Patents Assigned to The Upjohn Company
  • Process for preparing particle board
    Patent number: 4428897
    Abstract: Particle boards are currently prepared by treating the particles (e.g. wood chips) with a binder comprising an organic polyisocyanate and, optionally, a release agent and then subjecting the treated particles to a molding process involving heat and pressure. The resulting particle board will generally release well from the caul plates of the press after forming. However, it has been found that the ease of release is enhanced, particularly where the wood particles in the board are derived from hardwood, by utilizing a metal selected from magnesium and zinc in the metallic surfaces of the caul plates or platens which come into contact with the particle board during the application of heat and pressure.
    Type: Grant
    Filed: December 23, 1982
    Date of Patent: January 31, 1984
    Assignee: The Upjohn Company
    Inventors: Steven B. Lowenkron, Richard A. Prather, Howard R. Steele
  • Composition of matter and process
    Patent number: 4427776
    Abstract: Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus, antibiotic U-64,815 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: January 24, 1984
    Assignee: The Upjohn Company
    Inventors: Howard A. Whaley, William C. Snyder, John C. Greenfield, John H. Coats
  • Reduced A ring-.DELTA..sup.9(11) -corticoids
    Patent number: 4427591
    Abstract: 17.alpha.-Acyloxy-5.beta.-pregnanes (I) and 17.alpha.-acyloxy-5.alpha.-pregnanes (IV) have an excellent activity split providing high topical anti-inflammatory activity with very low systemic side effects.
    Type: Grant
    Filed: September 3, 1981
    Date of Patent: January 24, 1984
    Assignee: The Upjohn Company
    Inventors: Donald E. Ayer, Carl A. Schlagel
  • Process for making phosphorus derivatives of aminothiomethylcarbamates
    Patent number: 4426335
    Abstract: This invention pertains to novel processes for preparing phosphorus derivatives of aminothiomethylcarbamates known to be useful as pesticides. The processes use products prepared by a novel method which reacts disulfides of various amides of phosphoric acids with chlorine or bromine. Such sulfenyl halide products are advantageous and obtained in unexpected yields. Therefore, the method is also unobvious. When the novel sulfenyl bromides of this invention are intermediates unexpected yields of pesticides are obtained.
    Type: Grant
    Filed: May 14, 1982
    Date of Patent: January 17, 1984
    Assignee: The Upjohn Company
    Inventor: Clifford E. Sacks
  • Compositions and process
    Patent number: 4425208
    Abstract: The photopolymerization of ethylenically unsaturated compounds is effected using a combination of an aromatic ketone photosensitizer and a tetrasubstituted urea (e.g. N,N,N',N'-tetramethylurea) or N,N-disubstituted acid amide. Storage stable liquid photoinitiator compositions comprising an aromatic ketone sensitizer (e.g. benzophenone) and a tetrasubstituted urea (e.g. N,N,N',N'-tetramethylurea) are also disclosed. The use of the tetrasubstituted urea or N,N-disubstituted amide possesses advantages (storage stability, lack of discoloration on curing) over photosensitizers such as Michler's ketone which have been used previously in combination with aromatic ketone photosensitizers.
    Type: Grant
    Filed: August 6, 1981
    Date of Patent: January 10, 1984
    Assignee: The Upjohn Company
    Inventor: Anthony F. Jacobine
  • Composition of matter and process
    Patent number: 4425429
    Abstract: The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids.
    Type: Grant
    Filed: July 24, 1981
    Date of Patent: January 10, 1984
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha
  • 2-Decarboxy-2-tetrazolyl-PGI.sub.2 compounds
    Patent number: 4424350
    Abstract: The present invention relates to 2-decarboxy-2-tetrazolyl-PGI.sub.2 amides, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: January 3, 1984
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Process for making phosphorus derivatives of aminothiomethylcarbamates
    Patent number: 4424368
    Abstract: This invention pertains to novel processes for preparing phosphorus derivatives of aminothiomethylcarbamates using as intermediates corresponding phosphorus derivatives of aminothiocarbamic halides. The carbamates are useful as pesticides against insects, mites, and nematodes. Two processes for preparing the corresponding intermediates are described. One preparation generally reacts an appropriate N-chlorothiophosphoramide with N-methylcarbamoyl halide. The other preparation generally reacts an N-chlorothiomethylcarbamoyl halide with an appropriate phosphoramide. The intermediate will react with various alcohols to produce the desired carbamates in the process of the invention.
    Type: Grant
    Filed: June 18, 1982
    Date of Patent: January 3, 1984
    Assignee: The Upjohn Company
    Inventor: Stephen J. Nelson
  • 1,2,8,8a-Cyclopropa?c!benzo?1,2,-b:-4,3-b'!dipyrrol-4(5H)-ones
    Patent number: 4424365
    Abstract: Novel antibacterially active compound, 1,2,8,8a-cyclopropa?c!benzo?1,2-b:-4,3-b'!dipyrrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: January 3, 1984
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Gastric cytoprotection with heterocyclic sulfonamides
    Patent number: 4424227
    Abstract: The present invention provides a method for gastrointestinal cytoprotection using a class of heterocyclic sulfonamides.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: January 3, 1984
    Assignee: The Upjohn Company
    Inventor: Andre Robert
  • Preparation of an intermediate for N-(methylsulfonyl)-1,2,8,8a-cyclopropa[c][1,2-b:-4,3-b']dipyrol-4(5H)-on e
    Patent number: 4423230
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.Included is a process for the preparation of an intermediate compound of the formula ##STR1## wherein R.sub.2, R.sub.3 and R.sub.4 are as defined hereinafter.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Composition of matter and process
    Patent number: 4423229
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[ c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Benzothiazole derivatives
    Patent number: 4423223
    Abstract: Novel compounds of the formula ##STR1## wherein X and Y are the same or different and are hydrogen, fluora, chloro, bromo, alkyl of one to six carbon atoms, inclusive, alkoxy of one to six carbon atoms, inclusive, nitro, cyano, amino, trifluoromethyl, ##STR2## wherein R.sub.1 is alkyl of one to six carbon atoms, inclusive, ##STR3## wherein R.sub.2 and R.sub.3 are the same or different and are hydrogen or alkyl of one to three carbon atoms inclusive, or CO.sub.2 Q where Q is alkyl of one to six carbon atoms, inclusive, hydrogen or a physiologically acceptable metal or amine cation; and R is hydrogen, alkyl of one to eight carbon atoms, inclusive, --CH.sub.2).sub.m phenyl wherein m is 0, 1 or 2 or (CH.sub.2).sub.n NR.sub.4 R.sub.5 wherein n is 1 or 2, and R.sub.4 and R.sub.
    Type: Grant
    Filed: June 2, 1980
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventors: Charles M. Hall, John B. Wright
  • Radioenzymatic assay of catecholamines
    Patent number: 4423144
    Abstract: A new radioenzymatic assay for catecholamines utilizing the catechol-O-methyl transferase transfer of a methyl group from a labeled methyl donor to the catecholamines followed by isolation of the O-methylated(H)catecholamine and the subsequent measurement of radioactivity.
    Type: Grant
    Filed: September 2, 1981
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventors: Garland A. Johnson, Jacob D. Peuler
  • Amorphous copolyamide from lactam, dicarboxylic acid and bisimidazoline
    Patent number: 4423204
    Abstract: Novel amorphous copolyamides are provided which are the product of reaction of (A) a lactam, (B) a bisimidazoline, and (C) a dicarboxylic acid, wherein the proportions of reactants based on 100 mole percent are from about 43 to about 82 mole percent of lactam (A) and the remaining 18 to 57 mole percent divided between said (B) and said (C) in substantially equimolar proportions.The copolyamides are characterized by better resistance to elevated temperatures than 100 percent polycaprolactam polyamides but at the same time are easily molded because of their amorphous character.
    Type: Grant
    Filed: September 2, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventors: Edward A. Barsa, Kemal Onder
  • Composition of matter and process
    Patent number: 4423146
    Abstract: The subject invention concerns a novel fermentation process for making the useful steroid intermediate 24-nor-1,4-choladiene-3,22-dione (I). Compound (I) can be converted to valuable corticoids by known methods.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha
  • Nucleosides and process
    Patent number: 4423212
    Abstract: Novel 5,6-dihydro-syn(s)-triazine nucleosides and nucleotides and a novel process for preparing the same. The novel nucleosides and nucleotides are disclosed as active in vitro and/or in vivo against susceptible DNA viruses.
    Type: Grant
    Filed: December 18, 1980
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Harvey I. Skulnick
  • Process for preparing N-(methyl-sulfonyl)-1,2,8,8a-cyclopropa[c]benzo[1,2-b:4,3-b']dipyrrol-4( 5H)-one
    Patent number: 4423228
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Process and intermediates for preparing 6'-methylspectinomycin and analogs thereof
    Patent number: 4420623
    Abstract: A method for the preparation of 6'-methylspectinomycin and analogs thereof. Additionally provides novel intermediates utilized in said method.
    Type: Grant
    Filed: March 17, 1982
    Date of Patent: December 13, 1983
    Assignee: The Upjohn Company
    Inventor: David R. White
  • Tomato plant
    Patent number: PP5171
    Abstract: A new and distinct variety of a hybrid tomato plant substantially as herein shown and described, characterized as to novelty when compared to Flora-Dade, Tempo and Walter, the most similar cultivars to it, by uniform crop characteristics, low grading loss, high yield, large fruit, low percentage of fruit ripening defects and multiple disease resistance and tolerance.
    Type: Grant
    Filed: January 20, 1982
    Date of Patent: January 3, 1984
    Assignee: The Upjohn Company
    Inventor: Carroll G. Briggs