Abstract: A microfluidic sensor includes a microchannel that includes a reaction site with a reagent and a sample inlet. A liquid substance is received at the sample inlet and travels by capillary action to the reaction site. A temperature sensor measures a temperature as a result of a reaction between the reagent and a chemical in the liquid substance. A controller is communicatively connected to the temperature sensor, receives the temperature measured by the temperature sensor, and derives a concentration of the chemical in the liquid substance from the temperature.

Abstract: This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity thr the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

Abstract: A system for imaging a gamma source includes a pixelated Compton scattering layer, for Compton scattering of gamma photons emitted by the gamma source, and a non-pixelated full-energy detector for detecting at least a portion of Compton scattered gamma photons geometrically encoded by a coded aperture positioned between the pixelated Compton scattering layer and the full-energy detector at a distance from the pixelated Compton scattering layer. A method for imaging a gamma source includes (a) detecting coincidence events, each including Compton scattering in a pixelated Compton scattering layer, and transmission to a non-pixelated full-energy detector of a Compton scattered gamma photon transmitted through a coded aperture located at a distance from the pixelated Compton scattering layer, and (b) determining an image of the gamma source from the detection of the coincidence events.

Abstract: Lyophilized polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions and kits supplying the compositions.

Abstract: A true random number generator (TRNG) uses sources of uncertainty found within graphics processing units (GPUs) together with signal processing techniques, for example histogram equalization, to obtain maximum entropy.

Abstract: Systems and methods for magnetic resonance analysis and imaging are provided. IN particular, pulse sequences for DWI, APT, and MRS analysis and imaging are provided which rely on an RF excitation pulse for the signal of interest, followed by one or more refocusing pulses and acquisition steps, based on the type of imaging.

Abstract: The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.

Abstract: A continuously variable valve lift device with improved lift amount change accuracy includes a rocker arm causing an engine valve to perform an opening/closing operation with a cam of a cam shaft, and an engine valve lift amount change mechanism. The mechanism has a control shaft which has an eccentric circular disc cam, a control arm which swings about the eccentric circular disc cam and having a cam contact portion in contact with a first cam and a first aim, second biasing means for biasing the cam contact portion against the first cam, a second cam portion of a free-form surface shape contacting with the second arm and the rocker arm, a cam member supported so as to be capable of turning around the shall main body, and a link arm with both ends supported so as to be capable of turning by the first arm and the second arm.

Abstract: Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF.

Abstract: A method for detecting H2S produced by a microorganism comprising providing a thiazine dye to a culture medium; culturing a microorganism in the culture medium; and detecting H2S produced by the microorganism by determining a colour change of the culture medium from an interaction of the thiazine dye with H2S present in the culture medium.

Abstract: A thin film comprising a layer of dielectric material having electrically conductive inclusions, wherein the thin film has a first reflectivity due to surface plasmon resonance, and wherein the thin film is configured to provide one or more selected regions having a second reflectivity due to surface plasmon resonance.

Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.

Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.

Abstract: Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor.

Abstract: Use of an algal for biodiesel fuel selected for growing strain of production, the genus Desmodesmus wherein said strain was under high nutrient conditions and is characterized as having a determined fatty by acid nuclear methyl ester content of 2.6% magnetic resonance analysis, nitrogen content of 11.3% and a carbon content of 46.3%. Given the growth and elemental composition of this strain t the instant algal strain is of particular use as a biomass source for biofuel lipids and/or biodiesel fuel production.

Abstract: The disclosure relates to the extraction and detection of pathogens using carbohydrate-functionalized biosensors. Immobilized carbohydrate moieties on the biosensor provide a means for non-specific binding of a plurality of target analytes. When a sample containing the target analyte is applied or otherwise transported to the biosensor detection surface, non-specific binding interactions between the carbohydrate moiety and the analyte immobilize/retain the analyte at the detection surface. The carbohydrate moiety is a stable binding pair member that allows on-sensor rinsing of a sample to enhance detection of an analyte in the sample. Specific analyte identification can be achieved with an analyte probe having a detection moiety and a binding pair member specific to the target analyte of interest.

Abstract: The present invention relates to a method and device for quantizing voice signals in a band-selective manner. A voice decoding method may include inversely quantizing voice parameter information produced from a selectively quantized voice band and performing inverse transform on the basis of the inversely quantized voice parameter information. Thus, according to the present invention, coding/decoding efficiency in voice coding/decoding may be increased by selectively coding/decoding important information.

Abstract: Compounds and methods for treating or preventing a neurodegenerative disease, disorder or condition associated with the overall activity of hsp90 but not with the ATPase activity of hsp90, including peripheral neuropathy, such as peripheral neuropathy caused by chemotherapy or diabetes, disorders 5 of the central nervous system, such as Alzheimer's disease and Parkinsons disease, and motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), in a subject are provided.

Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of blood-brain barrier disorder comprising fluoxetine as an active ingredient. More particularly, fluoxetine inhibits the expressions of matrix metalloproteinase(MMP)-2, MMP-9, and MMP-12, which are reported to be related to blood-brain barrier (BBB) disruption and inflammatory reaction after spinal cord injury, specifically inhibits the activations of MMP-2 and MMP-9, inhibits the decomposition of ZO-1, the most representative tight junction protein, so as to maintain tight junction between endothelial cells and to protect blood-brain barrier thereby, inhibits the increase of blood-brain barrier permeability, and inhibits the expressions of chemoattractants of blood cells, such as CXCL-1, CXCL-2, CCL-2, CCL-3 and CCL-4 so as to reduce inflow of blood into spinal cord and recover exercise function which has been deteriorated by spinal cord injury.

Abstract: To image various soft tissues in the body using pulsed laser optical excitation delivered through a multi-mode optical fiber to create photoacoustic impulses, and then image the generated photoacoustic impulses with an acoustic detector array, a probe includes either a mirror and an acoustic lens or a special acoustic lens of variable focal length and magnification that can operate in a liquid environment that is aberration-corrected to a sufficient degree that high resolution images can be obtained with lateral as well as depth resolution.