xaa represents an amino acid residue; m represents an integer of 2 to 10; and Me represents a methyl group.

Abstract: Provided herein is technology relating to measuring temperature and particularly, but not exclusively, to devices, methods, systems, and kits for doing measuring temperature at high resolution, e.g., in living organisms.

Abstract: The present disclosure is directed to antibodies that bind to DC-HIL on the surface of myeloid-derived suppressor cells, and thus antagonize the T cell suppressor function of these cells, as well as their use in diagnosing and treating cancers such as melanoma.

Abstract: The present disclosure provides compounds of the formula: wherein the variables are defined herein. The present disclosure also provides methods of imaging Zn2+ within granules in cells, such as pancreatic ?-, ?-, and ?-cells. The present disclosure also provides methods of sorting cells comprising the use of the compounds of the present disclosure.

Abstract: Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

Abstract: A radio therapy system includes a first x-ray source. The first x-ray source is configured to produce first x-ray photons in a first energy range suitable for imaging and project the first x-ray photons onto an area designated for imaging. The system includes a second x-ray source configured to produce second x-ray photons in a second energy range higher energy than the first energy range, produce third x-ray photons in a third energy range higher energy than the first energy range, project the second x-ray photons onto the area designated for imaging, and project the third x-ray photons onto an area designated for treatment. The system includes an analytical portion configured to collect and combine data to create a composite output including at least one image, the combining based in part on a spectral analysis.